Does diabetes modify the effect of FRAX risk factors for predicting major osteoporotic and hip fracture?

Osteoporosis International

Volumn 25, Issue 12, 2014, Pages 2817-2824

  Leslie, W D ^a   Morin, S N ^b   Lix, L M ^a   Majumdar, S R ^c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Bone mineral density; Diabetes; Fracture; Fracture prediction; FRAX; Osteoporosis

Indexed keywords

ADULT; AGE; AGE DISTRIBUTION; AGED; BONE DENSITY; CANADA; DIABETES COMPLICATIONS; FEMALE; FOLLOW UP; HIP FRACTURES; HUMAN; MALE; MIDDLE AGED; OSTEOPOROTIC FRACTURES; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RISK ASSESSMENT; RISK FACTOR;

ADULT; AGE DISTRIBUTION; AGE FACTORS; AGED; BONE DENSITY; DIABETES COMPLICATIONS; FEMALE; FOLLOW-UP STUDIES; HIP FRACTURES; HUMANS; MALE; MANITOBA; MIDDLE AGED; OSTEOPOROTIC FRACTURES; RISK ASSESSMENT; RISK FACTORS;

EID: 84939894012     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-014-2822-2     Document Type: Article

References (27)

1. van Staa TP, Dennison EM, Leufkens HG et al (2001) Epidemiology of fractures in England and Wales. Bone 29:517–522
2. Blanchard JF, Ludwig S, Wajda A et al (1996) Incidence and prevalence of diabetes in Manitoba, 1986-1991. Diabetes Care 19:807–811
3. Wild S, Roglic G, Green A et al (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047–1053
4. Strotmeyer ES, Cauley JA, Schwartz AV et al (2005) Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. Arch Intern Med 165:1612–1617
5. Janghorbani M, Feskanich D, Willett WC et al (2006) Prospective study of diabetes and risk of hip fracture: the Nurses’ Health Study. Diabetes Care 29:1573–1578
6. Janghorbani M, Van Dam RM, Willett WC et al (2007) Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 166:495–505
7. De Liefde II, Van Der KM, de Laet CE et al (2005) Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study. Osteoporos Int 16:1713–1720
8. Hanley DA, Brown JP, Tenenhouse A et al (2003) Associations among disease conditions, bone mineral density, and prevalent vertebral deformities in men and women 50 years of age and older: cross-sectional results from the Canadian Multicentre Osteoporosis Study. J Bone Miner Res 18:784–790
9. Bonds DE, Larson JC, Schwartz AV et al (2006) Risk of fracture in women with type 2 diabetes: the Women’s Health Initiative Observational Study. J Clin Endocrinol Metab 91:3404–3410
10. Melton LJ III, Riggs BL, Leibson CL et al (2008) A bone structural basis for fracture risk in diabetes. J Clin Endocrinol Metab 93:4804–4809
11. Giangregorio LM, Leslie WD, Lix LM et al (2012) FRAX underestimates fracture risk in patients with diabetes. J Bone Miner Res 27:301–308
12. Schwartz AV, Vittinghoff E, Bauer DC et al (2011) Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes. JAMA 305:2184–2192
13. Kanis JA, Oden A, Johansson H et al (2009) FRAX and its applications to clinical practice. Bone 44:734–743
14. Leslie WD, Rubin MR, Schwartz AV et al (2012) Type 2 diabetes and bone. J Bone Miner Res 27:2231–2237
15. Leslie WD, Metge C (2003) Establishing a regional bone density program: lessons from the Manitoba experience. J Clin Densitom 6:275–282
16. Leslie WD, Caetano PA, MacWilliam LR et al (2005) Construction and validation of a population-based bone densitometry database. J Clin Densitom 8:25–30
17. Leslie WD (2006) The importance of spectrum bias on bone density monitoring in clinical practice. Bone 39:361–368
18. Looker AC, Wahner HW, Dunn WL et al (1998) Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 8:468–489
19. Leslie WD, Lix LM, Johansson H et al (2010) Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration. J Bone Miner Res 25:2350–2358
20. Klotzbuecher CM, Ross PD, Landsman PB et al (2000) Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 15:721–739
21. Morin SN, Lix LM, Leslie WD (2014) The importance of previous fracture site on osteoporosis diagnosis and incident fractures in women. J Bone Miner Res [Epub head of print]
22. WHO Collaborating Centre for Drug Statistics Methodology. (eds) (2005) Guidelines for ATC classification and DDD assignment. Oslo
23. Roos NP, Shapiro E (1999) Revisiting the Manitoba Centre for Health Policy and Evaluation and its population-based health information system. Med Care 37:JS10–JS14
24. Leslie WD, Tsang JF, Caetano PA et al (2007) Effectiveness of bone density measurement for predicting osteoporotic fractures in clinical practice. J Clin Endocrinol Metab 92:77–81
25. Kleinbaum DG, Klein M. (eds) (2010) Logistic regression: a self-learning text (3rd edition). Springer (New York)
26. Leslie WD, Lix LM, Wu X (2013) Competing mortality and fracture risk assessment. Osteoporos Int 24:681–688
27. Fraser LA, Pritchard J, Ioannidis G et al (2011) Clinical risk factors for fracture in diabetes: a matched cohort analysis. J Clin Densitom 14:416–421