Treatment with prolonged-release oxycodone/naloxone improves pain relief and opioid-induced constipation compared with prolonged-release oxycodone in patients with chronic severe pain and laxative-refractory constipation

Clinical Therapeutics

Volumn 37, Issue 4, 2015, Pages 784-792

  Poelaert, Jan ^a   Koopmans Klein, Gineke ^f   Dioh, Alioune ^b   Louis, Frédéric ^c   Gorissen, Mayken ^d   Logé, David ^e   Van Op Den Bosch, Joeri ^e   Van Megen, Yvonne J B ^f  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^b Les Cliniques ISOSL   (Belgium)

^c Clinique Sainte Elisabeth Heusy   (United States)

^d AZ Sint Jan   (Belgium)

^e AZ Sint Lucas ^*  (Belgium)

^f Mundipharma Pharmaceuticals BV   (Netherlands)

Author keywords

laxative refractory; laxatives; opioid induced constipation; pain; quality of life

Indexed keywords

DELAYED RELEASE FORMULATION; DRUG COMBINATION; LAXATIVE; NALOXONE; NARCOTIC ANALGESIC AGENT; OXYCODONE; OXYCODONE NALOXONE COMBINATION;

AGED; CHEMICALLY INDUCED; CHRONIC PAIN; COMPARATIVE STUDY; CONSTIPATION; DELAYED RELEASE FORMULATION; DRUG COMBINATION; FEMALE; HUMAN; MALE; MIDDLE AGED; QUALITY OF LIFE;

AGED; ANALGESICS, OPIOID; CHRONIC PAIN; CONSTIPATION; DELAYED-ACTION PREPARATIONS; DRUG COMBINATIONS; FEMALE; HUMANS; LAXATIVES; MALE; MIDDLE AGED; NALOXONE; OXYCODONE; QUALITY OF LIFE;

EID: 84939979461     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2015.02.010     Document Type: Article

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