Potential of Systemic Allogeneic Mesenchymal Stromal Cell Therapy for Children with Recessive Dystrophic Epidermolysis Bullosa

Journal of Investigative Dermatology

Volumn 135, Issue 9, 2015, Pages 2319-2321

  Petrof, Gabriela ^a   Lwin, Su M ^a   Martinez Queipo, Magdalena ^a   Abdul Wahab, Alya ^a   Tso, Simon ^a   Mellerio, Jemima E ^a,b   Slaper CortenbaC H , Ineke ^c   Boelens, Jaap J ^d   Tolar, Jakub ^e   Veys, Paul ^b   Ofuya, Mercy ^a   Peacock, Janet L ^a   Martinez, Anna E ^b   McGrath, John A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL THERAPY; EPIDERMOLYSIS BULLOSA DYSTROPHICA; FLUORESCENCE IN SITU HYBRIDIZATION; HLA MATCHING; HUMAN; IMMUNOREGULATION; LETTER; MESENCHYMAL STROMA CELL; PRIORITY JOURNAL; QUALITY OF LIFE; RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA; RETURN TO WORK; SKIN INFECTION; SYSTEMIC ALLOGENEIC MESENCHYMAL STROMAL CELL THERAPY; WOUND HEALING; ALLOTRANSPLANTATION; CHILD; CLINICAL TRIAL; FEMALE; FOLLOW UP; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; PRESCHOOL CHILD; PROCEDURES; PROSPECTIVE STUDY; TREATMENT OUTCOME;

CHILD; CHILD, PRESCHOOL; EPIDERMOLYSIS BULLOSA DYSTROPHICA; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; PROSPECTIVE STUDIES; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 84939473777     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2015.158     Document Type: Letter

References (13)

1. Baraniak PR, McDevitt TC (2010) Stem cell paracrine actions and tissue regeneration. Regen Med 5:121-43
2. Caplan AI (1991) Mesenchymal stem cells. J Orthopaed Res 9:641-50
3. Chen L, Tredget EE, Wu PY et al. (2008) Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 3:e1886
4. Conget P, Rodriguez F, Kramer S et al. (2010) Replenishment of type VII collagen and reepithelialization of chronically ulcerated skin after intradermal administration of allogeneic mesenchymal stromal cells in two patients with recessive dystrophic epidermolysis bullosa. Cytotherapy 12:429-31
5. El-Darouti M, Amin FM, Abdel Hay R et al. (2013) Allogeneic Bone marrow derived mesenchymal stem cells for the treatment of dystrophic epidermlysis bullosa. The European Society for Gene and Cell Therapy and the Spanish Society for Gene and Cell Therapy. Hum Gene Ther 24:A54
6. Fine JD, Mellerio JE (2009) Extracutaneous manifestations and complications of inherited epidermolysis bullosa: part II. Other organs. J Am Acad Dermatol 61:387-402
7. Fine JD, Bruckner-Tuderman L, Eady RA et al. (2014) Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification. J Am Acad Dermatol 70:1103-26
8. Kirkorian AY, Weitz NA, Tlougan B et al. (2014) Evaluation of wound care options in patients with recessive dystrophic epidermolysis bullosa: a costly necessity. Pediatr Dermatol 31: 33-7
9. Petrof G, Martinez-Queipo M, Mellerio JE et al. (2013) Fibroblast cell therapy enhances initial healing in recessive dystrophic epidermolysis bullosa wounds: results of a randomized, vehicle-controlled trial. Br J Dermatol 169: 1025-33
10. Phinney DG, Prockop DJ (2007) Mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair -current views. Stem Cells 25:2896-902
11. Siprashvili NN, Gorell E, Khuu P et al. (2014) Phase I clinical trial of genetically corrected autologous epidermal keratinocytes for recessive dystrophic epidermolysis bullosa. J Invest Dermatol 134:S75
12. Venugopal SS, Yan W, Frew JW et al. (2013) A phase II randomized vehicle-controlled trial of intradermal allogeneic fibroblasts for recessive dystrophic epidermolysis bullosa. J Am Acad Dermatol 69:898-908
13. Wagner JE, Ishida-Yamamoto A, McGrath JA et al. (2010) Bone marrow transplantation for recessive dystrophic epidermolysis bullosa. N Engl J Med 363:629-39