메뉴 건너뛰기




Volumn 37, Issue 4, 2015, Pages 842-857

Potential cost savings from chemotherapy-induced febrile neutropenia with biosimilar filgrastim and expanded access to targeted antineoplastic treatment across the european union G5 countries: A simulation study

Author keywords

biosimilar; budget impact; cost savings; febrile neutropenia; granulocyte colony stimulating factor

Indexed keywords

ANTINEOPLASTIC AGENT; BIOSIMILAR AGENT; FILGRASTIM; GRANULOCYTE COLONY STIMULATING FACTOR; PEGFILGRASTIM; RECOMBINANT PROTEIN; RITUXIMAB; TRASTUZUMAB;

EID: 84939986957     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2015.01.011     Document Type: Article
Times cited : (42)

References (57)
  • 1
    • 84939998505 scopus 로고    scopus 로고
    • European Medicines Agency. Guideline on similar biological medicinal products [EMEA/CHMP/437/04, London, 30 October 2005]
    • European Medicines Agency. Guideline on similar biological medicinal products [EMEA/CHMP/437/04, London, 30 October 2005]. http://www.ema.europa.eu/docs/en-GB/document-library/Scientific-guideline/2009/09/WC500003517.pdf.
  • 2
    • 84939964708 scopus 로고    scopus 로고
    • European Union. Directive 2001/83/EC of the European Parliament and of the Council of 6 November 2001 on the Community code relating to medicinal products for human use [2008]
    • European Union. Directive 2001/83/EC of the European Parliament and of the Council of 6 November 2001 on the Community code relating to medicinal products for human use [2008]. http://ec.europa.eu/health/files/eudralex/vol-1/dir-2001-83-cons/dir2001-83-cons-20081230-en.pdf.
  • 3
    • 84939973498 scopus 로고    scopus 로고
    • European Union. Commission Directive 2003/63/EC of 25 June 2003 amending Directive 2001/83/EC of the European Parliament and of the Council on the Community code relating to medicinal products for human use [L 159/46, 27.6.2003]
    • European Union. Commission Directive 2003/63/EC of 25 June 2003 amending Directive 2001/83/EC of the European Parliament and of the Council on the Community code relating to medicinal products for human use [L 159/46, 27.6.2003]. http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2003:159:0046:0094:en:PDF.
  • 4
    • 84939956171 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. Scientific considerations in demonstrating biosimilarity to a reference product [February 2012]
    • U.S. Food and Drug Administration. Scientific considerations in demonstrating biosimilarity to a reference product [February 2012]. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM291128.pdf.
  • 5
    • 84940000639 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. Quality considerations in demonstrating biosimilarity to a reference protein product [February 2012]
    • U.S. Food and Drug Administration. Quality considerations in demonstrating biosimilarity to a reference protein product [February 2012]. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM291134.pdf.
  • 6
    • 84939967052 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. Biosimilars: questions and answers regarding implementation of the Biologics Price Competition and Innovation Act of 2009 [February 2012]
    • U.S. Food and Drug Administration. Biosimilars: questions and answers regarding implementation of the Biologics Price Competition and Innovation Act of 2009 [February 2012]. http://www.fda.gov/downloads/Drugs/Guidances/UCM273001.pdf.
  • 7
    • 84939993107 scopus 로고    scopus 로고
    • World Health Organization. Guidelines on evaluation of similar biotherapeutic products (SBPs) [Geneva, 19 to 23 October 2009]
    • World Health Organization. Guidelines on evaluation of similar biotherapeutic products (SBPs) [Geneva, 19 to 23 October 2009]. http://www.who.int/biologicals/areas/biological-therapeutics/BIOTHERAPEUTICS-FOR-WEB-22APRIL2010.pdf.
