메뉴 건너뛰기




Volumn 11, Issue 7, 2015, Pages 458-466

New direct-acting antiviral therapies for treatment of chronic hepatitis C virus infection

Author keywords

Direct acting antiviral agents; Hepatitis C virus; Nucleoside inhibitors; Protease inhibitors; Special populations

Indexed keywords

ANTIVIRUS AGENT; DASABUVIR; LEDIPASVIR; OMBITASVIR; PARITAPREVIR; RITONAVIR; SIMEPREVIR; SOFOSBUVIR;

EID: 84938601795     PISSN: 15547914     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (27)

References (32)
  • 1
    • 84911409020 scopus 로고    scopus 로고
    • Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis c virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: The cosmos randomised study
    • Lawitz E, Sulkowski MS, Ghalib R, et al. Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study. Lancet. 2014;384(9956):1756-1765.
    • (2014) Lancet. , vol.384 , Issue.9956 , pp. 1756-1765
    • Lawitz, E.1    Sulkowski, M.S.2    Ghalib, R.3
  • 2
    • 84900339263 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for untreated hcv genotype 1 infection
    • ION-1 Investigators
    • Afdhal N, Z euzem S, Kwo P, et al; ION-1 Investigators. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014;370(20):1889-1898.
    • (2014) N Engl J Med. , vol.370 , Issue.20 , pp. 1889-1898
    • Afdhal, N.1    Zeuzem, S.2    Kwo, P.3
  • 3
    • 84898669547 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for previously treated hcv genotype 1 infection
    • ION-2 Investigators
    • Afdhal N, Reddy KR, Nelson DR, et al; ION-2 Investigators. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med. 2014;370(16):1483-1493.
    • (2014) N Engl J Med. , vol.370 , Issue.16 , pp. 1483-1493
    • Afdhal, N.1    Reddy, K.R.2    Nelson, D.R.3
  • 4
    • 84900326091 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic hcv without cirrhosis
    • ION-3 Investigators
    • Kowdley KV, Gordon SC, Reddy KR, et al; ION-3 Investigators. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014;370(20):1879-1888.
    • (2014) N Engl J Med. , vol.370 , Issue.20 , pp. 1879-1888
    • Kowdley, K.V.1    Gordon, S.C.2    Reddy, K.R.3
  • 5
    • 84892591928 scopus 로고    scopus 로고
    • Phase 2b trial of interferon-free therapy for hepatitis c virus genotype 1
    • Kowdley KV, Lawitz E, Poordad F, et al. Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1. N Engl J Med. 2014;370(3):222-232.
    • (2014) N Engl J Med. , vol.370 , Issue.3 , pp. 222-232
    • Kowdley, K.V.1    Lawitz, E.2    Poordad, F.3
  • 6
    • 84899068302 scopus 로고    scopus 로고
    • Treatment of hcv with abt-450/r-ombitasvir and dasabuvir with ribavirin
    • Feld JJ, Kowdley KV, Coakley E, et al. Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014;370(17):1594-1603.
    • (2014) N Engl J Med. , vol.370 , Issue.17 , pp. 1594-1603
    • Feld, J.J.1    Kowdley, K.V.2    Coakley, E.3
  • 7
    • 84901044326 scopus 로고    scopus 로고
    • Abt-450/r-ombitasvir and dasabuvir with or without ribavirin for hcv
    • PEARL-III Study; PEARL-IV Study
    • Ferenci P, Bernstein D, Lalezari J, et al; PEARL-III Study; PEARL-IV Study. ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV. N Engl J Med. 2014;370(21):1983-1992.
    • (2014) N Engl J Med. , vol.370 , Issue.21 , pp. 1983-1992
    • Ferenci, P.1    Bernstein, D.2    Lalezari, J.3
  • 8
    • 84901036125 scopus 로고    scopus 로고
    • Abt-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis c with cirrhosis
    • Poordad F, Hezode C, Trinh R, et al. ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis. N Engl J Med. 2014;370(21):1973-1982.
    • (2014) N Engl J Med. , vol.370 , Issue.21 , pp. 1973-1982
    • Poordad, F.1    Hezode, C.2    Trinh, R.3
  • 9
    • 84899106124 scopus 로고    scopus 로고
    • Retreatment of hcv with abt-450/r-ombitasvir and dasabuvir with ribavirin
    • Zeuzem S, Jacobson IM, Baykal T, et al. Retreatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014;370(17):1604-1614.
    • (2014) N Engl J Med. , vol.370 , Issue.17 , pp. 1604-1614
    • Zeuzem, S.1    Jacobson, I.M.2    Baykal, T.3
