메뉴 건너뛰기




Volumn 17, Issue 8, 2015, Pages

Optimizing Biologic Agents in Ulcerative Colitis and Crohn’s Disease

Author keywords

Adalimumab; Antibodies; Biologics; Crohn s disease; Inflammatory bowel disease; Infliximab; Therapeutic drug monitoring; Trough levels; Ulcerative colitis

Indexed keywords

ADALIMUMAB; ANRUKINZUMAB; AZATHIOPRINE; CERTOLIZUMAB PEGOL; ETROLIZUMAB; GOLIMUMAB; INFLIXIMAB; METHOTREXATE; NATALIZUMAB; PLACEBO; PREDNISONE; USTEKINUMAB; VEDOLIZUMAB; BIOLOGICAL FACTOR;

EID: 84938838849     PISSN: 15228037     EISSN: 1534312X     Source Type: Journal    
DOI: 10.1007/s11894-015-0453-1     Document Type: Review
Times cited : (17)

References (75)
  • 1
    • 0009775385 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor-alpha therapy in Crohn’s disease: a magic bullet finally hits its mark
    • COI: 1:STN:280:DC%2BC3s3mtFChtQ%3D%3D, PID: 23282526
    • Plevy SE, Targan SR. Anti-tumor necrosis factor-alpha therapy in Crohn’s disease: a magic bullet finally hits its mark. Inflamm Bowel Dis. 1996;2(2):158–9.
    • (1996) Inflamm Bowel Dis , vol.2 , Issue.2 , pp. 158-159
    • Plevy, S.E.1    Targan, S.R.2
  • 2
    • 84884577666 scopus 로고    scopus 로고
    • Infliximab reduces hospitalizations and surgery interventions in patients with inflammatory bowel disease: a systematic review and meta-analysis
    • PID: 23860567
    • Costa J et al. Infliximab reduces hospitalizations and surgery interventions in patients with inflammatory bowel disease: a systematic review and meta-analysis. Inflamm Bowel Dis. 2013;19(10):2098–110.
    • (2013) Inflamm Bowel Dis , vol.19 , Issue.10 , pp. 2098-2110
    • Costa, J.1
  • 3
    • 84896837990 scopus 로고    scopus 로고
    • Comparative effectiveness of anti-tumor necrosis factor drugs on health-related quality of life among patients with inflammatory arthritis
    • COI: 1:CAS:528:DC%2BC2cXjtlOlur8%3D
    • Chen JS et al. Comparative effectiveness of anti-tumor necrosis factor drugs on health-related quality of life among patients with inflammatory arthritis. Arthritis Care Res (Hoboken). 2014;66(3):464–72.
    • (2014) Arthritis Care Res (Hoboken) , vol.66 , Issue.3 , pp. 464-472
    • Chen, J.S.1
  • 4
    • 84879204639 scopus 로고    scopus 로고
    • Adalimumab and infliximab are equally effective for Crohn’s disease in patients not previously treated with anti-tumor necrosis factor-alpha agents
    • COI: 1:CAS:528:DC%2BC3sXnslChtr4%3D, PID: 23376000
    • Kestens C et al. Adalimumab and infliximab are equally effective for Crohn’s disease in patients not previously treated with anti-tumor necrosis factor-alpha agents. Clin Gastroenterol Hepatol. 2013;11(7):826–31.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , Issue.7 , pp. 826-831
    • Kestens, C.1
  • 5
    • 84899099903 scopus 로고    scopus 로고
    • Comparative effectiveness of infliximab and adalimumab for Crohn’s disease
    • COI: 1:CAS:528:DC%2BC3sXhsV2ms73L, PID: 23811254
    • Osterman MT et al. Comparative effectiveness of infliximab and adalimumab for Crohn’s disease. Clin Gastroenterol Hepatol. 2014;12(5):811–7.e3.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , Issue.5 , pp. 811
    • Osterman, M.T.1
  • 6
    • 84873129604 scopus 로고    scopus 로고
    • Comparative effectiveness of anti-TNF agents for Crohn’s disease in a tertiary referral IBD practice
    • COI: 1:CAS:528:DC%2BC3sXhvV2gu7w%3D, PID: 23014844
    • Patil SA et al. Comparative effectiveness of anti-TNF agents for Crohn’s disease in a tertiary referral IBD practice. Dig Dis Sci. 2013;58(1):209–15.
    • (2013) Dig Dis Sci , vol.58 , Issue.1 , pp. 209-215
    • Patil, S.A.1
  • 7
    • 27644441529 scopus 로고    scopus 로고
    • Natalizumab induction and maintenance therapy for Crohn’s disease
    • COI: 1:CAS:528:DC%2BD2MXhtF2rsbzF, PID: 16267322
    • Sandborn WJ et al. Natalizumab induction and maintenance therapy for Crohn’s disease. N Engl J Med. 2005;353(18):1912–25.
