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Volumn 90, Issue 9, 2015, Pages 825-830

Erythrocyte pyruvate kinase deficiency: 2015 status report

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DISEASE SEVERITY; ERYTHROCYTE DISORDER; ERYTHROCYTE PYRUVATE KINASE DEFICIENCY; ERYTHROCYTE TRANSFUSION; EXCHANGE BLOOD TRANSFUSION; HUMAN; PATIENT CARE; PATIENT MONITORING; PHOTOTHERAPY; PRIORITY JOURNAL; SPLENECTOMY; TREATMENT INDICATION; ADULT; ANEMIA, HEMOLYTIC, CONGENITAL NONSPHEROCYTIC; CHILD; DEFICIENCY; DISEASE MANAGEMENT; ENZYMOLOGY; NEWBORN; PATHOLOGY; PYRUVATE METABOLISM, INBORN ERRORS;

EID: 84939566700     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.24088     Document Type: Article
Times cited : (133)

References (56)
  • 1
    • 0014410425 scopus 로고
    • Life-span and organ sequestration of the red cells in pyruvate kinase deficiency
    • Nathan DG, Oski FA, Miller DR, Gardner FH. Life-span and organ sequestration of the red cells in pyruvate kinase deficiency. N Engl J Med 1968;278:73-81.
    • (1968) N Engl J Med , vol.278 , pp. 73-81
    • Nathan, D.G.1    Oski, F.A.2    Miller, D.R.3    Gardner, F.H.4
  • 2
    • 0015028149 scopus 로고
    • Selective reticulocyte destruction in erythrocyte pyruvate kinase deficiency
    • Mentzer WC, J, Baehner, RL, Schmidt-Schonbein H, et al. Selective reticulocyte destruction in erythrocyte pyruvate kinase deficiency. J Clin Invest 1971;50:688-699.
    • (1971) J Clin Invest , vol.50 , pp. 688-699
    • Mentzer, WC.1    Baehner, R.L.2    Schmidt-Schonbein, H.3
  • 3
    • 84881031013 scopus 로고    scopus 로고
    • Molecular and clinical heterogeneity in pyruvate kinase deficiency in India
    • Warang P, Kedar P, Ghosh K, Colah R. Molecular and clinical heterogeneity in pyruvate kinase deficiency in India. Blood Cells Mol Dis 2013;51:133-137.
    • (2013) Blood Cells Mol Dis , vol.51 , pp. 133-137
    • Warang, P.1    Kedar, P.2    Ghosh, K.3    Colah, R.4
  • 4
    • 33646703314 scopus 로고    scopus 로고
    • Pyruvate kinase deficiency in France: A 3-year study reveals 27 new mutations
    • Pissard S, Max-Audit, I, Skopinski L, et al. Pyruvate kinase deficiency in France: A 3-year study reveals 27 new mutations. Br J Haematol 2006;133:683-689.
    • (2006) Br J Haematol , vol.133 , pp. 683-689
    • Pissard, S.1    Max-Audit, I.2    Skopinski, L.3
  • 5
    • 0034431029 scopus 로고    scopus 로고
    • Red cell pyruvate kinase deficiency: From genetics to clinical manifestations
    • Zanella A, Bianchi P. Red cell pyruvate kinase deficiency: From genetics to clinical manifestations. Baillieres Best Pract Res Clin Haematol 2000;13:57-81.