  • 8
    • 80053573414 scopus 로고    scopus 로고
    • WHO/KFDA joint workshop on implementing WHO guidelines on evaluating similar biotherapeutic products, Seoul, Republic of Korea 24-26 August, 2010
    • M. Wadhwa, H.N. Kang, and I. Knezevic WHO/KFDA joint workshop on implementing WHO guidelines on evaluating similar biotherapeutic products, Seoul, Republic of Korea 24-26 August, 2010 Biologicals 39 2011 349 357
    • (2011) Biologicals , vol.39 , pp. 349-357
    • Wadhwa, M.1    Kang, H.N.2    Knezevic, I.3
  • 9
    • 84939961420 scopus 로고    scopus 로고
    • European Medicines Agency. Zarzio - filgrastim [28/08/2014]
    • European Medicines Agency. Zarzio - filgrastim [28/08/2014]. http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000917/human-med-001170.jsp&mid=WC0b01ac058001d124.
  • 10
    • 84940003218 scopus 로고    scopus 로고
    • European Medicines Agency. Summary of product characteristics - Zarzio. Accessed September 23, 2014
    • European Medicines Agency. Summary of product characteristics - Zarzio. http://www.ema.europa.eu/docs/en-GB/document-library/EPAR---Product-Information/human/000917/WC500046525.pdf. Accessed September 23, 2014.
  • 11
    • 84940003128 scopus 로고    scopus 로고
    • European Medicines Agency. Summary of product characteristics - Tevagrastim. Accessed September 23, 2014
    • European Medicines Agency. Summary of product characteristics - Tevagrastim. http://www.ema.europa.eu/docs/en-GB/document-library/EPAR---Product-Information/human/000827/WC500036664.pdf. Accessed September 23, 2014.
  • 12
    • 84939984454 scopus 로고    scopus 로고
    • European Medicines Agency. Tevagrastim - filgrastim. 2014
    • European Medicines Agency. Tevagrastim - filgrastim. 2014; http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000827/human-med-001089.jsp&mid=WC0b01ac058001d124.
  • 13
    • 84939941085 scopus 로고    scopus 로고
    • European Medicines Agency. Nivestim - filgrastim. 2014
    • European Medicines Agency. Nivestim - filgrastim. 2014; http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/001142/human-med-001344.jsp&mid=WC0b01ac058001d124.
  • 14
    • 84939988426 scopus 로고    scopus 로고
    • European Medicines Agency. Summary of product characteristics - Nivestim. Accessed September 23, 2014
    • European Medicines Agency. Summary of product characteristics - Nivestim. http://www.ema.europa.eu/docs/en-GB/document-library/EPAR---Product-Information/human/001142/WC500093661.pdf. Accessed September 23, 2014.
  • 15
    • 78650515906 scopus 로고    scopus 로고
    • 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours
    • M.S. Aapro, J. Bohlius, and D.A. Cameron 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours Eur J Cancer 47 2011 8 32
    • (2011) Eur J Cancer , vol.47 , pp. 8-32
    • Aapro, M.S.1    Bohlius, J.2    Cameron, D.A.3
  • 16
    • 77954335295 scopus 로고    scopus 로고
    • Hematopoietic growth factors: ESMO Clinical Practice Guidelines for the applications
    • Group EGW
    • J. Crawford, C. Caserta, F. Roila Group EGW Hematopoietic growth factors: ESMO Clinical Practice Guidelines for the applications Ann Oncol 21 suppl 5 2010 v248 v251
    • (2010) Ann Oncol , vol.21 , pp. v248-v251
    • Crawford, J.1    Caserta, C.2    Roila, F.3
  • 17
    • 77954338016 scopus 로고    scopus 로고
    • Management of febrile neutropenia: ESMO Clinical Practice Guidelines
    • J. de Naurois, I. Novitzky-Basso, and M.J. Gill Management of febrile neutropenia: ESMO Clinical Practice Guidelines Ann Oncol 21 suppl 5 2010 v252 v256
    • (2010) Ann Oncol , vol.21 , pp. v252-v256
    • De Naurois, J.1    Novitzky-Basso, I.2    Gill, M.J.3
  • 18
    • 84939978217 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology - Myeloid growth factors [Version 2.2014]
    • National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology - Myeloid growth factors [Version 2.2014]. http://www.nccn.org/store/login/login.aspx?ReturnURL=http://www.nccn.org/professionals/physician-gls/pdf/myeloid-growth.pdf.
