Prevalence Rates of Borrelia burgdorferi (Spirochaetales: Spirochaetaceae), Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae), and Babesia microti (Piroplasmida: Babesiidae) in Host-Seeking Ixodes scapularis (Acari: Ixodidae) from Pennsylvania

Journal of Medical Entomology

Volumn 52, Issue 4, 2015, Pages 693-698

  Hutchinson, M L ^a   Strohecker, M D ^a   Simmons, T W ^b   Kyle, A D ^a   Helwig, M W ^a  

^a Pennsylvania Department of Environmental Protection   (United States)

^b INDIANA UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Anaplasma phagocytophilum; Babesia microti; Borrelia burgdorferi; Ixodes scapularis; Lyme disease

Indexed keywords

ACARI; ANAPLASMA PHAGOCYTOPHILUM; ANAPLASMATACEAE; BABESIA MICROTI; BABESIIDAE; BORRELIA BURGDORFERI; IXODES SCAPULARIS; IXODIDA; IXODIDAE; PIROPLASMIDA; RICKETTSIALES; SPIROCHAETACEAE; SPIROCHAETALES;

ANAPLASMA PHAGOCYTOPHILUM; ANIMAL; BABESIA MICROTI; BORRELIA BURGDORFERI; FEMALE; HUMAN; IXODES; MALE; MICROBIOLOGY; PARASITE VECTOR; PREVALENCE; TICK-BORNE DISEASES; TRANSMISSION; UNITED STATES;

ANAPLASMA PHAGOCYTOPHILUM; ANIMALS; ARACHNID VECTORS; BABESIA MICROTI; BORRELIA BURGDORFERI; FEMALE; HUMANS; IXODES; MALE; PENNSYLVANIA; PREVALENCE; TICK-BORNE DISEASES;

EID: 84939219493     PISSN: 00222585     EISSN: 19382928     Source Type: Journal    
DOI: 10.1093/jme/tjv037     Document Type: Article

References (45)