    • (2000) Baillieres Best Pract Res Clin Haematol , vol.13 , pp. 57-81
    • Zanella, A.1    Bianchi, P.2
  • 6
    • 0027221646 scopus 로고
    • Analysis of pyruvate kinase-deficiency mutations that produce nonspherocytic hemolytic anemia
    • Baronciani L, Beutler E. Analysis of pyruvate kinase-deficiency mutations that produce nonspherocytic hemolytic anemia. Proc Natl Acad Sci USA 1993;90:4324-4327.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4324-4327
    • Baronciani, L.1    Beutler, E.2
  • 7
    • 7844234370 scopus 로고    scopus 로고
    • Molecular characterization of the PK-LR gene in pyruvate kinase deficient Spanish patients. Red Cell Pathology Group of the Spanish Society of Haematology (AEHH)
    • Zarza R, Alvarez, R, Pujades A, et al. Molecular characterization of the PK-LR gene in pyruvate kinase deficient Spanish patients. Red Cell Pathology Group of the Spanish Society of Haematology (AEHH). Br J Haematol 1998;103:377-382.
    • (1998) Br J Haematol , vol.103 , pp. 377-382
    • Zarza, R.1    Alvarez, R.2    Pujades, A.3
  • 8
    • 1842376276 scopus 로고    scopus 로고
    • Molecular analysis of 29 pyruvate kinase-deficient patients from central Europe with hereditary hemolytic anemia
    • Lenzner C, Nurnberg, P, Jacobasch G, et al. Molecular analysis of 29 pyruvate kinase-deficient patients from central Europe with hereditary hemolytic anemia. Blood 1997;89:1793-1799.
    • (1997) Blood , vol.89 , pp. 1793-1799
    • Lenzner, C.1    Nurnberg, P.2    Jacobasch, G.3
  • 9
    • 0034210203 scopus 로고    scopus 로고
    • Estimating the prevalence of pyruvate kinase deficiency from the gene frequency in the general white population
    • Beutler E, Gelbart T. Estimating the prevalence of pyruvate kinase deficiency from the gene frequency in the general white population. Blood 2000;95:3585-3588.
    • (2000) Blood , vol.95 , pp. 3585-3588
    • Beutler, E.1    Gelbart, T.2
  • 10
    • 0034551741 scopus 로고    scopus 로고
    • Prevalence of pyruvate kinase deficiency in northern European population in the north of England. Northern Region Haematologists Group
    • Carey PJ, Chandler, J, Hendrick A, et al. Prevalence of pyruvate kinase deficiency in northern European population in the north of England. Northern Region Haematologists Group. Blood 2000;96:4005-4006.
    • (2000) Blood , vol.96 , pp. 4005-4006
    • Carey, P.J.1    Chandler, J.2    Hendrick, A.3
  • 11
    • 0028902353 scopus 로고
    • Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia
    • Baronciani L, Beutler E. Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia. J Clin Invest 1995;95:1702-1709.
    • (1995) J Clin Invest , vol.95 , pp. 1702-1709
    • Baronciani, L.1    Beutler, E.2
  • 12
    • 80052815886 scopus 로고    scopus 로고
    • Six children with pyruvate kinase deficiency from one small town: Molecular characterization of the PK-LR gene
    • Christensen RD, Yaish, HM, Johnson CB, et al. Six children with pyruvate kinase deficiency from one small town: Molecular characterization of the PK-LR gene. J Pediatr 2011;159:695-697.
    • (2011) J Pediatr , vol.159 , pp. 695-697
    • Christensen, R.D.1    Yaish, H.M.2    Johnson, C.B.3
  • 13
    • 42549137072 scopus 로고    scopus 로고
    • Pyruvate kinase deficiency and malaria
    • Ayi K, Min-Oo, G, Serghides L, et al. Pyruvate kinase deficiency and malaria. N Engl J Med 2008;358:1805-1810.
    • (2008) N Engl J Med , vol.358 , pp. 1805-1810
    • Ayi, K.1    Min-Oo, G.2    Serghides, L.3
  • 14
    • 0033945866 scopus 로고    scopus 로고
    • Hydrops fetalis associated with erythrocyte pyruvate kinase deficiency
    • Ferreira P, Morais, L, Costa R, et al. Hydrops fetalis associated with erythrocyte pyruvate kinase deficiency. Eur J Pediatr 2000;159:481-482.
