Effect of aging on hemodynamic response to metaboreflex activation

European Journal of Applied Physiology

Volumn 115, Issue 8, 2015, Pages 1693-1703

  Milia, Raffaele ^a   Roberto, Silvana ^a   Mulliri, Gabriele ^a   Loi, Andrea ^a   Marcelli, Maura ^a   Sainas, Gianmarco ^a   Milia, Nicola ^a   Marongiu, Elisabetta ^a   Crisafulli, Antonio ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Blood pressure; Cardiac preload; Myocardial contractility; Stroke volume

Indexed keywords

ADULT; AGED; AGING; ARM; ARTERIAL PRESSURE; COMPARATIVE STUDY; DIASTOLE; EXERCISE; FEMALE; HAND STRENGTH; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HUMAN; ISCHEMIA; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; REFLEX; SKELETAL MUSCLE; VASCULAR RESISTANCE; VASCULARIZATION; YOUNG ADULT;

ADULT; AGED; AGING; ARM; ARTERIAL PRESSURE; CARDIAC OUTPUT; DIASTOLE; EXERCISE; FEMALE; HAND STRENGTH; HEART RATE; HEMODYNAMICS; HUMANS; ISCHEMIA; MALE; MUSCLE, SKELETAL; REFLEX; STROKE VOLUME; VASCULAR RESISTANCE; YOUNG ADULT;

EID: 84937970022     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-015-3153-5     Document Type: Article

References (42)

