Regional Variation in Medication Adherence

Forum for Health Economics and Policy

Volumn 14, Issue 1, 2011, Pages

  Gibson, Teresa B ^a   Landrum, Mary Beth ^b   Batata, Amber ^c   Fendrick, A Mark ^d   Wang, Sara ^a   Chernew, Michael E ^b  

^a THOMSON REUTERS   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c PFIZER INC   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

adherence; commercial insurance; prescription medication; regional variation

Indexed keywords

EID: 84939922252     PISSN: None     EISSN: 15589544     Source Type: Journal    
DOI: 10.2202/1558-9544.1249     Document Type: Article

References (43)

1. Baicker, K. & Chandra, A. (2004) Medicare spending, the physician workforce, and beneficiaries' quality of care. Health Affairs. Jan-Jun;Suppl Web Exclusives:W4-184-197.
2. Buntin, M.B., & Zaslavsky, A. (2004) Too much ado about two-part models and transformation: Comparing methods of modeling Medicare expenditures. Journal of Health Economics 23(3): 525-542.
3. Bryk AS and Raudenbush SW. (2002) Hierarchical Linear Models (2nd edition), Sage Publications.
4. Chandra, A., & Staiger, D.O. (2007) Productivity spillovers in healthcare: Evidence from the treatment of heart attacks. J Polit Econ,115:103-140.
5. Chernew, M.E., Gibson, T.B., Yu-Isenberg, K., Sokol, M.C., Rosen, A.B., & Fendrick, A.M. (2008) Effects of increased patient cost sharing on socioeconomic disparities in health care. Journal of General Internal Medicine, 23(8): 1131-1136.
6. Cunningham, P.J. (2002) Prescription drug access: not just a Medicare problem. Issue Brief Cent Stud Health Syst Change, (51): 1-4.
7. Dartmouth Atlas of Health Care (2009) Accessed online: http://www.dartmouthatlas.org
8. Deyo, R.A., Cherkin, D.C., & Ciol, M.A. (1992) Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol, 45(6):613-619.
9. Duan, N., Manning, W.G., Morris, C.N., & Newhouse, J.P. (1983) A comparison of alternative models for the demand for medical care. Journal of Business and Economic Statistics, 1:2, 115-126.
10. Duan, N., Manning, W.G., Morris, C.N., & Newhouse, J.P. (1984) Choosing between the sample-selection model and the multi-part model. Journal of Business and Economic Statistics, 2(3): 283-289.
11. Ellis, J.J., Erickson, S.R., Stevenson, J.G., Bernstein, S.J., Stiles, R.A., & Fendrick, A.M. (2004) Suboptimal statin adherence and discontinuation in primary and secondary prevention populations: Should we target patients with the most to gain? Journal of General Internal Medicine,19(6):638-645.
12. Fisher, E.S., Wennberg, D.E., Stukel, T.A., & Gottlieb, D.J. (2004) Variations in the longitudinal efficiency of academic medical centers. Health Affairs, Suppl web exclusives:VAR19-32.
13. Goldberger, A.S. (1991) A Course in Econometrics. Cambridge, MA: Harvard University Press.
14. Goldman, D.P., Joyce, G.F., & Zheng Y (2007) Prescription drug cost sharing: associations with medication and medical utilization and spending and health. JAMA, 298(1):61-69.
15. Gordis, L. (1979). Conceptual and methodologic problems in measuring patient compliance. Compliance in Health Care.
16. R. B. Haynes, D. W. Taylor and D. L. Sackett. Baltimore, Johns Hopkins University Press: 23-45.
17. Hox J., (2002). Multilevel Analysis, Techniques and Applications, Lawrence Erlbaum Associates.
18. Hunt, S.A., Baker, D.W., Chin, M.H., Cinquegrani, M.P., Feldman, A.M., Francis, G.S., Ganiats, T.G., fi, American College of Cardiology/American Heart Association (2001) ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to revise the 1995 Guidelines for the Evaluation and Management of Heart Failure). Journal of the American College of Cardiology, 38(7): 2101-2113.
19. Huskamp, H.A., Deverka, P.A., Epstein, A.M., Epstein, R.S., McGuigan, K.A., & Frank, R.G. (2003) The effect of incentive-based formularies on prescriptiondrug utilization and spending. New England Journal of Medicine, 349(23): 2224-2232.
20. Irvine, J., Baker, B., Smith, J., Jandciu, S., Paquette, M., Cairns, J., Connolly, S., Roberts, R., Gent, M., & Dorian, P. (1999) Poor adherence to placebo or amiodarone therapy predicts mortality: results from the CAMIAT study. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial. Psychosomatic Medicine, 61(4): 566-575.
21. Karve, S., Cleves, M.A., Helm, M., Hudson, T.J., West, D.S., & Martin, B.C. (2008) An empirical basis for standardizing adherence measures derived from administrative claims data among diabetic patients. Med Care, 46(11):1125-1133.