    • (2000) Eur J Pediatr , vol.159 , pp. 481-482
    • Ferreira, P.1    Morais, L.2    Costa, R.3
  • 15
    • 0014668144 scopus 로고
    • Oxygen-hemoglobulin dissociation curves: Effect of inherited enzyme defects of the red cell
    • Delivoria-Papadopoulos M, Oski FA, Gottlieb AJ. Oxygen-hemoglobulin dissociation curves: Effect of inherited enzyme defects of the red cell. Science 1969;165:601-602.
    • (1969) Science , vol.165 , pp. 601-602
    • Delivoria-Papadopoulos, M.1    Oski, F.A.2    Gottlieb, A.J.3
  • 16
    • 0014979430 scopus 로고
    • The role of the left-shifted or right-shifted oxygen-hemoglobin equilibrium curve
    • Oski FA, Marshall, BE, Cohen PJ, et al. The role of the left-shifted or right-shifted oxygen-hemoglobin equilibrium curve. Ann Intern Med 1971;74:44-46.
    • (1971) Ann Intern Med , vol.74 , pp. 44-46
    • Oski, F.A.1    Marshall, B.E.2    Cohen, P.J.3
  • 17
    • 0013366142 scopus 로고
    • Pyruvate kinase (PK) deficiency hereditary nonspherocytic hemolytic anemia
    • Tanaka KR, Valentine WN, Miwa S. Pyruvate kinase (PK) deficiency hereditary nonspherocytic hemolytic anemia. Blood 1962;19:267-295.
    • (1962) Blood , vol.19 , pp. 267-295
    • Tanaka, K.R.1    Valentine, W.N.2    Miwa, S.3
  • 18
    • 0028289419 scopus 로고
    • Mutations in the pyruvate kinase L gene in patients with hereditary hemolytic anemia
    • Lenzner C, Nurnberg, P, Thiele BJ, et al. Mutations in the pyruvate kinase L gene in patients with hereditary hemolytic anemia. Blood 1994;83:2817-2822.
    • (1994) Blood , vol.83 , pp. 2817-2822
    • Lenzner, C.1    Nurnberg, P.2    Thiele, B.J.3
  • 19
    • 0023634427 scopus 로고
    • Elevated pyruvate kinase activity in patients with hemolytic anemia due to red cell pyruvate kinase "deficiency"
    • Beutler E, Forman L, Rios-Larrain E. Elevated pyruvate kinase activity in patients with hemolytic anemia due to red cell pyruvate kinase "deficiency". Am J Med 1987;83:899-904.
    • (1987) Am J Med , vol.83 , pp. 899-904
    • Beutler, E.1    Forman, L.2    Rios-Larrain, E.3
  • 20
    • 56749092231 scopus 로고    scopus 로고
    • Relative red blood cell enzyme levels as a clue to the diagnosis of pyruvate kinase deficiency
    • Titapiwatanakun R, Hoyer JD, Crain K, Arndt CA. Relative red blood cell enzyme levels as a clue to the diagnosis of pyruvate kinase deficiency. Pediatr Blood Cancer 2008;51:819-821.
    • (2008) Pediatr Blood Cancer , vol.51 , pp. 819-821
    • Titapiwatanakun, R.1    Hoyer, J.D.2    Crain, K.3    Arndt, C.A.4
  • 21
    • 22144484881 scopus 로고    scopus 로고
    • Red cell pyruvate kinase deficiency: Molecular and clinical aspects
    • Zanella A, Fermo E, Bianchi P, Valentini G. Red cell pyruvate kinase deficiency: Molecular and clinical aspects. Br J Haematol 2005;130:11-25.
    • (2005) Br J Haematol , vol.130 , pp. 11-25
    • Zanella, A.1    Fermo, E.2    Bianchi, P.3    Valentini, G.4
  • 22
    • 0028817752 scopus 로고
    • [Diagnosis of pyruvate kinase deficiency in the presence of an elevated reticulocyte count]
    • Pekrun A, Lakomek, M, Eber S, et al. [Diagnosis of pyruvate kinase deficiency in the presence of an elevated reticulocyte count]. Dtsch Med Wochenschr 1995;120:1620-1624.
