BAG2 Is Repressed by NF-κB Signaling, and Its Overexpression Is Sufficient to Shift Aβ1-42 from Neurotrophic to Neurotoxic in Undifferentiated SH-SY5Y Neuroblastoma

Journal of Molecular Neuroscience

Volumn 57, Issue 1, 2015, Pages 83-89

  Santiago, Fernando E ^a   Almeida, Maria Camila ^a   Carrettiero, Daniel C ^a  

^a UNIVERSIDADE FEDERAL DO ABC   (Brazil)

Author keywords

Alzheimer s disease; BCL2 associated athanogene; Beta amyloid; Differentiation; NF kappaB

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JSH 23; MESSENGER RNA; PROTEIN; PROTEIN BAG2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); BAG2 PROTEIN, HUMAN; CHAPERONE; PEPTIDE FRAGMENT;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL STRESS; CONTROLLED STUDY; GENE EXPRESSION; GENE REPRESSION; MOLECULAR BIOLOGY; NEUROBLASTOMA CELL LINE; NEUROTOXICITY; NEUROTROPISM; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; NEUROBLASTOMA; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MOLECULAR CHAPERONES; NEUROBLASTOMA; NF-KAPPA B; PEPTIDE FRAGMENTS; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION;

EID: 84939572700     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-015-0579-5     Document Type: Article

References (45)

