Data Resource Profile: Clinical Practice Research Datalink (CPRD)

International Journal of Epidemiology

Volumn 44, Issue 3, 2015, Pages 827-836

  Herrett, Emily ^a   Gallagher, Arlene M ^b,c   Bhaskaran, Krishnan ^a   Forbes, Harriet ^a   Mathur, Rohini ^a   Staa, Tjeerd van ^a,c,d   Smeeth, Liam ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b MEDICINES AND HEALTHCARE PRODUCTS REGULATORY AGENCY   (United Kingdom)

^c UTRECHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGE CLASS; DATA ASSIMILATION; DATA QUALITY; DATABASE; DEMOGRAPHY; EPIDEMIOLOGY; ETHNICITY; HEALTH CARE; MORTALITY; SEX-RELATED DIFFERENCE; SYMPTOM;

ARTICLE; CLINICAL CLASSIFICATION; CLINICAL PRACTICE RESEARCH DATALINK; CONFIDENTIALITY; ELECTRONIC MEDICAL RECORD; FOLLOW UP; FUNDING; GENERAL PRACTICE; HUMAN; INFORMATION PROCESSING; INTERVENTION STUDY; LIFESTYLE; MEDICAL LITERATURE; MEDICAL RESEARCH; MORBIDITY; MORTALITY; OBSERVATIONAL STUDY; PREDICTIVE VALUE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PUBLICATION; READ CODE; REFERENCE DATABASE; RESEARCH ETHICS; RESOURCE MANAGEMENT; SECONDARY HEALTH CARE; UNITED KINGDOM; DATA BASE; ELECTRONIC HEALTH RECORD; GENERAL PRACTITIONER; MEASUREMENT ACCURACY; PRIMARY HEALTH CARE;

UNITED KINGDOM;

BIOMEDICAL RESEARCH; DATA ACCURACY; DATABASES AS TOPIC; ELECTRONIC HEALTH RECORDS; GENERAL PRACTITIONERS; HUMANS; PRIMARY HEALTH CARE; UNITED KINGDOM;

EID: 84939607655     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyv098     Document Type: Article

References (43)