    • (1995) Dtsch Med Wochenschr , vol.120 , pp. 1620-1624
    • Pekrun, A.1    Lakomek, M.2    Eber, S.3
  • 23
    • 34250023771 scopus 로고    scopus 로고
    • Pyruvate kinase deficiency: The genotype-phenotype association
    • Zanella A, Fermo, E, Bianchi P, et al. Pyruvate kinase deficiency: The genotype-phenotype association. Blood Rev 2007;21:217-231.
    • (2007) Blood Rev , vol.21 , pp. 217-231
    • Zanella, A.1    Fermo, E.2    Bianchi, P.3
  • 24
    • 0015478249 scopus 로고
    • Sequestration and destruction of reticulocyte in the spleen in pyruvate kinase deficiency hereditary nonspherocytic hemolytic anemia
    • Matsumoto N, Ishihara, T, Nakashima K, et al. Sequestration and destruction of reticulocyte in the spleen in pyruvate kinase deficiency hereditary nonspherocytic hemolytic anemia. Nihon Ketsueki Gakkai Zasshi 1972;35:525-537.
    • (1972) Nihon Ketsueki Gakkai Zasshi , vol.35 , pp. 525-537
    • Matsumoto, N.1    Ishihara, T.2    Nakashima, K.3
  • 25
    • 80052879260 scopus 로고    scopus 로고
    • Erythrocyte pyruvate kinase deficiency in an old-order Amish cohort: Longitudinal risk and disease management
    • Rider NL, Strauss, KA, Brown K, et al. Erythrocyte pyruvate kinase deficiency in an old-order Amish cohort: Longitudinal risk and disease management. Am J Hematol 2011;86:827-834.
    • (2011) Am J Hematol , vol.86 , pp. 827-834
    • Rider, N.L.1    Strauss, K.A.2    Brown, K.3
  • 26
    • 35549011509 scopus 로고    scopus 로고
    • Pyruvate kinase deficiency associated with severe liver dysfunction in the newborn
    • Raphael MF, Van Wijk, R, Schweizer JJ, et al. Pyruvate kinase deficiency associated with severe liver dysfunction in the newborn. Am J Hematol 2007;82:1025-1028.
    • (2007) Am J Hematol , vol.82 , pp. 1025-1028
    • Raphael, M.F.1    Van Wijk, R.2    Schweizer, J.J.3
  • 27
    • 0020481524 scopus 로고
    • [Hereditary haemolytic anaemia due to pyruvate kinase deficiency. Prognosis of neonatal forms (author's transl)]
    • Boivin P, Ottenwaelter T. [Hereditary haemolytic anaemia due to pyruvate kinase deficiency. Prognosis of neonatal forms (author's transl)]. Nouv Presse Med 1982;11:917-919.
    • (1982) Nouv Presse Med , vol.11 , pp. 917-919
    • Boivin, P.1    Ottenwaelter, T.2
  • 30
    • 0034970144 scopus 로고    scopus 로고
    • Recurrent thromboembolic disease following splenectomy for pyruvate kinase deficiency
    • Chou R, DeLoughery TG. Recurrent thromboembolic disease following splenectomy for pyruvate kinase deficiency. Am J Hematol 2001;67:197-199.
    • (2001) Am J Hematol , vol.67 , pp. 197-199
    • Chou, R.1    DeLoughery, T.G.2
  • 31
    • 0030900206 scopus 로고    scopus 로고
    • Failure of partial splenectomy to ameliorate the anemia of pyruvate kinase deficiency
    • Sandoval C, Stringel G, Weisberger J, Jayabose S. Failure of partial splenectomy to ameliorate the anemia of pyruvate kinase deficiency. J Pediatr Surg 1997;32:641-642.
