Reduced red blood cell deformability over time is associated with a poor outcome in septic patients

Microvascular Research

Volumn 101, Issue , 2015, Pages 8-14

  Donadello, Katia ^a   Piagnerelli, Michael ^b   Reggiori, Giulia ^a   Gottin, Leonardo ^c   Scolletta, Sabino ^a   Occhipinti, Giovanna ^a   Zouaoui Boudjeltia, Karim ^b   Vincent, Jean Louis ^a  

^a ERASME HOSPITAL   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIVERSITY OF VERONA   (Italy)

Author keywords

Deformability; Erythrocyte; Laser assisted Optical Rotational Cell Analyzer (LORCA); Microcirculation; Rheology; Sepsis

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN; LACTIC ACID;

ADULT; AGGREGATION INDEX; ANALYTICAL EQUIPMENT; APACHE; ARTICLE; BLOOD ANALYSIS; BLOOD RHEOLOGY; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; ELONGATION INDEX; ERYTHROCYTE AGGREGATION; ERYTHROCYTE COUNT; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE MEMBRANE; ERYTHROCYTE PARAMETERS; FEMALE; HEMOGLOBIN BLOOD LEVEL; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; KIDNEY FUNCTION; LACTATE BLOOD LEVEL; LASER ASSISTED OPTICAL ROTATIONAL CELL ANALYZER; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SEPSIS; SHEAR STRESS; SURVIVOR; THROMBOCYTE COUNT; BLOOD; CYTOLOGY; ERYTHROCYTE; FLOW KINETICS; INTENSIVE CARE; LASER; MECHANICAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PRESSURE; PROGNOSIS; SHEAR STRENGTH; TREATMENT OUTCOME;

ADULT; CRITICAL CARE; ERYTHROCYTE AGGREGATION; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; FEMALE; HUMANS; LASERS; MALE; MIDDLE AGED; PRESSURE; PROGNOSIS; PROSPECTIVE STUDIES; RHEOLOGY; SEPSIS; SHEAR STRENGTH; STRESS, MECHANICAL; TREATMENT OUTCOME;

EID: 84938884681     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2015.05.001     Document Type: Article

References (37)

