A Multivariate Computational Method to Analyze High-Content RNAi Screening Data

Journal of Biomolecular Screening

Volumn 20, Issue 8, 2015, Pages 985-997

  Rameseder, Jonathan ^a,b   Krismer, Konstantin ^a   Dayma, Yogesh ^a   Ehrenberger, Tobias ^b   Hwang, Mun Kyung ^a   Airoldi, Edoardo M ^c,d   Floyd, Scott R ^a,e   Yaffe, Michael B ^a,d,e  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c HARVARD UNIVERSITY   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

feature selection; high content screening; hit identification; multivariate data analysis; RNAi screening

Indexed keywords

B RAF KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; SHORT HAIRPIN RNA; MESSENGER RNA; SMALL INTERFERING RNA;

ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DNA DAMAGE; DNA DAMAGE RESPONSE; FOLLOW UP; GENE IDENTIFICATION; GENE SILENCING; HIGH CONTENT SCREENING; HIGH THROUGHPUT SCREENING; LASSO MODEL; MODEL; MULTIVARIATE ANALYSIS; MULTIVARIATE ROBUST ANALYSIS METHOD; OSTEOSARCOMA CELL LINE; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ALGORITHM; ANIMAL; BIOLOGICAL MODEL; CELL LINE; COMPUTER SIMULATION; GENETICS; HUMAN;

ALGORITHMS; ANIMALS; CELL LINE; COMPUTER SIMULATION; DNA DAMAGE; GENE KNOCKDOWN TECHNIQUES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, BIOLOGICAL; PHENOTYPE; PROTO-ONCOGENE PROTEINS B-RAF; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84939798578     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057115583037     Document Type: Article

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