Heat shock protein 70 and CHIP promote Nox4 ubiquitination and degradation within the losartan antioxidative effect in proximal tubule cells

Cellular Physiology and Biochemistry

Volumn 36, Issue 6, 2015, Pages 2183-2197

  Lorenzo, Andrea F Gil ^a   Costantino, Valeria V ^a   Appiolaza, Martin López ^a   Cacciamani, Valeria ^b   Benardon, Maria E ^b   Bocanegra, Victoria ^a   Vallés, Patricia G ^a,b  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

Author keywords

Angiotensin II; Losartan; Nox4 Hsp70 CHIP; Proximal tubule cells; Ubiquitination

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CAVEOLIN 1; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 72; LOSARTAN; PROTEIN CHIP; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ANTIOXIDANT; CHIP PROTEIN, RAT; NOX4 PROTEIN, RAT; PROTEASOME; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; KIDNEY TUBULE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RAT; UBIQUITINATION; ANIMAL; BIOLOGICAL MODEL; BLOOD PRESSURE; BODY WEIGHT; CELL MEMBRANE; CYTOLOGY; DRUG EFFECTS; GENE SILENCING; HUMAN; KIDNEY PROXIMAL TUBULE; METABOLISM; PROTEIN TRANSPORT; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

ANIMALS; ANTIOXIDANTS; BLOOD PRESSURE; BODY WEIGHT; CAVEOLIN 1; CELL MEMBRANE; GENE KNOCKDOWN TECHNIQUES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; KIDNEY TUBULES, PROXIMAL; LOSARTAN; MALE; MODELS, BIOLOGICAL; NADPH OXIDASE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; PROTEOLYSIS; RATS, INBRED SHR; RATS, INBRED WKY; REACTIVE OXYGEN SPECIES; RECEPTOR, ANGIOTENSIN, TYPE 1; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84939603518     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000430184     Document Type: Article

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