Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer - A pooled analysis of PORTEC 1 and 2 trials

European Journal of Cancer

Volumn 51, Issue 13, 2015, Pages 1742-1750

  Bosse, Tjalling ^a   Peters, Elke E M ^a   Creutzberg, Carien L ^a   Jürgenliemk Schulz, Ina M ^b   Jobsen, Jan J ^c   Mens, Jan Willem M ^d   Lutgens, Ludy C H W ^e   Van Der Steen Banasik, Elzbieta M ^f   Smit, Vincent T H B M ^a   Nout, Remi A ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c MEDISCH SPECTRUM TWENTE   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e MAASTtricht Radiation Oncology Clinic   (Netherlands)

^f Arnhems Radiotherapeutisch Instituut   (Netherlands)

Author keywords

Endometrial cancer; External beam radiotherapy; Lymph vascular space invasion; Prognostic factors; Vaginal brachytherapy

Indexed keywords

ARTICLE; BRACHYTHERAPY; CANCER GRADING; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RISK; DISTANT METASTASIS; ENDOMETRIUM CARCINOMA; EXTERNAL BEAM RADIOTHERAPY; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; HYSTERECTOMY; INTERMEDIATE RISK PATIENT; LYMPH VESSEL METASTASIS; OVERALL SURVIVAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECURRENCE RISK; SALPINGOOOPHORECTOMY; SCORING SYSTEM; TUMOR INVASION; ADJUVANT RADIOTHERAPY; ADULT; AGED; BLOOD VESSEL; CARCINOMA, ENDOMETRIOID; CHI SQUARE DISTRIBUTION; CONTROLLED STUDY; ENDOMETRIAL NEOPLASMS; KAPLAN MEIER METHOD; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; LYMPH VESSEL; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; OVARIECTOMY; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SALPINGECTOMY; SECONDARY; TIME FACTOR; TREATMENT OUTCOME; TUMOR RECURRENCE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BLOOD VESSELS; BRACHYTHERAPY; CARCINOMA, ENDOMETRIOID; CHI-SQUARE DISTRIBUTION; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; HYSTERECTOMY; KAPLAN-MEIER ESTIMATE; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; OVARIECTOMY; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY, ADJUVANT; RISK FACTORS; SALPINGECTOMY; TIME FACTORS; TREATMENT OUTCOME;

EID: 84938740095     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2015.05.015     Document Type: Article

References (26)