    • (2005) N Engl J Med , vol.353 , Issue.18 , pp. 1912-1925
    • Sandborn, W.J.1
  • 8
    • 57249089077 scopus 로고    scopus 로고
    • Treatment of active Crohn’s disease with MLN0002, a humanized antibody to the alpha4beta7 integrin
    • COI: 1:CAS:528:DC%2BD1MXhtFSlurY%3D, PID: 18829392
    • Feagan BG et al. Treatment of active Crohn’s disease with MLN0002, a humanized antibody to the alpha4beta7 integrin. Clin Gastroenterol Hepatol. 2008;6(12):1370–7.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , Issue.12 , pp. 1370-1377
    • Feagan, B.G.1
  • 9
    • 84882749768 scopus 로고    scopus 로고
    • Vedolizumab as induction and maintenance therapy for Crohn’s disease
    • COI: 1:CAS:528:DC%2BC3sXhtlCrsrbO, PID: 23964933
    • Sandborn WJ et al. Vedolizumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med. 2013;369(8):711–21.
    • (2013) N Engl J Med , vol.369 , Issue.8 , pp. 711-721
    • Sandborn, W.J.1
  • 10
    • 22844445587 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn’s disease
    • PID: 15947080
    • Van Assche G et al. Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn’s disease. N Engl J Med. 2005;353(4):362–8.
    • (2005) N Engl J Med , vol.353 , Issue.4 , pp. 362-368
    • Van Assche, G.1
  • 11
    • 81255210898 scopus 로고    scopus 로고
    • Discovery and mechanism of ustekinumab: a human monoclonal antibody targeting interleukin-12 and interleukin-23 for treatment of immune-mediated disorders
    • PID: 22123062
    • Benson JM et al. Discovery and mechanism of ustekinumab: a human monoclonal antibody targeting interleukin-12 and interleukin-23 for treatment of immune-mediated disorders. MAbs. 2011;3(6):535–45.
    • (2011) MAbs , vol.3 , Issue.6 , pp. 535-545
    • Benson, J.M.1
  • 12
    • 84871701834 scopus 로고    scopus 로고
    • Sandborn WJ, et al. Ustekinumab induction and maintenance therapy in refractory Crohn’s disease. N Engl J Med. 367(16):1519–28
    • Sandborn WJ, et al. Ustekinumab induction and maintenance therapy in refractory Crohn’s disease. N Engl J Med. 367(16):1519–28.
  • 13
    • 84927796919 scopus 로고    scopus 로고
    • Subcutaneous ustekinumab for the treatment of anti-TNF resistant Crohn’s disease-the McGill experience, J Crohns Colitis
    • Kopylov U, et al. Subcutaneous ustekinumab for the treatment of anti-TNF resistant Crohn’s disease-the McGill experience. J Crohns Colitis. 2014.
    • (2014) et al
    • Kopylov, U.1
  • 14
    • 84863923285 scopus 로고    scopus 로고
    • How to guide therapeutic decisions in a patient-tailored approach to treatment of IBD?
    • PID: 22796804
    • Rutgeerts P. How to guide therapeutic decisions in a patient-tailored approach to treatment of IBD? Dig Dis. 2012;30(4):396–9.
    • (2012) Dig Dis , vol.30 , Issue.4 , pp. 396-399
    • Rutgeerts, P.1
  • 15
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial
    • COI: 1:CAS:528:DC%2BD38Xkt1Gru70%3D, PID: 12047962
    • Hanauer SB et al. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial. Lancet. 2002;359(9317):1541–9.
    • (2002) Lancet , vol.359 , Issue.9317 , pp. 1541-1549
    • Hanauer, S.B.1
  • 16
    • 17144388945 scopus 로고    scopus 로고
    • Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn’s disease
    • COI: 1:CAS:528:DC%2BD2MXjvV2qtrY%3D, PID: 15825070
    • Lichtenstein GR et al. Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn’s disease. Gastroenterology. 2005;128(4):862–9.
    • (2005) Gastroenterology , vol.128 , Issue.4 , pp. 862-869
    • Lichtenstein, G.R.1
  • 17
    • 55449098725 scopus 로고    scopus 로고
    • Effects of adalimumab therapy on incidence of hospitalization and surgery in Crohn’s disease: results from the CHARM study
    • COI: 1:CAS:528:DC%2BD1cXhsVOhtb3L, PID: 18848553
    • Feagan BG et al. Effects of adalimumab therapy on incidence of hospitalization and surgery in Crohn’s disease: results from the CHARM study. Gastroenterology. 2008;135(5):1493–9.
    • (2008) Gastroenterology , vol.135 , Issue.5 , pp. 1493-1499
    • Feagan, B.G.1
  • 18
    • 77950988234 scopus 로고    scopus 로고
    • Infliximab, azathioprine, or combination therapy for Crohn’s disease
    • COI: 1:CAS:528:DC%2BC3cXkslajt78%3D, PID: 20393175, First randomized trial to determine the impact of concurrent immunomodulator therapy on outcomes with Infliximab
    • Colombel JF et al. Infliximab, azathioprine, or combination therapy for Crohn’s disease. N Engl J Med. 2010;362(15):1383–95. First randomized trial to determine the impact of concurrent immunomodulator therapy on outcomes with Infliximab.