1. Baskurt O.K. Pathophysiological significance of blood rheology. Turk. J. Med. Sci. 2003, 33:347-355.
2. Baskurt O.K., Meiselman H.J. Activated polymorphonuclear leukocytes affect red blood cell aggregability. J. Leukoc. Biol. 1998, 63:89-93.
3. Baskurt O.K., Farley R.A., Meiselman H.J. Erythrocyte aggregation tendency and cellular properties in horse, human, and rat: a comparative study. Am. J. Physiol. 1997, 273:H2604-H2612.
4. Baskurt O.K., Gelmont D., Meiselman H.J. Red blood cell deformability in sepsis. Am. J. Respir. Crit. Care Med. 1998, 157:421-427.
5. Baskurt O.K., Meiselman H.J., Kayar E. Measurement of red blood cell aggregation in a "plate-plate" shearing system by analysis of light transmission. Clin. Hemorheol. Microcirc. 1998, 19:307-314.
6. Bateman R.M., Jagger J.E., Sharpe M.D., Ellsworth M.L., Mehta S., Ellis C.G. Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis. Am. J. Physiol. Heart Circ. Physiol. 2001, 280:H2848-H2856.
7. Bulai T., Bratosin D., Artenie V., Montreuil J. Characterization of a sialate pyruvate-lyase in the cytosol of human erythrocytes. Biochimie 2002, 84:655-660.
8. Bulai T., Bratosin D., Artenie V., Montreuil J. Uptake of sialic acid by human erythrocyte. Characterization of a transport system. Biochimie 2003, 85:241-244.
9. Cabrales P. Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemia. Am. J. Physiol. Heart Circ. Physiol. 2007, 293:H1206-H1215.
10. Condon M.R., Kim J.E., Deitch E.A., Machiedo G.W., Spolarics Z. Appearance of an erythrocyte population with decreased deformability and hemoglobin content following sepsis. Am. J. Physiol. Heart Circ. Physiol. 2003, 284:H2177-H2184.
11. Condon M.R., Feketova E., Machiedo G.W., Deitch E.A., Spolarics Z. Augmented erythrocyte band-3 phosphorylation in septic mice. Biochim. Biophys. Acta 2007, 1772:580-586.
12. De Backer D., Creteur J., Preiser J.C., Dubois M.J., Vincent J.L. Microvascular blood flow is altered in patients with sepsis. Am. J. Respir. Crit. Care Med. 2002, 166:98-104.
13. Dobbe J.G., Streekstra G.J., Strackee J., Rutten M.C., Stijnen J.M., Grimbergen C.A. Syllectometry: the effect of aggregometer geometry in the assessment of red blood cell shape recovery and aggregation. IEEE Trans. Biomed. Eng. 2003, 50:97-106.
14. Edul V.S., Enrico C., Laviolle B., Vazquez A.R., Ince C., Dubin A. Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock. Crit. Care Med. 2012, 40:1443-1448.
15. Hardeman M.R., Dobbe J.G., Ince C. The Laser-assisted Optical Rotational Cell Analyzer (LORCA) as red blood cell aggregometer. Clin. Hemorheol. Microcirc. 2001, 25:1-11.
16. Johnson R.M. Ektacytometry of red blood cells. Methods Enzymol. 1989, 173:35-54.
17. Kaukonen K.M., Bailey M., Suzuki S., Pilcher D., Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA 2014, 311:1308-1316.
18. Kempe D.S., Akel A., Lang P.A., Hermle T., Biswas R., Muresanu J., Friedrich B., Dreischer P., Wolz C., Schumacher U., Peschel A., Gotz F., Doring G., Wieder T., Gulbins E., Lang F. Suicidal erythrocyte death in sepsis. J. Mol. Med. 2007, 85:273-281.
19. Knaus W.A., Draper E.A., Wagner D.P., Zimmerman J.E. APACHE II: a severity of disease classification system. Crit. Care Med. 1985, 13:818-829.
20. Levy M.M., Fink M.P., Marshall J.C., Abraham E., Angus D., Cook D., Cohen J., Opal S.M., Vincent J.L., Ramsay G. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit. Care Med. 2003, 31:1250-1256.
21. Moutzouri A.G., Skoutelis A.T., Gogos C.A., Missirlis Y.F., Athanassiou G.M. Red blood cell deformability in patients with sepsis: a marker for prognosis and monitoring of severity. Clin. Hemorheol. Microcirc. 2007, 36:291-299.
22. Piagnerelli M., Boudjeltia K.Z., Brohee D., Piro P., Carlier E., Vincent J.L., Lejeune P., Vanhaeverbeek M. Alterations of red blood cell shape and sialic acid membrane content in septic patients. Crit. Care Med. 2003, 31:2156-2162.
23. Piagnerelli M., Boudjeltia K.Z., Rapotec A., Richard T., Brohee D., Babar S., Bouckaert V., Simon A.C., Toko J.P., Walravens T., Vincent J.L., Vanhaeverbeek M. Neuraminidase alters red blood cells in sepsis. Crit. Care Med. 2009, 37:1244-1250.
24. Piagnerelli M., Cotton F., Van Nuffelen M., Vincent J.L., Gulbis B. Modifications in erythrocyte membrane protein content are not responsible for the alterations in rheology seen in sepsis. Shock 2012, 37:17-21.
25. Poschl J.M., Leray C., Ruef P., Cazenave J.P., Linderkamp O. Endotoxin binding to erythrocyte membrane and erythrocyte deformability in human sepsis and in vitro. Crit. Care Med. 2003, 31:924-928.
26. Reggiori G., Occhipinti G., De Gasperi A., Vincent J.L., Piagnerelli M. Early alterations of red blood cell rheology in critically ill patients. Crit. Care Med. 2009, 37:3041-3046.
27. Rogowski O., Zeltser D., Rotstein R., Shapira I., Avitzour D., Fusman R., Mardi T., Prochorov V., Arber N., Berliner S. Correlated expression of adhesive properties for both white and red blood cells during inflammation. Biorheology 2000, 37:361-370.
28. Sakr Y., Dubois M.J., De Backer D., Creteur J., Vincent J.L. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit. Care Med. 2004, 32:1825-1831.
29. Serroukh Y., Djebara S., Lelubre C., Zouaoui B.K., Biston P., Piagnerelli M. Alterations of the erythrocyte membrane during sepsis. Crit. Care Res. Pract. 2012, 2012:702956.
30. Simchon S., Jan K.M., Chien S. Influence of reduced red cell deformability on regional blood flow. Am. J. Physiol. 1987, 253:H898-H903.
31. Somer T., Meiselman H.J. Disorders of blood viscosity. Ann. Med. 1993, 25:31-39.
32. Spolarics Z., Condon M.R., Siddiqi M., Machiedo G.W., Deitch E.A. Red blood cell dysfunction in septic glucose-6-phosphate dehydrogenase-deficient mice. Am. J. Physiol. Heart Circ. Physiol. 2004, 286:H2118-H2126.
33. Top A.P., Ince C., de Meij N., van Dijk M., Tibboel D. Persistent low microcirculatory vessel density in nonsurvivors of sepsis in pediatric intensive care. Crit. Care Med. 2011, 39:8-13.
34. Trzeciak S., Dellinger R.P., Parrillo J.E., Guglielmi M., Bajaj J., Abate N.L., Arnold R.C., Colilla S., Zanotti S., Hollenberg S.M. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann. Emerg. Med. 2007, 49:88-98. 98.
35. Trzeciak S., McCoy J.V., Phillip D.R., Arnold R.C., Rizzuto M., Abate N.L., Shapiro N.I., Parrillo J.E., Hollenberg S.M. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24h in patients with sepsis. Intensive Care Med. 2008, 34:2210-2217.
36. Vincent J.L., Moreno R., Takala J., Willatts S., de Mendonça A., Bruining H., Reinhart C.K., Suter P.M., Thijs L.G. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med. 1996, 22:707-710.
37. Vincent J.L., Rello J., Marshall J., Silva E., Anzueto A., Martin C.D., Moreno R., Lipman J., Gomersall C., Sakr Y., Reinhart K. International study of the prevalence and outcomes of infection in intensive care units. JAMA 2009, 302:2323-2329.