1. Aldeson, M. E., R. S. Rao, R. C. Tilton, K. Cabets, E. Eskow, L. Fein, J. L. Occi, and E. Mordechai. 2004. Prevalence of Borrelia burgdorferi, Bartonella spp., Babesia microti, and Anaplasma phagocytophila in Ixodes scapularis ticks collected in northern New Jersey. J. Clin. Microbiol. 42: 2799-2801.
2. Amerasinghe, F. P. and T. W. Scott. 1993. Borrelia burgdorferi infection in Ixodes scapularis (Acari: Ixodidae) in Kent county, Maryland. Bull. Soc. Vector Ecol. 18: 99-104.
3. Barbour, A. G., and D. Fish. 1993. The biological and social phenomenon of Lyme disease. Science 260: 1610-1616.
4. Brownstein, J. S., T. R. Holford, and D. Fish. 2003. A climate-based mode predicts the spatial distribution of the Lyme disease vector Ixodes scapularis in the United States. Environ. Health Perspect. 111: 1152-1157.
5. (CDC) Centers for Disease Control and Prevention. 2014. Lyme disease data - cases by state. (http://www.cdc.gov/lyme/ stats/) (last accessed 26 March 2015)
6. Cherepko, J., G. J. Berry, S. P. Keeler, and J. E. Huffman. 2010. Prevalence of Borrelia burgdorferi, Bartonella spp., Bartonella henselae, Babesia microti, andAnaplasma phagocytophila in Ixodes scapularis ticks collected in Monroe County, Pennsylvania show a risk for co-and tri-infections. J. Penn. Acad. Sci. 84: 74-78.
7. Costello, C. M., A. C. Steere, R. E. Pinkerton, and H. M. Feder Fr. 1989. A prospective study of tick bites in an endemic area for Lyme disease. J. Infect. Dis. 159: 136-139.
8. Courtney, J. W., R. L. Dryden, J. Montgomery, B. S. Schneider, G. Smith and R. F. Massung. 2003. Molecular characterization of Anaplasma phagocytophilum and Borrelia burgdorferi in Ixodes scapularis ticks from Pennsylvania. J. Clin. Microbiol. 41: 1569-1573.
9. Curran, K. L., J. B. Kidd, J. Vassallo, and V. L. van Meter. 2000. Borrelia burgdorferi and the causative agent of human granulocytic ehrlichiosis in deer ticks, Delaware. Emerg. Infect. Dis. 6: 408-411.
10. Dennis, D. T., T. S. Nekomoto, J. C. Victor, W. S. Paul, and J. Piesman. 1998. Reported distribution of Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae) in the United States. J. Med. Entomol. 35: 629-638.
11. Diuk-Wasser, M. A., G. Vourc'h, P. Cislo, A. G. Hoen, F. Melton, S. A. Hamer, M. Rowland, R. Cortinas, G. J. Hickling, J. I. Tsao, et al. 2010. Field and climate-based model for predicting the density of host-seeking nymphal Ixodes scapularis, an important vector of tick-borne disease agents in the eastern United States. Global Ecol. Biogeogr. 19: 504-515.
12. Diuk-Wasser, M. A., A. G. Hoen, P. Cislo, R. Brinkerhoff, S. A. Hamer, M. Rowland, R. Cortinas, G. Vourc'h, F. Melton, G. J. Hickling, et al. 2012. Human risk of infection with Borrelia burgdorferi, the Lyme disease agent, in the Eastern United States. Am. J. Trop. Med. Hyg. 86: 320-327.
13. Falco, R. C. and D. Fish. 1988. Ticks parasitizing humans in a Lyme disease endemic area of southern New York State. Am. J. Epidemiol. 128: 1146-1152.
14. Han, G. S., E. Y. Stromdahl, D. Wong, and A. C. Weltman. 2014. Exposure to Borrelia burgdorferi and other tick-borne pathogens in Gettysburg National Military Park, south-central Pennsylvania. Vector Borne Zoonotic Dis. 14: 1-7.
15. Hodzic, E., D. Fish, C. M. Maretzki, A. M. De Silva, S. Feng, and S. W. Barthold. 1998. Acquisition and transmission of the agent of human granulocytic ehrlichiosis by Ixodes scapularis ticks. J. Clin. Microbiol. 36: 3574-3578.
16. Homer, M. J., I. Aguilar-Delfin, S. R. Telford, P. J. Krause, and D. H. Persing. 2000. Babesiosis. Clin. Microbiol. Rev. 13: 451-469.
17. Jin, H., F. Wei, Q. Liu, and J. Qian. 2012. Epidemiology and control of human granulocytic anaplasmosis: a systematic review. Vector Borne Zoonotic Dis. 12: 269-274.
18. Keirans, J. E., and T. R. Litwak. 1989. Pictorial key to the adults of hard ticks, family Ixodidae (Ixodida: Ixodoidea), east of the Mississippi river. J. Med. Entomol. 26: 435-448.
19. Keirans, J. E., H. J. Hutcheson, L. A. Durden, and J. S. H. Klompen. 1996. Ixodes (Ixodes) scapularis (Acari: Ixodidae): Redescription of all active stages, distribution, hosts, geographical variation, and medical and veterinary importance. J. Med. Entomol. 33: 297-318.
20. Krause, P. J., S. R. Telford III, A. Spielman, V. Sikand, R. Ryan, D. Christianson, G. Burke, P. Brassard, R. Pollack, J. Peck, etal. 1996. Concurrent Lyme disease and babesiosis. Evidence for increased severity and duration of illness. JAMA 275: 1657-1660.
21. Krause, P. J., K. McKay, C. A. Thompson, V. K. Sikand, R. Lentz, T. Lepore, L. Closter, D. Christianson, S. R. Telford, D. Persing, etal. 2002. Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease. Clin. Infect. Dis. 34: 1184-1191.
22. Lord, R. D., J. G. Humphreys, V. R. Lord, R. G. McLean, and C. L. Garland. 1992. Borrelia burgdorferi infection in white-footed mice (Peromyscus leucopus) in Hemlock (Tsuga canadensis) habitat in western Pennsylvania. J. Wildl. Dis. 28: 364-368.
23. Magid, D., B. Schwartz, J. Craft, and J. S. Schwartz. 1992. Prevention of Lyme disease after tick bites. A cost-effectiveness analysis. N. Engl. J. Med. 327: 534-541.