    • (2010) N Engl J Med , vol.362 , Issue.15 , pp. 1383-1395
    • Colombel, J.F.1
  • 19
    • 79958228566 scopus 로고    scopus 로고
    • Impact of azathioprine and tumour necrosis factor antagonists on the need for surgery in newly diagnosed Crohn’s disease
    • COI: 1:CAS:528:DC%2BC3MXpvFWhtbc%3D, PID: 21228429
    • Peyrin-Biroulet L et al. Impact of azathioprine and tumour necrosis factor antagonists on the need for surgery in newly diagnosed Crohn’s disease. Gut. 2011;60(7):930–6.
    • (2011) Gut , vol.60 , Issue.7 , pp. 930-936
    • Peyrin-Biroulet, L.1
  • 20
    • 79955859430 scopus 로고    scopus 로고
    • Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial
    • COI: 1:CAS:528:DC%2BC3MXpt1yktrs%3D, PID: 21209123
    • Reinisch W et al. Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial. Gut. 2011;60(6):780–7.
    • (2011) Gut , vol.60 , Issue.6 , pp. 780-787
    • Reinisch, W.1
  • 21
    • 84856163835 scopus 로고    scopus 로고
    • Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis
    • COI: 1:CAS:528:DC%2BC38XhsVOmu7o%3D, PID: 22062358
    • Sandborn WJ et al. Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology. 2012;142(2):257–65.e1-3.
    • (2012) Gastroenterology , vol.142 , Issue.2 , pp. 257
    • Sandborn, W.J.1
  • 22
    • 28844473957 scopus 로고    scopus 로고
    • Infliximab for induction and maintenance therapy for ulcerative colitis
    • COI: 1:CAS:528:DC%2BD2MXhtlShurjE, PID: 16339095
    • Rutgeerts P et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005;353(23):2462–76.
    • (2005) N Engl J Med , vol.353 , Issue.23 , pp. 2462-2476
    • Rutgeerts, P.1
  • 23
    • 84867027990 scopus 로고    scopus 로고
    • Mucosal healing in inflammatory bowel diseases: a systematic review
    • COI: 1:CAS:528:DC%2BC38XhslSnsbvL, PID: 22842618
    • Neurath MF, Travis SP. Mucosal healing in inflammatory bowel diseases: a systematic review. Gut. 2012;61(11):1619–35.
    • (2012) Gut , vol.61 , Issue.11 , pp. 1619-1635
    • Neurath, M.F.1    Travis, S.P.2
  • 24
    • 79955563439 scopus 로고    scopus 로고
    • Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    • COI: 1:CAS:528:DC%2BC3MXlsVGhsL0%3D, PID: 21530742
    • Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011;140(6):1756–67.
    • (2011) Gastroenterology , vol.140 , Issue.6 , pp. 1756-1767
    • Strober, W.1    Fuss, I.J.2
  • 25
    • 62049083383 scopus 로고    scopus 로고
    • Loss of response and requirement of infliximab dose intensification in Crohn’s disease: a review
    • COI: 1:CAS:528:DC%2BD1MXis1artbo%3D, PID: 19174781
    • Gisbert JP, Panes J. Loss of response and requirement of infliximab dose intensification in Crohn’s disease: a review. Am J Gastroenterol. 2009;104(3):760–7.
    • (2009) Am J Gastroenterol , vol.104 , Issue.3 , pp. 760-767
    • Gisbert, J.P.1    Panes, J.2
  • 26
    • 84899915498 scopus 로고    scopus 로고
    • Individualised therapy is more cost-effective than dose intensification in patients with Crohn’s disease who lose response to anti-TNF treatment: a randomised, controlled trial
    • PID: 23878167, Prospectively examined the impact of measuring drug levels on costs and outcomes in patients who lose response to anti-TNFs
    • Steenholdt C et al. Individualised therapy is more cost-effective than dose intensification in patients with Crohn’s disease who lose response to anti-TNF treatment: a randomised, controlled trial. Gut. 2014;63(6):919–27. Prospectively examined the impact of measuring drug levels on costs and outcomes in patients who lose response to anti-TNFs.
    • (2014) Gut , vol.63 , Issue.6 , pp. 919-927
    • Steenholdt, C.1
  • 27
    • 0037434552 scopus 로고    scopus 로고
    • Influence of immunogenicity on the long-term efficacy of infliximab in Crohn’s disease
    • COI: 1:CAS:528:DC%2BD3sXhtVyqtL0%3D, PID: 12584368
    • Baert F et al. Influence of immunogenicity on the long-term efficacy of infliximab in Crohn’s disease. N Engl J Med. 2003;348(7):601–8.
