Transient effects of levamisole on Brugia malayi microfilariae

Invertebrate Neuroscience

Volumn 15, Issue 3, 2015, Pages

  Mostafa, Eman ^a,b   Storey, Bob ^a   Farghaly, Adel Mohammed ^b   Afify, Hany Abd El Hai ^b   Taha, Afaf Abd El Raouf ^b   Wolstenholme, Adrian J ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b Zagazig University   (Egypt)

Author keywords

Anthelmintic; Brugia malayi; Nematode; Nicotinic acetylcholine receptor

Indexed keywords

ANTINEMATODAL AGENT; LEVAMISOLE; PYRANTEL;

ANIMAL; BRUGIA MALAYI; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; MICROFILARIA; PARALYSIS;

ANIMALS; ANTINEMATODAL AGENTS; BRUGIA MALAYI; DOSE-RESPONSE RELATIONSHIP, DRUG; LEVAMISOLE; MICROFILARIA; PARALYSIS; PYRANTEL;

EID: 84938087835     PISSN: 13542516     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10158-015-0181-0     Document Type: Article

References (16)

1. Bennett HM, Williamson SM, Walsh TK, Woods DJ, Wolstenholme AJ (2012) ACR-26: a novel nicotinic receptor subunit of parasitic nematodes. Mol Biochem Parasitol 183:151–157
2. Harrow ID, Gration AF (1985) Mode of action of the anthelmintics morantel, pyrantel and levamisole on muscle cell membrane of the nematode Ascaris suum. Pestic Sci 16:662–672
3. John PAS, Gordon H (2001) Agonists cause endocytosis of nicotinic acetylcholine receptors on cultured myotubes. J Neurobiol 49:212–223
4. Jones AK, Sattelle DB (2004) Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans. BioEssays 26:39–49
5. Li B-W, Rush AC, Weil GJ (2015) Expression of five acetylcholine receptor subunit genes in Brugia malayi adult worms. Int J Parasitol Drugs Drug Resist 5:100–109
6. Marcellino C, Gut J, Lim KC, Singh R, McKerrow J, Sakanari J (2012) WormAssay: a novel computer application for whole-plate motion-based screening of macroscopic parasites. PLoS Negl Trop Dis 6:e1494
7. Martin RJ (1997) Modes of action of anthelmintic drugs. Vet J 154:11–34
8. Qian H, Martin RJ, Robertson AP (2006) Pharmacology of N-, L-, and B-subtypes of nematode nAChR resolved at the single-channel level in Ascaris suum. FASEB J 20:E2108–E2116
9. Robertson AP, Puttachary S, Martin RJ (2011) Single-channel recording from adult Brugia malayi. Invertebr Neurosci 11:53–57
10. Robertson AP, Buxton SK, Martin RJ (2013) Whole-cell patch-clamp recording of nicotinic acetylcholine receptors in adult Brugia malayi muscle. Parasitol Int 62:616–618
11. Storey B, Marcellino C, Miller M, Maclean M, Mostafa E, Howell S et al (2014) Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: “The Worminator”. Int J Parasitol Drugs Drug Resist 4:233–243
12. Taly A, Corringer P-J, Guedin D, Lestage P, Changeux J-P (2009) Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov 8:733–750
13. Touroutine D, Fox RM, Von Stetina SE, Burdina A, Miller DM, Richmond JE (2005) acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction. J Biol Chem 280:27013–27021
14. Williamson SM, Walsh TK, Wolstenholme AJ (2007) The cys-loop ligand-gated ion channel gene family of Brugia malayi and Trichinella spiralis: a comparison with Caenorhabditis elegans. Invertebr Neurosci 7:219–226
15. Williamson SM, Robertson AP, Brown L, Williams T, Woods DJ, Martin RJ et al (2009) The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits. PLoS Pathog 5:e1000517
16. Zahner H, Schares G (1993) Experimental chemotherapy of filariasis—comparative-evaluation of the efficacy of filaricidal compounds in Mastomys coucha infected with Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi and Brugia pahangi. Acta Trop 52:221–266