Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene

Genetic Epidemiology

Volumn 39, Issue 6, 2015, Pages 489-497

  Singh, Abanish ^a,b   Babyak, Michael A ^a   Brummett, Beverly H ^a   Jiang, Rong ^a   Watkins, Lana L ^a   Barefoot, John C ^a   Kraus, William E ^a,b   Shah, Svati H ^a,b   Siegler, Ilene C ^a   Hauser, Elizabeth R ^a,b,c   Williams, Redford B ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DURHAM VA MEDICAL CENTER   (United States)

Author keywords

Central obesity, CVD risk gene, EBF1, gene by stress interaction; Chronic psychosocial stress

Indexed keywords

ALGORITHM; ARTICLE; ATHEROSCLEROSIS; CHRONIC STRESS; COHORT ANALYSIS; DATA BASE; DEPRESSION; DISEASE ASSOCIATION; EBF1 GENE; ETHNIC GROUP; GENE; GENE REPLICATION; GENETIC ASSOCIATION; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; MATHEMATICAL COMPUTING; MEASUREMENT; MENTAL STRESS; OBESITY; SCORING SYSTEM; SELF EVALUATION; SYMPTOM; VALIDATION STUDY; BODY MASS; CARDIOVASCULAR DISEASES; FACTUAL DATABASE; GENETICS; HUMAN; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM;

EBF1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

BODY MASS INDEX; CARDIOVASCULAR DISEASES; DATABASES, FACTUAL; GENE-ENVIRONMENT INTERACTION; GENOTYPE; HUMANS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; STRESS, PSYCHOLOGICAL; TRANS-ACTIVATORS;

EID: 84939466518     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.21910     Document Type: Article

References (27)

1. Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, Greenland P, Jacobs DR Jr, Kronmal R, Liu K and others. 2002. Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol 156(9):871-881.
2. Brummett BH, Boyle SH, Ortel TL, Becker RC, Siegler IC, Williams RB. 2010. Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recall. Psychosom Med 72(4):333-339.
3. Cohen S, Janicki-Deverts D, Miller GE. 2007. Psychological stress and disease. JAMA 298(14):1685-1687.
4. Curran PJ, Hussong AM. 2009. Integrative data analysis: the simultaneous analysis of multiple data sets. Psychol Methods 14:81-100.
5. Feinleib M, Kannel WB, Garrison RJ, McNamara PM, Castelli WP. 1975. The Framingham Offspring Study. Design and preliminary data. Prev Med 4:518-525.
6. Garmezy N. 1991. Resiliency and vulnerability to adverse developmental outcomes associated with poverty. Am Behav Sci 34:416-430.
7. Glantz MD, Johnson JL. 1999. Resilience and Development: Positive Life Adaptations. New York: Kluwer Acad/Plenum Publishers.
8. Jimenez MA, Akerblad P, Sigvardsson M, Rosen ED. 2007. Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade. Mol Cell Biol 27:743-757.
9. Kamarck T. 2012. Psychosocial stress and cardiovascular disease: an exposure science perspective. Psychol Sci Agenda 26(4).
10. Kaplan JR, Chen H, Manuck SB. 2009. The relationship between social status and atherosclerosis in male and female monkeys as revealed by meta-analysis. Am J Primatol 71(9):732-741.
11. Kring SI, Brummett BH, Barefoot J, Garrett ME, Ashley-Koch AE, Boyle SH, Siegler IC, Sorensen TI, Williams RB. 2010. Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls. Psychosom Med 72:427-433.
12. Lazarus RS. 1966. Psychological Stress and the Coping Process. New York: McGraw-Hill, Inc.
13. Lewis TG, Cook CR. 1988. Hashing for dynamic and static internal tables. Computer 21(10):45-56.
14. Lukin K, Fields S, Hartley J, Hagman J. 2008. Early B cell factor: regulator of B lineage specification and commitment. Semin Immunol 20:221-227.
15. Muthen LK, Muthen BO. 1998-2010. Mplus User's Guide Sixth Edition. Los Angeles, CA: Muthen & Muthen.
16. Rosengren A, Hawken S, Ounpuu S, Sliwa K, Zubaid M, Almahmeed WA, Blackett KN, Sitthi-amorn C, Sato H, Yusuf S. 2004. Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study. Lancet 364(9438):953-962.
17. Rozanski A, Blumenthal JA, Kaplan J. 1999. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation 99:2192-2217.
18. Schneiderman N, Ironson G, Siegel SD. 2005. Stress and health: psychological, behavioral, and biological determinants. Annu Rev Clin Psychol 1:607-628.
19. Shivpuri S, Gallo LC, Crouse JR. Allison MA. 2012. The association between chronic stress type and C-reactive protein in the Multi-Ethnic Study of Atherosclerosis (MESA): does gender make a difference? J Behav Med 35(1):74-85.
20. Singh A, Babyak MA, Nolan DK, Brummett BH, Jiang R, Siegler IC, Kraus WE, Shah SH, Williams RB, Hauser ER. 2015. Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene. Eur J Hum Genet. 23, 854-862 doi: 10.1038/ejhg.2014.189
21. Sterne JAC, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, Wood AM. 2009. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ 338:b2393.
22. Sutton BS, Crosslin DR, Shah SH, Nelson SC, Bassil A, Hale AB, Haynes C, Goldschmidt-Clermont PJ, Vance JM and others. 2008. Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets. Hum Mol Genet 17(9):1318-1328.
23. Thompson K. 1968. Programming techniques: regular expression search algorithm. Commun ACM 11(6):419-422.
24. Troxel WM, Matthews KA, Bromberger JT, Sutton-Tyrrell K. 2003. Chronic stress burden, discrimination, and subclinical carotid artery disease in African American and Caucasian women. Health Psychol 22(3):300-309.
25. Ward-Caviness CK. 2014. Gene-Environment Interactions in Cardiovascular Disease [Dissertation]. Durham, NC: Duke University.
26. Watkins LL, Blumenthal JA, Babyak MA, Davidson JR, McCants CB, O'Connor C, Sketch MH. 2010. Prospective association between phobic anxiety and cardiac mortality in individuals with coronary heart disease. Psychosom Med 72(7):664-671.
27. Williams RB. 2008. Psychosocial and biobehavioral factors and their interplay in coronary heart disease. Annu Rev Clin Psychol 4:349-365.