    • (2003) N Engl J Med , vol.348 , Issue.7 , pp. 601-608
    • Baert, F.1
  • 28
    • 84893700580 scopus 로고    scopus 로고
    • Antibodies to infliximab and risk of infusion reactions in patients with inflammatory bowel disease: a systematic review and meta-analysis
    • PID: 24280879
    • O’Meara S, Nanda KS, Moss AC. Antibodies to infliximab and risk of infusion reactions in patients with inflammatory bowel disease: a systematic review and meta-analysis. Inflamm Bowel Dis. 2014;20(1):1–6.
    • (2014) Inflamm Bowel Dis , vol.20 , Issue.1
    • O’Meara, S.1    Nanda, K.S.2    Moss, A.C.3
  • 29
    • 84872050633 scopus 로고    scopus 로고
    • Impact of antibodies to infliximab on clinical outcomes and serum infliximab levels in patients with inflammatory bowel disease (IBD): a meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXktFWlsw%3D%3D, PID: 23147525, quiz 48
    • Nanda KS, Cheifetz AS, Moss AC. Impact of antibodies to infliximab on clinical outcomes and serum infliximab levels in patients with inflammatory bowel disease (IBD): a meta-analysis. Am J Gastroenterol. 2013;108(1):40–7. quiz 48.
    • (2013) Am J Gastroenterol , vol.108 , Issue.1 , pp. 40-47
    • Nanda, K.S.1    Cheifetz, A.S.2    Moss, A.C.3
  • 30
    • 85033597671 scopus 로고    scopus 로고
    • Optimizing the use of biological therapy in patients with inflammatory bowel disease
    • Moss AC. Optimizing the use of biological therapy in patients with inflammatory bowel disease. Gastroenterol Rep (Oxf). 2015;3(1):63–8.
    • (2015) Gastroenterol Rep (Oxf) , vol.3 , Issue.1 , pp. 63-68
    • Moss, A.C.1
  • 31
    • 84878951773 scopus 로고    scopus 로고
    • First-line therapy in adult Crohn’s disease: who should receive anti-TNF agents?
    • COI: 1:CAS:528:DC%2BC3sXptVOls70%3D, PID: 23458890
    • Peyrin-Biroulet L et al. First-line therapy in adult Crohn’s disease: who should receive anti-TNF agents? Nat Rev Gastroenterol Hepatol. 2013;10(6):345–51.
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , Issue.6 , pp. 345-351
    • Peyrin-Biroulet, L.1
  • 32
    • 84908254592 scopus 로고    scopus 로고
    • Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn’s disease, J Crohns Colitis
    • Ruemmele FM, et al. Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn’s disease. J Crohns Colitis. 2014.
    • (2014) et al
    • Ruemmele, F.M.1
  • 33
    • 84873720197 scopus 로고    scopus 로고
    • Subgroup analysis of the placebo-controlled CHARM trial: increased remission rates through 3 years for adalimumab-treated patients with early Crohn’s disease
    • COI: 1:STN:280:DC%2BC38jitlelsA%3D%3D, PID: 22704916
    • Schreiber S et al. Subgroup analysis of the placebo-controlled CHARM trial: increased remission rates through 3 years for adalimumab-treated patients with early Crohn’s disease. J Crohns Colitis. 2013;7(3):213–21.
    • (2013) J Crohns Colitis , vol.7 , Issue.3 , pp. 213-221
    • Schreiber, S.1
  • 34
    • 77954423661 scopus 로고    scopus 로고
    • Increased response and remission rates in short-duration Crohn’s disease with subcutaneous certolizumab pegol: an analysis of PRECiSE 2 randomized maintenance trial data
    • COI: 1:CAS:528:DC%2BC3cXosVGlu7Y%3D, PID: 20234346
    • Schreiber S et al. Increased response and remission rates in short-duration Crohn’s disease with subcutaneous certolizumab pegol: an analysis of PRECiSE 2 randomized maintenance trial data. Am J Gastroenterol. 2010;105(7):1574–82.
    • (2010) Am J Gastroenterol , vol.105 , Issue.7 , pp. 1574-1582
    • Schreiber, S.1
  • 35
    • 39449085441 scopus 로고    scopus 로고
    • Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial
    • PID: 18295023, Assessed the impact of early combined therapy on mucosal healing in patients recently diagnosed with Crohn’s disease
    • D’Haens G et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial. Lancet. 2008;371(9613):660–7. Assessed the impact of early combined therapy on mucosal healing in patients recently diagnosed with Crohn’s disease.
    • (2008) Lancet , vol.371 , Issue.9613 , pp. 660-667
    • D’Haens, G.1
  • 36
    • 76349114941 scopus 로고    scopus 로고
    • The natural history of adult Crohn’s disease in population-based cohorts
    • PID: 19861953
    • Peyrin-Biroulet L et al. The natural history of adult Crohn’s disease in population-based cohorts. Am J Gastroenterol. 2010;105(2):289–97.
    • (2010) Am J Gastroenterol , vol.105 , Issue.2 , pp. 289-297
    • Peyrin-Biroulet, L.1
  • 37
    • 0034777502 scopus 로고    scopus 로고
    • Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: a pilot study
    • COI: 1:STN:280:DC%2BD3MzhtVKktg%3D%3D, PID: 11383595
    • Sands BE et al. Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: a pilot study. Inflamm Bowel Dis. 2001;7(2):83–8.