    • (1997) J Pediatr Surg , vol.32 , pp. 641-642
    • Sandoval, C.1    Stringel, G.2    Weisberger, J.3    Jayabose, S.4
  • 32
    • 40749151515 scopus 로고    scopus 로고
    • Partial splenectomy for children with congenital hemolytic anemia and massive splenomegaly
    • Diesen DL, Zimmerman, SA, Thornburg CD, et al. Partial splenectomy for children with congenital hemolytic anemia and massive splenomegaly. J Pediatr Surg 2008;43:466-472.
    • (2008) J Pediatr Surg , vol.43 , pp. 466-472
    • Diesen, D.L.1    Zimmerman, S.A.2    Thornburg, C.D.3
  • 33
    • 85047693774 scopus 로고    scopus 로고
    • Clinical and hematologic benefits of partial splenectomy for congenital hemolytic anemias in children
    • Rice HE, Oldham, KT, Hillery CA, et al. Clinical and hematologic benefits of partial splenectomy for congenital hemolytic anemias in children. Ann Surg 2003;237:281-288.
    • (2003) Ann Surg , vol.237 , pp. 281-288
    • Rice, H.E.1    Oldham, K.T.2    Hillery, C.A.3
  • 34
    • 0028803289 scopus 로고
    • Pyruvate kinase deficiency of mice associated with nonspherocytic hemolytic anemia and cure of the anemia by marrow transplantation without host irradiation
    • Morimoto M, Kanno, H, Asai H, et al. Pyruvate kinase deficiency of mice associated with nonspherocytic hemolytic anemia and cure of the anemia by marrow transplantation without host irradiation. Blood 1995;86:4323-4330.
    • (1995) Blood , vol.86 , pp. 4323-4330
    • Morimoto, M.1    Kanno, H.2    Asai, H.3
  • 35
    • 0033804518 scopus 로고    scopus 로고
    • Successful bone marrow transplantation in a child with red blood cell pyruvate kinase deficiency
    • Tanphaichitr VS, Suvatte, V, Issaragrisil S, et al. Successful bone marrow transplantation in a child with red blood cell pyruvate kinase deficiency. Bone Marrow Transplant 2000;26:689-690.
    • (2000) Bone Marrow Transplant , vol.26 , pp. 689-690
    • Tanphaichitr, V.S.1    Suvatte, V.2    Issaragrisil, S.3
  • 36
    • 0027408744 scopus 로고
    • Iron status in red cell pyruvate kinase deficiency: Study of Italian cases
    • Zanella A, Berzuini A, Colombo MB, et al. Iron status in red cell pyruvate kinase deficiency: Study of Italian cases. Br J Haematol 1993;83:485-490.
    • (1993) Br J Haematol , vol.83 , pp. 485-490
    • Zanella, A.1    Berzuini, A.2    Colombo, M.B.3
  • 38
    • 17944378860 scopus 로고    scopus 로고
    • Iron status and HFE genotype in erythrocyte pyruvate kinase deficiency: Study of Italian cases
    • Zanella A, Bianchi P, Iurlo A, et al. Iron status and HFE genotype in erythrocyte pyruvate kinase deficiency: Study of Italian cases. Blood Cells Mol Dis 2001;27:653-661.
    • (2001) Blood Cells Mol Dis , vol.27 , pp. 653-661
    • Zanella, A.1    Bianchi, P.2    Iurlo, A.3
  • 39
    • 58849084155 scopus 로고    scopus 로고
    • Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency
    • Finkenstedt A, Bianchi, P, Theurl I, et al. Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency. Br J Haematol 2009;144:789-793.
    • (2009) Br J Haematol , vol.144 , pp. 789-793
    • Finkenstedt, A.1    Bianchi, P.2    Theurl, I.3
  • 40
    • 60749089983 scopus 로고    scopus 로고
    • Deferasirox in pyruvate kinase deficiency
    • Deeren D. Deferasirox in pyruvate kinase deficiency. Ann Hematol 2009;88:397.