1. C.L. Creutzberg, W.L. van Putten, C.C. Warlam-Rodenhuis, and et al. Outcome of high-risk stage IC, grade 3, compared with stage I endometrial carcinoma patients: the postoperative radiation therapy in endometrial carcinoma trial J Clin Oncol 22 7 2004 1234 1241 10.1200/JCO.2004.08.159 [published Online First: Epub Date]|
2. D.S. Chi, R.R. Barakat, M.J. Palayekar, and et al. The incidence of pelvic lymph node metastasis by FIGO staging for patients with adequately surgically staged endometrial adenocarcinoma of endometrioid histology Int J Gynecol Cancer 18 2 2008 269 273 10.1111/j.1525-1438.2007.00996.x [published Online First: Epub Date]|
3. W.T. Creasman, C.P. Morrow, B.N. Bundy, and et al. Surgical pathologic spread patterns of endometrial cancer. A gynecologic oncology group study Cancer 60 8 Suppl. 1987 2035 2041
4. D.E. Cohn, N.S. Horowitz, D.G. Mutch, and et al. Should the presence of lymphvascular space involvement be used to assign patients to adjuvant therapy following hysterectomy for unstaged endometrial cancer? Gynecol Oncol 87 3 2002 243 246
5. A. Gadducci, A. Cavazzana, S. Cosio, and et al. Lymph-vascular space involvement and outer one-third myometrial invasion are strong predictors of distant haematogeneous failures in patients with stage I-II endometrioid-type endometrial cancer Anticancer Res 29 5 2009 1715 1720
6. O. Gemer, A.B. Arie, T. Levy, and et al. Lymphvascular space involvement compromises the survival of patients with stage I endometrial cancer: results of a multicenter study Eur J Surg Oncol 33 5 2007 644 647 10.1016/j.ejso.2007.01.009 [published Online First: Epub Date]|
7. S.R. Guntupalli, I. Zighelboim, N.T. Kizer, and et al. Lymphovascular space invasion is an independent risk factor for nodal disease and poor outcomes in endometrioid endometrial cancer Gynecol Oncol 124 1 2012 31 35 10.1016/j.ygyno.2011.09.017 [published Online First: Epub Date]|
8. H.S. Hahn, I.H. Lee, T.J. Kim, and et al. Lymphovascular space invasion is highly associated with lymph node metastasis and recurrence in endometrial cancer Aust N Z J Obstet Gynaecol 53 3 2013 293 297 10.1111/ajo.12089 [published Online First: Epub Date]|
9. D.J. O'Brien, G. Flannelly, E.E. Mooney, and et al. Lymphovascular space involvement in early stage well-differentiated endometrial cancer is associated with increased mortality BJOG 116 7 2009 991 994 10.1111/j.1471-0528.2009.02162.x [published Online First: Epub Date]|
10. F. Vaizoglu, K. Yuce, M.C. Salman, and et al. Lymphovascular space involvement is the sole independent predictor of lymph node metastasis in clinical early stage endometrial cancer Arch Gynecol Obstet 288 6 2013 1391 1397 10.1007/s00404-013-2913-x [published Online First: Epub Date]|
11. J.M. Briet, H. Hollema, N. Reesink, and et al. Lymphvascular space involvement: an independent prognostic factor in endometrial cancer Gynecol Oncol 96 3 2005 799 804 10.1016/j.ygyno.2004.11.033 [published Online First: Epub Date]|
12. H.M. Keys, J.A. Roberts, V.L. Brunetto, and et al. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study Gynecol Oncol 92 3 2004 744 751 10.1016/j.ygyno.2003.11.048 [published Online First: Epub Date]
13. C.L. Creutzberg, W.L. van Putten, P.C. Koper, and et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma Lancet 355 9213 2000 1404 1411
14. ASTEC Group, P. Blake, A.M. Swart, and et al. Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis Lancet 373 9658 2009 137 146 10.1016/S0140-6736(08)61767-5 [published Online First: Epub Date]
15. R.A. Nout, V.T. Smit, H. Putter, and et al. Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial Lancet 375 9717 2010 816 823 10.1016/S0140-6736(09)62163-2 [published Online First: Epub Date]
16. J. Aalders, V. Abeler, P. Kolstad, and et al. Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients Obstet Gynecol 56 4 1980 419 427
17. S.K. Murray, R.H. Young, and R.E. Scully Unusual epithelial and stromal changes in myoinvasive endometrioid adenocarcinoma: a study of their frequency, associated diagnostic problems, and prognostic significance Int J Gynecol Pathol 22 4 2003 324 333 10.1097/01.pgp.0000092161.33490.a9 [published Online First: Epub Date]
18. T. Fujimoto, H. Nanjyo, J. Fukuda, and et al. Endometrioid uterine cancer: histopathological risk factors of local and distant recurrence Gynecol Oncol 112 2 2009 342 347 10.1016/j.ygyno.2008.10.019 [published Online First: Epub Date]
19. T. Hachisuga, T. Kaku, K. Fukuda, and et al. The grading of lymphovascular space invasion in endometrial carcinoma Cancer 86 10 1999 2090 2097
20. R.A. Ambros, and R.J. Kurman Combined assessment of vascular and myometrial invasion as a model to predict prognosis in stage I endometrioid adenocarcinoma of the uterine corpus Cancer 69 6 1992 1424 1431
21. R.A. Nout, H. Putter, I.M. Jurgenliemk-Schulz, and et al. Quality of life after pelvic radiotherapy or vaginal brachytherapy for endometrial cancer: first results of the randomized PORTEC-2 trial J Clin Oncol 27 21 2009 3547 3556 10.1200/JCO.2008.20.2424 [published Online First: Epub Date]
22. J.G. Aalders, and G. Thomas Endometrial cancer-revisiting the importance of pelvic and para aortic lymph nodes Gynecol Oncol 104 1 2007 222 231 10.1016/j.ygyno.2006.10.013 [published Online First: Epub Date]
23. A. Mariani, S.C. Dowdy, W.A. Cliby, and et al. Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging Gynecol Oncol 109 1 2008 11 18 10.1016/j.ygyno.2008.01.023 [published Online First: Epub Date]
24. R.A. Nout, H. Putter, I.M. Jurgenliemk-Schulz, and et al. Five-year quality of life of endometrial cancer patients treated in the randomised Post Operative Radiation Therapy in Endometrial Cancer (PORTEC-2) trial and comparison with norm data Eur J Cancer 48 11 2012 1638 1648 10.1016/j.ejca.2011.11.014 [published Online First: Epub Date]
25. R.A. Nout, L.V. van de Poll-Franse, M.L. Lybeert, and et al. Long-term outcome and quality of life of patients with endometrial carcinoma treated with or without pelvic radiotherapy in the post operative radiation therapy in endometrial carcinoma 1 (PORTEC-1) trial J Clin Oncol 29 13 2011 1692 1700 10.1200/JCO.2010.32.4590 [published Online First: Epub Date]
26. McMeekin DS, Filiaci VL, Aghajanian C. A randomized phase III trial of pelvic radiation therapy (PXRT) versus vaginal cuff brachytherapy followed by paclitaxel/carboplatin chemotherapy (VCB/C) in patients with high risk (HR), early stage endometrial cancer (EC): a Gynecologic Oncology Group trial. Late-breaking Abstract 1, Society of Gynecological Oncology Meeting 2014 2014.