    • (2001) Inflamm Bowel Dis , vol.7 , Issue.2 , pp. 83-88
    • Sands, B.E.1
  • 38
    • 0029010945 scopus 로고
    • Significance of systemic endotoxaemia in inflammatory bowel disease
    • COI: 1:STN:280:DyaK2MzktVWqsA%3D%3D, PID: 7615280
    • Gardiner KR et al. Significance of systemic endotoxaemia in inflammatory bowel disease. Gut. 1995;36(6):897–901.
    • (1995) Gut , vol.36 , Issue.6 , pp. 897-901
    • Gardiner, K.R.1
  • 39
    • 84866444830 scopus 로고    scopus 로고
    • Accelerated clearance of serum infliximab during induction therapy for acute ulcerative colitis is associated with treatment failure
    • Kevans D, Murthy S, Iacono A, Silverberg MS, Greenberg GR. Accelerated clearance of serum infliximab during induction therapy for acute ulcerative colitis is associated with treatment failure. Gastroenterology. 2012;142(Issue 5, Supplement 1):S-384–5.
    • (2012) Gastroenterology , vol.142 , Issue.5
    • Kevans, D.1    Murthy, S.2    Iacono, A.3    Silverberg, M.S.4    Greenberg, G.R.5
  • 40
    • 84938868749 scopus 로고    scopus 로고
    • Brandse JF, et al. 157 fecal loss of infliximab as a cause of lack of response in severe inflammatory bowel disease. Gastroenterology. 144(5):S-36
    • Brandse JF, et al. 157 fecal loss of infliximab as a cause of lack of response in severe inflammatory bowel disease. Gastroenterology. 144(5):S-36.
  • 41
    • 84858793037 scopus 로고    scopus 로고
    • Anti-TNF monoclonal antibodies in inflammatory bowel disease: pharmacokinetics-based dosing paradigms
    • COI: 1:CAS:528:DC%2BC38XksVOktbg%3D, PID: 22357456
    • Ordas I et al. Anti-TNF monoclonal antibodies in inflammatory bowel disease: pharmacokinetics-based dosing paradigms. Clin Pharmacol Ther. 2012;91(4):635–46.
    • (2012) Clin Pharmacol Ther , vol.91 , Issue.4 , pp. 635-646
    • Ordas, I.1
  • 42
    • 77952778634 scopus 로고    scopus 로고
    • Serum albumin concentration: a predictive factor of infliximab pharmacokinetics and clinical response in patients with ulcerative colitis
    • COI: 1:CAS:528:DC%2BC3cXotVWlsbw%3D, PID: 20420786, Demonstrates the role of pharmacokinetics of anti-TNFs in determining clinical outcomes in IBD
    • Fasanmade AA et al. Serum albumin concentration: a predictive factor of infliximab pharmacokinetics and clinical response in patients with ulcerative colitis. Int J Clin Pharmacol Ther. 2010;48(5):297–308. Demonstrates the role of pharmacokinetics of anti-TNFs in determining clinical outcomes in IBD.
    • (2010) Int J Clin Pharmacol Ther , vol.48 , Issue.5 , pp. 297-308
    • Fasanmade, A.A.1
  • 43
    • 17644382690 scopus 로고    scopus 로고
    • Relationship between serum trough infliximab levels, pretreatment C reactive protein levels, and clinical response to infliximab treatment in patients with rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BD2MXksFWru74%3D, PID: 15485995
    • Wolbink GJ et al. Relationship between serum trough infliximab levels, pretreatment C reactive protein levels, and clinical response to infliximab treatment in patients with rheumatoid arthritis. Ann Rheum Dis. 2005;64(5):704–7.
    • (2005) Ann Rheum Dis , vol.64 , Issue.5 , pp. 704-707
    • Wolbink, G.J.1
  • 44
    • 84913534923 scopus 로고    scopus 로고
    • Association between serum concentration of infliximab and efficacy in adult patients with ulcerative colitis, Gastroenterology
    • Adedokun OJ, et al. Association between serum concentration of infliximab and efficacy in adult patients with ulcerative colitis. Gastroenterology. 2014.
    • (2014) et al
    • Adedokun, O.J.1
  • 46
    • 84903853083 scopus 로고    scopus 로고
    • Early combined immunosuppression for the management of Crohn’s disease: a community-based cluster randomized trial
    • Khanna R, Levesque BG, Bressler B, Zou G, Stitt L, Greenberg GR, et al. Early combined immunosuppression for the management of Crohn’s disease: a community-based cluster randomized trial. J Crohn’s Colitis. 2014;8(Supplement 1):S2.
