Carotid body chemoreflex mediates intermittent hypoxia-induced oxidative stress in the adrenal medulla

Advances in Experimental Medicine and Biology

Volumn 860, Issue , 2015, Pages 195-199

  Kumar, Ganesh K ^a   Peng, Ying Jie ^a   Nanduri, Jayasri ^a   Prabhakar, Nanduri R ^a  

^a University of Chicago   (United States)

Author keywords

Carotid body ablation; Hypoxia inducible factors; Pro oxidant and anti oxidant; Reactive oxygen species; Sleep disordered breathing

Indexed keywords

ACONITATE HYDRATASE; ADRENALIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MANGANESE SUPEROXIDE DISMUTASE; NORADRENALIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; HIF1A PROTEIN, RAT;

ADRENAL MEDULLA; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID BODY CHEMORECEPTOR; CATECHOLAMINE UPTAKE; CHEMORECEPTOR CELL; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; CRYOCOAGULATION; CYTOSOL; DOWN REGULATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENE EXPRESSION REGULATION; INTERMITTENT HYPOXIA; MALE; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SLEEP DISORDERED BREATHING; SPLANCHNIC NERVE; UPREGULATION; ANIMAL; ANOXIA; CAROTID BODY; METABOLISM; PHYSIOLOGY; REFLEX; SPRAGUE DAWLEY RAT;

GLOMUS; RATTUS;

ADRENAL MEDULLA; ANIMALS; ANOXIA; CAROTID BODY; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REFLEX;

EID: 84940046732     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-18440-1_21     Document Type: Article

References (7)

1. Carreau A, El Hafny-Rahbi B, Matejuk A et al (2011) Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia. J Cell Mol Med 15:1239–1253
2. Gardner PR (2002) Aconitase sensitive target and measure of superoxide. Methods Enzymol 349:9–23
3. Kumar GK, Rai V, Sharma SD et al (2006) Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress. J Physiol 575:229–239
4. Kuri BA, Khan SA, Chan SA et al (2007) Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C. J Physiol 584:313–319
5. Peng YJ, Yuan G, Khan S et al (2014) Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats. J Physiol 592:3841–3858
6. Prabhakar NR, Kumar GK, Nanduri J et al (2007) ROS signaling in systemic and cellular responses to chronic intermittent hypoxia. Antioxid Redox Signal 9:1397–1403
7. Verna A, Roumy M, Leitner LM (1975) Loss of chemoreceptive properties of the rabbit carotid body after destruction of the glomus cells. Brain Res 100:13–23