1. Health and Social Care Information Centre. Attribution Data Set GP-Registered Populations Scaled to ONS Population Estimates-2011 2012. http://www.hscic.gov.uk/catalogue/PUB05054 (6 August 2014, date last accessed).
2. Kousoulis AA, Rafi I, de Lusignan S. The CPRD and the RCGP: building on research success by enhancing benefits for patients and practices. Br J Gen Pract 2015;65:54-55.
3. Williams T, van Staa T, Puri S, Eaton S. Recent advances in the utility and use of the General Practice Research Database as an example of a UK Primary Care Data resource. Ther Adv Drug Saf 2012;3:89-99.
4. Health and Social Care Information Centre (HSCIC). http://www.hscic.gov.uk/(6 August 2014, date last accessed).
5. Hospital Episode Statistics. http://www.hscic.gov.uk/hes (21 January 2015, date last accessed).
6. Office for National Statistics. Mortality Statistics: Metadata. Cardiff, UK: ONS, 2014.
7. National Cancer Intelligence Network. http://www.ncin.org.uk/home (23 January 2015, date last accessed).
8. Herrett E, Smeeth L, Walker L, Weston C. The Myocardial Ischaemia National Audit Project (MINAP). Heart 2010;96: 1264-67.
9. The Clinical Practice Research Datalink (CPRD) www.cprd.com (6 August 2014, date last accessed).
10. Carr DF, O'Meara H, Jorgensen AL et al. SLCO1B1 genetic variant associated with statin-induced myopathy: a proof-of-concept study using the clinical practice research datalink. Clin Pharmacol Ther 2013;94:695-701.
11. O'Meara H, Carr DF, Evely J et al. Electronic health records for biological sample collection: feasibility study of statin-induced myopathy using the Clinical Practice Research Datalink. Br J Clin Pharmacol 2014;77:831-38.
12. Horspool MJ, Julious SA, Boote J et al. Preventing and lessening exacerbations of asthma in school-age children associated with a new term (PLEASANT): study protocol for a cluster randomised control trial. Trials 2013;14:297.
13. Gulliford MC, van Staa TP, McDermott L et al. Cluster randomized trials utilizing primary care electronic health records: methodological issues in design, conduct, and analysis (eCRT Study). Trials 2014;15:220.
14. van Staa TP, Dyson L, McCann G et al. The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials. Health Technol Assess 2014;18: 1-146.
15. Chisholm J. The Read clinical classification. BMJ 1990;300: 1092.
16. Chen YC, Wu JC, Haschler I, Majeed A, Chen TJ, Wetter T. Academic impact of a public electronic health database: bibliometric analysis of studies using the general practice research database. PLoS One 2011;6:e21404.
17. Clinical Practice Research Datalink. CPRD Bibliography. http://www.cprd.com/bibliography/(12 February 2015, date last accessed).
18. van Staa TP, Goldacre B, Gulliford M et al. Pragmatic randomised trials using routine electronic health records: putting them to the test. BMJ 2012;344:e55.
19. Smeeth L, Cook C, Fombonne E et al. MMR vaccination and pervasive developmental disorders: a case-control study. Lancet 2004;364:963-69.
20. Smeeth L, Thomas SL, Hall AJ, Hubbard R, Farrington P, Vallance P. Risk of myocardial infarction and stroke after acute infection or vaccination. NEngl J Med 2004;351:2611-18.
21. Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Statins and the risk of dementia. Lancet 2000;356:1627-31.
22. Gelfand JM, Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB. Risk of myocardial infarction in patients with psoriasis. JAMA 2006;296:1735-41.
23. Van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C. Use of oral corticosteroids and risk of fractures. J Bone Miner Res 2000;15:993-1000.
24. Bhaskaran K, Douglas I, Forbes H, dos-Santos-Silva I, Leon DA, Smeeth L. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet 2014;384:755-65.
25. Dommett RM, Redaniel T, Stevens MC, Martin RM, Hamilton W. Risk of childhood cancer with symptoms in primary care: a population-based case-control study. Br J Gen Pract 2013;63: e22-29.
26. Douglas I, Evans S, Rawlins MD, Smeeth L, Tabrizi SJ, Wexler NS. Juvenile Huntington's disease: a population-based study using the General Practice Research Database. BMJ Open 2013; 3:pii: e002085.
27. Crooks CJ, Card TR, West J. Excess long-term mortality following non-variceal upper gastrointestinal bleeding: a population-based cohort study. PLoS Med 2013;10:e1001437.
28. Cotton SJ, Belcher J, Rose PK, Jaqadeesan S, Neal RD. The risk of a subsequent cancer diagnosis after herpes zoster infection: primary care database study. Br J Cancer 2013;108:721-26.
29. Lalmohamed A, Bazelier MT, Van Staa TP et al. Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study. Eur J Neurol 2012;19: 1007-14.
30. Office for National Statistics. 2011 Census-Population and Household Estimates for England and Wales, March 2011. Cardiff, UK: ONS, 2012.
31. Mathur R, Bhaskaran K, Chaturvedi N et al. Completeness and usability of ethnicity data in UK-based primary care and hospital databases. J Public Health (Oxf) 2013;34:684-92.
32. Bhaskaran K, Forbes HJ, Douglas I, Leon DA, Smeeth L. Representativeness and optimal use of body mass index (BMI) in the UK Clinical Practice Research Datalink (CPRD). BMJ Open 2013;3:e003389.
33. Campbell J, Dedman DJ, Eaton SC, Gallagher AM, Williams TJ. Is the GPRD GOLD population comparable to the UK population? Pharmacoepidemiol Drug Saf 2013;22(Suppl 1):280.
34. Quality and Outcomes Framework. http://www.hscic.gov.uk/qof (6 August 2014, date last accessed).
35. van Staa TP, Dennison EM, Leufkens HG, Cooper C. Epidemiology of fractures in England and Wales. Bone 2001;29: 517-22.
36. Ryan R, Majeed A. Prevalence of treated hypertension in general practice in England and Wales, 1994 and 1998. Health Stat Q 2002;16:14-18.
37. Ronquist G, Rodriguez LA, Ruigomez A, et al. Association between captopril, other antihypertensive drugs and risk of prostate cancer. Prostate 2004;58:50-56.
38. Meier CR, Napalkov PN, Wegmuller Y, Jefferson T, Jick H. Population-based study on incidence, risk factors, clinical complications and drug utilisation associated with influenza in the United Kingdom. Eur J Clin Microbiol InfectDis 2000;19:834-42.
39. Herrett E, Thomas SL, Schoonen WM, Smeeth L, Hall AJ. Validation and validity of diagnoses in the General Practice Research Database: a systematic review. Br J Clin Pharmacol 2010;69:4-14.
40. Tate R, Kalra D, Boggon R, Beloff N, Puri S, Williams TJ. Data quality in European primary care research databases. Report of a workshop held in London September 2013. 2014 IEEE-EMBS International Conference on Biomedical and Health Informatics. BHI 2014;6864310:85-88.
41. Dave S, Petersen I. Creating medical and drug code lists to identify cases in primary care databases. Pharmacoepidemiol Drug Saf 2009;18:704-07.
42. Springate DA, Kontopantelis E, Ashcroft DM et al. ClinicalCodes: an online clinical codes repository to improve the validity and reproducibility of research using electronic medical records. PLoS One 2014;9:e99825.
43. CALIBER Research Portal. https://www.caliberresearch.org/portal/(23 January 2015, date last accessed).