Risk assessment in a research laboratory during sol-gel synthesis of nano-TiO2

Safety Science

Volumn 80, Issue , 2015, Pages 201-212

  Silva, Francisco ^a,b   Arezes, Pedro ^b   Swuste, Paul ^c  

^a Technological Centre for Ceramic and Glass   (Portugal)

^b UNIVERSITY OF MINHO   (Portugal)

^c DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

Control banding; Exposure; Inhalation; Nanoparticles; Occupational hygiene

Indexed keywords

NANOPARTICLES; OCCUPATIONAL RISKS; OCCUPATIONAL THERAPY; RESEARCH LABORATORIES; SOL-GELS; TITANIUM DIOXIDE;

CONDENSATION PARTICLE COUNTERS; CONTROL BANDING; EXPOSURE; INHALATION; NANOTECHNOLOGY RESEARCH; OCCUPATIONAL HYGIENE; QUALITATIVE RISK ASSESSMENT; SCIENTIFIC COMMUNITY;

RISK ASSESSMENT;

TITANIUM DIOXIDE NANOPARTICLE;

AIRBORNE PARTICLE; ARTICLE; DANGEROUS GOODS; HAZARD ASSESSMENT; HEALTH HAZARD; INTERMETHOD COMPARISON; LABORATORY; MEASUREMENT; NANOTECHNOLOGY; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; WORK ENVIRONMENT;

EID: 84939551133     PISSN: 09257535     EISSN: 18791042     Source Type: Journal    
DOI: 10.1016/j.ssci.2015.07.010     Document Type: Article

References (57)