1. Alam M, Smirk FH (1937) Observations in man upon a blood pressure raising reflex arising from the voluntary muscles. J Physiol 89:372–383
2. Amann M, Runnels S, Morgan DE, Trinity JD, Fjeldstad AS, Walter Wray D, Reese VR, Richardson RS (2011) On the contribution of group III and IV muscle afferents to the circulatory response to rhythmic exercise in humans. J Physiol 589:3855–3866
3. Arbab-Zadeh A, Dijk E, Prasad A, Fu Q, Torres P, Zhang R, Thomas JD, Palmer D, Levine BD (2004) Effect of aging and physical activity on left ventricular compliance. Circulation 110:1799–1805
4. Baldi JC, McFarlane K, Oxenham HC, Whalley GA, Walsh HJ, Doughty RN (2003) Left ventricular diastolic filling and systolic function of young and older trained and untrained men. J Appl Physiol 95:2570–2575
5. Baldi JC, Lalande S, Carrick-Ranson G, Johnson BD (2007) Postural differences in hemodynamics and diastolic function in healthy older men. Eur J Appl Physiol 99:651–657
6. Bastos BG, Williamson JW, Harrelson T, Nôbrega ACL (2000) Left ventricular volumes and hemodynamic responses to postexercise ischemia in healthy humans. Med Sci Sports Exerc 32:1114–1118
7. Bernstein DP (1986) A new stroke volume equation for thoracic electrical bioimpedance: theory and rationale. Crit Care Med 14:904–909
8. Boushel R (2010) Muscle metaboreflex control of the circulation during exercise. Acta Physiol 199:367–383
9. Christie J, Sheldahl LM, Tristani FE, Sagar KB, Ptacin MJ, Wann S (1987) Determination of stroke volume and cardiac output during exercise: comparison of two-dimensional and Doppler echocardiography, Fick oxymetry, and thermodiluition. Circulation 76:539–547
10. Cohen GI, Pietrolungo JF, Thomas JD, Klein AL (1996) A practical guide to assessment of ventricular diastolic function using Doppler echocardiography. J Am Coll Cardiol 27:1753–1760
11. Crisafulli A, Melis F, Orrù V, Lener R, Lai C, Concu A (2001) Impedance cardiography for non invasive assessment of systolic time intervals during exercise. Sports Med Train Rehab 10:13–27
12. Crisafulli A, Scott AC, Wensel R, Davos CH, Francis DP, Pagliaro P, Coats AJS, Concu A, Piepoli MF (2003) Muscle metaboreflex-induced increases in stroke volume. Med Sci Sports Exerc 35:221–228
13. Crisafulli A, Salis E, Pittau G, Lorrai L, Tocco F, Melis F, Pagliaro P, Concu A (2006) Modulation of cardiac contractility by muscle metaboreflex following efforts of different intensities in humans. Am J Physiol (Heart Circ Physiol) 291:H3035–H3042
14. Crisafulli A, Salis E, Tocco F, Melis F, Milia R, Pittau G, Caria MA, Solinas R, Meloni L, Pagliaro P, Concu A (2007) Impaired central hemodynamic response and exaggerated vasoconstriction during muscle metaboreflex activation in heart failure patients. Am J Physiol (Heart Circ Physiol) 292:H2988–H2996
15. Crisafulli A, Milia R, Lobina A, Caddeo M, Tocco F, Concu A, Melis F (2008) Hemodynamic effect of metaboreflex activation in men after running above and below the velocity of the anaerobic threshold. Exp Physiol 93:447–457
16. Crisafulli A, Milia R, Vitelli S, Caddeo M, Tocco F, Melis F, Concu A (2009) Hemodynamic responses to metaboreflex activation: insights from spinal cord-injured humans. Eur J Appl Physiol 106:525–533
17. Crisafulli A, Piras F, Filippi M, Piredda C, Chiappori P, Melis F, Milia R, Tocco F, Concu A (2011) Role of heart rate and stroke volume during muscle metaboreflex-induced cardiac output increase: differences between activation during and after exercise. J Physiol Sci 61:385–394
18. Crisafulli A, Tocco F, Milia R, Angius L, Pinna M, Olla S, Roberto S, Marongiu E, Porcu M, Concu A (2013) Progressive improvement in hemodynamic response to muscle metaboreflex in heart transplant recipients. J Appl Physiol 114:421–427
19. De Souza RR (2002) Aging of myocardial collagen. Biogerontology 3:325–335
20. Fisher JP, Seifert T, Hartwich D, Young CN, Secher NH, Fadel PJ (2010) Autonomic control of heart rate by metabolically sensitive skeletal muscle afferents in humans. J Physiol 588:1117–1127
21. Gardin JM, Dabestani A, Takenaka K, Rohan MK, Knoll M, Russell D, Henry WL (1986) Effect of imaging view and sample volume location on evaluation of mitral flow velocity by pulsed Doppler echocardiogaphy. Am J Cardiol 57:1335–1339