  • 10
    • 84900992889 scopus 로고    scopus 로고
    • Sofosbuvir and ribavirin in hcv genotypes 2 and 3
    • VALENCE Investigators
    • Zeuzem S, Dusheiko GM, Salupere R, et al; VALENCE Investigators. Sofosbuvir and ribavirin in HCV genotypes 2 and 3. N Engl J Med. 2014;370(21):1993-2001.
    • (2014) N Engl J Med. , vol.370 , Issue.21 , pp. 1993-2001
    • Zeuzem, S.1    Dusheiko, G.M.2    Salupere, R.3
  • 11
    • 84925436650 scopus 로고    scopus 로고
    • Virologic response following combined ledipasvir and sofosbuvir administration in patients with hcv g enotype 1 and HIV co-infection
    • Osinusi A, Townsend K, Kohli A, et al. Virologic response following combined ledipasvir and sofosbuvir administration in patients with HCV g enotype 1 and HIV co-infection. JAMA. 2015;313(12):1232-1239.
    • (2015) JAMA. , vol.313 , Issue.12 , pp. 1232-1239
    • Osinusi, A.1    Townsend, K.2    Kohli, A.3
  • 12
    • 84925428093 scopus 로고    scopus 로고
    • Ombitasvir, paritaprevir co-dosed with ritonavir, dasabuvir, and ribavirin for hepatitis c in patients co-infected with HIV-1: A randomized trial
    • Sulkowski MS, Eron JJ, Wyles D, et al. Ombitasvir, paritaprevir co-dosed with ritonavir, dasabuvir, and ribavirin for hepatitis C in patients co-infected with HIV-1: a randomized trial. JAMA. 2015;313(12):1223-1231.
    • (2015) JAMA. , vol.313 , Issue.12 , pp. 1223-1231
    • Sulkowski, M.S.1    Eron, J.J.2    Wyles, D.3
  • 13
    • 84919360641 scopus 로고    scopus 로고
    • An interferon-free antiviral regimen for hcv after liver transplantation
    • Kwo PY, Mantry PS, Coakley E, et al. An interferon-free antiviral regimen for HCV after liver transplantation. N Engl J Med. 2014;371(25):2375-2382.
    • (2014) N Engl J Med. , vol.371 , Issue.25 , pp. 2375-2382
    • Kwo, P.Y.1    Mantry, P.S.2    Coakley, E.3
  • 14
    • 84892619580 scopus 로고    scopus 로고
    • Daclatasvir plus sofosbuvir for previously treated or untreated chronic hcv infection
    • AI444040 Study Group
    • Sulkowski MS, Gardiner DF, Rodriguez-Torres M, et al; AI444040 Study Group. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med. 2014;370(3):211-221.
    • (2014) N Engl J Med. , vol.370 , Issue.3 , pp. 211-221
    • Sulkowski, M.S.1    Gardiner, D.F.2    Rodriguez-Torres, M.3
  • 15
    • 84925364974 scopus 로고    scopus 로고
    • Ally-3 study team. All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis c virus genotype 3 infection: Ally-3 phase III study
    • Nelson DR, Cooper JN, Lalezari JP, et al; ALLY-3 Study Team. All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: ALLY-3 phase III study. Hepatology. 2015;61(4):1127-1135.
    • (2015) Hepatology. , vol.61 , Issue.4 , pp. 1127-1135
    • Nelson, D.R.1    Cooper, J.N.2    Lalezari, J.P.3
  • 16
    • 84929208843 scopus 로고    scopus 로고
    • Daclatasvir in combination with asunaprevir and beclabuvir for hepatitis c virus genotype 1 infection with compensated cirrhosis
    • Muir AJ,Poordad F,Lalezari J,et al. Daclatasvir in combination with asunaprevir and beclabuvir for hepatitis C virus genotype 1 infection with compensated cirrhosis JAMA. 2015;313 17 1736-1744.
    • (2015) JAMA. , vol.313 , Issue.17 , pp. 1736-1744
    • Muir, A.J.1    Poordad, F.2    Lalezari, J.3
  • 17
    • 84929207643 scopus 로고    scopus 로고
    • Fixed-dose combination th erapy with daclatasvir, asunaprevir, and beclabuvir for noncirrhotic patients with hcv genotype 1 infection
    • UNITY-1 Study Group
    • Poordad F, Sievert W, Mollison L, et al; UNITY-1 Study Group. Fixed-dose combination th erapy with daclatasvir, asunaprevir, and beclabuvir for noncirrhotic patients with HCV genotype 1 infection. JAMA. 2015;313(17):1728-1735.
    • (2015) JAMA. , vol.313 , Issue.17 , pp. 1728-1735
    • Poordad, F.1    Sievert, W.2    Mollison, L.3
  • 18
    • 84920972417 scopus 로고    scopus 로고
    • Drug-induced immunoallergic hepatitis during combination therapy with daclatasvir and asunaprevir
    • Fujii Y, Uchida Y, Mochida S. Drug-induced immunoallergic hepatitis during combination therapy with daclatasvir and asunaprevir. Hepatology. 2015;61(1):400-401.