1. Beaudrie C.E.H., Kandlikar M. Horses for courses: risk information and decision making in the regulation of nanomaterials. J. Nanoparticle Res. 2011, 13:1477-1488. 10.1007/s11051-011-0234-1.
2. Brouwer D. Exposure to manufactured nanoparticles in different workplaces. Toxicology 2010, 269:120-127. 10.1016/j.tox.2009.11.017.
3. Brouwer D. Control banding approaches for nanomaterials. Ann. Occup. Hyg. 2012, 56:506-514. 10.1093/anhyg/mes039.
4. BSI - British Standards, 2007. Guide to Safe Handling and Disposal of Manufactured Nanomaterials. BSI, London.
5. CEN/TC 137, 1995. EN 689:1995 - Workplace Atmospheres - Guidance for the Assessment of Exposure by Inhalation to Chemical Agents for Comparison with Limit Values and Measurement Strategy.
6. Clift M.J.D., Gehr P., Rothen-Rutishauser B. Nanotoxicology: a perspective and discussion of whether or not in vitro testing is a valid alternative. Arch. Toxicol. 2011, 85:723-731. 10.1007/s00204-010-0560-6.
7. Cornelissen I.R., Jongeneelen F., van Broekhuizen P., van Broekhuizen F. Guidance Working Safely with Nanomaterials and Nanoproducts, the Guide for Employers and Employees 2011, IVAM, Amsterdam, The Netherlands.
8. Creutzenberg, O., 2013. Toxic Effects of Various Modifications of a Nanoparticle Following Inhalation. Dortmund/Berlin/Dresden.
9. Donaldson K., Poland C.a. Respiratory system. Adverse Effects of Engineered Nanomaterials 2012, 121-137. Academic Press. 10.1016/B978-0-12-386940-1.00007-6. B. Fadeel, A. Pietroiusti, A. Shvedova (Eds.).
10. Eastlake A., Hodson L., Geraci C., Crawford C. A critical evaluation of material safety data sheets (MSDSs) for engineered nanomaterials. J. Chem. Heal. Saf. 2012, 19:1-8. 10.1016/j.jchas.2012.02.002.
11. Environment Directorate OECD, 2010a. Compilation of Nanomaterial Exposure Mitigation Guidelines Relating to Laboratories. Development.
12. Environment Directorate OECD, 2010b. List of Manufactured Nanomaterials and List of Endpoints for Phase One of the Sponsorship Programme for the Testing of Manufactured Nanomaterials: Revision. Paris.
13. Eugénio, J., Fatal, V., 2010. Evolução da Nanotecnologia. Lisboa.
14. Fleury D., Bomfim J.A.S., Vignes A., Girard C., Metz S., Muñoz F., R'Mili B., Ustache A., Guiot A., Bouillard J.X. Identification of the main exposure scenarios in the production of CNT-polymer nanocomposites by melt-moulding process. J. Clean. Prod. 2013, 53:22-36. 10.1016/j.jclepro.2011.11.009.
15. Gonzalez L., Lison D., Kirsch-Volders M. Genotoxicity of engineered nanomaterials: a critical review. Nanotoxicology 2008, 2:252-273. 10.1080/17435390802464986.
16. Groso A., Meyer T. Concerns related to safety management of engineered nanomaterials in research environment. J. Phys: Conf. Ser. 2013, 429:012065. 10.1088/1742-6596/429/1/012065.
17. Groso A., Petri-Fink A., Magrez A., Riediker M., Meyer T. Management of nanomaterials safety in research environment. Part. Fibre Toxicol. 2010, 7:40. 10.1186/1743-8977-7-40.
18. Hankin S., Boraschi D., Duschl A., Lehr C.M., Lichtenbeld H. Towards nanotechnology regulation - publish the unpublishable. Nano Today 2011, 6:228-231. 10.1016/j.nantod.2011.03.002.
19. Höck J., Epprecht T., Furrer E., Hofmann H., Höhner K., Krug H., Lorenz C., Limbach L., Gehr P., Nowack B., Riediker M., Schirmer K., Schmid B., Som C., Stark W., Studer C., Ulrich A., von Götz N., Weber A., Wengert S., Wick P. Precautionary Matrix for Synthetic Nanomaterials, Version 2 2011, Federal Office of Public Health and Federal Office for the Environment, Berne.
20. IARC, 2010. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 93. Carbon Black, Titanium Dioxide, and Talc. International Agency for Research on Cancer, Lyon.
21. IFA, 2013. Technical Information: Ultrafine Aerosols and Nanoparticles at the Workplace - Criteria for Assessment of the Effectiveness of Protective Measures [WWW Document]. http://www.dguv.de/ifa/Fachinfos/Nanopartikel-am-Arbeitsplatz/Beurteilung-von-Schutzma%C3%9Fnahmen/index-2.jsp.
22. Jaeger A., Weiss D.G., Jonas L., Kriehuber R. Oxidative stress-induced cytotoxic and genotoxic effects of nano-sized titanium dioxide particles in human HaCaT keratinocytes. Toxicology 2012, 296:27-36. 10.1016/j.tox.2012.02.016.
23. Kuempel E.D., Geraci C.L., Schulte P. Risk assessment and risk management of nanomaterials in the workplace: translating research to practice. Ann. Occup. Hyg. 2012, 56:491-505. 10.1093/annhyg/mes040.
24. Lee J.H., Kuk W.K., Kwon M., Lee J.H., Lee K.S., Yu I.J. Evaluation of information in nanomaterial safety data sheets and development of international standard for guidance on preparation of nanomaterial safety data sheets. Nanotoxicology 2013, 7:338-345. 10.3109/17435390.2012.658095.
25. Leidel, N.A., Bush, K.A., Lynch, J.R., 1977. Occupational Exposure Sampling Strategy Manual. National Institute for Occupational Safety and Health, Cincinnati, OH.
26. Long T.C., Saleh N., Tilton R.D., Lowry G.V., Veronesi B. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity. Environ. Sci. Technol. 2006, 40:4346-4352.
27. Ma-Hock L., Burkhardt S., Strauss V., Gamer A.O., Wiench K., van Ravenzwaay B., Landsiedel R. Development of a short-term inhalation test in the rat using nano-titanium dioxide as a model substance. Inhal. Toxicol. 2009, 21:102-118. 10.1080/08958370802361057.
28. Maynard A.D. Nanotechnology: assessing the risks. Nano Today 2006, 1:22-33. 10.1016/S1748-0132(06)70045-7.
29. Murashov V., Howard J. Essential features for proactive risk management. Nat. Nanotechnol. 2009, 4:467-470. 10.1038/nnano.2009.205.
