Sweating the small stuff: Adequacy and accuracy in sweat chloride determination

Clinical Biochemistry

Volumn 48, Issue 6, 2015, Pages 443-447

  DeMarco, Mari L ^a   Dietzen, Dennis J ^b   Brown, Sarah M ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biological variability; Cystic fibrosis; Limit of quantitation; Sweat chloride; Sweat rate

Indexed keywords

CHLORIDE;

ADOLESCENT; ADULT; AGED; CHILD; CYSTIC FIBROSIS; HUMAN; INFANT; LIMIT OF DETECTION; METABOLISM; MIDDLE AGED; NEWBORN; PRESCHOOL CHILD; RETROSPECTIVE STUDY; SWEAT; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; CHLORIDES; CYSTIC FIBROSIS; HUMANS; INFANT; INFANT, NEWBORN; LIMIT OF DETECTION; MIDDLE AGED; RETROSPECTIVE STUDIES; SWEAT; YOUNG ADULT;

EID: 84939976808     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2014.12.011     Document Type: Article

References (16)

1. Farrell P.M., Rosenstein B.J., White T.B., Accurso F.J., Castellani C., Cutting G.R., et al. Guidelines for diagnosis of cystic fibrosis in newborns through older adults: cystic fibrosis foundation consensus report. J Pediatr 2008, 153:S4-S14.
2. Wagener J.S., Zemanick E.T., Sontag M.K. Newborn screening for cystic fibrosis. Curr Opin Pediatr 2012, 24:329-335.
3. Kirk J.M. A continuing role for sweat testing in an era of newborn screening for cystic fibrosis. Clin Biochem 2011, 44:487-488.
4. Eckford P.D.W., Li C., Ramjeesingh M., Bear C.E. Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant cftr in a phosphorylation-dependent but atp-independent manner. J Biol Chem 2012, 287:36639-36649.
5. Ramsey B.W., Davies J., McElvaney N.G., Tullis E., Bell S.C., Dřevínek P., et al. A cftr potentiator in patients with cystic fibrosis and the G551D mutation. N Engl J Med 2011, 365:1663-1672.
6. Legrys V.A., McColley S.A., Li Z., Farrell P.M. The need for quality improvement in sweat testing infants after newborn screening for cystic fibrosis. J Pediatr 2010, 157:1035-1037.
7. Eng W., LeGrys V.A., Schechter M.S., Laughon M.M., Barker P.M. Sweat-testing in preterm and full-term infants less than 6weeks of age. Pediatr Pulmonol 2005, 40:64-67.
8. Sands D., Oltarzewski M., Nowakowska A., Zybert K. Bilateral sweat tests with two different methods as a part of cystic fibrosis newborn screening (CF NBS) protocol and additional quality control. Folia Histochem Cytobiol/Pol Acad Sci, Pol Histochem Cytochem Soc 2010, 48:358-365.
9. Gibson L.E., Cooke R.E. A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis. Pediatrics 1959, 23:545-549.
10. Goldberg S., Schwartz S., Francis M., Stankiewicz H., Izbicki G., Picard E. Does sweat volume influence the sweat test result?. Arch Dis Child 2010, 95:377-381.
11. CLSI Sweat testing: sample collection and quantitative chloride analysis; approved guideline. CLSI document C34-A3 2009, Clinical and Laboratory Standards Institute. 3rd ed.
12. LeGrys V.A., Yankaskas J.R., Quittell L.M., Marshall B.C., Mogayzel P.J. Diagnostic sweat testing: the cystic fibrosis foundation guidelines. J Pediatr 2007, 151:85-89.
13. Holmes DT. cp-R, an interface the R programming language for clinical laboratory method comparisons. Clinical Biochemistry.
14. Harris E.K., Yasaka T. On the calculation of a "reference change" for comparing two consecutive measurements. Clin Chem 1983, 29:25-30.
15. Gibson L.E., Disant Agnese P.A. Studies of salt excretion in sweat. Relationships between rate, conductivity, and electrolyte composition of sweat from patients with cystic fibrosis and from control subjects. J Pediatr 1963, 62:855-867.
16. Barry P.J., Jones A.M., Webb A.K., Horsley A.R. Sweat chloride is not a useful marker of clinical response to ivacaftor. Thorax 2014, 69:586-587.