Keratins stabilize hemidesmosomes through regulation of β4-integrin turnover

Journal of Investigative Dermatology

Volumn 135, Issue 6, 2015, Pages 1609-1620

  Seltmann, Kristin ^a   Cheng, Fang ^b   Wiche, Gerhard ^c   Eriksson, John E ^b   Magin, Thomas M ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BETA4 INTEGRIN; CAVEOLIN; EPIDERMAL GROWTH FACTOR RECEPTOR; KERATIN; MITOGEN ACTIVATED PROTEIN KINASE 3; PLECTIN; SERINE; PROTEIN BINDING; PROTEIN KINASE C ALPHA; RAB PROTEIN; RAB11 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOCYTOSIS; EPIDERMIS; EPIDERMOLYSIS BULLOSA; HEMIDESMOSOME; MUTANT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; ANIMAL; CELL SEPARATION; CHEMISTRY; CYTOLOGY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENE EXPRESSION REGULATION; GENOTYPE; KERATINOCYTE; LASER; METABOLISM; MOUSE; MUTATION; PHENOTYPE; PHOSPHORYLATION;

ANIMALS; CAVEOLINS; CELL SEPARATION; ENDOCYTOSIS; EPIDERMIS; FLOW CYTOMETRY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENE EXPRESSION REGULATION; GENOTYPE; HEMIDESMOSOMES; INTEGRIN BETA4; KERATINOCYTES; KERATINS; LASERS; MICE; MICROSCOPY, FLUORESCENCE; MUTATION; PHENOTYPE; PHOSPHORYLATION; PLECTIN; PROTEIN BINDING; PROTEIN KINASE C-ALPHA; RAB GTP-BINDING PROTEINS; RAB5 GTP-BINDING PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SERINE;

EID: 84938061164     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2015.46     Document Type: Article

References (41)

