Analyses of drugs stored at home by elderly patients with chronic heart failure

Clinical Research in Cardiology

Volumn 104, Issue 4, 2015, Pages 320-327

  Ewen, Sebastian ^a   Baumgarten, Tanja ^a   Rettig Ewen, Volker ^b   Mahfoud, Felix ^a   Griese Mammen, Nina ^c   Schulz, Martin ^c   Böhm, Michael ^a   Laufs, Ulrich ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Schwemlinger Gemeinschaftspraxis   (Germany)

^c ABDA Bundesvereinigung Deutscher Apothekerverbande   (Germany)

Author keywords

Chronic heart failure; Drugs at home; Elderly; Healthcare costs; Medicines management

Indexed keywords

CARDIOVASCULAR AGENT; NON PRESCRIPTION DRUG;

CHRONIC DISEASE; FEMALE; GERMANY; HEART FAILURE; HUMAN; MALE; MEDICATION COMPLIANCE; MIDDLE AGED; POLYPHARMACY; SELF MEDICATION; STATISTICS AND NUMERICAL DATA; UTILIZATION;

CARDIOVASCULAR AGENTS; CHRONIC DISEASE; FEMALE; GERMANY; HEART FAILURE; HUMANS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; NONPRESCRIPTION DRUGS; POLYPHARMACY; SELF MEDICATION;

EID: 84940007560     PISSN: 18610684     EISSN: 18610692     Source Type: Journal    
DOI: 10.1007/s00392-014-0783-2     Document Type: Article

References (44)