24. Magnarelli, L. A., K. C. Stafford, III., T. N. Mather, M. Yeh, K. D. Horn, and J. S. Dumler. 1995. Hemocytic rickettsia-like organisms in ticks: serologic reactivity with antisera to Ehrlichiae and detection of DNA of agent of human granulocytic ehrlichiosis by PCR. J. Clin. Microbiol. 2710-2714.
25. Massung, R. F. and K. G. Slater. 2003. Comparison of PCR assays for detection of the agent of human granulocytic ehrlichiosis, Anaplasma phagocytophilum.J.Clin.Microbiol.41: 717-722.
26. Nadelman, R. B., H. W. Horowitz, T. C. Hsieh, J. M. Wu, M. E. Aguero-Rosenfeld, I. Schwartz, J. Nowakowski, S. Varde, and G. P. Wormser. 1997. Simultaneous human granulocytic ehrlichiosis and Lyme borreliosis. N. Engl. J. Med. 337: 27-30.
27. (PA DOH) Pennsylvania Department of Health. 2014. Lyme disease cases and incidence reported in PA by county (link embedded in fact sheet). (http://www.portal.state.pa.us/ portal/server.pt?open=514&objID=1866194&mode=2) (last accessed 26 March 2015)
28. Persing, D. H., D. Mathiesen, W. F. Marshall, S. R. Telford, A. Spielman, J. W. Thomford, and P. A. Conrad. 1992. Detection of Babesia microti by polymerase chain reaction. J. Clin. Microbiol. 30: 2097-2103.
29. Picken, R. N. 1992. Polymerase chain reaction primers and probes derived from flagellin gene sequences for specific detection of the agents of Lyme disease and North American relapsing fever. J. Clin. Microbiol. 30: 99-114.
30. Prusinski, M. A., J. E. Kokas, K. T. Hukey, S. J. Kogut, J. Lee and P. B. Backenson. 2014. Prevalence of Borrelia burgdorferi (Spirochaetales: Spirochaetaceae), Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae), and Babesia microti (Piroplasmida: Babesiidae) in Ixodes scapularis (Acari: Ixodida) collected from recreational lands in the Hudson Valley Region, New York State. J. Med. Entomol. 51: 226-236.
31. Rollend, L., D. Fish, and J. E. Childs. 2013. Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: a summary of the literature and recent observations. Ticks Tick Borne Dis. 4: 46-51.
32. Schmid, G. P., R. Horsley, A. C. Steere, J. P. Hanrahan, J. P. Davis, G. S. Bowen, M. T. Osterholm, J. S. Wiesfield, A. W. Hightower, and C. V. Broome. 1985. Surveillance of Lyme diseae in the United States. J. Infect. Dis. 151: 1144-1149.
33. Schulze, T. L., R. A. Jordan, R. W. Hung, R. S. Puelle, D. Markowski, and M. S. Chomsky. 2003. Prevalence of Borrelia burgdorferi (Spirochaetales: Spirochaetaceae) in Ixodes scapularis (Acari: Ixodidae) adults in New Jersey, 2000-2001. J. Med. Entomol. 40: 555-558.
34. Shapiro, E. D., M. A. Gerber, N. B. Holabird, A. T. Berg, H. M. Feder, Jr., G. L. Bell, P. N. Rys, and D. H. Persing. 1992. A controlled trial of antimicrobial prophylaxis for Lyme disease after deer-tick bites. N. Engl. J. Med. 327: 1769-1773.
35. Snetsinger, R. 1968. Distribution of ticks and tick-borne diseases in Pennsylvania, pp. 1-8. Progress Report. The Pennsylvania State University, College of Agriculture, Agricultural Experiment Station, University Park, Pennsylvania.
36. Spielman, A., M. L. Wilson, J. F. Levine, and J. Piesman. 1985. Evology of dammini-borne human babesiosis and Lyme disease. Annu. Rev. Entomol. 30: 439-460.
37. Steiner, F. E., R. R. Pinger, C. N. Vann, N. Grindle, D. Civitello, K. Clay, and C. Fuqua. 2008. Infection and co-infection rates of Anaplasma phagocytophilum variants, Babesia spp., Borrelia burgdorferi, and the rickettsial endosymbiont in Ixodes scapularis (Acari: Ixodida) from sites in Indiana, Maine, Pennsylvania, and Wisconsin. J. Med. Entomol. 45: 289-297.
38. Stromdahl, E., S. Hamer, S. Jenkins, L. Sloan, P. William-son, E. Foster, R. Nadolny, C. Elkins, M. Vince, and B. Pritt. 2014. Comparison of phenology and pathogen prevalence, including infection with the Ehrlichia muris-like (EML) agent, of Ixodes scapularis removed from soldiers in the Midwestern and the northeastern United States over a 15 year period (1997-2012). Parasit. Vectors 7: 553.
39. Swanson, K. I., and D. E. Norris. 2007. Co-circulating micro-organisms in questing Ixodes scapularis nymphs in Maryland. J. Vector Ecol. 32: 243-251.
40. Teal, A. E., A. Habura, J. Ennis, J. S. Keithly, and S. Madison-Antenucci. 2012. A new real-time PCR assay for improved detection of the parasite Babesia microti. J. Clin. Microbiol. 50: 903-908.
41. Varde, S., J. Beckley and I. Schwartz. 1998. Prevalence of tick-borne pathogens in Ixodes scapularis in a rural New Jersey county. Emerg. Infect. Dis. 4: 97-98.
42. Walk, S. T., X. G. Xu, W. S. Stull, and S. M. Rich. 2009. Correlation between tick density and pathogen endemicity, New Hampshire. Emerg. Infect. Dis. 15: 585-587.
43. Wang, P., M. N. Glowacki, A. E. Hoet, G. R. Needham, K. A. Smith, R. E. Gary, and X. Li. 2014. Emergence of Ixodes scapularis and Borrelia burgdorferi, the Lyme disease vector and agent, in Ohio. Front. Cell. Infect. Microbiol. 4: 70.
44. Wormser, G. P., R. J. Dattwyler, E. D. Shapiro, J. J. Halperin, A. C. Steere, M. S. Klempner, P. J. Krause, J. S. Bakken, F. Strie, G. Stanek, et al. 2006. The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the infectious disease society of America. Clin. Infect. Dis. 43: 1089-1134.
45. Yeh, M. T., J. M. Bak, R. Hu, M. C. Nicholson, C. Kelly, and T. N. Mather 1995. Determining the duration of Ixodes scapularis (Acari: Ixodidae) attachment to tick-bite victims. J. Med. Entomol. 32: 853-858.