    • (2009) Ann Hematol , vol.88 , pp. 397
    • Deeren, D.1
  • 41
    • 0142165789 scopus 로고    scopus 로고
    • Pyruvate kinase deficiency in pregnancy complicated by iron overload
    • Dolan LM, Ryan M, Moohan J. Pyruvate kinase deficiency in pregnancy complicated by iron overload. Bjog 2002;109:844-846.
    • (2002) Bjog , vol.109 , pp. 844-846
    • Dolan, L.M.1    Ryan, M.2    Moohan, J.3
  • 42
    • 0021968402 scopus 로고
    • Pyruvate kinase deficiency hemolytic anemia: Two successful pregnancy outcomes
    • Fanning J, Hinkle RS. Pyruvate kinase deficiency hemolytic anemia: Two successful pregnancy outcomes. Am J Obstet Gynecol 1985;153:313-314.
    • (1985) Am J Obstet Gynecol , vol.153 , pp. 313-314
    • Fanning, J.1    Hinkle, R.S.2
  • 43
    • 0018905007 scopus 로고
    • Hemolytic anemia and pyruvate kinase deficiency in pregnancy
    • Amankwah KS, Dick BW, Dodge S. Hemolytic anemia and pyruvate kinase deficiency in pregnancy. Obstet Gynecol 1980;55:42S-44S.
    • (1980) Obstet Gynecol , vol.55 , pp. 42S-44S
    • Amankwah, K.S.1    Dick, B.W.2    Dodge, S.3
  • 45
    • 0018403970 scopus 로고
    • Spinal cord compression by extramedullary hemopoietic tissue in pyruvate-kinase-deficiency-caused hemolytic anemia
    • Rutgers MJ, van der Lugt PJ, van Turnhout JM. Spinal cord compression by extramedullary hemopoietic tissue in pyruvate-kinase-deficiency-caused hemolytic anemia. Neurology 1979;29:510-513.
    • (1979) Neurology , vol.29 , pp. 510-513
    • Rutgers, M.J.1    van der Lugt, P.J.2    van Turnhout, J.M.3
  • 46
    • 70349904433 scopus 로고    scopus 로고
    • Images in haematology. Paravertebral extramedullary haemopoiesis associated with pyruvate kinase deficiency
    • Hipkins R, Thompson, J, Naidoo P, et al. Images in haematology. Paravertebral extramedullary haemopoiesis associated with pyruvate kinase deficiency. Br J Haematol 2009;147:275.
    • (2009) Br J Haematol , vol.147 , pp. 275
    • Hipkins, R.1    Thompson, J.2    Naidoo, P.3
  • 47
  • 48
    • 1342266600 scopus 로고    scopus 로고
    • Myelodysplastic syndrome in a patient with hereditary pyruvate kinase deficiency
    • Ryan C, Percy M, O'Brien D, et al. Myelodysplastic syndrome in a patient with hereditary pyruvate kinase deficiency. Hematol J 2004;5:91-92.
    • (2004) Hematol J , vol.5 , pp. 91-92
    • Ryan, C.1    Percy, M.2    O'Brien, D.3
  • 49
    • 0018763890 scopus 로고
    • Chronic myelomonocytic leukemia associated with hereditary pyruvate kinase deficiency and multiple acquired erythrocyte abnormalities
    • Vives-Corrons JL, Florensa L, Muncunill J, et al. Chronic myelomonocytic leukemia associated with hereditary pyruvate kinase deficiency and multiple acquired erythrocyte abnormalities. Acta Haematol 1979;61:168-174.
