News feature: Microbes on the mind: Could the gut microbiome have a critical role in brain and behavior? The notion is starting to gain acceptance amongst both researchers and funders

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 30, 2015, Pages 9143-9145

  Shen, Helen H ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANGER; ANXIETY; ARTICLE; BEHAVIOR; BRAIN BIOCHEMISTRY; BRAIN DISEASE; BRAIN FUNCTION; BRAIN MATURATION; COGNITION; DEPRESSION; DIABETES MELLITUS; HOSTILITY; HUMAN; INTESTINE FLORA; MALNUTRITION; MICROBIOME; NONHUMAN; OBESITY; PERSONALITY; PRIORITY JOURNAL; SCHIZOPHRENIA; STRESS; ANIMAL; BACTERIAL INFECTION; BACTERIUM; BAGG ALBINO MOUSE; BRAIN; ETIOLOGY; INTESTINE; METABOLISM; MICROBIOLOGY; MICROFLORA; MOUSE; PATHOPHYSIOLOGY;

ANIMALS; ANXIETY; BACTERIA; BACTERIAL INFECTIONS; BRAIN; HUMANS; INTESTINES; MICE; MICE, INBRED BALB C; MICROBIOTA;

EID: 84938153242     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1509590112     Document Type: Article

References (14)

1. Neufeld KM, Kang N, Bienenstock J, Foster JA (2011) Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil 23(3):255-264, e119.
2. Sudo N, et al. (2004) Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol 558(Pt 1):263-275.
3. Diaz Heijtz R, et al. (2011) Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci USA 108(7):3047-3052.
4. Clarke G, et al. (2013) The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry 18(6):666-673.
5. Bercik P, et al. (2011) The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 141(2):599-609, e1-e3.
6. Savignac HM, Kiely B, Dinan TG, Cryan JF (2014) Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB/c mice. Neurogastroenterol Motil 26(11):1615-1627.
7. Foster JA, McVey Neufeld KA (2013) Gut-brain axis: How the microbiome influences anxiety and depression. Trends Neurosci 36(5):305-312.
8. Hsiao EY, et al. (2013) Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155(7):1451-1463.
9. Dance A (2014) Microbes take charge. Proc Natl Acad Sci USA 111(6):2051-2053.
10. Messaoudi M, et al. (2011) Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 105(5):755-764.
11. Cryan JF, Dinan TG (2012) Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13(10):701-712.
12. Bravo JA, et al. (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 108(38):16050-16055.
13. Felger JC, Lotrich FE (2013) Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications. Neuroscience 246:199-229.
14. Smythies LE, Smythies JR (2014) Microbiota, the immune system, black moods and the brain-melancholia updated. Front Hum Neurosci 8:720.