Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei

Trends in Parasitology

Volumn 31, Issue 8, 2015, Pages 346-349

  McCulloch, Richard ^a   Field, Mark C ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Antigenic variation; Immune evasion; Recombination; Trypanosoma brucei; VSG

Indexed keywords

DOUBLE STRANDED DNA; VARIANT SURFACE GLYCOPROTEIN;

AMINO ACID SEQUENCE; ANTIGEN RECOGNITION; ANTIGENIC VARIATION; CROSS REACTION; GENE CONVERSION; GENE EXPRESSION; GENETIC VARIABILITY; IMMUNE EVASION; IMMUNE RESPONSE; NONHUMAN; QUANTITATIVE ANALYSIS; SHORT SURVEY; SUPERINFECTION; TRANSCRIPTION INITIATION; TRYPANOSOMA BRUCEI; GENETICS; HOST PARASITE INTERACTION; HUMAN; IMMUNOLOGY; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA BRUCEI;

ANTIGENIC VARIATION; HOST-PARASITE INTERACTIONS; HUMANS; IMMUNE EVASION; TRYPANOSOMA BRUCEI BRUCEI; VARIANT SURFACE GLYCOPROTEINS, TRYPANOSOMA;

EID: 84938740782     PISSN: 14714922     EISSN: 14715007     Source Type: Journal    
DOI: 10.1016/j.pt.2015.05.001     Document Type: Short Survey

References (10)

1. Deitsch K.W., et al. Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens. Nat. Rev. Microbiol. 2009, 7:493-503.
2. Marcello L., Barry J.D. Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure. Genome Res. 2007, 17:1344-1352.
3. Glover L., et al. Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control. Cell. Microbiol. 2013, 15:1984-1993.
4. Glover L., et al. DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. PLoS Pathog. 2013, 9:e1003260.
5. Palmer G.H., et al. 'Nothing is permanent but change' - antigenic variation in persistent bacterial pathogens. Cell. Microbiol. 2009, 11:1697-70512.
6. Hall J.P., et al. Mosaic VSGs and the scale of Trypanosoma brucei antigenic variation. PLoS Pathog. 2013, 9:e1003502.
7. Mugnier M.R., et al. The in vivo dynamics of antigenic variation in Trypanosoma brucei. Science 2015, 347:1470-1473.
8. Morrison L.J., et al. Probabilistic order in antigenic variation of Trypanosoma brucei. Int. J. Parasitol. 2005, 35:961-972.
9. Gjini E., et al. Critical interplay between parasite differentiation, host immunity, and antigenic variation in trypanosome infections. Am. Nat. 2010, 176:424-439.
10. MacGregor P., et al. Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act. Nat. Rev. Microbiol. 2012, 10:431-438.