Effectiveness of Minocycline and Rifampin vs Chlorhexidine and Silver Sulfadiazine-Impregnated Central Venous Catheters in Preventing Central Line-Associated Bloodstream Infection in a High-Volume Academic Intensive Care Unit: A before and after Trial

Journal of the American College of Surgeons

Volumn 221, Issue 3, 2015, Pages 739-747

  Bonne, Stephanie ^a   Mazuski, John E ^a   Sona, Carie ^b   Schallom, Marilyn ^b   Boyle, Walter ^a   Buchman, Timothy G ^c   Bochicchio, Grant V ^a   Coopersmith, Craig M ^c   Schuerer, Douglas J E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BARNES JEWISH HOSPITAL   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Abbreviations and Acronyms CLABSI central line associated blood stream infection; CSS chlorhexidine and silver sulfadiazine; CVC central venous catheter; MR minocycline and rifampin; NHSN National Healthcare Safety Network; SICU surgical ICU

Indexed keywords

CHLORHEXIDINE; MINOCYCLINE; RIFAMPICIN; SULFADIAZINE SILVER; ANTIINFECTIVE AGENT;

ADULT; APACHE; ARTICLE; CATHETER INFECTION; CENTRAL VENOUS CATHETER; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DISEASE DURATION; DRUG EFFICACY; ENTEROCOCCUS; FEMALE; HUMAN; INFECTION CONTROL; INFECTION PREVENTION; INFECTION RATE; INTENSIVE CARE UNIT; INTERNAL JUGULAR VEIN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; STAPHYLOCOCCUS; ADVERSE EFFECTS; BACTEREMIA; CATHETER-RELATED INFECTIONS; COMPARATIVE STUDY; MIDDLE AGED; TREATMENT OUTCOME; UNIVERSITY HOSPITAL;

ACADEMIC MEDICAL CENTERS; ANTI-INFECTIVE AGENTS; BACTEREMIA; CATHETER-RELATED INFECTIONS; CENTRAL VENOUS CATHETERS; CHLORHEXIDINE; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MINOCYCLINE; RIFAMPIN; SILVER SULFADIAZINE; TREATMENT OUTCOME;

EID: 84939568352     PISSN: 10727515     EISSN: 18791190     Source Type: Journal    
DOI: 10.1016/j.jamcollsurg.2015.05.013     Document Type: Article

References (43)

