Total Number of Lymph Nodes in Oncologic Resections, Is There More to Be Found?

Journal of Gastrointestinal Surgery

Volumn 19, Issue 5, 2015, Pages 943-948

  de Burlet, Kirsten J ^a   van den Hout, Mari F C M ^a   Putter, Hein ^a   Smit, Vincent T H B M ^a   Hartgrink, Henk H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Lymph node count; Oncologic resections; Staging; TNM classification

Indexed keywords

CANCER STAGING; FEMALE; GASTROINTESTINAL TUMOR; HUMAN; LYMPH NODE; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MALE; PATHOLOGY; PROCEDURES; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; STANDARDS;

FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MALE; NEOPLASM STAGING; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES;

EID: 84939980699     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-015-2764-9     Document Type: Article

References (26)

1. Chang GJ, Rodriguez-Bigas MA, Skibber JM, Moyer VA. Lymph node evaluation and survival after curative resection of colon cancer: Systematic review. J Natl Cancer Inst 2007;99:433-441.
2. Le Voyer TE, Sigurdson ER, Hanlon AL, Mayer RJ, Macdonald JS, Catalano PJ, Haller DG. Colon cancer survival is associated with increasing number of lymph nodes analyzed: A secondary survey of intergroup trial INT-0089. J Clin Oncol 2003;21:2912-2919.
3. Swanson RS, Compton CC, Stewart AK, Bland KI. The prognosis of T3N0 colon cancer is dependent on the number of lymph nodes examined. Ann Surg Oncol 2003;10:65-71.
4. Cianchi F, Palomba A, Boddi V, Messerini L, Pucciani F, Perigli G, Bechi P, Cortesini C. Lymph node recovery from colorectal tumor specimens: Recommendation for a minimum number of lymph nodes to be examined. World J Surg 2002;26:384-389.
5. Greenstein AJ, Litle VR, Swanson SJ, Divino CM, Packer S, Wisnivesky JP. Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancer. Cancer 2008;112:1239-1246.
6. Yang HX, Xu Y, Fu JH, Wang JY, Lin P, Rong TH. An evaluation of the number of lymph nodes examined and survival for node-negative esophageal carcinoma: Data from china. Ann Surg Oncol 2010;17:1901-1911.
7. Park IJ, Yu CS, Lim SB, Yoon YS, Kim CW, Kim TW, Kim JH, Kim JC. Prognostic implications of the number of retrieved lymph nodes of patients with rectal cancer treated with preoperative chemoradiotherapy. J Gastrointest Surg. 2014;18:1845-1851
8. Block MI. Transthoracic vs. transhiatal esophagectomy: Stage migration muddies the water. J Surg Oncol 2006;93:519-520.
9. Baxter NN, Morris AM, Rothenberger DA, Tepper JE. An evaluation of the relationship between lymph node number and staging in pT3 colon cancer using population-based data. Dis Colon Rectum 2010;53: 65–70
10. Wright FC, Law CHL, Berry S, SMITH AJ. Clinically Important Aspects of Lymph Node Assessment in Colon Cancer. J. Surg. Oncol 2009;99:248–255
11. Baxter NN. Is Lymph Node Count an Ideal Quality Indicator for Cancer Care? J. Surg. Oncol 2009;99:265–268
12. Rodriguez-Bigas MA, Maamoun S, Weber TK, Penetrante RB, Blumenson LE, Petrelli NJ. Clinical significance of colorectal cancer: Metastases in lymph nodes < 5 mm in size. Ann Surg Oncol 1996;3:124-130.
13. Haboubi NY, Clark P, Kaftan SM, Schofield PF. The importance of combining xylene clearance and immunohistochemistry in the accurate staging of colorectal carcinoma. J R Soc Med 1992;85:386-388.
