Autophagy-lysosome pathway in renal tubular epithelial cells is disrupted by advanced glycation end products in diabetic nephropathy

Journal of Biological Chemistry

Volumn 290, Issue 33, 2015, Pages 20499-20510

  Liu, Wei Jing ^a   Shen, Ting Ting ^a   Chen, Rui Hong ^a   Wu, Hong Luan ^a   Wang, Yan Jin ^a   Deng, Jian Kun ^a   Chen, Qiu Hua ^a   Pan, Qingjun ^a   Fu, Chang Mei Huang ^a   Tao, Jing Li ^a   Liang, Dong ^a   Liu, Hua Feng ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CYTOLOGY; DISEASES; GLYCOSYLATION; PATIENT TREATMENT; PROTEINS;

ADVANCED GLYCATION END PRODUCTS; DIABETIC NEPHROPATHY; ENZYMATIC ACTIVITIES; EPITHELIAL CELLS; HUMAN RENAL TUBULAR EPITHELIAL CELLS; LYSOSOMAL DEGRADATION; LYSOSOMAL MEMBRANES; UBIQUITINATED PROTEINS;

CELLS;

ADVANCED GLYCATION END PRODUCT;

ADULT; AGED; AUTOPHAGY; CELL MEMBRANE PERMEABILITY; DIABETIC NEPHROPATHY; EPITHELIUM CELL; FEMALE; HUMAN; IMMUNOLOGY; KIDNEY TUBULE; LYSOSOME; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AUTOPHAGY; CELL MEMBRANE PERMEABILITY; DIABETIC NEPHROPATHIES; EPITHELIAL CELLS; FEMALE; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; KIDNEY TUBULES; LYSOSOMES; MALE; MIDDLE AGED;

EID: 84939865350     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.666354     Document Type: Article

References (39)

