Short-term high glucose exposure impairs insulin signaling in endothelial cells

Cardiovascular Diabetology

Volumn 14, Issue 1, 2015, Pages

  De Nigris, Valeria ^a   Pujadas, Gemma ^a   La Sala, Lucia ^a   Testa, Roberto ^b   Genovese, Stefano ^c   Ceriello, Antonio ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b INRCA   (Italy)

^c IRCCS MULTIMEDICA   (Italy)

Author keywords

Endothelium; eNOS; High glucose; HUVECs; Physiological insulin

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA SUBUNIT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; INSR PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; NOS3 PROTEIN, HUMAN;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; HORMONE ACTION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN RESPONSE; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; AGONISTS; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; TIME FACTOR; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTIGENS, CD; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INSULIN; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84939527014     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/s12933-015-0278-0     Document Type: Article

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