Does Corneal Collagen Cross-linking Reduce the Need for Keratoplasties in Patients with Keratoconus?

Cornea

Volumn 34, Issue 9, 2015, Pages 991-995

  Sandvik, Gunhild Falleth ^a   Thorsrud, Andreas ^a   Råen, Marianne ^a   Østern, Atle E ^a   Sæthre, Marit ^a   Drolsum, Liv ^a,b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

corneal collagen cross linking; keratoconus; keratoplasty

Indexed keywords

COLLAGEN; CROSS LINKING REAGENT; PHOTOSENSITIZING AGENT; RIBOFLAVIN;

ADULT; AGE DISTRIBUTION; ARTICLE; CENTRAL CORNEAL THICKNESS; CLINICAL PRACTICE; CONTACT LENS; CORNEA TRANSPLANTATION; FEMALE; HUMAN; KERATOCONUS; KERATOMETRY; KERATOPLASTY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; SEX RATIO; ADOLESCENT; AGED; CORNEA STROMA; METABOLISM; MIDDLE AGED; PENETRATING KERATOPLASTY; STATISTICS AND NUMERICAL DATA; ULTRAVIOLET RADIATION; VISUAL ACUITY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; COLLAGEN; CORNEAL STROMA; CORNEAL TOPOGRAPHY; CROSS-LINKING REAGENTS; FEMALE; HUMANS; KERATOCONUS; KERATOPLASTY, PENETRATING; MALE; MIDDLE AGED; PHOTOSENSITIZING AGENTS; RIBOFLAVIN; ULTRAVIOLET RAYS; VISUAL ACUITY; YOUNG ADULT;

EID: 84939806881     PISSN: 02773740     EISSN: 15364798     Source Type: Journal    
DOI: 10.1097/ICO.0000000000000460     Document Type: Article

References (32)

1. Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28: 293-322.
2. Gordon MO, Steger-May K, Szczotka-Flynn L, et al. Baseline factors predictive of incident penetrating keratoplasty in keratoconus. Am J Ophthalmol. 2006;142:923-930.
3. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620-627.
4. Spoerl E, Seiler T. Techniques for stiffening the cornea. J Refract Surg. 1999;15:711-713.
5. Caporossi A, Mazzotta C, Baiocchi S, et al. Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol. 2010;149:585-593.
6. Wittig-Silva C, Chan E, Islam FM, et al. A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: three-year results. Ophthalmology. 2014;121:812-821.
7. Colin J, Cochener B, Savary G, et al. INTACS inserts for treating keratoconus: one-year results. Ophthalmology. 2001;108:1409-1414.
8. Buzard KA, Tuengler A, Febbraro JL. Treatment of mild to moderate keratoconus with laser in situ keratomileusis. J Cataract Refract Surg. 1999;25:1600-1609.
9. Kamiya K, Shimizu K, Kobashi H, et al. Three-year follow-up of posterior chamber toric phakic intraocular lens implantation for the correction of high myopic astigmatism in eyes with keratoconus. Br J Ophthalmol. 2015;99:177-183.
10. Leccisotti A. Refractive lens exchange in keratoconus. J Cataract Refract Surg. 2006;32:742-746.
11. Hashemi H, Shaygan N, Asgari S, et al. ClearKone-Synergeyes or rigid gas-permeable contact lens in keratoconic patients: a clinical decision. Eye Contact Lens. 2014;40:95-98.
12. Vazirani J, Basu S. Keratoconus: current perspectives. Clin Ophthalmol. 2013;7:2019-2030.
13. Krumeich JH, Daniel J, Knulle A. Live-epikeratophakia for keratoconus. J Cataract Refract Surg. 1998;24:456-463.
14. Raiskup F, Theuring A, Pillunat LE, et al. Corneal collagen crosslinking with riboflavin and ultraviolet-A light in progressive keratoconus: ten-year results. J Cataract Refract Surg. 2015;41:41-46.
15. Hashemi H, Seyedian MA, Miraftab M, et al. Corneal collagen crosslinking with riboflavin and ultraviolet a irradiation for keratoconus: longterm results. Ophthalmology. 2013;120:1515-1520.
16. Kymionis GD, Grentzelos MA, Liakopoulos DA, et al. Long-term follow-up of corneal collagen cross-linking for keratoconus-the Cretan study. Cornea. 2014;33:1071-1079.
17. Sharma N, Maharana P, Singh G, et al. Pseudomonas keratitis after collagen crosslinking for keratoconus: case report and review of literature. J Cataract Refract Surg. 2010;36:517-520.
18. Lam FC, Geourgoudis P, Nanavaty MA, et al. Sterile keratitis after combined riboflavin-UVA corneal collagen cross-linking for keratoconus. Eye (Lond). 2014;28:1297-1303.
19. Bakke EF, Stojanovic A, Chen X, et al. Penetration of riboflavin and postoperative pain in corneal collagen crosslinking: excimer laser superficial versus mechanical full-thickness epithelial removal. J Cataract Refract Surg. 2009;35:1363-1366.
20. Thorsrud A, Nicolaissen B, Drolsum L. Corneal collagen crosslinking in vitro: inhibited regeneration of human limbal epithelial cells after riboflavinultraviolet-A exposure. J Cataract Refract Surg. 2012;38:1072-1076.
21. Spoerl E, Mrochen M, Sliney D, et al. Safety of UVA-riboflavin crosslinking of the cornea. Cornea. 2007;26:385-389.
22. Olson RJ, Pingree M, Ridges R, et al. Penetrating keratoplasty for keratoconus: a long-term review of results and complications. J Cataract Refract Surg. 2000;26:987-991.
23. Purcell JJ Jr, Krachmer JH, Doughman DJ, et al. Expulsive hemorrhage in penetrating keratoplasty. Ophthalmology. 1982;89:41-43.
24. Tan JC, Holland SP, Dubord PJ, et al. Evolving indications for and trends in keratoplasty in British Columbia, Canada, from 2002 to 2011: a 10-year review. Cornea. 2014;33:252-256.
25. Wang J, Hasenfus A, Schirra F, et al. Changing indications for penetrating keratoplasty in Homburg/Saar from 2001 to 2010-histopathology of 1,200 corneal buttons. Graefes Arch Clin Exp Ophthalmol. 2013;251:797-802.
26. Coster DJ, Lowe MT, Keane MC, et al. A comparison of lamellar and penetrating keratoplasty outcomes: a registry study. Ophthalmology. 2014;121:979-987.
27. Lang SJ, Bischoff M, Bohringer D, et al. Analysis of the changes in keratoplasty indications and preferred techniques. PLoS One. 2014;9:e112696.
28. Saethre M, Drolsum L. The role of postoperative positioning after DSAEK in preventing graft dislocation. Acta Ophthalmol. 2014;92:77-81.
29. Randleman JB, Woodward M, Lynn MJ, et al. Risk assessment for ectasia after corneal refractive surgery. Ophthalmology. 2008;115:37-50.
30. O'Brart DP, Chan E, Samaras K, et al. A randomised, prospective study to investigate the efficacy of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linkage to halt the progression of keratoconus. Br J Ophthalmol. 2011;95:1519-1524.
31. Smiddy WE, Hamburg TR, Kracher GP, et al. Keratoconus. Contact lens or keratoplasty? Ophthalmology. 1988;95:487-492.
32. Kanellopoulos AJ, Asimellis G. Revisiting keratoconus diagnosis and progression classification based on evaluation of corneal asymmetry indices, derived from Scheimpflug imaging in keratoconic and suspect cases. Clin Ophthalmol. 2013;7:1539-1548.