    • (2014) J Crohn’s Colitis , vol.8 , pp. 2
    • Khanna, R.1    Levesque, B.G.2    Bressler, B.3    Zou, G.4    Stitt, L.5    Greenberg, G.R.6
  • 47
    • 84884352968 scopus 로고    scopus 로고
    • Dual therapy with infliximab and immunomodulator reduces one-year rates of hospitalization and surgery among veterans with inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC3sXhtlahu7bO, PID: 23792295
    • Abraham NS et al. Dual therapy with infliximab and immunomodulator reduces one-year rates of hospitalization and surgery among veterans with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2013;11(10):1281–7.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , Issue.10 , pp. 1281-1287
    • Abraham, N.S.1
  • 48
    • 84892737455 scopus 로고    scopus 로고
    • Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in ulcerative colitis
    • COI: 1:CAS:528:DC%2BC2cXhsVOlt78%3D, PID: 24512909
    • Panaccione R et al. Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in ulcerative colitis. Gastroenterology. 2014;146(2):392–400.e3.
    • (2014) Gastroenterology , vol.146 , Issue.2 , pp. 392-400
    • Panaccione, R.1
  • 49
    • 84904425206 scopus 로고    scopus 로고
    • Review article: why, when and how to de-escalate therapy in inflammatory bowel diseases
    • COI: 1:CAS:528:DC%2BC2cXhtFOltL%2FJ, PID: 24957164
    • Pariente B, Laharie D. Review article: why, when and how to de-escalate therapy in inflammatory bowel diseases. Aliment Pharmacol Ther. 2014;40(4):338–53.
    • (2014) Aliment Pharmacol Ther , vol.40 , Issue.4 , pp. 338-353
    • Pariente, B.1    Laharie, D.2
  • 50
    • 77956997278 scopus 로고    scopus 로고
    • Usefulness of co-treatment with immunomodulators in patients with inflammatory bowel disease treated with scheduled infliximab maintenance therapy
    • COI: 1:CAS:528:DC%2BC3cXhtlWhsb%2FE, PID: 20587545
    • Sokol H et al. Usefulness of co-treatment with immunomodulators in patients with inflammatory bowel disease treated with scheduled infliximab maintenance therapy. Gut. 2010;59(10):1363–8.
    • (2010) Gut , vol.59 , Issue.10 , pp. 1363-1368
    • Sokol, H.1
  • 51
    • 84875490499 scopus 로고    scopus 로고
    • Long-term outcome of perianal fistulizing Crohn’s disease treated with infliximab
    • COI: 1:CAS:528:DC%2BC3sXhtFektr%2FN, PID: 23376316
    • Bouguen G et al. Long-term outcome of perianal fistulizing Crohn’s disease treated with infliximab. Clin Gastroenterol Hepatol. 2013;11(8):975–81.e1-4.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , Issue.8 , pp. 975
    • Bouguen, G.1
  • 52
    • 84875875397 scopus 로고    scopus 로고
    • Does co-treatment with immunosuppressors improve outcome in patients with Crohn’s disease treated with adalimumab?
    • COI: 1:CAS:528:DC%2BC3sXhsFCjurc%3D, PID: 23061650
    • Reenaers C et al. Does co-treatment with immunosuppressors improve outcome in patients with Crohn’s disease treated with adalimumab? Aliment Pharmacol Ther. 2012;36(11–12):1040–8.
    • (2012) Aliment Pharmacol Ther , vol.36 , Issue.11-12 , pp. 1040-1048
    • Reenaers, C.1
  • 53
    • 84894302120 scopus 로고    scopus 로고
    • Methotrexate in combination with infliximab is no more effective than infliximab alone in patients with Crohn’s disease
    • COI: 1:CAS:528:DC%2BC2cXhsV2itrs%3D, PID: 24269926
    • Feagan BG et al. Methotrexate in combination with infliximab is no more effective than infliximab alone in patients with Crohn’s disease. Gastroenterology. 2014;146(3):681–688.e1.
    • (2014) Gastroenterology , vol.146 , Issue.3 , pp. 681-688
    • Feagan, B.G.1
  • 54
    • 84859631532 scopus 로고    scopus 로고
    • Patient-specific approach to combination versus monotherapy with the use of antitumor necrosis factor alpha agents for inflammatory bowel disease
    • Devlin SM, Cheifetz AS, Siegel CA. Patient-specific approach to combination versus monotherapy with the use of antitumor necrosis factor alpha agents for inflammatory bowel disease. Gastroenterol Clin N Am. 2012;41(2):411–28.
    • (2012) Gastroenterol Clin N Am , vol.41 , Issue.2 , pp. 411-428
    • Devlin, S.M.1    Cheifetz, A.S.2    Siegel, C.A.3
  • 55
    • 78650239266 scopus 로고    scopus 로고
    • A systematic review of factors that contribute to hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC3cXhsF2isr%2FF, PID: 20888436
    • Kotlyar DS et al. A systematic review of factors that contribute to hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2011;9(1):36–41.e1.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , Issue.1 , pp. 36-41
    • Kotlyar, D.S.1
  • 56
    • 84872024555 scopus 로고    scopus 로고
    • T-cell non-Hodgkin’s lymphomas reported to the FDA AERS with tumor necrosis factor-alpha (TNF-alpha) inhibitors: results of the REFURBISH study
    • COI: 1:CAS:528:DC%2BC3sXktFWltg%3D%3D, PID: 23032984
    • Deepak P et al. T-cell non-Hodgkin’s lymphomas reported to the FDA AERS with tumor necrosis factor-alpha (TNF-alpha) inhibitors: results of the REFURBISH study. Am J Gastroenterol. 2013;108(1):99–105.
