Prostacyclin receptor expression on platelets of humans with type 2 diabetes is inversely correlated with hemoglobin A1c levels

Prostaglandins and Other Lipid Mediators

Volumn 116-117, Issue , 2015, Pages 131-135

  Knebel, Stephanie M ^a   Sprague, Randy S ^a   Stephenson, Alan H ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Platelet cAMP; Prostacyclin receptor; Radioligand binding; Type 2 diabetes; Western blot

Indexed keywords

GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; ILOPROST; PROSTAGLANDIN RECEPTOR; PTGIR PROTEIN, HUMAN;

BIOSYNTHESIS; FEMALE; GENE EXPRESSION REGULATION; HUMAN; MALE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; THROMBOCYTE; THROMBOCYTE AGGREGATION;

BLOOD PLATELETS; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION REGULATION; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; ILOPROST; MALE; PLATELET AGGREGATION; RECEPTORS, PROSTAGLANDIN;

EID: 84939957131     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2014.12.002     Document Type: Article

References (37)

1. J.A. Colwell, P.D. Winocour, M. Lopes-Virella, and P.V. Halushka New concepts about the pathogenesis of atherosclerosis in diabetes mellitus Am J Med 75 1983 67 80
2. K. Pyorala, M. Laakso, and M. Uusitupa Diabetes and atherosclerosis: an epidemiologic view Diabetes Metab Rev 3 1987 463 524
3. N. Winer, and J.R. Sowers Epidemiology of diabetes J Clin Pharmacol 44 2004 397 405
4. M.A. Bethel, F.A. Sloan, D. Belsky, and M.N. Feinglos Longitudinal incidence and prevalence of adverse outcomes of diabetes mellitus in elderly patients Arch Intern Med 167 2007 921 927
5. P. Ferroni, S. Basili, A. Falco, and G. Davi Platelet activation in type 2 diabetes mellitus J Thromb Haemost 2 2004 1282 1291
6. Y. Li, V. Woo, and R. Bose Platelet hyperactivity and abnormal Ca(2+) homeostasis in diabetes mellitus Am J Physiol Heart Circ Physiol 280 2001 H1480 H1489
7. M.M. Bern Platelet functions in diabetes mellitus Diabetes 27 1978 342 350
8. G. Davi, G.B. Rini, and M. Averna Thromboxane B2 formation and platelet sensitivity to prostacyclin in insulin-dependent and insulin-independent diabetics Thromb Res 26 1982 359 370
9. D.J. Betteridge, K.E. El Tahir, J.P. Reckless, and K.I. Williams Platelets from diabetic subjects show diminished sensitivity to prostacyclin Eur J Clin Invest 12 1982 395 398
10. T. Akai, K. Naka, K. Okuda, T. Takemura, and S. Fujii Decreased sensitivity of platelets to prostacyclin in patients with diabetes mellitus Horm Metab Res 15 1983 523 526
11. G. Anfossi, E.M. Mularoni, and S. Burzacca Platelet resistance to nitrates in obesity and obese NIDDM, and normal platelet sensitivity to both insulin and nitrates in lean NIDDM Diabetes Care 21 1998 121 126
12. Y.Y. Chirkov, and J.D. Horowitz Impaired tissue responsiveness to organic nitrates and nitric oxide: a new therapeutic frontier? Pharmacol Ther 116 2007 287 305
13. M. Johnson, H.E. Harrison, A.T. Raftery, and J.B. Elder Vascular prostacyclin may be reduced in diabetes in man Lancet 1 1979 325 326
14. A. Schafer, and J. Bauersachs Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosis Curr Vasc Pharmacol 6 2008 52 60
15. B. Ashby, J.L. Daniel, and J.B. Smith Mechanisms of platelet activation and inhibition Hematol Oncol Clin North Am 4 1990 1 26
16. R.A. Armstrong, R.A. Lawrence, R.L. Jones, N.H. Wilson, and A. Collier Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors Br J Pharmacol 97 1989 657 668
17. Z. Zhang, S.C. Austin, and E.M. Smyth Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction Mol Pharmacol 60 2001 480 487
18. E.M. Smyth, P.V. Nestor, and G.A. FitzGerald Agonist-dependent phosphorylation of an epitope-tagged human prostacyclin receptor J Biol Chem 271 1996 33698 33704
19. S. Moncada, R. Gryglewski, S. Bunting, and J.R. Vane An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation Nature 263 1976 663 665
20. R.J. Gryglewski, R.M. Botting, and J.R. Vane Mediators produced by the endothelial cell Hypertension 12 1988 530 548
21. 3H]iloprost binding sites and cAMP synthesis activity of a 3-oxa-methano prostaglandin I1 analog, SM-10906, in human platelets and endothelial cells Jpn J Pharmacol 74 1997 37 43
22. A.L. Tsai, H. Vijjeswarapu, and K.K. Wu Interaction between platelet receptor and iloprost isomers Biochim Biophys Acta 942 1988 220 226
23. P.A. Modesti, A. Fortini, G.F. Gensini, D. Vanni, D. Prisco, and R. Abbate Human prostacyclin platelet receptors in diabetes mellitus Thromb Res 63 1991 541 548
24. 2) binding and activation of adenylate cyclase in platelets of diabetic and control subjects Br J Clin Pharmacol 15 1983 77 81
25. M.J. Cho, and M.A. Allen Chemical stability of prostacyclin (PGI2) in aqueous solutions Prostaglandins 15 1978 943 954
26. G. Davi, I. Catalano, and M. Averna Thromboxane biosynthesis and platelet function in type II diabetes mellitus N Engl J Med 322 1990 1769 1774
27. P.V. Halushka, R.C. Rogers, C.B. Loadholt, and J.A. Colwell Increased platelet thromboxane synthesis in diabetes mellitus J Lab Clin Med 97 1981 87 96
28. U.R. Schwarz, U. Walter, and M. Eigenthaler Taming platelets with cyclic nucleotides Biochem Pharmacol 62 2001 1153 1161
29. 1/prostacyclin receptor of human blood platelets J Biol Chem 262 1987 12685 12691
30. J.E. Tateson, S. Moncada, and J.R. Vane Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets Prostaglandins 13 1977 389 397
31. N.N. Kahn, and A.K. Sinha Stimulation of prostaglandin E1 binding to human blood platelet membrane by insulin and the activation of adenylate cyclase J Biol Chem 265 1990 4976 4981
32. 2 receptor activity of human blood platelets in acute ischemic heart disease Circ Res 66 1990 932 940
33. C. Van Geet, B. Izzi, V. Labarque, and K. Freson Human platelet pathology related to defects in the G-protein signaling cascade J Thromb Haemost 7 Suppl. 1 2009 282 286
34. E.C. Turner, and B.T. Kinsella Regulation of the human prostacyclin receptor gene by the cholesterol-responsive SREBP1 J Lipid Res 53 2012 2390 2404
35. U.N. Das A defect in Delta6 and Delta5 desaturases may be a factor in the initiation and progression of insulin resistance, the metabolic syndrome and ischemic heart disease in South Asians Lipids Health Dis 9 2010 130
36. i alpha protein Life Sci 63 1998 2031 2038
37. N.N. Kahn, W.A. Bauman, and A.K. Sinha Loss of high-affinity prostacyclin receptors in platelets and the lack of prostaglandin-induced inhibition of platelet-stimulated thrombin generation in subjects with spinal cord injury Proc Natl Acad Sci U S A 93 1996 245 249