22. Gledhill N, Cox D, Jamnik R (1994) Endurance athletes’ stroke volume does not plateau: major advantage is diastolic function. Med Sci Sports Exerc 26:1116–1121
23. Ichinose MJ, Sala-Mercado JA, Coutsos M, Li ZH, Ichinose TK, Dawe E, O’Leary DS (2009) Modulation of cardiac output alters the mechanisms of the muscle metaboreflex pressor response. Am J Physiol (Heart Circ Physiol) 298:H245–H250
24. Ichinose M, Maeda S, Kondo N, Nishiyasu T (2014) Blood pressure regulation II: what happens when one system must serve two masters-oxygen delivery and pressure regulation? Eur J Appl Physiol 114:451–465
25. Lakatta EG (2002) Cardiovascular ageing in health sets the stage for cardiovascular disease. Heart Lung and Circ 11:76–91
26. Marongiu E, Piepoli MF, Milia R, Angius L, Pinna M, Bassareo P, Roberto S, Tocco F, Concu A, Crisafulli A (2013) Effects of acute vasodilation on the hemodynamic response to muscle metaboreflex. Am J Physiol (Heart Circ Physiol) 305:H1387–H1396
27. McNully CL, Moody WE, Wagenmakers AJ, Fisher JP (2014) Effect of muscle metaboreflex activation on central hemodynamics and cardiac function in humans. App Physiol Nutr Metab 39:861–870
28. Milia R, Roberto S, Marongiu E, Olla S, Sanna I, Angius L, Bassareo P, Pinna M, Tocco F, Concu A, Crisafulli A (2014). Improvement in hemodynamic responses to metaboreflex activation after one year of training in spinal cord injured humans. Biomed Res Int, ID 893468, http://doi.org/10.1155/2014/893468
29. Moran D, Epstein Y, Keren G, Laor A, Sherez J, Shapir Y (1995) Calculation of mean arterial pressure during exercise as a function of heart rate. Appl Human Sci 14:293–295
30. Murphy MN, Mizuno M, Mitchell JH, Smith A (2011) Cardiovascular regulation by skeletal muscle reflexes in health and disease. Am J Physiol (Heart Circ Physiol) 2011(301):H1191–H1204
31. Nóbrega ACL, O’Leary DS, Silva BM, Marongiu E, Piepoli MF, Crisafulli A (2014). Neural regulation of cardiovascular response to exercise: role of central command and peripheral afferents. Biomed Res Int; 478965, http://doi.org/10.1155/2014/478965
32. O’Leary DS, Augustyniak RA (1998) Muscle metaboreflex increases ventricular performance in conscious dogs. Am J Physiol (Heart Circ Physiol) 275:H220–H224
33. O’Leary DS, Sala-Mercado JA, Augustyniak RA, Hammond RL, Rossi NF, Ansorge EJ (2004) Impaired muscle metaboreflex-induced increases in ventricular function in heart failure. Am J Physiol (Heart Circ Physiol) 287:H2612–H2618
34. O’Leary DS (2006) Altered reflex cardiovascular control during exercise in heart failure: animal studies. Exp Physiol 91:73–77
35. Oxenham H, Young A, Cowan B, Gentles T, Occleshaw C, Fonseca C, Doughty R, Sharpe N (2003) Age related changes in myocardial relaxation using three-dimensional tagged magnetic resonance imaging. J Cardiovs Magn Reson 5:421–430
36. Roberto S, Marongiu E, Pinna M, Angius L, Olla S, Bassareo P, Tocco F, Concu A, Milia R, Crisafulli A (2012) Altered hemodynamics during muscle metaboreflex in young, type 1 diabetes patients. J Appl Physiol 113:1323–1331
37. Sala-Mercado JA, Hammond RL, Kim JK, Rossi NF, Stephenson LW, O’Leary DS (2006) Muscle metaboreflex control of ventricular contractility during dynamic exercise. Am J Physiol (Heart Circ Physiol) 290:H751–H757
38. Sheriff DD, Augstyniak RA, O’Leary DS (1998) Muscle chemoreflex-induced increases in right atrial pressure. Am J Physiol (Heart Circ Physiol) 275:H767–H775
39. Shoemaker JK, Mattar L, Kerbeci P, Trotter S, Arbeille P, Hughson RL (2007) WISE 2005: stroke volume changes contribute to the pressor response during ischemic handgrip exercise in women. J Appl Physiol 103:228–233
40. Spranger MD, Sala-Mercado JA, Coutsos M, Kaur J, Styer D, Augustyniak RA, O’Leary DS (2013) Role of cardiac output vs peripheral vasoconstriction in mediating muscle metaboreflex pressor responses: dynamic exercise vs post-exercise muscle ischemia. Am J Physiol (Regul Integr Comp Physiol) 304:R657–R663
41. Strange S, Secher NH, Pawelczyk JA, Karpakka J, Christensen NJ, Mitchell JH, Saltin B (1993) Neural control of cardiovascular responses and of ventilation during dynamic exercise in man. J Physiol 470:693–704
42. Stratton JR, Levy WC, Cerqueira MD, Schwartz RS, Abrass IB (1994) Cardiovascular responses to exercise. Effects of aging and exercise training in healthy men. Circulation 89:1648–1655