1. Arevalo MA, Roldan PM, Chacón PJ, Rodríguez-Tebar A (2009) Amyloid beta serves as an NGF-like neurotrophic factor or acts as a NGF antagonist depending on its concentration. J Neurochem 111(6):1425–1433
2. Arndt V, Daniel C, Nastainczyk W, Alberti S, Höhfeld J (2005) BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Mol Biol Cell 16(12):5891–5900
3. Barrett T, Suzek TO, Troup DB, Wilhite SE, Ngau W-C, Ledoux P, Rudnev D, Lash AE, Fujibuchi W, Edgar R (2005) NCBI GEO: mining millions of expression profiles—database and tools. Nucleic Acids Res 33(suppl 1):D562–D566. doi:10.1093/nar/gki022
4. Baxter FO, Came PJ, Abell K, Kedjouar B, Huth M, Rajewsky K, Pasparakis M, Watson CJ (2006) IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells. Development 133(17):3485–3494
5. Benvegnù S, Roncaglia P, Agostini F, Casalone C, Corona C, Gustincich S, Legname G (2011) Developmental influence of the cellular prion protein on the gene expression profile in mouse hippocampus. Physiol Genomics 43(12):711–725. doi:10.1152/physiolgenomics.00205.2010
6. Brenner RM, Nayak NR, Slayden OD, Critchley HO, Kelly RW (2002) Premenstrual and menstrual changes in the macaque and human endometrium: relevance to endometriosis. Ann N Y Acad Sci 955:60–74, discussion 86-8, 396-406
7. Carrettiero DC, Hernandez I, Neveu P, Papagiannakopoulos T, Kosik KS (2009) The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule. J Neurosci 29(7):2151–2161. doi:10.1523/JNEUROSCI.4660-08.2009
8. Chen G, Shi J, Jin W, Wang L, Xie W, Sun J, Hang C (2008) Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion. Ann Clin Lab Sci 38(1):65–74
9. Chen G, Ke Z, Xu M, Liao M, Wang X, Qi Y, Zhang T, Frank JA, Bower KA, Shi X, Luo J (2012) Autophagy is a protective response to ethanol neurotoxicity. Autophagy 8(11):1577–1589. doi:10.4161/auto.21376
10. Cheung YT, Lau WK, Yu MS, Lai CS, Yeung SC, So KF, Chang RC (2009) Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research. Neurotoxicology 30(1):127–135. doi:10.1016/j.neuro.2008.11.001
11. Chung YW, Kim HK, Kim IY, Yim MB, Chock PB (2011) Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. J Biol Chem 286(34):29681–29690. doi:10.1074/jbc.M111.264945
12. Eberle KE, Sansing HA, Szaniszlo P, Resto VA, Berrier AL (2011) Carcinoma matrix controls resistance to cisplatin through talin regulation of NF-kB. PLoS One 6(6), e21496. doi:10.1371/journal.pone.0021496
13. Frasca G, Chiechio S, Vancheri C, Nicoletti F, Copani A, Angela SM (2004) Beta-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: correlation with the MAP kinase pathway. J Mol Neurosci 22(3):231–236
14. Gallego MJ, Porayette P, Kaltcheva MM, Meethal SV, Atwood CS (2009) Opioid and progesterone signaling is obligatory for early human embryogenesis. Stem Cells Dev 18(5):737–740. doi:10.1089/scd.2008.0190
15. Gallego MJ, Porayette P, Kaltcheva MM, Bowen RL, Vadakkadath Meethal S, Atwood CS (2010) The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes. Stem Cell Res Ther 1(4):28. doi:10.1186/scrt28
16. Geetha T, Zheng C, McGregor WC, Douglas White B, Diaz-Meco MT, Moscat J, Babu JR (2012) TRAF6 and p62 inhibit amyloid ß-induced neuronal death through p75 neurotrophin receptor. Neurochem Int 61(8):1289–1293. doi:10.1016/j.neuint.2012.09.005
17. Guo Q, Wang Z, Li H, Wiese M, Zheng H (2012) APP physiological and pathophysiological functions: insights from animal models. Cell Res 22(1):78–89. doi:10.1038/cr.2011.116
18. Hartl D, Irmler M, Römer I, Mader MT, Mao L, Zabel C, de Angelis MH, Beckers J, Klose J (2008) Transcriptome and proteome analysis of early embryonic mouse brain development. Proteomics 8(6):1257–1265. doi:10.1002/pmic.200700724
19. Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT (2010) Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway. Antioxid Redox Signal 13(11):1713–1748. doi:10.1089/ars.2010.3221
20. Hofer-Warbinek R, Schmid JA, Mayer H, Winsauer G, Orel L, Mueller B, Wiesner C, Binder BR, de Martin R (2004) A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53. Cell Death Differ 11(12):1317–1325
21. Kaltschmidt B, Kaltschmidt C (2009) NF-kappaB in the nervous system. Cold Spring Harb Perspect Biol 1(3):a001271. doi:10.1101/cshperspect.a001271, Review. Erratum in: Cold Spring Harb Perspect Biol. 2010 Jan;2(1):a001271