    • (2013) Am J Gastroenterol , vol.108 , Issue.1 , pp. 99-105
    • Deepak, P.1
  • 58
    • 84866122837 scopus 로고    scopus 로고
    • Serious infection and mortality in patients with Crohn’s disease: more than 5 years of follow-up in the TREAT registry
    • COI: 1:CAS:528:DC%2BC38XhtlWqt7zI, PID: 22890223
    • Lichtenstein GR et al. Serious infection and mortality in patients with Crohn’s disease: more than 5 years of follow-up in the TREAT registry. Am J Gastroenterol. 2012;107(9):1409–22.
    • (2012) Am J Gastroenterol , vol.107 , Issue.9 , pp. 1409-1422
    • Lichtenstein, G.R.1
  • 59
    • 84893787330 scopus 로고    scopus 로고
    • Drug therapies and the risk of malignancy in Crohn’s disease: results from the TREAT Registry
    • COI: 1:CAS:528:DC%2BC2cXitFals7Y%3D, PID: 24394749
    • Lichtenstein GR et al. Drug therapies and the risk of malignancy in Crohn’s disease: results from the TREAT Registry. Am J Gastroenterol. 2014;109(2):212–23.
    • (2014) Am J Gastroenterol , vol.109 , Issue.2 , pp. 212-223
    • Lichtenstein, G.R.1
  • 60
    • 80955130782 scopus 로고    scopus 로고
    • Meta-analysis: efficacy and safety of combination therapy of infliximab and immunosuppressives for Crohn’s disease
    • COI: 1:CAS:528:DC%2BC3MXhsVequ7jI, PID: 21971373
    • Lin Z, Bai Y, Zheng P. Meta-analysis: efficacy and safety of combination therapy of infliximab and immunosuppressives for Crohn’s disease. Eur J Gastroenterol Hepatol. 2011;23(12):1100–10.
    • (2011) Eur J Gastroenterol Hepatol , vol.23 , Issue.12 , pp. 1100-1110
    • Lin, Z.1    Bai, Y.2    Zheng, P.3
  • 61
    • 84855648247 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of biologics for inflammatory bowel disease
    • PID: 22021134
    • Colombel JF et al. Therapeutic drug monitoring of biologics for inflammatory bowel disease. Inflamm Bowel Dis. 2012;18(2):349–58.
    • (2012) Inflamm Bowel Dis , vol.18 , Issue.2 , pp. 349-358
    • Colombel, J.F.1
  • 62
    • 78951478130 scopus 로고    scopus 로고
    • Long-term durability of infliximab treatment in Crohn’s disease and efficacy of dose “escalation” in patients losing response
    • COI: 1:CAS:528:DC%2BC3MXnsVylsQ%3D%3D, PID: 21242747
    • Chaparro M et al. Long-term durability of infliximab treatment in Crohn’s disease and efficacy of dose “escalation” in patients losing response. J Clin Gastroenterol. 2011;45(2):113–8.
    • (2011) J Clin Gastroenterol , vol.45 , Issue.2 , pp. 113-118
    • Chaparro, M.1
  • 63
    • 84892979466 scopus 로고    scopus 로고
    • Postinduction serum infliximab trough level and decrease of C-reactive protein level are associated with durable sustained response to infliximab: a retrospective analysis of the ACCENT I trial
    • Cornillie F, et al. Postinduction serum infliximab trough level and decrease of C-reactive protein level are associated with durable sustained response to infliximab: a retrospective analysis of the ACCENT I trial. Gut. 2014.
    • (2014) Gut
    • Cornillie, F.1
  • 64
    • 84938881939 scopus 로고    scopus 로고
    • Withdrawal of immunomodulators after co-treatment does not reduce trough level of infliximab in patients with Crohn’s disease, Clin Gastroenterol Hepatol
    • Drobne D, et al. Withdrawal of immunomodulators after co-treatment does not reduce trough level of infliximab in patients with Crohn’s disease. Clin Gastroenterol Hepatol. 2014.
    • (2014) et al
    • Drobne, D.1
  • 65
    • 84888322157 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of infliximab and mucosal healing in inflammatory bowel disease: a prospective study
    • PID: 24013361
    • Paul S et al. Therapeutic drug monitoring of infliximab and mucosal healing in inflammatory bowel disease: a prospective study. Inflamm Bowel Dis. 2013;19(12):2568–76.
    • (2013) Inflamm Bowel Dis , vol.19 , Issue.12 , pp. 2568-2576
    • Paul, S.1
  • 66
    • 70449727863 scopus 로고    scopus 로고
    • Open-label study of adalimumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab
    • PID: 19408340
    • Afif W et al. Open-label study of adalimumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab. Inflamm Bowel Dis. 2009;15(9):1302–7.
