Amplification of IL-21 signalling pathway through bruton's tyrosine kinase in human B cell activation

Rheumatology (United Kingdom)

Volumn 54, Issue 8, 2015, Pages 1488-1497

  Wang, Sheau Pey ^a   Iwata, Shigeru ^a   Nakayamada, Shingo ^a   Niiro, Hiroaki ^b   Jabbarzadeh Tabrizi, Siamak ^b   Kondo, Masahiro ^a   Kubo, Satoshi ^a   Yoshikawa, Maiko ^a   Tanaka, Yoshiya ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Autoimmune diseases; B cells; BCR signalling; Class switch DNA recombination; IL 21; Rheumatoid arthritis; STAT1

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; B CELL ACTIVATING FACTOR; B LYMPHOCYTE RECEPTOR; BRUTON TYROSINE KINASE; BRUTON TYROSINE KINASE INHIBITOR; C REACTIVE PROTEIN; CD19 ANTIGEN; CD40 ANTIGEN; IMMUNOGLOBULIN G; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; JANUS KINASE; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2; PROTEIN BCL 6; STAT1 PROTEIN; STAT3 PROTEIN; STROMELYSIN; X BOX BINDING PROTEIN 1;

ADULT; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CELL STIMULATION; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GENE AMPLIFICATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SIMPLIFIED DISEASE ACTIVITY INDEX;

EID: 84939548568     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keu532     Document Type: Article

References (23)

1. Edwards JC, Szczepanski L, Szechinski J et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 2004;350:2572-81.
2. Satterthwaite AB, Li Z, Witte ON. Btk function in B cell development and response. Semin Immunol 1998;10: 309-16.
3. Kil LP, de Bruijn MJ, van Nimwegen M et al. Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice. Blood 2012;119:3744-56.
4. Conley ME, Cooper MD. Genetic basis of abnormal B cell development. Curr Opin Immunol 1998;10:399-406.
5. Khan WN. Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase. Immunol Res 2001; 23:147-56.
6. Davis RE, Ngo VN, Lenz G et al. Chronic active B-cellreceptor signalling in diffuse large B-cell lymphoma. Nature 2010;463:88-92.
7. Honigberg LA, Smith AM, Sirisawad M et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci USA 2010;107: 13075-80.
8. Coquet JM, Kyparissoudis K, Pellicci DG et al. IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol 2007;178:2827-34.
9. Vogelzang A, McGuire HM, Yu D et al. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008;29:127-37.
10. Zotos D, Coquet JM, Zhang Y et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 2010;207: 365-78.
11. Young DA, Hegen M, Ma HL et al. Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum 2007;56:1152-63.
12. Ettinger R, Sims GP, Fairhurst AM et al. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol 2005;175: 7867-79.
13. Rasmussen TK, Andersen T, Hvid M et al. Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis. J Rheumatol 2010; 37:2014-20.
14. Aletaha D, Neogi T, Silman AJ et al. 2010 rheumatoid arthritis classification criteria. Arthritis Rheumatol 2010;62: 2569-81.
15. Rasmussen AM, Smeland EB, Erikstein BK, Caignault L, Funderud S. A new method for detachment of Dynabeads from positively selected B lymphocytes. J Immunol Methods 1992;146:195-202.
16. Paddison PJ, Cleary M, Silva JM et al. Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat Methods 2004;1:163-7.
17. Avery DT, Deenick EK, Ma CS et al. B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med 2010;207:155-71.
18. Khan WN, Alt FW, Gerstein RM et al. Defective B cell development and function in Btk-deficient mice. Immunity 1995;3:283-99.
19. Ettinger R, Sims GP, Robbins R et al. IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells. J Immunol 2007;178:2872-82.
20. O'Shea JJ, Murray PJ. Cytokine signaling modules in inflammatory responses. Immunity 2008;28:477-87.
21. Avery DT, Ma CS, Bryant VL et al. STAT3 is required for IL-21-induced secretion of IgE from human naive B cells. Blood 2008;112:1784-93.
22. Carson DA, Chen PP, Kipps TJ. New roles for rheumatoid factor. J Clin Invest 1991;87:379-83.
23. Rokosz LL, Beasley JR, Carroll CD et al. Kinase inhibitors as drugs for chronic inflammatory and immunological diseases: progress and challenges. Expert Opin Ther Targets 2008;12:883-903.