Does oxytocin affect mind-reading? A replication study

Psychoneuroendocrinology

Volumn 60, Issue , 2015, Pages 75-81

  Radke, Sina ^a,b   de Bruijn, Ellen R A ^c  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b Jülich Aachen Research Alliance   (Germany)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Empathy; Mind reading; Oxytocin; Replication; RMET; Social cognition

Indexed keywords

OXYTOCIN; PLACEBO;

ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG MECHANISM; EMPATHY; EMPATHY QUOTIENT; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; INTERPERSONAL REACTIVITY INDEX; MALE; MENTAL FUNCTION ASSESSMENT; MENTAL PERFORMANCE; MIND READING; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; READING THE MIND IN THE EYES TEST; REPLICATION STUDY; REPRODUCIBILITY; SEX DIFFERENCE; SOCIAL COGNITION; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; EYE; FACIAL EXPRESSION; FEMALE; HUMAN RELATION; NEUROPSYCHOLOGICAL TEST; PERCEPTION; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; YOUNG ADULT;

ADULT; DOUBLE-BLIND METHOD; EMPATHY; EYE; FACIAL EXPRESSION; FEMALE; HUMANS; INTERPERSONAL RELATIONS; MALE; NEUROPSYCHOLOGICAL TESTS; OXYTOCIN; PSYCHOMOTOR PERFORMANCE; REPRODUCIBILITY OF RESULTS; SOCIAL PERCEPTION; YOUNG ADULT;

EID: 84938274535     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2015.06.006     Document Type: Article

References (27)

1. Amodio D.M., Frith C.D. Meeting of minds: the medial frontal cortex and social cognition. Nat. Rev. Neurosci. 2006, 7:268-277.
2. Bakermans-Kranenburg M.J., van Ijzendoorn M.H. Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy. Transl. Psychiatry 2013, 3:e258.
3. Baron-Cohen S., Richler J., Bisarya D., Gurunathan N., Wheelwright S. The systemizing quotient: an investigation of adults with Asperger syndrome or high-functioning autism, and normal sex differences. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2003, 358:361-374.
4. Baron-Cohen S., Wheelwright S., Hill J., Raste Y., Plumb I. The Reading the Mind in the Eyes Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J. Child Psychol. Psychiatry 2001, 42:241-251.
5. Baron-Cohen S., Wheelwright S.J. The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. J. Autism Dev. Disord. 2004, 34:163-175.
6. Bartz J.A., Zaki J., Bolger N., Ochsner K.N. Social effects of oxytocin in humans: context and person matter. Trends Cogn. Sci. 2011, 15:301-309.
7. Davis M.H. Measuring individual-differences in empathy - evidence for a multidimensional approach. J. Pers. Soc. Psychol. 1983, 44:113-126.
8. Domes G., Heinrichs M., Michel A., Berger C., Herpertz S.C. Oxytocin improves mind-reading in humans. Biol. Psychiatry 2007, 61:731-733.
9. Domes G., Lischke A., Berger C., Grossmann A., Hauenstein K., Heinrichs M., Herpertz S.C. Effects of intranasal oxytocin on emotional face processing in women. Psychoneuroendocrinology 2010, 35:83-93.
10. Dziobek I., Rogers K., Fleck S., Bahnemann M., Heekeren H.R., Wolf O.T., Convit A. Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET). J. Autism Dev. Disord. 2008, 38:464-473.
11. Feeser M., Fan Y., Weigand A., Hahn A., Gartner M., Boker H., Grimm S., Bajbouj M. Oxytocin improves mentalizing - pronounced effects for individuals with attenuated ability to empathize. Psychoneuroendocrinology 2015, 53c:223-232.
12. Guastella A.J., Einfeld S.L., Gray K.M., Rinehart N.J., Tonge B.J., Lambert T.J., Hickie I.B. Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biol. Psychiatry 2010, 67:692-694.
13. Guastella A.J., Hickie I.B., McGuinness M.M., Otis M., Woods E.A., Disinger H.M., Chan H.-K., Chen T.F., Banati R.B. Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research. Psychoneuroendocrinology 2013, 38:612-625.
14. Guastella A.J., Mitchell P.B., Dadds M.R. Oxytocin increases gaze to the eye region of human faces. Biol. Psychiatry 2008, 63:3-5.
15. Hurlemann R., Patin A., Onur O.A., Cohen M.X., Baumgartner T., Metzler S., Dziobek I., Gallinat J., Wagner M., Maier W., Kendrick K.M. Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans. J. Neurosci. 2010, 30:4999-5007.
16. Kuypers K.P., de la Torre R., Farre M., Yubero-Lahoz S., Dziobek I., Van den Bos W., Ramaekers J.G. No evidence that MDMA-induced enhancement of emotional empathy is related to peripheral oxytocin levels or 5-HT1a receptor activation. PLoS ONE 2014, 9:e100719.
17. Liebowitz M.R. Social phobia. Mod. Probl. Pharmacopsychiatry 1987, 22:141-173.
18. Lischke A., Berger C., Prehn K., Heinrichs M., Herpertz S., Domes G. Intranasal oxytocin enhances emotion recognition from dynamic facial expressions and leaves eye-gaze unaffected. Psychoneuroendocrinology 2012, 37:475-481.
19. Luminet O., Grynberg D., Ruzette N., Mikolajczak M. Personality-dependent effects of oxytocin: greater social benefits for high alexithymia scorers. Biol. Psychol. 2011, 87:401-406.
20. Pincus D., Kose S., Arana A., Johnson K., Morgan P.S., Borckardt J., Herbsman T., Hardaway F., George M.S., Panksepp J., Nahas Z. Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study. Front. Psychiatry 2010, 1:134.
21. Radke S., De Bruijn E.R.A. The other side of the coin: oxytocin decreases the adherence to fairness norms. Front. Hum. Neurosci 2012, 6:193.
22. Radke S., Roelofs K., De Bruijn E.R.A. Acting on anger: social anxiety modulates approach-avoidance tendencies after oxytocin administration. Psychol. Sci. 2013, 24:1573-1578.
23. Riem M.M., Bakermans-Kranenburg M.J., Voorthuis A., van IJzendoorn M.H. Oxytocin effects on mind-reading are moderated by experiences of maternal love withdrawal: an fMRI study. Prog. Neuropsychopharmacol. Biol. Psychiatry 2014, 51:105-112.
24. Shamay-Tsoory S.G. The neural bases for empathy. Neuroscientist 2011, 17:18-24.
25. Shamay-Tsoory S.G., Aharon-Peretz J., Perry D. Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain 2009, 132:617-627.
26. Spielberger C.D., Gorsuch R.L., Lushene R., Vagg P.R., Jacobs G.A. Manual for the State-Trait Anxiety Inventory 1983, Consulting Psychologists Press, Palo Alto, CA.
27. Woolley J.D., Chuang B., Lam O., Lai W., O'Donovan A., Rankin K.P., Mathalon D.H., Vinogradov S. Oxytocin administration enhances controlled social cognition in patients with schizophrenia. Psychoneuroendocrinology 2014, 47:116-125.