  • 19
    • 33745989223 scopus 로고    scopus 로고
    • 2006 update of recommendations for the use of white blood cell growth factors: An evidence-based clinical practice guideline
    • T.J. Smith, J. Khatcheressian, and G.H. Lyman 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline J Clin Oncol 24 2006 3187 3205
    • (2006) J Clin Oncol , vol.24 , pp. 3187-3205
    • Smith, T.J.1    Khatcheressian, J.2    Lyman, G.H.3
  • 20
    • 84962736671 scopus 로고    scopus 로고
    • Saving money in the European healthcare systems with biosimilars
    • R. Haustein, C. de Millas, A. Höer, and B. Häussler Saving money in the European healthcare systems with biosimilars GaBI Journal 1 2012 120 126
    • (2012) GaBI Journal , vol.1 , pp. 120-126
    • Haustein, R.1    De Millas, C.2    Höer, A.3    Häussler, B.4
  • 21
    • 84940003664 scopus 로고    scopus 로고
    • Walsh K. Biosimilars' utilization and the role payers do play in driving uptake in Europe: an industry perspective [Biosimilar Medicines 11th EGA International Symposium, April 2013]. Walsh EGA Annual Meeting 2013.pdf
    • Walsh K. Biosimilars' utilization and the role payers do play in driving uptake in Europe: an industry perspective [Biosimilar Medicines 11th EGA International Symposium, April 2013]. http://www.sandoz-biosimilars.com/cs/www.sandoz-biosimilars.com-v3/assets/media/shared/documents/presentations/Ken Walsh EGA Annual Meeting 2013.pdf.
  • 22
    • 80051984166 scopus 로고    scopus 로고
    • Biosimilars of biological drug therapies: Regulatory, clinical and commercial considerations
    • G. Dranitsaris, E. Amir, and K. Dorward Biosimilars of biological drug therapies: regulatory, clinical and commercial considerations Drugs 71 2011 1527 1536
    • (2011) Drugs , vol.71 , pp. 1527-1536
    • Dranitsaris, G.1    Amir, E.2    Dorward, K.3
  • 23
    • 84871355839 scopus 로고    scopus 로고
    • Comparative cost-efficiency across the European G5 countries of various regimens of filgrastim, biosimilar filgrastim, and pegfilgrastim to reduce the incidence of chemotherapy-induced febrile neutropenia
    • M. Aapro, P. Cornes, and I. Abraham Comparative cost-efficiency across the European G5 countries of various regimens of filgrastim, biosimilar filgrastim, and pegfilgrastim to reduce the incidence of chemotherapy-induced febrile neutropenia J Oncol Pharm Pract 18 2012 171 179
    • (2012) J Oncol Pharm Pract , vol.18 , pp. 171-179
    • Aapro, M.1    Cornes, P.2    Abraham, I.3
  • 24
    • 38849152398 scopus 로고    scopus 로고
    • Targeted therapies: A new generation of cancer treatments
    • D.E. Gerber Targeted therapies: a new generation of cancer treatments Am Fam Physician 77 2008 311 319
    • (2008) Am Fam Physician , vol.77 , pp. 311-319
    • Gerber, D.E.1
  • 25
    • 67649126886 scopus 로고    scopus 로고
    • Cost-effectiveness of pegfilgrastim versus six days of filgrastim for preventing febrile neutropenia in breast cancer patients
    • M. Danova, S. Chiroli, G. Rosti, and Q.V. Doan Cost-effectiveness of pegfilgrastim versus six days of filgrastim for preventing febrile neutropenia in breast cancer patients Tumori 95 2009 219 226
    • (2009) Tumori , vol.95 , pp. 219-226
    • Danova, M.1    Chiroli, S.2    Rosti, G.3    Doan, Q.V.4
  • 26
    • 50249172718 scopus 로고    scopus 로고
    • Low-dose filgrastim in patients with breast cancer treated with docetaxel, doxorubicin, and cyclophosphamide
    • E.J. Ip, A. Lee-Ma, L.S. Troxell, and J. Chan Low-dose filgrastim in patients with breast cancer treated with docetaxel, doxorubicin, and cyclophosphamide Am J Health Syst Pharm 65 2008 1552 1555
    • (2008) Am J Health Syst Pharm , vol.65 , pp. 1552-1555
    • Ip, E.J.1    Lee-Ma, A.2    Troxell, L.S.3    Chan, J.4
  • 27
    • 70349897133 scopus 로고    scopus 로고
    • The economic value of primary prophylaxis using pegfilgrastim compared with filgrastim in patients with breast cancer in the UK
