Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer

Investigational New Drugs

Volumn 33, Issue 3, 2015, Pages 720-728

  Do, Khanh ^a   Speranza, Giovanna ^a   Bishop, Rachel ^b   Khin, Sonny ^c   Rubinstein, Larry ^a   Kinders, Robert J ^c   Datiles, Manuel ^b   Eugeni, Michelle ^a   Lam, Michael H ^d   Doyle, L Austin ^a   Doroshow, James H ^a   Kummar, Shivaani ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

^c FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Colorectal carcinoma; MK 2206; pAKT; pERK; Selumetinib

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; FUSED HETEROCYCLIC RINGS; SELUMETINIB; TUMOR MARKER;

ADOLESCENT; ADULT; AGED; CLINICAL TRIAL; COLORECTAL NEOPLASMS; DRUG SCREENING; FEMALE; HCT116 CELL LINE; HUMAN; MALE; METABOLISM; MIDDLE AGED; PHASE 2 CLINICAL TRIAL; TOMOGRAPHY; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BENZIMIDAZOLES; BIOMARKERS, TUMOR; COLORECTAL NEOPLASMS; FEMALE; HCT116 CELLS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MALE; MIDDLE AGED; TOMOGRAPHY; TREATMENT OUTCOME; XENOGRAFT MODEL ANTITUMOR ASSAYS; YOUNG ADULT;

EID: 84939934190     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-015-0212-z     Document Type: Article

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