Biotransformation of artemisinin by Aspergillus niger

Applied Microbiology and Biotechnology

Volumn 99, Issue 8, 2015, Pages 3443-3446

  Zhan, Yulian ^a,b   Liu, Hua ^b   Wu, Yunshan ^b   Wei, Pingying ^a   Chen, Zhencheng ^a   Williamson, John S ^b,c  

^a GUILIN UNIVERSITY OF ELECTRONIC TECHNOLOGY   (China)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Antimalarial drugs; Artemisinin; Aspergillus niger; Biotransformation

Indexed keywords

BIOCONVERSION; CHEMICAL MODIFICATION; SCAFFOLDS;

ANTIMALARIAL DRUG; ARTEMISININ; ASPERGILLUS NIGER; BIOTRANSFORMATION; CHEMICAL AND BIOLOGICALS; MICROBIAL STRAIN; NIGER; STRUCTURAL MODIFICATIONS;

ASPERGILLUS;

ARTEMISININ; ARTEMISININ DERIVATIVE;

ASPERGILLUS NIGER; BIOTRANSFORMATION; METABOLISM; PH; TEMPERATURE;

ARTEMISININS; ASPERGILLUS NIGER; BIOTRANSFORMATION; HYDROGEN-ION CONCENTRATION; TEMPERATURE;

EID: 84939934359     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-015-6464-x     Document Type: Article

References (15)

1. Acton N (1999) Semisynthesis of 3-β-hydroxyartemisinin. J Nat Prod 62:790–793
2. 13C-NMR assignments of artemisinin (qinghaosu). J Nat Prod 51:1273–1276
3. Brown GD, Liang GY, Sy LK (2003) Terpenoids from the seeds of Artemisia annua. Phytochemistry 64:303–323
4. Bruker (2002) SMART, SAINT and SHELXTL. Bruker AXS Inc., Madison, Wisconsin, USA
5. Gaur R, Darokar MP, Ajayakumar PV, Shukla RS, Bhakuni RS (2014) In vitro antimalarial studies of novel artemisinin biotransformed products and its derivatives. Phytochemistry 107:135–140
6. Goswami A, Saikia PP, Barua NC, Bordoloi M, Yadav A, Bora TC, Gogoi BK, Saxena AK, Suri N, Sharma M (2010) Bio-transformation of artemisinin using soil microbe: direct C-acetoxylation of artemisinin at C-9 by Penicillium simplicissimum. Bioorg Med Chem Lett 20:359–361
7. Klayman DL (1985) Qinghaosu (artemisinin): an antimalarial drug from China. Science 228:1049–1055
8. Liu JM, Ni MY, Fan JF, YY TU, WU ZH, WU YL, Zhou WS (1979) Structure and reaction of arteannuin. Acta Chim Sinica 37:129–143
9. Parshikov IA, Miriyala B, Avery MA, Williamson JS (2004a) Hydroxylation of 10-deoxoartemisinin to 15-hydroxy-10-deoxoartemisinin by Aspergillus niger. Biotechnol Lett 26:607–610
10. Parshikov IA, Muraleedharan KM, Avery MA, Williamson JS (2004b) Transformation of artemisinin by Cunninghamella elegans. Appl Microbiol Biotechnol 64:782–786
11. Parshikov IA, Miriyala B, Muraleedharan KM, Avery MA, Williamson JS (2006) Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger. J Ind Microbiol Biotechnol 33:349–352
12. Sheldrick GM (2008) A short history of SHELX. Acta Cryst A64:112–122
13. Wei ZX, Pan JP, Li Y (1992) Artemisinin G: a sesquiterpene from Artemisia annua. Planta Med 58:300
14. World Health Organization (2011) World Malaria Report 2011. World Health Organization, Geneva
15. Zhan J, Zhang Y, Guo H, Han J, Ning L, Guo D (2002) Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger. J Nat Prod 65:1693–1695