Transnitrilation from Dimethylmalononitrile to Aryl Grignard and Lithium Reagents: A Practical Method for Aryl Nitrile Synthesis

Journal of the American Chemical Society

Volumn 137, Issue 29, 2015, Pages 9481-9488

  Reeves, Jonathan T ^a   Malapit, Christian A ^a,b   Buono, Frederic G ^a   Sidhu, Kanwar P ^a   Marsini, Maurice A ^a   Sader, C Avery ^a   Fandrick, Keith R ^a   Busacca, Carl A ^a   Senanayake, Chris H ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETONES; NITROGEN COMPOUNDS; TRANSITION METALS;

ARYL BROMIDES; ARYLLITHIUM SPECIES; CHEMICAL EQUATIONS; COMPUTATIONAL STUDIES; DIRECTED ORTHO -LITHIATION; MILD REACTION CONDITIONS; PRACTICAL METHOD; TOXIC REAGENTS;

CHEMICAL REACTIONS;

BROMINE DERIVATIVE; DIMETHYLMALONONITRILE DERIVATIVE; GRIGNARD REAGENT; IODINE DERIVATIVE; LITHIUM; MALONONITRILE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; REAGENT; UNCLASSIFIED DRUG; DIMETHYLMALONONITRILE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; NITRILE; ORGANOMETALLIC COMPOUND;

ARTICLE; CHEMICAL BOND; CHEMICAL MODIFICATION; CYANATION; ELECTROPHILICITY; LITHIATION; SYNTHESIS; TRANSNITRILATION; CATALYSIS; CHEMISTRY;

CATALYSIS; CHEMISTRY TECHNIQUES, SYNTHETIC; INDICATORS AND REAGENTS; LITHIUM; NITRILES; ORGANOMETALLIC COMPOUNDS;

EID: 84938332366     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b06136     Document Type: Article

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