SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 17, 2015, Pages 3626-3629

Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase

(7) Bagdanoff, Jeffrey T a Jain, Rama b Han, Wooseok b Poon, Daniel b Lee, Patrick S b Bellamacina, Cornelia b Lindvall, Mika b

a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH (United States)

b Norvartis Institute for BioMedical Research (United States)

Author keywords

ATP binding cleft; ERK2 kinase; Extraction ratio; Fragment lead; Structure based drug design

Indexed keywords

LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 1 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; ASPARTIC ACID; MAPK1 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PYRAZOLOPYRIDINE;

A375 CELL LINE; ANTAGONIST POTENCY; ARTICLE; CELL MEMBRANE PERMEABILITY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG BINDING SITE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; ENZYME CONFORMATION; HYDROGEN BOND; IC50; IN VITRO STUDY; LIPOPHILICITY; METHYLATION; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; PRECLINICAL STUDY; PROCEDURES; PROTEIN CONFORMATION; RAT; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ASPARTIC ACID; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84938290778 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.06.063 Document Type: Article

Times cited : (14)

References (15)

1
- 84895794537
- M.D. Thakur, and D.D. Stuart Clin. Cancer Res. 20 2013 1074
- (2013) Clin. Cancer Res. , vol.20 , pp. 1074
- Thakur, M.D.¹ Stuart, D.D.²

2
- 84898998810
- A.M. Menzies, and G.V. Long Clin. Cancer Res. 20 2014 2035
- (2014) Clin. Cancer Res. , vol.20 , pp. 2035
- Menzies, A.M.¹ Long, G.V.²

3
- 84879795966
- G.T. Gibney, J.L. Messina, I.V. Fedorenko, V.K. Sondak, and K.S. Smalley Nat. Rev. Clin. Oncol. 10 2013 390
- (2013) Nat. Rev. Clin. Oncol. , vol.10 , pp. 390
- Gibney, G.T.¹ Messina, J.L.² Fedorenko, I.V.³ Sondak, V.K.⁴ Smalley, K.S.⁵

4
- 80051794730
- A.E. Aplin, F.M. Kaplan, and Y. Shao J. Invest. Dermatol. 131 2011 1817
- (2011) J. Invest. Dermatol. , vol.131 , pp. 1817
- Aplin, A.E.¹ Kaplan, F.M.² Shao, Y.³

5
- 84910023724
- D.J.L. Wong, L. Robert, M.S. Atefi, A. Lassen, G. Avarappatt, M. Cerniglia, E. Avramis, J. Tsoi, D. Foulad, T.G. Graeber, B. Comin-Anduix, A. Ahmed, R.S. Lo, and A. Ribas Mol. Cancer 13 2014 194
- (2014) Mol. Cancer , vol.13 , pp. 194
- Wong, D.J.L.¹ Robert, L.² Atefi, M.S.³ Lassen, A.⁴ Avarappatt, G.⁵ Cerniglia, M.⁶ Avramis, E.⁷ Tsoi, J.⁸ Foulad, D.⁹ Graeber, T.G.¹⁰ Comin-Anduix, B.¹¹ Ahmed, A.¹² Lo, R.S.¹³ Ribas, A.¹⁴

6
- 84938284691
- San Diego, CA
- Robarge, K. et al. GDC-0994, AACR Annual Meeting, San Diego, CA, 2014.
- (2014) GDC-0994, AACR Annual Meeting
- Robarge, K.¹

7
- 84938288982
- BVD-523; Kansas City, MO
- BVD-523; BioMed Valley Discoveries: Kansas City, MO. < https://biomed-valley.com/portfolio/bvd-523 >.
- BioMed Valley Discoveries

8
- 70350066163
- A.M. Aronov, Q. Tang, G. Martinez-Botella, G.W. Bemis, J. Cao, G. Chen, N.P. Ewing, P.J. Ford, U.A. Germann, J. Green, M.R. Hale, M. Jacobs, J.W. Janetka, F. Maltais, W. Markland, M.N. Namchuk, S. Nanthakumar, S. Poondru, J. Straub, E. ter Haar, and X. Xie J. Med. Chem. 52 2009 6362
- (2009) J. Med. Chem. , vol.52 , pp. 6362
- Aronov, A.M.¹ Tang, Q.² Martinez-Botella, G.³ Bemis, G.W.⁴ Cao, J.⁵ Chen, G.⁶ Ewing, N.P.⁷ Ford, P.J.⁸ Germann, U.A.⁹ Green, J.¹⁰ Hale, M.R.¹¹ Jacobs, M.¹² Janetka, J.W.¹³ Maltais, F.¹⁴ Markland, W.¹⁵ Namchuk, M.N.¹⁶ Nanthakumar, S.¹⁷ Poondru, S.¹⁸ Straub, J.¹⁹ Ter Haar, E.²⁰ Xie, X.²¹ more..