1. A. Srinivasan, M. Wise, M. Bell, and et al. Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention MMWR Morb Mortal Wkly Rep 60 2011 1 6
2. National Nosocomial Infections Surveillance National Nosocomial Infections Surveillance (NNIs) system report, data summary from January 1992 through June 2004 Am J Infect Control 32 2004 470 485
3. CDC. Bloodstream infection event (central-line associated bloodstream infection and non-central line-associated bloodstream infection). January 2015 (modified April 2015). Available at: http://www.cdc.gov/nhsn/pdfs/pscmanual/4psc-clabscurrent.pdf. Accessed December 18, 2014.
4. R.P. Wenzel, and M.B. Edmond The impact of hospital-acquired bloodstream infections Emerg Infect Dis 7 2001 174 177
5. D. Pittet, D. Tarara, and R.P. Wenzel Nosocomial bloodstream infection in critically ill patients. excess length of stay, extra costs, and attributable mortality JAMA 271 1994 1598 1601
6. R.L. Smith, S.M. Meixler, and M.S. Simberkoff Excess mortality in critically ill patients with nosocomial bloodstream infections Chest 100 1991 164 167
7. B. Digiovine, C. Chenoweth, C. Watts, and et al. The attributable mortality and costs of primary nosocomial bloodstream infections in the intensive care unit Am J Respir Crit Care Med 160 1999 976 981
8. L. Soufir, J.F. Timsit, C. Mahe, and et al. Attributable morbidity and mortality of catheter-related septicemia in critically ill patients: a matched, risk-adjusted, cohort study Infect Control Hosp Epidemiol 20 1999 396 401
9. J. Rello, A. Ochagavia, E. Sabanes, and et al. Evaluation of outcome of intravenous catheter-related infections in critically ill patients Am J Respir Crit Care Med 162 2000 1027 1030
10. J.E. Nowak, R.J. Brilli, M.R. Lake, and et al. Reducing catheter-associated bloodstream infections in the pediatric intensive care unit: business case for quality improvement Pediatr Crit Care Med 11 2010 579 587
11. J.B. Dimick, R.K. Pelz, R. Consunji, and et al. Increased resource use associated with catheter-related bloodstream infection in the surgical intensive care unit Arch Surg 136 2001 229 234
12. D.K. Warren, W.W. Quadir, C.S. Hollenbeak, and et al. Attributable cost of catheter-associated bloodstream infections among intensive care patients in a nonteaching hospital Crit Care Med 34 2006 2084 2089
13. K.B. Laupland, H. Lee, D.B. Gregson, and B.J. Manns Cost of intensive care unit-acquired bloodstream infections J Hosp Infect 63 2006 124 132
14. N.P. O'Grady, M. Alexander, L.A. Burns, et al. Healthcare Infection Control Practices Advisory Committee (HICPAC) Guidelines for the prevention of intravascular catheter-related infections Clin Infect Dis 52 2011 e162 e193
15. C.M. Coopersmith, T.L. Rebmann, J.E. Zack, and et al. Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit Crit Care Med 30 2002 59 64
16. A. Pérez Parra, M. Cruz Menárguez, M.J. Pérez Granda, and et al. A simple educational intervention to decrease incidence of central line-associated bloodstream infection (CLABSI) in intensive care units with low baseline incidence of CLABSI Infect Control Hosp Epidemiol 31 2010 964 967
17. C.M. Coopersmith, J.E. Zack, M.R. Ward, and et al. The impact of bedside behavior on catheter-related bacteremia in the intensive care unit Arch Surg 139 2004 131 136
18. R.J. Sherertz, E.W. Ely, D.M. Westbrook, and et al. Education of physicians-in-training can decrease the risk for vascular catheter infection Ann Intern Med 132 2000 641 648
19. I.I. Raad, D.C. Hohn, B.J. Gilbreath, and et al. Prevention of central venous catheter-related infections by using maximal sterile barrier precautions during insertion Infect Control Hosp Epidemiol 15 1994 231 238
20. A. Humar, A. Ostromecki, J. Direnfeld, and et al. Prospective randomized trial of 10% povidone-iodine versus 0.5% tincture of chlorhexidine as cutaneous antisepsis for prevention of central venous catheter infection Clin Infect Dis 31 2000 1001 1007
21. W. Zingg, A. Imhof, M. Maggiorini, and et al. Impact of a prevention strategy targeting hand hygiene and catheter care on the incidence of catheter-related bloodstream infections Crit Care Med 37 2009 2167 2173 quiz 2180
22. E. Maury, M. Alzieu, J.L. Baudel, and et al. Availability of an alcohol solution can improve hand disinfection compliance in an intensive care unit Am J Respir Crit Care Med 162 2000 324 327
23. J. Merrer, B. De Jonghe, F. Golliot, and et al. Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial JAMA 286 2001 700 707
24. A.M. Goetz, M.M. Wagener, J.M. Miller, and et al. Risk of infection due to central venous catheters: effect of site of placement and catheter type Infect Control Hosp Epidemiol 19 1998 842 845
25. B.M. Hales, and P.J. Pronovost The checklist - a tool for error management and performance improvement J Crit Care 21 2006 231 235
26. E.Y. Furuya, A. Dick, E.N. Perencevich, and et al. Central line bundle implementation in US intensive care units and impact on bloodstream infections PLoS One 6 2011 e15452
27. S.M. Berenholtz, P.J. Pronovost, P.A. Lipsett, and et al. Eliminating catheter-related bloodstream infections in the intensive care unit Crit Care Med 32 2004 2014 2020
28. D.J. Weber, V.M. Brown, E.E. Sickbert-Bennett, and W.A. Rutala Sustained and prolonged reduction in central line-associated bloodstream infections as a result of multiple interventions Infect Control Hosp Epidemiol 31 2010 875 877
29. L. Lorente, M. Lecuona, M.J. Ramos, and et al. Lower assistance costs using rifampicin-miconazole-impregnated catheters than standard catheters Am J Infect Control 39 2011 895 897
30. L. Lorente, M. Lecuona, A. Jiménez, and et al. Chlorhexidine-silver sulfadiazine-impregnated venous catheters save costs Am J Infect Control 42 2014 321 324
31. C.J. Crnich, and D.G. Maki Are antimicrobial-impregnated catheters effective? When does repetition reach the point of exhaustion? Clin Infect Dis 41 2005 681 685
32. M.G. Marin, J.C. Lee, and J.H. Skurnick Prevention of nosocomial bloodstream infections: effectiveness of antimicrobial-impregnated and heparin-bonded central venous catheters Crit Care Med 28 2000 3332 3338
33. D.L. Veenstra, S. Saint, S. Saha, and et al. Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection: a meta-analysis JAMA 28 1999 261 267
34. K.G. Shojania, B.W. Duncan, K.M. McDonald, and R.M. Wachter Making Healthcare Safer: A Critical Analyses of Patient Safety Practices (AHRQ publication no. 01-EO58) 2001 Agency for Healthcare Research and Quality Rockville, MD
35. C.J. Crnich, and D.G. Maki Are antimicrobial-impregnated catheters effective? Don't throw out the baby with the bathwater Clin Infect Dis 38 2004 1287 1292
36. D.C. McGee, and M.K. Gould Preventing complications of central venous catheterization N Engl J Med 348 2003 1123 1133
37. S.A. McConnell, P.O. Gubbins, and E.J. Anaissie Do antimicrobial-impregnated central venous catheters prevent catheter-related bloodstream infection? Clin Infect Dis 37 2003 65 72
38. D.J. Schuerer, J.E. Zack, J. Thomas, and et al. Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unity with a low blood stream infection rate after implementation of an educational program: a before-after trial Surg Infect 8 2007 445 454
39. Centers for Disease Control and Prevention. Vital signs: central line-associated blood stream infections - United States, 2001, 2008, and 2009. MMWR Morb Mortal Wkly Rep. Available at: http://www.cdc.gov/mmwr/pdf/wk/mm60e0301.pdf. Accessed July 20, 2014.
40. Centers for Disease Control and Prevention. Guidelines for the prevention of intravascular catheter-related infections, 2011. Available at: http://www.cdc.gov/hicpac/pdf/guidelines/bsi-guidelines-2011.pdf. Accessed July 20, 2014.
41. I. Raad, R. Darouiche, J. Dupuis, and et al. Central venous catheters coated with minocycline and rifampin for the prevention of catheter related colonization and bloodstream infections. A randomized, double-blind trial Ann Intern Med 127 1997 267 274
42. P. Ramritu, K. Halton, P. Collignon, and et al. A systematic review comparing the relative effectiveness of antimicrobial-coated catheters in intensive care units Am J Infect Control 36 2008 104 117
43. E.R. Ramos, R. Reitzel, Y. Jiang, and et al. Clinical effectiveness and risk of emerging resistance associated with prolonged use of antibiotic-impregnated catheters: more than 0.5 million catheter days and 7 years of clinical experience Crit Care Med 39 2011 245 251