In vitro modeling of emulsification of silicone oil as intraocular tamponade using microengineered eye-on-a-chip

Investigative Ophthalmology and Visual Science

Volumn 56, Issue 5, 2015, Pages 3314-3319

  Chan, Yau Kei ^a   Sy, Kwun Hei Samuel ^a   Wong, Chun Yu ^a   Man, Ping Kwan ^a   Wong, David ^a   Shum, Ho Cheung ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (China)

Author keywords

Emulsification; Eye on a chip; Silicone oil; Tamponade; Vitreoretinal surgery

Indexed keywords

FIBRONECTIN; POLY(METHYL METHACRYLATE); SILICONE OIL; EMULSION; POLYMETHACRYLIC ACID DERIVATIVE;

ARTICLE; BIOCHIP; CELL METABOLISM; CELL VIABILITY; CLOSED ANGLE GLAUCOMA; EYE MOVEMENT; IN VITRO STUDY; MICROCHIP ANALYSIS; MICROSCOPY; PHACOEMULSIFICATION; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; VITREORETINAL SURGERY; AUDIOVISUAL EQUIPMENT; BIOLOGICAL MODEL; CELL LINE; CHEMISTRY; EMULSION; ENDOTAMPONADE; HUMAN; PHYSIOLOGY; RETINA GANGLION CELL; SURFACE PROPERTY; VISCOSITY;

CELL LINE; EMULSIONS; ENDOTAMPONADE; HUMANS; MODELS, ANATOMIC; MODELS, BIOLOGICAL; POLYMETHACRYLIC ACIDS; RETINAL GANGLION CELLS; SACCADES; SILICONE OILS; SURFACE PROPERTIES; VISCOSITY;

EID: 84939817193     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.15-16728     Document Type: Article

References (46)