30. NIOSH, 2011. Current Intelligence Bulletin 63. Occupational Exposure to Titanium Dioxide, Scanning Electron Microscopy. DHHS (NIOSH), Cincinnati, OH.
31. NIOSH, 2012. General Safe Practices for Working with Engineered Nanomaterials in Research Laboratories. National Institute for Occupational Safety and Health (NIOSH), Cincinnati.
32. OECD, 2009. Inventory of National Science, Technology and Innovation Policies for Nanotechnology 2008 (No. DSTI/STP/NANO(2008) 18/FINAL), Nanotechnology.
33. Ostiguy C., Roberge B., Ménard L., Endo C.a. A good practice guide for safe work with nanoparticles: the Quebec approach. J. Phys: Conf. Ser. 2009, 151:012037. 10.1088/1742-6596/151/1/012037.
34. Ostiguy, C., Riediker, M., Triolet, J., Troisfontaines, P., Vernez, D., 2010. Development of a Specific Control Banding Tool for Nanomaterials. Maison-Alfort.
35. Paik S.Y., Zalk D.M., Swuste P. Application of a pilot control banding tool for risk level assessment and control of nanoparticle exposures. Ann. Occup. Hyg. 2008, 52:419-428. 10.1093/annhyg/men041.
36. Ramachandran G., Ostraat M., Evans D.E., Methner M.M., O'Shaughnessy P., D'Arcy J., Geraci C.L., Stevenson E., Maynard A., Rickabaugh K. A strategy for assessing workplace exposures to nanomaterials. J. Occup. Environ. Hyg. 2011, 8:673-685. 10.1080/15459624.2011.623223.
37. Schulte P., Geraci C., Hodson L., Zumwalde R., Castranova V., Kuempel E., Methner M.M., Hoover M., Murashov V. Nanotechnologies and nanomaterials in the occupational setting. Ital. J. Occup. Env. Hyg. 2010, 1:63-68.
38. Schulte P., Murashov V., Zumwalde R., Kuempel E.D., Geraci C.L. Occupational exposure limits for nanomaterials: state of the art. J. Nanoparticle Res. 2010, 12:1971-1987. 10.1007/s11051-010-0008-1.
39. Shi H., Magaye R., Castranova V., Zhao J. Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol. 2013, 10:15. 10.1186/1743-8977-10-15.
40. Silva F., Arezes P., Swuste P. Risk assessment and control in engineered nanoparticles occupational exposure. Occupational Safety and Hygiene 2013, CRC Press, Guimarães. P. Arezes (Ed.).
41. State Secretariat for Economic Affairs (SECO) Safety Data Sheet (SDS): Guidelines for Synthetic Nanomaterials 2010, SECO, Zurich.
42. Stern S.T., McNeil S.E. Nanotechnology safety concerns revisited. Toxicol. Sci. 2008, 101:4-21. 10.1093/toxsci/kfm169.
43. Swuste P., Zalk D.M. Risk management and nanomaterials. Nanotechnology, Fundamentals and Applications 2013, vol. 1:155-173. Studium Press LLC, Houston. J.N. Govil, N.K. Navani, S. Sinha (Eds.).
44. Technical Committee ISO/TC 229, 2012a. Nanotechnologies-Guidelines for Occupational Risk Management Applied to Engineered Nanomaterials-Part 2: The Use of the Control Banding Approach in Occupational Risk Management (No. ISO/PDTS 12901-2). Geneva.
45. Technical Committee ISO/TC 229, 2012b. Technical Report ISO/TR 13329 Nanomaterials-Preparation of Material Safety Data Sheet (MSDS). Geneva.
46. The UK NanoSafety Partnership Group, 2012. Working Safely with Nanomaterials in Research & Development. London.
47. 2 nanopowders. Chem. Eng. J. 2013, 214:364-375. 10.1016/j.cej.2012.11.018.
48. van Broekhuizen P., van Broekhuizen F., Cornelissen R., Reijnders L. Workplace exposure to nanoparticles and the application of provisional nanoreference values in times of uncertain risks. J. Nanoparticle Res. 2012, 14. 10.1007/s11051-012-0770-3.
49. van Broekhuizen P., van Veelen W., Streekstra W.-H., Schulte P., Reijnders L. Exposure limits for nanoparticles: report of an international workshop on nano reference values. Ann. Occup. Hyg. 2012, 56:515-524. 10.1093/annhyg/mes043.
50. van Duuren-Stuurman, B., Vink, S., Brouwer, D., Kroese, D., Heussen, H., Verbist, K., Tielemans, E., Niftrik, M. van, Fransman, W., 2011. Stoffenmanager Nano: Description of the Conceptual Control Banding Model. Zeist.
51. van Duuren-Stuurman B., Vink S.R., Verbist K.J.M., Heussen H.G.a., Brouwer D., Kroese D.E.D., van Niftrik M.F.J., Tielemans E., Fransman W. Stoffenmanager Nano version 1.0: a web-based tool for risk prioritization of airborne manufactured nano objects. Ann. Occup. Hyg. 2012, 56:525-541. 10.1093/annhyg/mer113.
52. van Tongeren, M., Aitken, R., Brouwer, D., Christensen, F.M., Clark, K., Friedrichs, S., Peters, S., Rashid, S., Riediker, M., Ritchie, P., Vaquero, C., 2010. Development of Generic Exposure Scenario Descriptions.
53. Vervoort, M.B.H.J., 2012. A Comparison of Risk Assessment Methods in order to Determine the Risk of Occupational Used Nanomaterials in a Research Environment. NSPOH.
54. Wang J., Asbach C., Fissan H., Hülser T., Kaminski H., Kuhlbusch T.a.J., Pui D.Y.H. Emission measurement and safety assessment for the production process of silicon nanoparticles in a pilot-scale facility. J. Nanoparticle Res. 2012, 14:759. 10.1007/s11051-012-0759-y.
55. Warheit D.B. How to measure hazards/risks following exposures to nanoscale or pigment-grade titanium dioxide particles. Toxicol. Lett. 2013, 220:193-204. 10.1016/j.toxlet.2013.04.002.
56. Zalk D.M., Paik S.Y., Swuste P. Evaluating the Control Banding Nanotool: a qualitative risk assessment method for controlling nanoparticle exposures. J. Nanoparticle Res. 2009, 11:1685-1704. 10.1007/s11051-009-9678-y.
57. Zimmermann E., Derrough S., Locatelli D., Durand C., Fromaget J.L., Lefranc E., Ravanel X., Garrione J. Results of potential exposure assessments during the maintenance and cleanout of deposition equipment. J. Nanoparticle Res. 2012, 14:1209. 10.1007/s11051-012-1209-6.