    • (2009) Inflamm Bowel Dis , vol.15 , Issue.9 , pp. 1302-1307
    • Afif, W.1
  • 67
    • 84875732731 scopus 로고    scopus 로고
    • OP11 Individualised infliximab treatment using therapeutic drug monitoring: a prospective controlled Trough level Adapted infliXImab Treatment (TAXIT) trial
    • Vande Casteele N et al. OP11 Individualised infliximab treatment using therapeutic drug monitoring: a prospective controlled Trough level Adapted infliXImab Treatment (TAXIT) trial. J Crohn’s Colitis. 2012;6:S6.
    • (2012) J Crohn’s Colitis , vol.6 , pp. 6
    • Vande Casteele, N.1
  • 69
    • 84872487090 scopus 로고    scopus 로고
    • Adalimumab dose escalation and dose de-escalation success rate and predictors in a large national cohort of Crohn’s patients
    • PID: 22537637
    • Baert F et al. Adalimumab dose escalation and dose de-escalation success rate and predictors in a large national cohort of Crohn’s patients. J Crohns Colitis. 2013;7(2):154–60.
    • (2013) J Crohns Colitis , vol.7 , Issue.2 , pp. 154-160
    • Baert, F.1
  • 70
    • 84925623006 scopus 로고    scopus 로고
    • Proactive therapeutic concentration monitoring of infliximab may improve outcomes for patients with inflammatory bowel disease: results from a pilot observational study
    • PID: 25192499, First study to report improved clinical benefits when serum biologic levels are monitered in a pro-active manner, rather than in a reactive manner to loss of response
    • Vaughn BP et al. Proactive therapeutic concentration monitoring of infliximab may improve outcomes for patients with inflammatory bowel disease: results from a pilot observational study. Inflamm Bowel Dis. 2014;20(11):1996–2003. First study to report improved clinical benefits when serum biologic levels are monitered in a pro-active manner, rather than in a reactive manner to loss of response.
    • (2014) Inflamm Bowel Dis , vol.20 , Issue.11 , pp. 1996-2003
    • Vaughn, B.P.1
  • 71
    • 84855690453 scopus 로고    scopus 로고
    • Anti-TNF trough levels and detection of antibodies to anti-TNF in inflammatory bowel disease: are they ready for everyday clinical use?
    • COI: 1:CAS:528:DC%2BC38XntFKgtA%3D%3D, PID: 22149260
    • Miheller P et al. Anti-TNF trough levels and detection of antibodies to anti-TNF in inflammatory bowel disease: are they ready for everyday clinical use? Expert Opin Biol Ther. 2012;12(2):179–92.
    • (2012) Expert Opin Biol Ther , vol.12 , Issue.2 , pp. 179-192
    • Miheller, P.1
  • 72
    • 84893981377 scopus 로고    scopus 로고
    • Therapeutic drug monitoring, mucosal healing, deep remission: the path to nirvana in Crohn’s disease?
    • PID: 24370555
    • Moss AC. Therapeutic drug monitoring, mucosal healing, deep remission: the path to nirvana in Crohn’s disease? Clin Gastroenterol Hepatol. 2014;12(3):432–3.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , Issue.3 , pp. 432-433
    • Moss, A.C.1
  • 73
    • 84876458649 scopus 로고    scopus 로고
    • Letter: dry blood spots for anti-TNF treatment monitoring in IBD
    • COI: 1:STN:280:DC%2BC3srlvVeltw%3D%3D, PID: 23590542
    • Vande Casteele N et al. Letter: dry blood spots for anti-TNF treatment monitoring in IBD. Aliment Pharmacol Ther. 2013;37(10):1024–5.
    • (2013) Aliment Pharmacol Ther , vol.37 , Issue.10 , pp. 1024-1025
    • Vande Casteele, N.1
  • 74
    • 84925695001 scopus 로고    scopus 로고
    • Antibodies against infliximab are associated with de novo development of antibodies to adalimumab and therapeutic failure in infliximab-to-adalimumab switchers with IBD, Inflamm Bowel Dis
    • Frederiksen MT, et al. Antibodies against infliximab are associated with de novo development of antibodies to adalimumab and therapeutic failure in infliximab-to-adalimumab switchers with IBD. Inflamm Bowel Dis. 2014.
    • (2014) et al
    • Frederiksen, M.T.1
  • 75
    • 84855161776 scopus 로고    scopus 로고
    • Switch to adalimumab in patients with Crohn’s disease controlled by maintenance infliximab: prospective randomised SWITCH trial
    • PID: 21948942
    • Van Assche G et al. Switch to adalimumab in patients with Crohn’s disease controlled by maintenance infliximab: prospective randomised SWITCH trial. Gut. 2012;61(2):229–34.
    • (2012) Gut , vol.61 , Issue.2 , pp. 229-234
    • Van Assche, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.