Reaction Time is a Marker of Early Cognitive and Behavioral Alterations in Pure Cerebral Small Vessel Disease

Journal of Alzheimer's Disease

Volumn 47, Issue 2, 2015, Pages 413-419

  Jouvent, Eric ^a,b,c   Reyes, Sonia ^a,b,c   De Guio, François ^a,b,c   Chabriat, Hugues ^a,b,c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b HÔPITAL LARIBOISIÈRE   (France)

^c DHU NeuroVasc Paris Sorbonne   (France)

Author keywords

Apathy; CADASIL; cerebral small vessel disease; cognitive impairment; processing speed; reaction time

Indexed keywords

ADULT; AGED; APATHY; ARTICLE; ATTENTION; BEHAVIOR DISORDER; CADASIL; CLINICAL ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DEPRESSION; EXECUTIVE FUNCTION; FEMALE; HUMAN; INHIBITION (PSYCHOLOGY); MALE; MEMORY; MENTAL DISEASE; MINI MENTAL STATE EXAMINATION; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; RANKIN SCALE; RESPONSE TIME; WORKING MEMORY; COGNITION DISORDERS; COMPUTER; DISABILITY; DISEASE COURSE; GENETICS; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; PSYCHOMOTOR PERFORMANCE; REACTION TIME; SHORT TERM MEMORY; TIME FACTOR;

NOTCH RECEPTOR; NOTCH3 PROTEIN, HUMAN;

ADULT; AGED; CADASIL; COGNITION; COGNITION DISORDERS; COMPUTERS; DISABILITY EVALUATION; DISEASE PROGRESSION; EXECUTIVE FUNCTION; FEMALE; HUMANS; MALE; MEMORY, SHORT-TERM; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE; REACTION TIME; RECEPTORS, NOTCH; TIME FACTORS;

EID: 84938675912     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-150083     Document Type: Article

References (23)

1. Pantoni L (2010) Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 9, 689-701.
2. Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser M-G (2009) CADASIL. Lancet Neurol 8, 643-653.
3. Liem MK, Lesnik Oberstein SAJ, Haan J, van der Neut IL, Ferrari MD, van Buchem MA, Middelkoop HAM, van der Grond J (2009) MRI correlates of cognitive decline in CADASIL:A7-year follow-up study. Neurology 72, 143-148.
4. Valenti R, Salvadori E, Pescini F, Poggesi A, Castellini G, Antonini S, Bianchi S, Inzitari D, Pallanti S, Pantoni L (2013) Facial affect recognition in CADASIL patients. Arch Clin Neuropsychol 28, 65-71.
5. Kerchner GA, Racine CA, Hale S, Wilheim R, LaluzV, Miller BL, Kramer JH (2012) Cognitive processing speed in older adults: Relationship with white matter integrity. PLoS One 7, e50425.
6. Dichgans M, Markus HS, Salloway S, Verkkoniemi A, Moline M, Wang Q, Posner H, Chabriat HS (2008) Donepezil in patients with subcortical vascular cognitive impairment: A randomised double-blind trial in CADASIL. Lancet Neurol 7, 310-318.
7. Reyes S, Viswanathan A, Godin O, Dufouil C, Benisty S, Hernandez K, Kurtz A, Jouvent E, O'Sullivan M, Czernecki V, Bousser MG, Dichgans M, Chabriat H (2009) Apathy: A major symptom in CADASIL. Neurology 72, 905-910.
8. Epelbaum S, Benisty S, Reyes S, O'Sullivan M, Jouvent E, Duering M, Herve D, Opherk C, Hernandez K, Kurtz A, Viswanathan A, Bousser MG, Dichgans M, ChabriatH(2011) Verbal memory impairment in subcortical ischemic vascular disease A descriptive analysis in CADASIL. Neurobiol Aging 32, 2172-2182.
9. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
10. Poitrenaud J (2007)CVLT, Test d'apprentissage et demémoire verbale, version française, Ecpa Editions.
11. Agniel A, Joanette Y, Doyon B, Duchein C (1992) Protocole d'évaluation des gnosies visuelles Montréal-Toulouse (PEGV), Ortho Editions.
12. Warrington EK, JamesM(1991) The Visual Object and Space Perception Battery (VOSP), Bury St, Edmunds, England.
13. Deloche G, Hannequin D (1997) Test de dénomination orale de 80 images: DO80, Edition du Centre de Psychologie Appliquée, Paris.
14. Mahieux-Laurent F, Fabre C, Galbrun E, Dubrulle A, Moroni C (2009) Validation of a brief screening scale evaluating praxic abilities for use in memory clinics. Evaluation in 419 controls, 127 mild cognitive impairment and 320 demented patients. Rev Neurol (Paris) 165, 560-567.
15. Association AP (1994) Diagnostic and statistical manual of mental health disorders (4th ed), Washington DC: Author.
16. Montgomery SA, Asberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134, 382-389.
17. Starkstein SE, Ingram L, Garau ML, Mizrahi R (2005) On the overlap between apathy and depression in dementia. J Neurol Neurosurg Psychiatry 76, 1070-1074.
18. Royall DR, Cordes JA, Polk M (1998) CLOX: An executive clock drawing task. J Neurol Neurosurg Psychiatry 64, 588-594.
19. Cardebat D, Doyon B, Puel M, Goulet P, Joanette Y (1990) Formal and semantic lexical evocation in normal subjects. Performance and dynamics of production as a function of sex, age and educational level. Acta Neurol Belg 90, 207-217.
20. Wechsler D (2001) MEM-III: Manuel de l'échelle clinique de mémoire (3ème édition), Paris.
21. Zimmermann P, Fimm B (2009) Test for attentional performance (TAP) 2.2 version, Psytest edition.
22. Herbert V, Brookes RL, Markus HS, Morris RG (2014) Verbal fluency in cerebral small vessel disease and Alzheimer's disease. J Int Neuropsychol Soc 20, 413-421.
23. Neumann M, Sterr A, Claros-Salinas D, Gutler R, Ulrich R, Dettmers C (2014) Modulation of alertness by sustained cognitive demand in MS as surrogate measure of fatigue and fatigability. J Neurol Sci 340, 178-182.