Considerations when using pharmacokinetic/pharmacodynamic modeling to determine the effectiveness of simple analgesics in children

Expert Opinion on Drug Metabolism and Toxicology

Volumn 11, Issue 9, 2015, Pages 1393-1408

  Anderson, Brian J ^a   Hannam, Jacqueline A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Acetaminophen; Analgesia; Efficacy; Nonsteroidal anti inflammatory drugs; Pharmacodynamics; Pharmacokinetics; Pharmacometrics; Population modeling

Indexed keywords

ANALGESIC AGENT; DICLOFENAC; DRUG METABOLITE; IBUPROFEN; INDOMETACIN; KETOPROFEN; KETOROLAC; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; REMIFENTANIL; TRAMADOL;

ALLOMETRY; ANALGESIA; BASAL METABOLIC RATE; CHILD GROWTH; CHIRALITY; CIRCADIAN RHYTHM; DISEASE COURSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; GLUCURONIDATION; HUMAN; LIVER BLOOD FLOW; MATHEMATICAL MODEL; MATURATION; NOCEBO EFFECT; NONHUMAN; PAIN; PAIN ASSESSMENT; PATIENT DROPOUTS; PEDIATRIC SURGERY; PHARMACOGENOMICS; PLACEBO EFFECT; PLASMA PROTEIN BINDING; RACE DIFFERENCE; REVIEW; SEX DIFFERENCE; VOLUME OF DISTRIBUTION; VOLUME OF DISTRIBUTION AT STEADY-STATE; BIOLOGICAL MODEL; CHILD; DOSE RESPONSE; NONLINEAR SYSTEM; PAIN MEASUREMENT; PHARMACOGENETICS;

ANALGESICS; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PAIN; PAIN MEASUREMENT; PHARMACOGENETICS;

EID: 84939804849     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2015.1061505     Document Type: Review

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