    • Z. Liu, Q.V. Doan, J. Malin, and R. Leonard The economic value of primary prophylaxis using pegfilgrastim compared with filgrastim in patients with breast cancer in the UK Appl Health Econ Health Policy 7 2009 193 205
    • (2009) Appl Health Econ Health Policy , vol.7 , pp. 193-205
    • Liu, Z.1    Doan, Q.V.2    Malin, J.3    Leonard, R.4
  • 28
    • 0028580535 scopus 로고
    • Filgrastim in patients with chemotherapy-induced febrile neutropenia. A double-blind, placebo-controlled trial
    • D.W. Maher, G.J. Lieschke, and M. Green Filgrastim in patients with chemotherapy-induced febrile neutropenia. A double-blind, placebo-controlled trial Ann Intern Med 121 1994 492 501
    • (1994) Ann Intern Med , vol.121 , pp. 492-501
    • Maher, D.W.1    Lieschke, G.J.2    Green, M.3
  • 29
    • 77649126999 scopus 로고    scopus 로고
    • [Pegfilgrastim vs filgrastim in primary prophylaxis of febrile neutropenia in patients with breast cancer after chemotherapy: A cost-effectiveness analysis for Germany]
    • J. Sehouli, A. Goertz, and T. Steinle [Pegfilgrastim vs filgrastim in primary prophylaxis of febrile neutropenia in patients with breast cancer after chemotherapy: a cost-effectiveness analysis for Germany] Dtsch Med Wochenschr 135 2010 385 389
    • (2010) Dtsch Med Wochenschr , vol.135 , pp. 385-389
    • Sehouli, J.1    Goertz, A.2    Steinle, T.3
  • 30
    • 0036467835 scopus 로고    scopus 로고
    • Blinded, randomized, multicenter study to evaluate single administration pegfilgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients with high-risk stage II or stage III/IV breast cancer
    • F.A. Holmes, J.A. O'Shaughnessy, and S. Vukelja Blinded, randomized, multicenter study to evaluate single administration pegfilgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients with high-risk stage II or stage III/IV breast cancer J Clin Oncol 20 2002 727 731
    • (2002) J Clin Oncol , vol.20 , pp. 727-731
    • Holmes, F.A.1    O'Shaughnessy, J.A.2    Vukelja, S.3
  • 31
    • 0037250159 scopus 로고    scopus 로고
    • A randomized double-blind multicenter phase III study of fixed-dose single-administration pegfilgrastim versus daily filgrastim in patients receiving myelosuppressive chemotherapy
    • M.D. Green, H. Koelbl, and J. Baselga A randomized double-blind multicenter phase III study of fixed-dose single-administration pegfilgrastim versus daily filgrastim in patients receiving myelosuppressive chemotherapy Ann Oncol 14 2003 29 35
    • (2003) Ann Oncol , vol.14 , pp. 29-35
    • Green, M.D.1    Koelbl, H.2    Baselga, J.3
  • 32
    • 84874121792 scopus 로고    scopus 로고
    • Clinical safety of biosimilar recombinant human granulocyte colony-stimulating factors
    • I. Abraham, S. Tharmarajah, and K. MacDonald Clinical safety of biosimilar recombinant human granulocyte colony-stimulating factors Expert Opin Drug Saf 12 2013 235 246
    • (2013) Expert Opin Drug Saf , vol.12 , pp. 235-246
    • Abraham, I.1    Tharmarajah, S.2    Macdonald, K.3
  • 33
    • 77955925048 scopus 로고    scopus 로고
    • Trends in G-CSF use in 990 patients after EORTC and ASCO guidelines
    • C. Falandry, M. Campone, and G. Cartron Trends in G-CSF use in 990 patients after EORTC and ASCO guidelines Eur J Cancer 46 2010 2389 2398
    • (2010) Eur J Cancer , vol.46 , pp. 2389-2398
    • Falandry, C.1    Campone, M.2    Cartron, G.3
  • 34
    • 65349169512 scopus 로고    scopus 로고
    • Pegfilgrastim and daily granulocyte colony-stimulating factor: Patterns of use and neutropenia-related outcomes in cancer patients in Spain - Results of the LEARN Study
    • D. Almenar, J. Mayans, and O. Juan Pegfilgrastim and daily granulocyte colony-stimulating factor: patterns of use and neutropenia-related outcomes in cancer patients in Spain - results of the LEARN Study Eur J Cancer Care (Engl) 18 2009 280 286
    • (2009) Eur J Cancer Care (Engl) , vol.18 , pp. 280-286
    • Almenar, D.1    Mayans, J.2    Juan, O.3
  • 35
    • 33645048438 scopus 로고    scopus 로고
    • Are shorter courses of filgrastim prophylaxis associated with increased risk of hospitalization?