1. Arjonen A, Alanko J, Veltel S et al. (2012) Distinct recycling of active and inactive β1 integrins. Traffic 13:610-25
2. Ashton GHS, Sorelli P, Mellerio JE et al. (2001) α6β4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia. Br J Dermatol 144: 408-14
3. Bär J, Kumar V, Roth W et al. (2014) Skin fragility and impaired desmo-somal adhesion in mice lacking all keratins. J Invest Dermatol 134: 1012-22
4. Borradori L, Sonnenberg A (1999) Structure and function of hemidesmo-somes: more than simple adhesion complexes. J Invest Dermatol 112: 411-8
5. Bouameur JE, Favre B, Borradori L (2013) Plakins, a versatile family of cytolinkers: roles in skin integrity and in human diseases. J Invest Dermatol 134:885-94
6. Caswell PT, Norman JC (2006) Integrin trafficking and the control of cell migration. Traffic 7:14-21
7. Chen Q, Xu R, Zeng C et al. (2014) Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin β4-mediated FAK signaling. PLoS One 9:e88386
8. Coulombe PA, Fuchs E (1993) Epidermolysis bullosa simplex. Semin Dermatol 12:173-90
9. Coulombe PA, Lee CH (2012) Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath. J Invest Dermatol 132:763-75
10. Frijns E, Sachs N, Kreft M et al. (2010) EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin β4. J Biol Chem 285:37650-62
11. Frijns E, Kuikman I, Litjens S et al. (2012) Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly. Mol Biol Cell 23:1475-85
12. Geuijen CAW, Sonnenberg A (2002) Dynamics of the alpha6beta4 integrin in keratinocytes. Mol Biol Cell 13:3845-58
13. Hopkinson SB, Findlay K, deHart GW et al. (1998) Interaction of BP180 (type XVII collagen) and alpha6 integrin is necessary for stabilization of hemidesmosome structure. J Invest Dermatol 111:1015-22
14. Jones JC, Hopkinson SB, Goldfinger LE (1998) Structure and assembly of hemidesmosomes. BioEssays News Rev Mol Cell Dev Biol 20: 488-94
15. Kashyap T, Rabinovitz I (2012) The calcium/calcineurin pathway promotes hemidesmosome stability through inhibition of β4 integrin phosphoryla-tion. J Biol Chem 287:32440-9
16. Koster J, Geerts D, Favre B et al. (2003) Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly. J Cell Sci 116:387-99
17. Kröger C, Loschke F, Schwarz N et al. (2013) Keratins control intercellular adhesion involving PKC-α-mediated desmoplakin phosphorylation. J Cell Biol 201:681-92
18. Li Q, Yang XH, Xu F et al. (2013) Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Oncogene 32:1772-83
19. Litjens SHM, de Pereda JM, Sonnenberg A (2006) Current insights into the formation and breakdown of hemidesmosomes. Trends Cell Biol 16: 376-83
20. Maxfield FR, McGraw TE (2004) Endocytic recycling. Nat Rev Mol Cell Biol 5: 121-32
21. Niessen CM, Hulsman EH, Oomen LC et al. (1997) A minimal region on the integrin beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells. J Cell Sci 110: 1705-16
22. Nievers MG, Schaapveld RQ, Oomen LC et al. (1998) Ligand-independent role of the beta 4 integrin subunit in the formation of hemidesmosomes. J Cell Sci 111:1659-72
23. Osmanagic-Myers S, Gregor M, Walko G et al. (2006) Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration. J Cell Biol 174:557-68
24. De Pereda JM, Lillo MP, Sonnenberg A et al. (2009) Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmo-somes. EMBO J 28:1180-90
25. Pfendner E, Uitto J (2005) Plectin gene mutations can cause epidermolysis bullosa with pyloric atresia. J Invest Dermatol 124:111-5
26. Porter RM, Lane BE (2003) Phenotypes, genotypes and their contribution to understanding keratin function. Trends Genet 19:278-85
27. Puklin-Faucher E, Sheetz MP (2009) The mechanical integrin cycle. J Cell Sci 122:179-86
28. Raymond K, Kreft M, Janssen H et al. (2005) Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice. J Cell Sci 118:1045-60
29. Raymond K, Kreft M, Song JY et al. (2007) Dual Role of alpha6beta4 integrin in epidermal tumor growth: tumor-suppressive versus tumor-promoting function. Mol Biol Cell 18:4210-21
30. Rezniczek GA, de Pereda JM, Reipert S et al. (1998) Linking integrin alpha6beta4-based cell adhesion to the intermediate filament cytoskeleton: direct interaction between the beta4 subunit and plectin at multiple molecular sites. J Cell Biol 141:209-25
31. Rezniczek GA, Walko G, Wiche G (2010) Plectin gene defects lead to various forms of epidermolysis bullosa simplex. Dermatol Clin 28:33-41
32. Ridley AJ, Schwartz MA, Burridge K et al. (2003) Cell migration: integrating signals from front to back. Science 302:1704-9
33. Scartozzi M, Giampieri R, Loretelli C et al. (2013) Role of β4 integrin in HER-3-negative, K-RAS wild-type metastatic colorectal tumors receiving cetux-imab. Future Oncol Lond Engl 9:1207-14
34. Seltmann K, Roth W, Kröger C et al. (2013a) Keratins mediate localization of hemidesmosomes and repress cell motility. J Invest Dermatol 133:181-90
35. Seltmann K, Fritsch AW, Käs JA et al. (2013b) Keratins significantly contribute to cell stiffness and impact invasive behavior. Proc Natl Acad Sci USA 110: 18507-12
36. Sterk LM, Geuijen CA, Oomen LC et al. (2000) The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmo-somes. J Cell Biol 149:969-82
37. Tsuruta D, Hashimoto T, Hamill KJ et al. (2011) Hemidesmosomes and focal contact proteins: functions and cross-talk in keratinocytes, bullous diseases and wound healing. J Dermatol Sci 62:1-7
38. Vijayaraj P, Kröger C, Reuter U et al. (2009) Keratins regulate protein biosynthesis through localization of GLUT1 and-3 upstream of AMP kinase and Raptor. J Cell Biol 187:175-84
39. Wilhelmsen K, Litjens SHM, Kuikman I et al. (2007) Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Mol Biol Cell 18:3512-22
40. Winter L, Wiche G (2013) The many faces of plectin and plectinopathies: pathology and mechanisms. Acta Neuropathol 125:77-93
41. Zhang H, Landmann F, Zahreddine H et al. (2011) A tension-induced mechanotransduction pathway promotes epithelial morphogenesis. Nature 471:99-103