9
- 84923805796
- Y. Deng, G.W. Shipps Jr., A. Cooper, J.M. English, D.A. Annis, D. Carr, Y. Nan, T. Wang, H.Y. Zhu, C.C. Chuang, P. Dayananth, A.W. Hruza, L. Xiao, W. Jin, P. Kirschmeier, W.T. Windsor, and A.A. Samatar J. Med. Chem. 57 2014 8817
- (2014) J. Med. Chem. , vol.57 , pp. 8817
- Deng, Y.¹ Shipps, G.W.² Cooper, A.³ English, J.M.⁴ Annis, D.A.⁵ Carr, D.⁶ Nan, Y.⁷ Wang, T.⁸ Zhu, H.Y.⁹ Chuang, C.C.¹⁰ Dayananth, P.¹¹ Hruza, A.W.¹² Xiao, L.¹³ Jin, W.¹⁴ Kirschmeier, P.¹⁵ Windsor, W.T.¹⁶ Samatar, A.A.¹⁷

10
- 84900821225
- J.F. Blake, J.J. Gaudino, J. De Meese, P. Mohr, M. Chicarelli, H. Tian, R. Garrey, A. Thomas, C.S. Siedem, M.B. Welch, G. Kolakowski, R. Kaus, M. Burkard, M. Martinson, H. Chen, B. Dean, D.A. Dudley, S.E. Gould, P. Pacheco, S. Shahidi-Latham, W. Wang, K. West, J. Yin, J. Moffat, and J.B. Schwarz Bioorg. Med. Chem. Lett. 24 2014 2635
- (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 2635
- Blake, J.F.¹ Gaudino, J.J.² De Meese, J.³ Mohr, P.⁴ Chicarelli, M.⁵ Tian, H.⁶ Garrey, R.⁷ Thomas, A.⁸ Siedem, C.S.⁹ Welch, M.B.¹⁰ Kolakowski, G.¹¹ Kaus, R.¹² Burkard, M.¹³ Martinson, M.¹⁴ Chen, H.¹⁵ Dean, B.¹⁶ Dudley, D.A.¹⁷ Gould, S.E.¹⁸ Pacheco, P.¹⁹ Shahidi-Latham, S.²⁰ more..

11
- 84931266450
- R.A. Ward, N. Colclough, M. Challinor, J.E. Debreczeni, K. Eckersley, G. Fairley, L. Feron, V. Flemington, M.A. Graham, R. Greenwood, P. Hopcroft, T.D. Howard, M. James, C.D. Jones, C.R. Jones, J. Renshaw, K. Roberts, L. Snow, M. Tonge, and K. Yeung J. Med. Chem. 2015 10.1021/acs.jmedchem.5b00466
- (2015) J. Med. Chem.
- Ward, R.A.¹ Colclough, N.² Challinor, M.³ Debreczeni, J.E.⁴ Eckersley, K.⁵ Fairley, G.⁶ Feron, L.⁷ Flemington, V.⁸ Graham, M.A.⁹ Greenwood, R.¹⁰ Hopcroft, P.¹¹ Howard, T.D.¹² James, M.¹³ Jones, C.D.¹⁴ Jones, C.R.¹⁵ Renshaw, J.¹⁶ Roberts, K.¹⁷ Snow, L.¹⁸ Tonge, M.¹⁹ Yeung, K.²⁰ more..

12
- 84973303948
- Villa, M.; Abrate, F.; Fancelli, D.; Varasi, M.; Vulpetti, A. WO 2004014374, 2004.
- (2004)
- Villa, M.¹ Abrate, F.² Fancelli, D.³ Varasi, M.⁴ Vulpetti, A.⁵

13
- 79251600617
- D.S. Surry, and S.L. Buchwald Chem. Sci. 2 2011 27
- (2011) Chem. Sci. , vol.2 , pp. 27
- Surry, D.S.¹ Buchwald, S.L.²

14
- 84938290643
- WO
- For an example, see PDB file contained within: Martinez-Botella, G.; Hale, M. R.; Maltais, F.; Tang, Q.; Straub, J. WO 2005113541, 2005.
- (2005)
- Martinez-Botella, G.¹ Hale, M.R.² Maltais, F.³ Tang, Q.⁴ Straub, J.⁵

15
- 77953631827
- C. Bizzantz, B. Kuhn, and M. Stahl J. Med. Chem. 53 2010 5061
- (2010) J. Med. Chem. , vol.53 , pp. 5061
- Bizzantz, C.¹ Kuhn, B.² Stahl, M.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.