    • D. Weycker, J. Hackett, and J.S. Edelsberg Are shorter courses of filgrastim prophylaxis associated with increased risk of hospitalization? Ann Pharmacother 40 2006 402 407
    • (2006) Ann Pharmacother , vol.40 , pp. 402-407
    • Weycker, D.1    Hackett, J.2    Edelsberg, J.S.3
  • 36
    • 84939938985 scopus 로고    scopus 로고
    • Lauer Fischer. Accessed June 11, 2013
    • Lauer Fischer. http://www2.lauer-fischer.de/home/. Accessed June 11, 2013.
  • 37
    • 84939973085 scopus 로고    scopus 로고
    • Gestion risques maladie. Accessed June 11, 2013
    • Gestion risques maladie. http://www.codage.ext.cnamts.fr/. Accessed June 11, 2013.
  • 38
    • 84939935043 scopus 로고    scopus 로고
    • The riaque. Accessed June 11, 2013
    • The riaque. http://www.theriaque.org/apps/recherche/rch-simple.php. Accessed June 11, 2013.
  • 39
    • 84939976457 scopus 로고    scopus 로고
    • Codifa. Accessed June 11, 2013
    • Codifa. http://www.codifa.it/. Accessed June 11, 2013.
  • 40
    • 84939970951 scopus 로고    scopus 로고
    • Portalfarma. Accessed June 11, 2013
    • Portalfarma. http://www.portalfarma.com/Paginas/default.aspx. Accessed June 11, 2013.
  • 41
    • 84939947900 scopus 로고    scopus 로고
    • Pharmacy2U. Accessed September 26, 2014
    • Pharmacy2U. https://http://www.pharmacy2u.co.uk/. Accessed September 26, 2014.
  • 42
    • 84939986950 scopus 로고    scopus 로고
    • Oanda. Accessed June 11, 2013
    • Oanda. http://www.oanda.com/currency/historical-rates/. Accessed June 11, 2013.
  • 43
    • 3242802160 scopus 로고    scopus 로고
    • Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: Results of the NHL-B2 trial of the DSHNHL
    • M. Pfreundschuh, L. Trumper, and M. Kloess Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL Blood 104 2004 634 641
    • (2004) Blood , vol.104 , pp. 634-641
    • Pfreundschuh, M.1    Trumper, L.2    Kloess, M.3
  • 44
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • D.J. Slamon, B. Leyland-Jones, and S. Shak Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2 N Engl J Med 344 2001 783 792
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 45
    • 76049128595 scopus 로고    scopus 로고
    • Estimates of cancer incidence and mortality in Europe in 2008
    • J. Ferlay, D.M. Parkin, and E. Steliarova-Foucher Estimates of cancer incidence and mortality in Europe in 2008 Eur J Cancer 46 2010 765 781
    • (2010) Eur J Cancer , vol.46 , pp. 765-781
    • Ferlay, J.1    Parkin, D.M.2    Steliarova-Foucher, E.3
  • 46
    • 84902341215 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor (G-CSF) patterns of use in cancer patients receiving myelosuppressive chemotherapy
    • M.R. Choi, C.A. Solid, and V.M. Chia Granulocyte colony-stimulating factor (G-CSF) patterns of use in cancer patients receiving myelosuppressive chemotherapy Support Care Cancer 22 2014 1619 1628
    • (2014) Support Care Cancer , vol.22 , pp. 1619-1628
    • Choi, M.R.1    Solid, C.A.2    Chia, V.M.3
  • 48
    • 84857905655 scopus 로고    scopus 로고
    • The economic pressures for biosimilar drug use in cancer medicine
    • P. Cornes The economic pressures for biosimilar drug use in cancer medicine Targeted Oncol 7 suppl 1 2012 S57 S67
    • (2012) Targeted Oncol , vol.7 , pp. S57-S67
    • Cornes, P.1
  • 49
    • 56749163625 scopus 로고    scopus 로고
    • Biosimilars and biopharmaceuticals: What the nephrologists need to know - A position paper by the ERA-EDTA Council
    • A. Covic, J. Cannata-Andia, and G. Cancarini Biosimilars and biopharmaceuticals: what the nephrologists need to know - a position paper by the ERA-EDTA Council Nephrol Dial Transplant 23 2008 3731 3737
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 3731-3737
    • Covic, A.1    Cannata-Andia, J.2    Cancarini, G.3
  • 50
    • 80051490700 scopus 로고    scopus 로고
    • Biosimilars: Are they ready for primetime in the United States?