22. Kirking, D.M., Lee, J.A., Ellis, J.J., Briesacher, B., & McKercher, P.L. (2006) Patient-reported underuse of prescription medications: a comparison of nine surveys. Medical Care Research and Review, 63(4): 427-446.
23. Leibowitz A., Manning W., & Newhouse J.P. The demand for prescription drugs as a function of cost-sharing. Social Science and Medicine. 1985;21(10):1063-1069.
24. Mark, D.B., Naylor, C.D., Hlatky, M.A., Califf, R.M., Topol, E.J., Granger, C.B., Knight, J.D., Nelson, C.L., Lee, K.L, Clapp-Channing, N.E., Sutherland, W., Pilote, L., & Armstrong, P.W. (1994) Use of medical resources and quality of life after acute myocardial infarction in Canada and the United States. New England Journal of Medicine, 331(17): 1130-1135.
25. Nathan, D.M., Buse, J.B., Davidson, M.B., Ferrannini, E., Holman, R.R., Sherwin, R., & Zinman, B., American Diabetes Association; European Association for Study of Diabetes. (2009). Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care, 32(1): 193-203.
26. National Cholesterol Education Program. (2002) Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). National Heart Lung and Blood Institute. Retrieved June 26, 2010 from www.nhlbi.gov.
27. National Heart Lung and Blood Institute. (2004) The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure-Complete Report. Retrieved June 26, 2010 from www.nhlbi.gov.
28. Osterberg, L., & Blaschke T. (2005) Adherence to medication. New England Journal of Medicine, 353(5): 487-497.
29. Pilote, L., Califf, R.M., Sapp, S., Miller, D.P., Mark, D.B., Weaver, W.D., Gore, J.M., Armstrong, P.W., Ohman, E.M., & Topol, E.J. (1995) Regional variation across the United States in the management of acute myocardial infarction. GUSTO-1 Investigators. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries. New England Journal of Medicine, 333(9): 565-572.
30. Roebuck, M.C., Liberman, J.N., Gemmill-Toyama, M., Brennan, T.A. (2011) Medication adherence leads to lower health care use and costs despite increased drug spending. Health Affairs. Jan;30(1):91-9.
31. Romano, P.S., Roos, J.J., & Jollis, J.G. (1993) Adapting a clinical comorbidity index for use with ICD-9-CM administrative data: Differing perspectives. J Clinical Epidemiology, 46(10): 1075-1079.
32. Rosenheck, R., Cramer, J., Xu, W., Thomas, J., Henderson, W., Frisman, L., Fye, C., & Charney, D. (1997) A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia. New England Journal of Medicine, 337(12): 809-815.
33. Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study. Lancet. 1994;344(8934):1383-1389.
34. Sokol, M.C., McGuigan, K.A., Verbrugge, R.R., & Epstein, R.S.. (2005) Impact of medication adherence on hospitalization risk and healthcare cost. Medical Care, 43(6): 517-520.
35. SOLVD Investigators (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators. New England Journal of Medicine, 325(5): 293-302.
36. Soumerai, S.B., McLaughlin, T.J., Spiegelman, D., Hertzmark, E., Thibault, G., & Goldman, L. (1997) Adverse outcomes of underuse of beta-blockers in elderly survivors of acute myocardial infarction. JAMA, 277(2): 115-121.
37. Tu, J.V., Pashos, C.L., Naylor, C.D., Chen, E., Normand, S.L., Newhouse, J.P., & McNeil, B.J., (1997) Use of cardiac procedures and outcomes in elderly patients with myocardial infarction in the United States and Canada. New England Journal of Medicine, 336(21): 1500-1505.
38. US Census Bureau. (2003) Census 2000 Summary File 3. Washington, DC, United States Census Bureau. www.census.gov.
39. Vella, F. (1998) Estimating models with sample selection bias: A survey. Journal of Human Resources, 33: 127-169.
40. Weinstein, J.N., Bronner, K.K., Morgan, T.S., & Wennbert, J.E. (2004) Trends and geographic variations in major surgery for degenerative diseases of the hip, knee, and spine. Health Affairs, Suppl web exclusives:VAR81-89.
41. Weinstein, J.N., Lurie, J.D., Olson, P.R., Bronner, K.K., & Fisher, E.S. (2006) United States' trends and regional variations in lumbar spine surgery: 1992-2003. Spine, 31(23): 2707-2714.
42. Wennberg, D.E., Kellett, M.A., Dickens, J.D., Malenka, D.J., Keilson, L.M., & Keller, R.B. (1996) The association between local diagnostic testing intensity and invasive cardiac procedures. JAMA, 275(15): 1161-1164.
43. Zhang, Y., Baicker, K., & Newhouse, J.P. (2010) Geographic variation in Medicare drug spending. New England Journal of Medicine, 363(5): 405-409.