Lack of replication of four candidate SNPs implicated in human male fertility traits: A large-scale population-based study

Human Reproduction

Volumn 30, Issue 6, 2015, Pages 1505-1509

  Sato, Youichi ^a   Tajima, Atsushi ^a,b   Tsunematsu, Kouki ^a   Nozawa, Shiari ^c   Yoshiike, Miki ^c   Koh, Eitetsue ^b   Kanaya, Jiro ^b   Namiki, Mikio ^b   Matsumiya, Kiyomi ^d   Tsujimura, Akira ^e   Komatsu, Kiyoshi ^f   Itoh, Naoki ^g   Eguchi, Jiro ^h   Imoto, Issei ^a   Yamauchi, Aiko ^a   Iwamoto, Teruaki ^c,i  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d OSAKA POLICE HOSPITAL   (Japan)

^e OSAKA UNIVERSITY   (Japan)

^f Harasanshinkai Hospital   (Japan)

^g SAPPORO MEDICAL UNIVERSITY   (Japan)

^h NAGASAKI UNIVERSITY   (Japan)

ⁱ International University of Health and Welfare   (Japan)

Author keywords

Japanese population; male fertility; replication study; semen quality

Indexed keywords

ADULT; ARTICLE; BIRTH RATE; FAMILY SIZE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUTTERITE; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; MALE; MALE FERTILITY; META ANALYSIS (TOPIC); POLYMERASE CHAIN REACTION; POPULATION RESEARCH; REPLICATION STUDY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; SPERM QUALITY; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; UNITED STATES; YOUNG ADULT; ASIAN AMERICAN; COHORT ANALYSIS; ETHNOLOGY; FERTILITY; GENETIC MARKER; GENETICS; JAPAN; META ANALYSIS; SEMEN ANALYSIS;

GENETIC MARKER;

ADULT; ASIAN AMERICANS; COHORT STUDIES; FERTILITY; GENETIC MARKERS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; JAPAN; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEMEN ANALYSIS; SPERM COUNT; SPERM MOTILITY; UNITED STATES;

EID: 84939638739     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dev081     Document Type: Article

References (12)

1. AstonKI,CarrellDT.Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. J Androl 2009; 30:711-725.
2. Clarke GM, Carter KW, Palmer LJ, Morris AP, Cardon LR. Fine mapping versus replication in whole-genome association studies. Am J Hum Genet 2007;81:995-1005.
3. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-560.
4. Hu Z, Xia Y, Guo X, Dai J, Li H, Hu H, Jiang Y, Lu F, Wu Y, Yang X et al. A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. Nat Genet 2012;44:183-186.
5. Iwamoto T, Nozawa S, YoshiikeM, Namiki M, Koh E, Kanaya J, Okuyama A, Matsumiya K, Tsujimura A, Komatsu K et al. Semen quality of fertile Japanese men: a cross-sectional population-based study of 792 men. BMJ Open 2013a;3:e002223.
6. Iwamoto T, Nozawa S, Mieno MN, Yamakawa K, Baba K, Yoshiike M, Namiki M, Koh E, Kanaya J, Okuyama A et al. Semen quality of 1559 young men from four cities in Japan: a cross-sectional population-based study. BMJ Open 2013b;3:e002222.
7. JinamTA,NakaokaH,HosomichiK,MitsunagaS,OkadaH,TanakaA,TanakaK, Inoue I. HLA-DPB1 04:01 allele is associated with non-obstructive azoospermia in Japanese patients. Hum Genet 2013;132:1405-1411.
8. Kosova G, Scott NM, Niederberger C, Prins GS, Ober C. Genome-wide association study identifies candidate genes for male fertility traits in humans. Am J Hum Genet 2012;90:950-961.
9. SatoY, JinamT, IwamotoT,Yamauchi A, ImotoI, Inoue I,TajimaA.Replication study and meta-analysis of human nonobstructive azoospermia in Japanese populations. Biol Reprod 2013;88:87.
10. Sato Y, Tajima A, Tsunematsu K, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A et al. An association study of four candidate loci for human male fertility traits with male infertility. Hum Reprod. 2015;30:1510-1514.
11. World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction, 4th edn. Cambridge: Cambridge University Press, 1999.
12. Zhao H, Xu J, Zhang H, Sun J, Sun Y,Wang Z, Liu J, Ding Q, Lu S, Shi R et al.A genome-wide association study reveals that variants within theHLAregion are associated with risk for nonobstructive azoospermia. Am J Hum Genet 2012;90:900-906.