22. Lei B, Mace B, Dawson HN, Warner DS, Laskowitz DT, James ML (2014) Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. PLoS One 9(7), e103969. doi:10.1371/journal.pone.0103969. eCollection 2014
23. Li YP, Bushnell AF, Lee CM, Perlmutter LS, Wong SK (1996) Beta-amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells. Brain Res 738(2):196–204
24. Li S, Banck M, Mujtaba S, Zhou MM, Sugrue MM, Walsh MJ (2010) p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. PLoS One 5(5), e10486. doi:10.1371/journal.pone.0010486
25. Liu T, Perry G, Chan HW, Verdile G, Martins RN, Smith MA, Atwood CS (2004) Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. J Neurochem 88(3):554–563
26. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4):402–408
27. Marrero MB, Bencherif M (2009) Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaB. Brain Res 1256:1–7. doi:10.1016/j.brainres.2008.11.053
28. McLaughlin D, Tsirimonaki E, Vallianatos G, Sakellaridis N, Chatzistamatiou T, Stavropoulos-Gioka C, Tsezou A, Messinis I, Mangoura D (2006) Stable expression of a neuronal dopaminergic progenitor phenotype in cell lines derived from human amniotic fluid cells. J Neurosci Res 83(7):1190–1200
29. Mellett M, Atzei P, Jackson R, O’Neill LA, Moynagh PN (2011) Mal mediates TLR-induced activation of CREB and expression of IL-10. J Immunol 186(8):4925–4935. doi:10.4049/jimmunol.1002739
30. Miloso M, Villa D, Crimi M, Galbiati S, Donzelli E, Nicolini G, Tredici G (2004) Retinoic acid-induced neuritogenesis of human neuroblastoma SH-SY5Y cells is ERK independent and PKC dependent. J Neurosci Res 75(2):241–252
31. Motif Mapper, Max-Planck Institute for Plant Breeding Research, 2004. http://www2.mpiz-koeln.mpg.de/coupland/coupland/mm3/html/
32. Mucke L, Selkoe DJ (2012) Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med 2(7):a006338. doi:10.1101/cshperspect.a006338
33. Nicolas M, Hassan BA (2014) Amyloid precursor protein and neural development. Development Jul;141(13):2543–8. doi:10.1242/dev.108712
34. Parry GC, Mackman N (1994) A set of inducible genes expressed by activated human monocytic and endothelial cells contain kappa B-like sites that specifically bind c-Rel-p65 heterodimers. J Biol Chem 269(33):20823–20825
35. Patil SP, Tran N, Geekiyanage H, Liu L, Chan C (2013) Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons. Neurosci Lett 554:121–125. doi:10.1016/j.neulet.2013.09.008
36. Rapoport M, Dawson HN, Binder LI, Vitek MP, Ferreira A (2002) Tau is essential to ß-amyloid-induced neurotoxicity. Proc Natl Acad Sci U S A 99(9):6364–6369
37. Reisman D, Elkind NB, Roy B, Beamon J, Rotter V (1993) c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif. Cell Growth Differ 4(2):57–65
38. Rosenbloom KR, Sloan CA, Malladi VS, Dreszer TR, Learned K, Kirkup VM, Wong MC, Maddren M, Fang R, Heitner SG, Lee BT, Barber GP, Harte RA, Diekhans M, Long JC, Wilder SP, Zweig AS, Karolchik D, Kuhn RM, Haussler D, Kent WJ (2013) ENCODE data in the UCSC Genome Browser: year 5 update. Nucleic Acids Res 41(Database issue):D56–D63
39. Ruiz-León Y, Pascual A (2003) Induction of tyrosine kinase receptor b by retinoic acid allows brain-derived neurotrophic factor-induced amyloid precursor protein gene expression in human SH-SY5Y neuroblastoma cells. Neuroscience 120(4):1019–1026
40. Simmons SO, Fan CY, Ramabhadran R (2009) Cellular stress response pathway system as a sentinel ensemble in toxicological screening. Toxicol Sci 111(2):202–225. doi:10.1093/toxsci/kfp140
41. Slocum HK, Pavelic ZP, Rustum YM, Creaven PJ, Karakousis C, Takita H, Greco WR (1981) Characterization of cells obtained by mechanical and enzymatic means from human melanoma, sarcoma, and lung tumors. Cancer Res 41(4):1428–1434
42. Stine WB, Jungbauer L, Yu C, LaDu MJ (2011) Preparing synthetic Aβ in different aggregation states. Methods Mol Biol 670:13–32. doi:10.1007/978-1-60761-744-0_2
43. Wang HQ, Zhang HY, Hao FJ, Meng X, Guan Y, Du ZX (2008) Induction of BAG2 protein during proteasome inhibitor-induced apoptosis in thyroid carcinoma cells. Br J Pharmacol 155(5):655–660. doi:10.1038/bjp.2008.302
44. Yankner BA, Duffy LK, Kirschner DA (1990) Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 250(4978):279–282
45. Zhang J, Lou X, Yang S, He S, Yang L, Liu M, Zhu H, Shan Q, Su S, Zhan Q, Xu N, Liu S (2012) BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21(CIP1) pathway. Cancer Lett 318(1):34–41. doi:10.1016/j.canlet.2011.11.033