    • (2015) Hepatology. , vol.61 , Issue.1 , pp. 400-401
    • Fujii, Y.1    Uchida, Y.2    Mochida, S.3
  • 19
    • 84925424553 scopus 로고    scopus 로고
    • Efficacy and safety of 12 weeks versus 18 weeks of treatment with grazoprevir (mk-5172) and elbasvir (mk-8742) with or without ribavirin for hepatitis c virus genotype 1 infection in previously untreated patients with cirrhosis and patients with previous null response with or without cirrhosis (c-worthy): A randomised, open-label phase 2 trial
    • Lawitz E, Gane E, Pearlman B, et al. Efficacy and safety of 12 weeks versus 18 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin for hepatitis C virus genotype 1 infection in previously untreated patients with cirrhosis and patients with previous null response with or without cirrhosis (C-WORTHY): a randomised, open-label phase 2 trial. Lancet. 2015;385(9973):1075-1086.
    • (2015) Lancet. , vol.385 , Issue.9973 , pp. 1075-1086
    • Lawitz, E.1    Gane, E.2    Pearlman, B.3
  • 20
    • 84925423399 scopus 로고    scopus 로고
    • Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (mk-5172) and elbasvir (mk-8742) with or without ribavirin in patients with hepatitis c virus genotype 1 mono-infection and HIV /hepatitis c virus co-infection (c-worthy): A randomised, open-label phase 2 trial
    • Sulkowsk i M, Hezode C, Gerstoft J, et al. Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono-infection and HIV /hepatitis C virus co-infection (C-WORTHY): a randomised, open-label phase 2 trial. Lancet. 2015;385(9973):1087-1097.
    • (2015) Lancet. , vol.385 , Issue.9973 , pp. 1087-1097
    • Sulkowski, M.1    Hezode, C.2    Gerstoft, J.3
  • 21
    • 84937064772 scopus 로고    scopus 로고
    • Grazoprevir-elbasvir combination therapy for treatment-naive cirrhotic and noncirrhotic patients with chronic hcv genotype 1, 4, or 6 infection: A randomized trial [published online April 24 2015
    • Zeuzem S, Ghalib R, Reddy KR, et al. Grazoprevir-elbasvir combination therapy for treatment-naive cirrhotic and noncirrhotic patients with chronic HCV genotype 1, 4, or 6 infection: a randomized trial [published online April 24, 2015]. Ann Intern Med. doi:10.7326/M15-0785.
    • Ann Intern Med
    • Zeuzem, S.1    Ghalib, R.2    Reddy, K.R.3
  • 22
    • 84934286397 scopus 로고    scopus 로고
    • C-swift: Grazoprevir/elbasvir sofosbuvir in cirrhotic and noncirrhotic, treatment-naï ve patients with hepatitis c virus genotype 1 infection, for durations of 4, 6 or 8 weeks and genotype 3 infection for durations of 8 or 12 weeks
    • Poordad F, L awitz E, Gutierrez JA, et al. C-SWIFT: Grazoprevir/elbasvir sofosbuvir in cirrhotic and noncirrhotic, treatment-naï ve patients with hepatitis C virus genotype 1 infection, for durations of 4, 6 or 8 weeks and genotype 3 infection for durations of 8 or 12 weeks. J Hepatol. 2015;(62):S192.
    • (2015) J Hepatol. , vol.62 , pp. S192
    • Poordad, F.1    Awitz E, L.2    Gutierrez, J.A.3
  • 23
    • 84939254831 scopus 로고    scopus 로고
    • Grazoprevir/elbasvir plus ribavirin for chronic hcv genotype 1 infection after failure of combination the rapy containing a direct-Acting antiviral agent [published online April 17 2015
    • Forns X, Gordon S, Zuckerman E, et al. Grazoprevir/elbasvir plus ribavirin for chronic HCV genotype 1 infection after failure of combination the rapy containing a direct-Acting antiviral agent [published online April 17, 2015]. J Hepatol. doi:10.1016/j.jhep.2015.04.009.
    • J Hepatol
    • Forns, X.1    Gordon, S.2    Zuckerman, E.3
  • 24
    • 84938572955 scopus 로고    scopus 로고
    • Efficacy and safet y of grazoprevir and elbasvir in hepatitis c genotype 1-infected patients with child-pugh class b cirrhosis (c-salt part a
    • Jacobson I, Poordad F, Firpi-Morell R, et al. Efficacy and safet y of grazoprevir and elbasvir in hepatitis C genotype 1-infected patients with Child-Pugh class B cirrhosis (C-SALT Part A). J Hepatol. 2015;(62):S193.
    • (2015) J Hepatol. , vol.62 , pp. S193