    • (quiz 943)
    • B.R. Hirsch, and G.H. Lyman Biosimilars: are they ready for primetime in the United States? J Natl Compr Canc Netw 9 2011 934 942 (quiz 943)
    • (2011) J Natl Compr Canc Netw , vol.9 , pp. 934-942
    • Hirsch, B.R.1    Lyman, G.H.2
  • 51
    • 84939995592 scopus 로고    scopus 로고
    • Association EGM. Vision 2015. The EGA's thoughts on how to improve the legal and regulatory framework for generic and biosimilar medicines [October 2010]
    • Association EGM. Vision 2015. The EGA's thoughts on how to improve the legal and regulatory framework for generic and biosimilar medicines [October 2010]. http://www.hup.hr/EasyEdit/UserFiles/Granske-udruge/HUP-UPL/EGA-Vision-2015.pdf.
  • 52
    • 8344222959 scopus 로고    scopus 로고
    • How similar do 'biosimilars' need to be?
    • H. Schellekens How similar do 'biosimilars' need to be? Nat Biotechnol 22 2004 1357 1359
    • (2004) Nat Biotechnol , vol.22 , pp. 1357-1359
    • Schellekens, H.1
  • 53
    • 10644268697 scopus 로고    scopus 로고
    • Biosimilar therapeutic agents: Issues with bioequivalence and immunogenicity
    • H. Schellekens Biosimilar therapeutic agents: issues with bioequivalence and immunogenicity Eur J Clin Invest 34 2004 797 799
    • (2004) Eur J Clin Invest , vol.34 , pp. 797-799
    • Schellekens, H.1
  • 54
    • 0036598634 scopus 로고    scopus 로고
    • Bioequivalence and the immunogenicity of biopharmaceuticals
    • H. Schellekens Bioequivalence and the immunogenicity of biopharmaceuticals Nat Rev Drug Discov 1 2002 457 462
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 457-462
    • Schellekens, H.1
  • 55
    • 84884283941 scopus 로고    scopus 로고
    • Clinical experience with Zarzio(R) in Europe: What have we learned?
    • P. Gascón, H. Tesch, and K. Verpoort Clinical experience with Zarzio(R) in Europe: what have we learned? Support Care Cancer 21 2013 2925 2932
    • (2013) Support Care Cancer , vol.21 , pp. 2925-2932
    • Gascón, P.1    Tesch, H.2    Verpoort, K.3
  • 56
    • 69449095403 scopus 로고    scopus 로고
    • Biosimilar therapeutics-what do we need to consider?
    • H. Schellekens Biosimilar therapeutics-what do we need to consider? NDT Plus 2 Suppl 1 2009 i27 i36
    • (2009) NDT Plus , vol.2 , pp. i27-i36
    • Schellekens, H.1
  • 57
    • 84857903642 scopus 로고    scopus 로고
    • What do prescribers think of biosimilars?
    • M.S. Aapro What do prescribers think of biosimilars? Target Oncol 7 suppl 1 2012 S51 S55
    • (2012) Target Oncol , vol.7 , pp. S51-S55
    • Aapro, M.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.