    • (1979) Acta Haematol , vol.61 , pp. 168-174
    • Vives-Corrons, J.L.1    Florensa, L.2    Muncunill, J.3
  • 50
    • 0028349214 scopus 로고
    • Retrovirus-mediated gene transfer of human pyruvate kinase (PK) cDNA into murine hematopoietic cells: Implications for gene therapy of human PK deficiency
    • Tani K, Yoshikubo T, Ikebuchi K, et al. Retrovirus-mediated gene transfer of human pyruvate kinase (PK) cDNA into murine hematopoietic cells: Implications for gene therapy of human PK deficiency. Blood 1994;83:2305-2310.
    • (1994) Blood , vol.83 , pp. 2305-2310
    • Tani, K.1    Yoshikubo, T.2    Ikebuchi, K.3
  • 51
    • 34347213775 scopus 로고    scopus 로고
    • Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency
    • Kanno H, Utsugisawa, T, Aizawa S, et al. Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency. Haematologica 2007;92:731-737.
    • (2007) Haematologica , vol.92 , pp. 731-737
    • Kanno, H.1    Utsugisawa, T.2    Aizawa, S.3
  • 52
    • 0017230089 scopus 로고
    • Effects of sulphydryl compounds on abnormal red cell pyruvate kinase
    • Zanella A, Rebulla P, Giovanetti AM, et al. Effects of sulphydryl compounds on abnormal red cell pyruvate kinase. Br J Haematol 1976;32:373-385.
    • (1976) Br J Haematol , vol.32 , pp. 373-385
    • Zanella, A.1    Rebulla, P.2    Giovanetti, A.M.3
  • 53
    • 0017124910 scopus 로고
    • Effect of riboflavin treatment on human red cell pyruvate kinase deficiency
    • Blume KG, Arnold H, Hasslinger K, Lohr GW. Effect of riboflavin treatment on human red cell pyruvate kinase deficiency. Clin Chim Acta 1976;71:331-334.
    • (1976) Clin Chim Acta , vol.71 , pp. 331-334
    • Blume, K.G.1    Arnold, H.2    Hasslinger, K.3    Lohr, G.W.4
  • 54
    • 0016668294 scopus 로고
    • Normalisation of red blood cell pyruvate kinase in pyruvate kinase deficiency by riboflavin treatment
    • Staal GE, van Berkel TJ, Nijessen JG, Koster JF. Normalisation of red blood cell pyruvate kinase in pyruvate kinase deficiency by riboflavin treatment. Clin Chim Acta 1975;60:323-327.
    • (1975) Clin Chim Acta , vol.60 , pp. 323-327
    • Staal, G.E.1    van Berkel, T.J.2    Nijessen, J.G.3    Koster, J.F.4
  • 55
    • 84939572761 scopus 로고    scopus 로고
    • Phase 1 single (SAD) and multiple (MAD) ascending dose studies of the safety, tolerability, and pharmacokinetics/pharmacodynamics (PK/PD) of AG-348, a first-in- -class allosteric activator of pyruvate kinase-R, in healthy subjects
    • Yang H, Merica E, Chen Y, et al. Phase 1 single (SAD) and multiple (MAD) ascending dose studies of the safety, tolerability, and pharmacokinetics/pharmacodynamics (PK/PD) of AG-348, a first-in- -class allosteric activator of pyruvate kinase-R, in healthy subjects. Am Soc Hematol 2014;124:4007.
    • (2014) Am Soc Hematol , vol.124 , pp. 4007
    • Yang, H.1    Merica, E.2    Chen, Y.3
  • 56
    • 84939574086 scopus 로고    scopus 로고
    • AG-348 activation of pyruvate kinase in vivo enhances red cell glycolysis in mice
    • Kung C, Hill, C, Chen Y, et al. AG-348 activation of pyruvate kinase in vivo enhances red cell glycolysis in mice. Am Soc Hematol, 2014;124:4010.
    • (2014) Am Soc Hematol , vol.124 , pp. 4010
    • Kung, C.1    Hill, C.2    Chen, Y.3


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