1. Kume, S., Kitada, M., Kanasaki, K., Maegawa, H., and Koya, D. (2013) Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy. Arch. Pharm. Res. 36, 230-236
2. Daroux, M., Prévost, G., Maillard-Lefebvre, H., Gaxatte, C., D'Agati, V. D., Schmidt, A. M., and Boulanger, E. (2010) Advanced glycation end-products: implications for diabetic and non-diabetic nephropathies. Diabetes Metab. 36, 1-10
3. Furukawa, M., Gohda, T., Tanimoto, M., and Tomino, Y. (2013) Pathogenesis and novel treatment from the mouse model of type 2 diabetic nephropathy. Scientific World Journal 2013, 928197
4. Mizushima, N. (2007) Autophagy: process and function. Genes Dev. 21, 2861-2873
5. Malicdan, M. C., Noguchi, S., and Nishino, I. (2007) Autophagy in a mouse model of distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy. Autophagy 3, 396-398
6. Yu, C., Huang, X., Xu, Y., Li, H., Su, J., Zhong, J., Kang, J., Liu, Y., and Sun, L. (2013) Lysosome dysfunction enhances oxidative stress-induced apoptosis through ubiquitinated protein accumulation in HeLa cells. Anat. Rec. (Hoboken) 296, 31-39
7. Pan, T., Kondo, S., Le, W., and Jankovic, J. (2008) The role of autophagylysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 131, 1969-1978
8. Phillips, A. O., and Steadman, R. (2002) Diabetic nephropathy: the central role of renal proximal tubular cells in tubulointerstitial injury. Histol. Histopathol. 17, 247-252
9. Pallet, N., Bouvier, N., Legendre, C., Gilleron, J., Codogno, P., Beaune, P., Thervet, E., and Anglicheau, D. (2008) Autophagy protects renal tubular cells against cyclosporine toxicity. Autophagy 4, 783-791
10. Zeng, Y., Yang, X., Wang, J., Fan, J., Kong, Q., and Yu, X. (2012) Aristolochic acid I induced autophagy extenuates cell apoptosis via ERK 1/2 pathway in renal tubular epithelial cells. PLoS One 7, e30312
11. Takahashi, A., Kimura, T., Takabatake, Y., Namba, T., Kaimori, J., Kitamura, H., Matsui, I., Niimura, F., Matsusaka, T., Fujita, N., Yoshimori, T., Isaka, Y., and Rakugi, H. (2012) Autophagy guards against cisplatin-induced acute kidney injury. Am. J. Pathol 180, 517-525
12. Howell, G. M., Gomez, H., Collage, R. D., Loughran, P., Zhang, X., Escobar, D. A., Billiar, T. R., Zuckerbraun, B. S., and Rosengart, M. R. (2013) Augmenting autophagy to treat acute kidney injury during endotoxemia in mice. PLoS One 8, e69520
13. Liu, W. J., Luo, M. N., Tan, J., Chen, W., Huang, L. Z., Yang, C., Pan, Q., Li, B., and Liu, H. F. (2014) Autophagy activation reduces renal tubular injury induced by urinary proteins. Autophagy 10, 243-256
14. Tanaka, Y., Kume, S., Kitada, M., Kanasaki, K., Uzu, T., Maegawa, H., and Koya, D. (2012) Autophagy as a therapeutic target in diabetic nephropathy. Exp. Diabetes Res. 2012, 628978
15. Liu, W. J., Xie, S. H., Liu, Y. N., Kim, W., Jin, H. Y., Park, S. K., Shao, Y. M., and Park, T. S. (2012) Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats. J. Pharmacol. Exp. Ther. 340, 248-255
16. Kimura, S., Noda, T., and Yoshimori, T. (2007) Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3, 452-460
17. Shi, L., Yu, X., Yang, H., and Wu, X. (2013) Advanced glycation end products induce human corneal epithelial cells apoptosis through generation of reactive oxygen species and activation of JNK and p38 MAPK pathways. PLoS One 8, e66781
18. Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., and Akira, S., et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8, 445-544
19. Rubinsztein, D. C., Cuervo, A. M., Ravikumar, B., Sarkar, S., Korolchuk, V., Kaushik, S., and Klionsky, D. J. (2009) In search of an "autophagomometer." Autophagy 5, 585-589
20. Boya, P., and Kroemer, G. (2008) Lysosomal membrane permeabilization in cell death. Oncogene 27, 6434-6451
21. Sakurai, S., Yonekura, H., Yamamoto, Y., Watanabe, T., Tanaka, N., Li, H., Rahman, A. K., Myint, K. M., Kim, C. H., and Yamamoto, H. (2003) The AGE-RAGE system and diabetic nephropathy. J. Am. Soc. Nephrol. 14, S259-S263
22. Lim, C. H., Bijvelds, M. J., Nigg, A., Schoonderwoerd, K., Houtsmuller, A. B., de Jonge, H. R., and Tilly, B. C. (2007) Cholesterol depletion and genistein as tools to promote F508delCFTR retention at the plasma membrane. Cell Physiol. Biochem. 20, 473-482
23. Sevillano, N., Girón, M. D., Salido, M., Vargas, A. M., Vilches, J., and Salto, R. (2009) Internalization of the receptor for advanced glycation end products (RAGE) is required to mediate intracellular responses. J. Biochem. 145, 21-30
24. Rubinsztein, D. C. (2006) The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443, 780-786
25. Osicka, T. M., Kiriazis, Z., Pratt, L. M., Jerums, G., and Comper, W. D. (2001) Ramipril and aminoguanidine restore renal lysosomal processing in streptozotocin diabetic rats. Diabetologia 44, 230-236
26. Shechter, P., Boner, G., and Rabkin, R. (1994) Tubular cell protein degradation in early diabetic renal hypertrophy. J. Am. Soc. Nephrol. 4, 1582-1587
27. Osicka, T. M., Houlihan, C. A., Chan, J. G., Jerums, G., and Comper, W. D. (2000) Albuminuria in patients with type 1 diabetes is directly linked to changes in the lysosome-mediated degradation of albumin during renal passage. Diabetes 49, 1579-1584
28. Johansson, A. C., Appelqvist, H., Nilsson, C., Kågedal, K., Roberg, K., and Ollinger, K. (2010) Regulation of apoptosis-associated lysosomal membrane permeabilization. Apoptosis 15, 527-540
29. Repnik, U., Stoka, V., Turk, V., and Turk, B. (2012) Lysosomes and lysosomal cathepsins in cell death. Biochim. Biophys. Acta 1824, 22-33
30. Lee, A. S., Kim, D. H., Lee, J. E., Jung, Y. J., Kang, K. P., Lee, S., Park, S. K., Kwak, J. Y., Lee, S. Y., Lim, S. T., Sung, M. J., Yoon, S. R., and Kim, W. (2011) Erythropoietin induces lymph node lymphangiogenesis and lymph node tumor metastasis. Cancer Res. 71, 4506-4517
31. Pangare, M., and Makino, A. (2012) Mitochondrial function in vascular endothelial cell in diabetes. J. Smooth Muscle Res. 48, 1-26
32. Zhan, M., Usman, I. M., Sun, L., and Kanwar, Y. S. (2015) Disruption of renal tubular mitochondrial quality control by myo-inositol oxygenase in diabetic kidney disease. J. Am. Soc. Nephrol. 26, 1304-1321
33. Zhao, X., Liu, G., Shen, H., Gao, B., Li, X., Fu, J., Zhou, J., and Ji, Q. (2015) Liraglutide inhibits autophagy and apoptosis induced by high glucose through GLP-1R in renal tubular epithelial cells. Int. J. Mol. Med. 35, 684-692
34. Fang, L., Zhou, Y., Cao, H., Wen, P., Jiang, L., He, W., Dai, C., and Yang, J. (2013) Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. PLoS One 8, e60546
35. Ma, T., Zhu, J., Chen, X., Zha, D., Singhal, P. C., and Ding, G. (2013) High glucose induces autophagy in podocytes. Exp. Cell Res. 319, 779-789
36. Mizushima, N., Yoshimori, T., and Levine, B. (2010) Methods in mammalian autophagy research. Cell 140, 313-326
37. Tojo, A., Onozato, M. L., Ha, H., Kurihara, H., Sakai, T., Goto, A., Fujita, T., and Endou, H. (2001) Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats. Histochem. Cell Biol. 116, 269-276
38. Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., and Chiba, T. (2005) Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 169, 425-434
39. Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Overvatn, A., Stenmark, H., and Johansen, T. (2005) p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 171, 603-614