1. Roger VL, Go AS, Lloyd-Jones DM et al (2012) Heart disease and stroke statistics–2012 update: a report from the American Heart Association. Circulation 125(1):e2–e220. doi:10.1161/CIR.0b013e31823ac046
2. McMurray JJ, Adamopoulos S, Anker SD et al (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 33(14):1787–1847. doi:10.1093/eurheartj/ehs104
3. Mosterd A, Hoes AW (2007) Clinical epidemiology of heart failure. Heart 93(9):1137–1146. doi:10.1136/hrt.2003.025270
4. Fitzgerald AA, Powers JD, Ho PM et al (2011) Impact of medication non-adherence on hospitalizations and mortality in heart failure. J Card Fail 17(8):664–669. doi:10.1016/j.cardfail.2011.04.011
5. De Geest S, Sabate E (2003) Adherence to long-term therapies: evidence for action. Eur J Cardiovasc Nurs 2(4):323
6. Laufs U, Rettig-Ewen V, Böhm M (2011) Strategies to improve drug adherence. Eur Heart J 32(3):264–268. doi:10.1093/eurheartj/ehq297
7. Baroletti S, Dell’Orfano H (2010) Medication adherence in cardiovascular disease. Circulation 121(12):1455–1458. doi:10.1161/CIRCULATIONAHA.109.904003
8. Claxton AJ, Cramer J, Pierce C (2001) A systematic review of the associations between dose regimens and medication compliance. Clin Ther 23(8):1296–1310
9. Ambardekar AV, Fonarow GC, Hernandez AF et al (2009) Characteristics and in-hospital outcomes for nonadherent patients with heart failure: findings from get with the guidelines-heart failure (GWTG-HF). Am Heart J 158(4):644–652. doi:10.1016/j.ahj.2009.07.034
10. Michalsen A, Konig G, Thimme W (1998) Preventable causative factors leading to hospital admission with decompensated heart failure. Heart 80(5):437–441
11. Böhm M, Schumacher H, Laufs U et al (2013) Effects of nonpersistence with medication on outcomes in high-risk patients with cardiovascular disease. Am Heart J 166(2):306–314.e307. doi:10.1016/j.ahj.2013.04.016
12. Granger BB, Swedberg K, Ekman I et al (2005) Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: double-blind, randomised, controlled clinical trial. Lancet 366(9502):2005–2011. doi:10.1016/s0140-6736(05)67760-4
13. Gorenoi V, Schonermark MP, Hagen A (2008) Interventions for enhancing medication compliance/adherence with benefits in treatment outcomes. GMS Health Technol Assess 3:Doc14
14. Esposito D, Bagchi AD, Verdier JM et al (2009) Medicaid beneficiaries with congestive heart failure: association of medication adherence with healthcare use and costs. Am J Manag Care 15(7):437–445
15. Yue Z, Cai C, Ai-Fang Y et al (2014) The effect of placebo adherence on reducing cardiovascular mortality: a meta-analysis. Clin Res Cardiol 103(3):229–235. doi:10.1007/s00392-013-0642-6
16. Montalescot G, Sechtem U et al (2013) 2013 ESC guidelines on the management of stable coronary artery disease: the task force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J 34(38):2949–3003. doi:10.1093/eurheartj/eht296
17. Charlson ME, Pompei P, Ales KL et al (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383
18. Cho H, Klabunde CN, Yabroff KR et al (2013) Comorbidity-adjusted life expectancy: a new tool to inform recommendations for optimal screening strategies. Ann Intern Med 159(10):667–676. doi:10.7326/0003-4819-159-10-201311190-00005
19. Dodson JA, Truong TT, Towle VR et al (2013) Cognitive impairment in older adults with heart failure: prevalence, documentation, and impact on outcomes. Am J Med 126(2):120–126. doi:10.1016/j.amjmed.2012.05.029
20. Rector TS, Cohn JN (1992) Assessment of patient outcome with the Minnesota Living with Heart Failure questionnaire: reliability and validity during a randomized, double-blind, placebo-controlled trial of pimobendan. Pimobendan Multicenter Research Group. Am Heart J 124(4):1017–1025
21. ATC/DDD Index (2013) WHO Collaborating Centre for Drug Statistics Methodology. Oslo, Norway (http://www.whocc.no/atc_ddd_index)
22. Zannad F, Agrinier N, Alla F (2009) Heart failure burden and therapy. Europace 11(Suppl 5):v1–v9. doi:10.1093/europace/eup304
23. Stanley M, Prasun M (2002) Heart failure in older adults: keys to successful management. AACN Clin Issues 13(1):94–102
24. Alla F, Zannad F, Filippatos G (2007) Epidemiology of acute heart failure syndromes. Heart Fail Rev 12(2):91–95. doi:10.1007/s10741-007-9009-2
25. Stewart S, MacIntyre K, Capewell S et al (2003) Heart failure and the aging population: an increasing burden in the 21st century? Heart 89(1):49–53
26. Rich MW, Beckham V, Wittenberg C et al (1995) A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med 333(18):1190–1195. doi:10.1056/NEJM199511023331806
27. Wu JR, Moser DK, Lennie TA et al. (2008) Factors influencing medication adherence in patients with heart failure. Heart Lung 37 (1):8-16, 16.e11. doi:10.1016/j.hrtlng.2007.02.003
28. Miura T, Kojima R, Mizutani M et al (2001) Effect of digoxin noncompliance on hospitalization and mortality in patients with heart failure in long-term therapy: a prospective cohort study. Eur J Clin Pharmacol 57(1):77–83
29. Tebbe U, Tschope C, Wirtz JH et al (2014) Registry in Germany focusing on level-specific and evidence-based decision finding in the treatment of heart failure: REFLECT-HF. Clin Res Cardiol. doi:10.1007/s00392-014-0678-2 (published online)
30. Ekman I, Andersson G, Boman K et al (2006) Adherence and perception of medication in patients with chronic heart failure during a five-year randomised trial. Patient Educ Couns 61(3):348–353. doi:10.1016/j.pec.2005.04.005
31. Muzzarelli S, Brunner-La Rocca H, Pfister O et al (2010) Adherence to the medical regime in patients with heart failure. Eur J Heart Fail 12(4):389–396. doi:10.1093/eurjhf/hfq015
32. Mazzaglia G, Ambrosioni E, Alacqua M et al (2009) Adherence to antihypertensive medications and cardiovascular morbidity among newly diagnosed hypertensive patients. Circulation 120(16):1598–1605. doi:10.1161/CIRCULATIONAHA.108.830299
33. Simpson SH, Eurich DT, Majumdar SR et al (2006) A meta-analysis of the association between adherence to drug therapy and mortality. BMJ 333(7557):15. doi:10.1136/bmj.38875.675486.55
34. Wong CY, Chaudhry SI, Desai MM et al (2011) Trends in comorbidity, disability, and polypharmacy in heart failure. Am J Med 124(2):136–143. doi:10.1016/j.amjmed.2010.08.017
35. Braunstein JB, Anderson GF, Gerstenblith G et al (2003) Noncardiac comorbidity increases preventable hospitalizations and mortality among medicare beneficiaries with chronic heart failure. J Am Coll Cardiol 42(7):1226–1233. doi:10.1016/s0735-1097(03)00947-1
36. Böhm M, Pogue J, Kindermann I et al (2014) Effect of comorbidities on outcomes and angiotensin converting enzyme inhibitor effects in patients with predominantly left ventricular dysfunction and heart failure. Eur J Heart Fail 16(3):325–333. doi:10.1002/ejhf.23
37. Wasserfallen J-B, Bourgeois R, Büla C et al (2003) Composition and cost of drugs stored at home by elderly patients. Ann Pharmacother 37:731–737. doi:10.1345/aph.1C310
38. Düsing R (2006) Therapietreue bei medikamentöser Behandlung. Dtsch Med Wochenschr 131:H28–H30. doi:10.1055/s-2006-955059
39. Nöthen M, Böhm K (2009) Gesundheitsberichterstattung des Bundes. Berlin: Robert-Koch-Institut, Germany (http://www.rki.de/DE/Content/Gesundheitsmonitoring/Gesundheitsberichterstattung/GBEDownloadsT/Krankheitskosten.pdf?__blob=publicationFile)
40. Flesch M, Erdmann E (2006) The problem of polypharmacy in heart failure. Curr Cardiol Rep 8(3):217–225
41. Ewen S, Rettig-Ewen V, Mahfoud F et al (2014) Drug adherence in patients taking oral anticoagulation therapy. Clin Res Cardiol 103(3):173–182. doi:10.1007/s00392-013-0616-8
42. Kindermann I, Fischer D, Karbach J et al (2012) Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study. Eur J Heart Fail 14(4):404–413. doi:10.1093/eurjhf/hfs015
43. Vogels RL, Scheltens P, Schroeder-Tanka JM et al (2007) Cognitive impairment in heart failure: a systematic review of the literature. Eur J Heart Fail 9(5):440–449. doi:10.1016/j.ejheart.2006.11.001
44. Kripalani S, Yao X, Haynes RB (2007) Interventions to enhance medication adherence in chronic medical conditions: a systematic review. Arch Intern Med 167(6):540–550. doi:10.1001/archinte.167.6.540