    • Jacobson, I.1    Poordad, F.2    Firpi-Morell, R.3
  • 25
    • 84938580302 scopus 로고    scopus 로고
    • C-surfer: Grazoprevir plus elbasvir in treatment-naï ve and treatment-experienced patients with hepatitis c virus genotype 1 infection and chronic kidney disease
    • Roth D, Hezode C, Zuckerman E, et al. C-SURFER: grazoprevir plus elbasvir in treatment-naï ve and treatment-experienced patients with hepatitis C virus genotype 1 infection and chronic kidney disease. J Hepatol. 2015;(62):S263.
    • (2015) J Hepatol. , vol.62 , pp. S263
    • Roth, D.1    Hezode, C.2    Zuckerman, E.3
  • 26
    • 84925842961 scopus 로고    scopus 로고
    • Once-daily sofosbuvir with gs-5816 for 8 weeks with or without ribavirin in patients with hcv genotype 3 without cirrhosis results in high rates of svr12: The electron-2 study
    • Gane EJ, Hylan d RH, An D, et al. Once-daily sofosbuvir with GS-5816 for 8 weeks with or without ribavirin in patients with HCV genotype 3 without cirrhosis results in high rates of SVR12: the ELECTRON-2 study. Hepatology. 2014;60(4 suppl):236A.
    • (2014) Hepatology. , vol.60 , Issue.4 , pp. 236A
    • Gane, E.J.1    Hyland, R.H.2    An, D.3
  • 27
    • 84927926102 scopus 로고    scopus 로고
    • High efficacy of ldv/sof regimens for 12 weeks for patients with hcv genotype 3 or 6 infection
    • Gane EJ, Hyland RH, An D, et al. High efficacy of LDV/SOF regimens for 12 weeks for patients with HCV genotype 3 or 6 infection. Hepatology. 2014;60(4 suppl):LB-11.
    • (2014) Hepatology. , vol.60 , Issue.4 , pp. LB-11
    • Gane, E.J.1    Hyland, R.H.2    An, D.3
  • 28
    • 84923842138 scopus 로고    scopus 로고
    • Decision-Analytic markov model to evaluate the health outcomes of ledipasvir/sofosbuvir (ldv/sof) for patients with chronic hepatitis c (hcv) genotype 1 (gt1) infection
    • Younossi Z, Saab S, Ahmed A, Gordon SCA. Decision-Analytic Markov model To evaluate the health outcomes of ledipasvir/sofosbuvir (LDV/SOF) for patients with chronic hepatitis C (HCV) genotype 1 (GT1) infection. Hepatology. 2014;60(4 suppl):1043A .
    • (2014) Hepatology. , vol.60 , Issue.4 , pp. 1043A
    • Younossi, Z.1    Saab, S.2    Ahmed, A.3    Gordon, S.C.A.4
  • 29
    • 84923845937 scopus 로고    scopus 로고
    • Evaluation of the health outcomes for ledipasvir/sofosbuvir in early vs. Delayed treatment according to fibrosis stage of patients with chronic hepatitis c virus (hcv) gen otype 1 infection: Results from a decision-Analytic markov model
    • Ahmed A, Gordon SC, Saab S, Younossi Z. Evaluation of the health outcomes for ledipasvir/sofosbuvir in early vs. delayed treatment according to fibrosis stage of patients with chronic hepatitis c virus (HCV) gen otype 1 infection: results from a decision-Analytic Markov model. Hepatology. 2014;60(4 suppl):1041A.
    • (2014) Hepatology. , vol.60 , Issue.4 , pp. 1041A
    • Ahmed, A.1    Gordon, S.C.2    Saab, S.3    Younossi, Z.4
  • 30
    • 85053329781 scopus 로고    scopus 로고
    • Sales of sovaldi, new gilead hepatitis c drug, soar to 10.3 billion
    • Feb
    • Pollock A. Sales of Sovaldi, new Gilead hepatitis C drug, soar to 10.3 billion. New York Times. Feb 3, 2015.
    • (2015) New York Times , vol.3
    • Pollock, A.1
  • 31
    • 84898606534 scopus 로고    scopus 로고
    • American Association for the Study of Liver Diseases and the Infectious Diseases Society of America Accessed F ebruary 2 2015
    • American Association for the Study of Liver Diseases and the Infectious Diseases Society of America. Recommendations for testing, managing, and treating hepatitis C. http://www.hcvguidelines.org. Accessed F ebruary 2, 2015.
    • Recommendations for Testing, Managing, and Treating Hepatitis C
  • 32
    • 85048985233 scopus 로고    scopus 로고
    • Direct-Acting antivirals for the treatment of hepatitis c virus infection
    • Accessed February 28
    • Pockros PJ. Direct-Acting antivirals for the treatment of hepatitis C virus infection. UpToDate. Accessed February 28, 2015.
    • (2015) UpToDate
    • Pockros, P.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.