Cannabinoids suppress acute and anticipatory nausea in preclinical rat models of conditioned gaping

Clinical Pharmacology and Therapeutics

Volumn 97, Issue 6, 2015, Pages 559-561

  Parker, L A ^a   Rock, E M ^a   Sticht, M A ^a   Wills, K L ^a   Limebeer, C L ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONYL GLYCEROL; ANANDAMIDE; CANNABIDIOL; CANNABINOID; DRONABINOL; ENDOCANNABINOID; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG; CANNABINOID 1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICIPATORY NAUSEA AND VOMITING; AREA POSTREMA; ARTICLE; CONDITIONED GAPING; CONDITIONED REFLEX; DRUG EFFECT; DRUG MECHANISM; INSULA; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; ACUTE DISEASE; ANIMAL; BRAIN CORTEX; DISEASE MODEL; NAUSEA; PHYSIOLOGY;

ACUTE DISEASE; ANIMALS; CANNABIDIOL; CANNABINOIDS; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; NAUSEA; RATS; RECEPTOR, CANNABINOID, CB1;

EID: 84938948546     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1002/cpt.98     Document Type: Article

References (5)

1. Parker, L.A. Conditioned taste avoidance versus conditioned gaping: rat models of nausea-induced behavior. Eur. J. Pharmacol. 722, 122-133 (2014
2. Sharkey, K.A., Darmani N.A., & Parker, L.A. Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. Eur. J. Pharmacol. 722, 134-146 (2014
3. Rock, E.M., Sticht, M.A., & Parker, L.A. Effect of phytocannabinoids on nausea and vomiting. In Handbook of Cannabis (ed. Pertwee, R.J.) 435-454 (Oxford University Press, UK, 2014
4. Contreras, M., Ceric, F., & Torrealba, F. Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium. Science 318, 655-658 (2007
5. Tuerke, K.J., Limebeer, C.L., Fletcher, P.J., & Parker, L.A. Double dissociation between regulation of conditioned disgust and taste avoidance by serotonin availability at the 5-HT3 receptor in the posterior and anterior insular cortex. J. Neurosci. 32, 13709-13717 (2012