Preparation and Evaluation of 68Ga-ECC as a PET Renal Imaging Agent

Nuclear Medicine and Molecular Imaging

Volumn 49, Issue 3, 2015, Pages 208-216

  Mirzaei, Alireza ^a   Jalilian, Amir Reza ^a   Aghanejad, Ayuob ^a   Mazidi, Mohammad ^a   Yousefnia, Hassan ^a   Shabani, Gholamali ^a   Ardaneh, Khosro ^a   Geramifar, Parham ^b   Beiki, Davood ^b  

^a NUCLEAR SCIENCE AND TECHNOLOGY RESEARCH INSTITUTE   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

68Ga; Biodistribution; Ethylenecysteamine cysteine; PET CT; Renal agent

Indexed keywords

GALLIUM 68; GALLIUM 68 ETHYLENECYSTEAMINE CYSTEINE; GALLIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC IMAGING; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INDUCTIVELY COUPLED PLASMA OPTICAL EMISSION SPECTROMETRY; ISOTOPE LABELING; MOLECULAR STABILITY; NONHUMAN; PARTITION COEFFICIENT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN INTERACTION; QUALITY CONTROL; RADIOACTIVITY; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPECTROMETRY; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; VOLUME OF DISTRIBUTION;

EID: 84937984498     PISSN: 18693474     EISSN: 18693482     Source Type: Journal    
DOI: 10.1007/s13139-015-0323-7     Document Type: Article

References (14)

1. Firestone RB, Shirley VS, Baglin CM, Zipkin J. Table of isotopes. 8th ed. New York: John Wiley and Sons; 1996. p. 1447.
2. DDEP, Decay Data Evaluation Project Data (2008) http://www.nucleide.org/DDEP_WG/DDEPdata.htm.
3. Lee JY, Jeong JM, Kim YJ, Jeong HJ, Lee YS, Lee DS, et al. Preparation of Ga-68-NOTA as a renal PET agent and feasibility tests in mice. Nucl Med Biol. 2014;41(2):210–5.
4. Anderson CJ, John CS, Li YJ, Hancock RD, McCarthy TJ, Martell AE, et al. N, N’-ethylene-di-L-cysteine (EC) complexes of Ga(III) and In(III): molecular modeling, thermodynamic stability and in vivo studies. Nucl Med Biol. 1995;22(2):165–73.
5. Li Y, Martell AE, Hancock RD, Reibenspies JH, Anderson CJ, Welch MJ. N, N¢-Ethylenedi-L-cysteine (EC) and its metal complexes: synthesis, characterization, crystal structures, and equilibrium constants. Inorg Chem. 1996;35:404–14.
6. Vanbilloen HP, Cleynhens BJ, Verbruggen AM. Synthesis and biological evaluation of the four isomers of technetium-99m radiolabeled ethylenecysteamine cysteine (99mTc-ECC), the mono-acid derivative of 99mTc-L,L-ethylenedicysteine. Nucl Med Biol. 2000;27:207–14.
7. Jalilian AR, Yousefnia H, Zolghadri S, Khoshdel MR, Bolourinovin F, Rahiminejad A. Development of radiogallium–ethylenecysteamine cysteine complex as a possible renal imaging agent. J Radioanal Nucl Chem. 2010;284(1):49–54.
8. 67Ga-ECC based on biodistribution rat data. Ann Nucl Med. 2014;14.
9. Blondeau P, Berse C, Gracel D. Dimerization of an intermediate during the sodium in liquid ammonia reduction of L-thiazolidine-4-carboxylic acid. Can J Chem. 1967;45:49–52.
10. 66Ga]Bleomycin complex as a possible PET radiopharmaceutical. J Radioanal Nucl Chem. 2005;264:617.
11. Fritzberg AR, Kasina S, Eshima D, Johnson DL. Synthesis and biological evaluation of technetium-99m MAG3 as a hippuran replacement. J Nucl Med. 1986;27:111–6.
12. Despopoulos A. A definition of substrate specificity in renal transport of organic anions. J Theor Biol. 1965;8:163–92.
13. Taylor AT, Lipowska M, Hansen L, Malveaux E, Marzilli LG. 99mTc-MAEC complexes: new renal radiopharmaceuticals combining characteristics of (99m)Tc-MAG3 and (99m)Tc-EC. J Nucl Med. 2004;45(5):885–91.
14. Verbruggen AM, Nosco DL, Van Nerom CG, Bormans GM, Adnaens PJ, Dc Roo MJ. Technetium-99m-L, L-Ethylenedicysteine: a renal imaging agent. I. Radiolabeling and evaluation in animals. J Nucl Med. 1992;33:551–7.