14. Monig SP, Baldus SE, Zirbes TK, Schroder W, Lindemann DG, Dienes HP, Holscher AH. Lymph node size and metastatic infiltration in colon cancer. Ann Surg Oncol 1999;6:579-581.
15. Schroder W, Baldus SE, Monig SP, Beckurts TK, Dienes HP, Holscher AH. Lymph node staging of esophageal squamous cell carcinoma in patients with and without neoadjuvant radiochemotherapy: Histomorphologic analysis. World J Surg 2002;26:584-587.
16. Herrera-Ornelas L, Justiniano J, Castillo N, Petrelli NJ, Stulc JP, Mittelman A. Metastases in small lymph nodes from colon cancer. Arch Surg 1987;122:1253-1256.
17. Ostadi MA, Harnish JL, Stegienko S, Urbach DR. Factors affecting the number of lymph nodes retrieved in colorectal cancer specimens. Surg Endosc 2007;21:2142-2146.
18. Evans MD, Barton K, Rees A, Stamatakis JD, Karandikar SS. The impact of surgeon and pathologist on lymph node retrieval in colorectal cancer and its impact on survival for patients with dukes’ stage B disease. Colorectal Dis 2008;10:157-164.
19. Kuijpers CC, van Slooten HJ, Schreurs WH, Moormann GR, Abtahi MA, Slappendel A, Cliteur V, van Diest PJ, Jiwa NM. Better retrieval of lymph nodes in colorectal resection specimens by pathologists’ assistants. J Clin Pathol 2013;66:18-23.
20. Mekenkamp LJ, van Krieken JH, Marijnen CA, van de Velde CJ, Nagtegaal ID, Pathology Review Committee and the Co-operative Clinical Investigators. Lymph node retrieval in rectal cancer is dependent on many factors--the role of the tumor, the patient, the surgeon, the radiotherapist, and the pathologist. Am J Surg Pathol 2009;33:1547-1553.
21. Hartgrink HH, van de Velde CJ, Putter H, Bonenkamp JJ, Klein Kranenbarg E, Songun I, Welvaart K, van Krieken JH, Meijer S, Plukker JT, van Elk PJ, Obertop H, Gouma DJ, van Lanschot JJ, Taat CW, de Graaf PW, von Meyenfeldt MF, Tilanus H, Sasako M. Extended lymph node dissection for gastric cancer: Who may benefit? final results of the randomized Dutch gastric cancer group trial. J Clin Oncol 2004;22:2069-2077.
22. Miller ED, Robb BW, Cummings OW, Johnstone PA. The effects of preoperative chemoradiotherapy on lymph node sampling in rectal cancer. Dis Colon Rectum 2012;55:1002-1007.
23. Chao YK, Liu HP, Hsieh MJ, Wu YC, Liu YH, Yeh CH, Chang HK, Tseng CK. Lymph node dissection after chemoradiation in esophageal cancer: A subgroup analysis of patients with and without pathological response. Ann Surg Oncol 2012;19:3500-3505.
24. Sprenger T, Rothe H, Homayounfar K, Beissbarth T, Ghadimi BM, Becker H, Liersch T. Preoperative chemoradiotherapy does not necessarily reduce lymph node retrieval in rectal cancer specimens--results from a prospective evaluation with extensive pathological work-up. J Gastrointest Surg 2010;14:96-103.
25. Gehoff A, Basten O, Sprenger T, Conradi LC, Bismarck C, Bandorski D, Merkelbach-Bruse S, Schneider-Stock R, Stoehr R, Wirtz RM, Kitz J, Muller A, Hartmann A, Becker H, Ghadimi BM, Liersch T, Ruschoff J. Optimal lymph node harvest in rectal cancer (UICC stages II and III) after preoperative 5-FU-based radiochemotherapy. acetone compression is a new and highly efficient method. Am J Surg Pathol 2012;36:202-213.
26. Wang H, Safar B, Wexner SD, Denoya P, Berho M. The clinical significance of fat clearance lymph node harvest for invasive rectal adenocarcinoma following neoadjuvant therapy. Dis Colon Rectum 2009;52:1767-1773.