1. Budenz DL, Taba KE, Feuer WJ, et al. Surgical management of secondary glaucoma after pars plana vitrectomy and silicone oil injection for complex retinal detachment. Ophthalmology. 2001;108:1628-1632.
2. Garnier S, Rahmi A, Grasswil C, Kodjikian L. Three hundred and sixty degree retinotomy for retinal detachments with severe proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol. 2013;251:2081-2085.
3. Giordano GG, Refojo MF. Silicone oils as vitreous substitutes. Prog Polym Sci. 1998;23:509-532.
4. Gonzalez MA, Flynn HWJ, Smiddy WE, Albini TA, Berrocal AM, Tenzel P. Giant retinal tears after prior pars plana vitrectomy: management strategies and outcomes. Clin Ophthalmol. 2013;7:1687-1691.
5. Cibis PA, Becker B, Okun E, Canaan S. The use of liquid silicone in retinal detachment surgery. Arch Ophthalmol. 1962;68:590-599.
6. Haut J, Ullern M, Boulard ML, Cedah A. Utilisation du silicone intra-oculaire après vitrectomie comme traitement des retractions massives du vitré (note préliminaire). Bull Soc OphtalmolFr. 1978;78:361-165.
7. Toklu Y, Cakmak HB, Ergun SB, Yorgun MA, Simsek S. Time course of silicone oil emulsification. Retina. 2012;32:2039-2044.
8. Chan YK, Ng CO, Knox PC, Garvey MJ, Williams RL, Wong D. Emulsification of silicone oil and eye movements. Invest Ophthalmol Vis Sci. 2011;52:9721-9727.
9. Colthurst MJ, Williams RL, Hiscott PS, Grierson I. Biomaterials used in the posterior segment of the eye. Biomaterials. 2000; 21:649-665.
10. Baino F. Towards an ideal biomaterial for vitreous replacement: historical overview and future trends. Acta Biomater. 2011;7:921-935.
11. Williams RL, Day MJ, Garvey MJ, et al. Injectability of silicone oil-based tamponade agents. Br J Ophthalmol. 2011;95:273-276.
12. Fawcett IM, Williams RL, Wong D. Contact angles of substances used for internal tamponade in retinal detachment surgery. Graefes Arch Clin Exp Ophthalmol. 1994;232:438-444.
13. Wetterqvist C, Wong D, Williams R, Stappler T, Herbert E, Freeburn S. Tamponade efficiency of perfluorohexyloctane and silicone oil solutions in a model eye chamber. Br J Ophthalmol. 2004;88:692-696.
14. Herbert E, Stappler T, Wetterqvist C, Williams R, Wong D. Tamponade properties of double-filling with perfluorohexy-loctane and silicone oil in a model eye chamber. Graefes Arch Clin Exp Ophthalmol. 2004;242:250-254.
15. Bartov E, Pennarola F, Savion N, Naveh N, Treister GA. Quantitative in vitro model for silicone oil emulsification: role of blood constituents. Retina. 1992;12:S23-S27.
16. Caramoy A, Schroder S, Fauser S, Kirchhof B. In vitro emulsification assessment of new silicone oils. Br J Ophthalmol. 2010;94:509-512.
17. Chan YK. Reducing the Complications Associated With Emulsification in the Use of Polydimethylsiloxane (PDMS) Based Silicone Oil in Vitreous Surgery by Engineering Approaches [postgraduate thesis]. Hong Kong: University of Hong Kong; 2014.
18. Lai W, Wong D, Li K, Leow P-l. Emulsification and inverted hypopyon formation of oxane HD in the anterior chamber. Graefes Arch Clin Exp Ophthalmol. 2008;246:1633-1635.
19. Chan YK, Cheung N, Chan W, Wong D. Quantifying silicone oil emulsification in patients: are we only seeing the tip of the iceberg? [published online ahead of print November 25, 2014]. Graefes Arch Clin Exp Ophthalmol. doi:1007/s00417-014-2866-1.
20. Bhatia SN, Ingber DE. Microfluidic organs-on-chips. Nat Biotech. 2014;32:760-772.
21. Tavana H, Zamankhan P, Christensen P, Grotberg J, Takayama S. Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model. Biomed Microdevices. 2011;13:731-742.
22. Agarwal A, Goss JA, Cho A, McCain ML, Parker KK. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab Chip. 2013;13:3599-3608.
23. Jang K-J, Suh K-Y. A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab Chip. 2010;10: 36-42.
24. Puleo CM, McIntosh AW, Takezawa T, Elisseeff J, Wang T-H. Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture. Lab Chip. 2009;9:3221-3227.
25. Krishnamoorthy RR, Agarwal P, Prasanna G, et al. Characterization of a transformed rat retinal ganglion cell line. Mol Brain Res. 2001;86:1-12.
26. Lancaster WB. Fifty years experience in ocular motility. Am J Ophthalmol 1941;24:485-496.
27. Harris CM, Wolpert DM. Signal-dependent noise determines motor planning. Nature. 1998;394:780-784.
28. Knox PC, Weir CR, Murphy PJ. Modification of visually guided saccades by a nonvisual afferent feedback signal. Invest Ophthalmol Vis Sci 2000;41:2561-2565.
29. Chen SI, Knox PC, Hiscott P, Marsh IB. Detection of the slipped extraocular muscle after strabismus surgery. Ophthalmology. 2005;112:686-693.
30. Ichhpujani P, Jindal A, Katz JL. Silicone oil induced glaucoma: a review. Graefes Arch Clin Exp Ophthalmol. 2009;247:1585-1593.
31. Errera M-H, Liyanage SE, Elgohary M, et al. Using spectral-domain optical coherence tomography imaging to identify the presence of retinal silicone oil emulsification after silicone oil tamponade. Retina. 2013;33:1567-1573.
32. Chan YK, Cheung N, Wong D. Factors influencing the shear rate acting on silicone oil to cause silicone oil emulsification. Invest Ophthalmol Vis Sci. 2014;55:7451-7456.
33. Heidenkummer H-P, Kampik A, Thierfelder S. Emulsification of silicone oils with specific physicochemical characteristics. Graefes Arch Clin Exp Ophthalmol. 1991;229:88-94.
34. Chiou AG, Florakis GJ, Herbort CP. Correlation between anterior chamber IgG/albumin concentrations and laser flare photometry in eyes with endogenous uveitis. Ophthalmolog-ica. 1998;212:275-277.
35. Bali E, Feron E, Peperkamp E, Veckeneer M, Mulder P, van Meurs J. The effect of a preoperative subconjuntival injection of dexamethasone on blood-retinal barrier breakdown following scleral buckling retinal detachment surgery: a prospective randomized placebo-controlled double blind clinical trial. Graefes Arch Clin Exp Ophthalmol. 2010;248:957-962.
36. Williams RL, Kearns VR, Lo AC, et al. Novel heavy tamponade for vitreoretinal surgery. Invest Ophthalmol Vis Sci. 2013;54: 7284-7292.
37. Zeana D, Becker J, Kuckelkorn R, Kirchhof B. Perfluorohex-yloctane as a long-term vitreous tamponade in the experimental animal. Experimental perfluorohexyloctane substitution. Int Ophthalmol. 1999;23:17-24.
38. Toklu Y, Cakmak HB, Ergun SB, Yorgun MA, Simsek S. Time course of silicone oil emulsification. Retina. 2012;32:2039-2044.
39. Wong D, Lai W, Yusof W. The use of continuous silicone oil infusion as a perioperative tool to facilitate break localisation, vitreous base dissection, and drainage of subretinal fluid. Ophthalmologica. 2011;226(Suppl 1):53-57.
40. Riedel KG, Gabel VP, Neubauer L, Kampik A, Lund OE. Intravitreal silicone oil injection: complications and treatment of 415 consecutive patients. Graefes Arch Clin Exp Ophthalmol. 1990;228:19-23.
41. Scott IU, Flynn HWJ, Murray TG, Smiddy WE, Davis JL, Feuer WJ. Outcomes of complex retinal detachment repair using 1000- vs 5000-centistoke silicone oil. Arch Ophthalmol. 2005; 123:473-478.
42. Binks BP, Whitby CP. Silica particle-stabilized emulsions of silicone oil and water: aspects of emulsiication. Langmuir. 2004;20:1130-1137.
43. Voorhees PW. The theory of Ostwald ripening. J Stat Phys. 1985;38:231-252.
44. Brubaker RF. Measurement of aqueous flow by fluorophotom-etry. In: Ritch R, Shields MB, Krupin T, eds. The Glaucomas. St. Louis: Mosby; 1989:337-344.
45. Girard MJA, Suh J-KF, Bottlang M, Burgoyne CF, Downs JC. Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations. Invest Ophthalmol Vis Sci. 2011;52: 5656-5669.
46. Abdallah W, Ameri H, Barron E, et al. Vitreal oxygenation in retinal ischemia reperfusion. Invest Ophthalmol Vis Sci. 2011; 52:1035-1042.