Influence of age, severity of infection, and co-infection on the duration of respiratory syncytial virus (RSV) shedding

Epidemiology and Infection

Volumn 143, Issue 4, 2015, Pages 804-812

  Munywoki, P K ^a   Koech, D C ^a   Agoti, C N ^a   Kibirige, N ^a   Kipkoech, J ^a   Cane, P A ^b   Medley, G F ^c   Nokes, D J ^a,c  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Developing countries; Kenya; respiratory syncytial virus; shedding duration; transmission dynamics

Indexed keywords

VIRUS ANTIGEN;

ADOLESCENT; ADULT; AGE; ANTIGEN DETECTION; ARTICLE; CHILD; COHORT ANALYSIS; DISEASE DURATION; DISEASE SEVERITY; FEMALE; GENE SEQUENCE; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; HUMAN TISSUE; KENYA; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; NONHUMAN; NOSE SMEAR; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PROSPECTIVE STUDY; RSV G GENE; RURAL AREA; THROAT CULTURE; VIRUS GENE; VIRUS SHEDDING; PHYSIOLOGY; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; TIME; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; CHILD; CHILD, PRESCHOOL; COINFECTION; FEMALE; HUMANS; KENYA; MALE; PROSPECTIVE STUDIES; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; RESPIRATORY SYNCYTIAL VIRUSES; TIME FACTORS; VIRUS SHEDDING; YOUNG ADULT;

EID: 84937969067     PISSN: 09502688     EISSN: 14694409     Source Type: Journal    
DOI: 10.1017/S0950268814001393     Document Type: Article

References (22)

1. Nair H, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010; 375: 1545-1555.
2. Glezen WP, et al. Risk of primary infection and reinfection with respiratory syncytial virus. American Journal of Diseases of Children 1986; 140: 543-546.
3. Waris M, et al. Shedding of infectious virus and virus antigen during acute infection with respiratory syncytial virus. Journal of Medical Virology 1992; 38: 111-116.
4. Hall CB, Douglas Jr. RG, Geiman JM. Respiratory syncytial virus infections in infants: quantitation and duration of shedding. Journal of Pediatrics 1976; 89: 11-15.
5. Hall CB, Douglas Jr. RG, Geiman JM. Quantitative shedding patterns of respiratory syncytial virus in infants. Journal of Infectious Diseases 1975; 132: 151-156.
6. Frank AL, et al. Patterns of shedding of myxoviruses and paramyxoviruses in children. Journal of Infectious Diseases 1981; 144: 433-441.
7. Munywoki PK, et al. The source of respiratory syncytial virus infection in infants: a household cohort study in rural Kenya. Journal of Infectious Diseases. Published online: 25 December 2013. doi: 10.1093/infdis/jit828.
8. Scott JA, et al. Profile: The Kilifi Health and Demographic Surveillance System (KHDSS). International Journal of Epidemiology 2012; 41: 650-657.
9. Agoti CN, et al. Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural kenya. Journal of Infectious Diseases 2012; 206: 1532-1541.
10. Hall CB, et al. Respiratory syncytial virus infections within families. New England Journal Medicine 1976; 294: 414-419.
11. Hall CB, Long CE, Schnabel KC. Respiratory syncytial virus infections in previously healthy working adults. Clinical Infectious Diseases 2001; 33: 792-796.
12. Okiro EA, et al. Duration of shedding of respiratory syncytial virus in a community study of Kenyan children. BMC Infectious Diseases 2010; 10: 15.
13. Munywoki PK, et al. Improved detection of respiratory viruses in pediatric outpatients with acute respiratory illness by real-time PCR using nasopharyngeal flocked swabs. Journal of Clinical Microbiology 2011; 49: 3365-3367.
14. Reis AD, et al. Comparison of direct immunofluorescence, conventional cell culture and polymerase chain reaction techniques for detecting respiratory syncytial virus in nasopharyngeal aspirates from infants. Journal of the So Paulo Institute of Tropical Medicine 2008; 50: 37-40.
15. Madhi SA, et al. Increased burden of respiratory viral associated severe lower respiratory tract infections in children infected with human immunodeficiency virus type-1. Journal of Pediatrics 2000; 137: 78-84.
16. Kenya National Bureau of Statistics (KNBS) and ICF Macro. Kenya Demograpghic and Health Survey 2008-09. Calverton, Maryland, USA: KNBS and ICF Macro, 2010.
17. Cubie HA, et al. Detection of respiratory syncytial virus nucleic acid in archival postmortem tissue from infants. Pediatric Pathology and Laboratory Medicine 1997; 17: 927-938.
18. Schwarze J, et al. Latency and persistence of respiratory syncytial virus despite T cell immunity. American Journal of Respiratory Critical Care Medicine 2004; 169: 801-805.
19. Lin WH, et al. Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics. Proceedings of the National Academy of Sciences USA 2012; 109: 14989-14994.
20. DeVincenzo JP, El Saleeby CM, Bush AJ. Respiratory syncytial virus load predicts disease severity in previously healthy infants. Journal of Infectious Diseases 2005; 191: 1861-1868.
21. Kuypers J, Wright N, Morrow R. Evaluation of quantitative and type-specific real-time RT-PCR assays for detection of respiratory syncytial virus in respiratory specimens from children. Journal of Clinical Virology 2004; 31: 123-129.
22. Devincenzo JP. Natural infection of infants with respiratory syncytial virus subgroups A and B: a study of frequency, disease severity, and viral load. Pediatric Research 2004; 56: 914-917.