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Volumn 60, Issue 5, 2015, Pages 1414-1423

Withdrawal of Long-Term Maintenance Treatment with Azathioprine Tends to Increase Relapse Risk in Patients with Crohn’s Disease

Author keywords

Azathioprine; Clinical trails; Crohn s disease; Immunomodulators

Indexed keywords

ANTIINFLAMMATORY AGENT; AZATHIOPRINE; GASTROINTESTINAL AGENT;

EID: 84937965684     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-014-3419-5     Document Type: Article
Times cited : (31)

References (45)
  • 1
    • 79955561083 scopus 로고    scopus 로고
    • Epidemiology and natural history of inflammatory bowel diseases
    • PID: 21530745
    • Cosnes J, Gower-Rousseau C, Seksik P, Cortot A. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology. 2011;140:1785–1794.
    • (2011) Gastroenterology , vol.140 , pp. 1785-1794
    • Cosnes, J.1    Gower-Rousseau, C.2    Seksik, P.3    Cortot, A.4
  • 2
    • 84872164075 scopus 로고    scopus 로고
    • Incidence of inflammatory bowel disease in the province of Styria, Austria, from 1997 to 2007: a population-based study
    • COI: 1:STN:280:DC%2BC38rovVehsg%3D%3D
    • Petritsch W, Fuchs S, Berghold A, et al. Incidence of inflammatory bowel disease in the province of Styria, Austria, from 1997 to 2007: a population-based study. J Crohn’s Colitis. 2013;7:58–69.
    • (2013) J Crohn’s Colitis , vol.7 , pp. 58-69
    • Petritsch, W.1    Fuchs, S.2    Berghold, A.3
  • 3
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC38Xhs1ajtbzP, PID: 23128233
    • Jostins L, Ripke S, Weersma RK, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012;491:119–124.
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3
  • 4
    • 77953381829 scopus 로고    scopus 로고
    • Immunomodulators for all patients with inflammatory bowel disease?
    • COI: 1:CAS:528:DC%2BC3cXhs1aktbfM, PID: 21180588
    • Ardizzone S, Cassinotti A, Manes G, Porro GB. Immunomodulators for all patients with inflammatory bowel disease? Therap Adv Gastroenterol. 2010;3:31–42.
    • (2010) Therap Adv Gastroenterol , vol.3 , pp. 31-42
    • Ardizzone, S.1    Cassinotti, A.2    Manes, G.3    Porro, G.B.4
  • 5
    • 0028790186 scopus 로고
    • A controlled double blind study of azathioprine in the management of Crohn’s disease
    • COI: 1:CAS:528:DyaK28XktVWhsA%3D%3D, PID: 8549944
    • Candy S, Wright J, Gerber M, Adams G, Gerig M, Goodman R. A controlled double blind study of azathioprine in the management of Crohn’s disease. Gut. 1995;37:674–678.
    • (1995) Gut , vol.37 , pp. 674-678
    • Candy, S.1    Wright, J.2    Gerber, M.3    Adams, G.4    Gerig, M.5    Goodman, R.6
  • 6
    • 0029134702 scopus 로고
    • Azathioprine and 6-mercaptopurine in Crohn Disease. A meta-analysis
    • COI: 1:CAS:528:DyaK2MXntl2qu7s%3D, PID: 7778826
    • Pearson DC, May GR, Fick GH, Sutherland LR. Azathioprine and 6-mercaptopurine in Crohn Disease. A meta-analysis. Ann Intern Med. 1995;123:132–142.
    • (1995) Ann Intern Med , vol.123 , pp. 132-142
    • Pearson, D.C.1    May, G.R.2    Fick, G.H.3    Sutherland, L.R.4
  • 7
    • 67650416300 scopus 로고    scopus 로고
    • Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn’s disease
    • CD000067
    • Prefontaine E, Sutherland LR, Macdonald JK, Cepoiu M. Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn’s disease. Cochrane Database Syst Rev. 2009;(1):CD000067. doi:10.1002/14651858.CD000067.pub2.
    • (2009) Cochrane Database Syst Rev. , vol.1
    • Prefontaine, E.1    Sutherland, L.R.2    Macdonald, J.K.3    Cepoiu, M.4
  • 8
    • 68349137946 scopus 로고    scopus 로고
    • Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn’s disease: a meta-analysis
    • COI: 1:CAS:528:DC%2BD1MXps1WqtLs%3D, PID: 19568226
    • Peyrin-Biroulet L, Deltrenre P, Ardizzone S, et al. Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn’s disease: a meta-analysis. Am J Gastroenterol. 2009;104:2089–2096.
    • (2009) Am J Gastroenterol , vol.104 , pp. 2089-2096
    • Peyrin-Biroulet, L.1    Deltrenre, P.2    Ardizzone, S.3
  • 9
    • 75149161836 scopus 로고    scopus 로고
    • The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: current management
    • COI: 1:STN:280:DC%2BC3M%2Fjs1OmsA%3D%3D
    • Dignass A, Van Assche G, Lindsay JO, et al. The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: current management. J Crohn’s Colitis. 2010;4:28–62.
    • (2010) J Crohn’s Colitis , vol.4 , pp. 28-62
    • Dignass, A.1    Van Assche, G.2    Lindsay, J.O.3
  • 10
    • 0018888679 scopus 로고
    • Treatment of Crohn’s disease with 6-mercaptopurine. A long-term, randomized, double-blind study
    • COI: 1:STN:280:DyaL3c7msFelsw%3D%3D, PID: 6102739
    • Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pasternack BS. Treatment of Crohn’s disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med. 1980;302:981–987.
    • (1980) N Engl J Med , vol.302 , pp. 981-987
    • Present, D.H.1    Korelitz, B.I.2    Wisch, N.3    Glass, J.L.4    Sachar, D.B.5    Pasternack, B.S.6
  • 11
    • 0027317141 scopus 로고
    • Long-term experience with 6-mercaptopurine in the treatment of Crohn’s disease
    • COI: 1:STN:280:DyaK3szjt1SntA%3D%3D, PID: 8338087
    • Korelitz BI, Adler DJ, Mendelsohn RA, Sacknoff A. Long-term experience with 6-mercaptopurine in the treatment of Crohn’s disease. Am J Gastroenterol. 1993;88:1198–1205.
    • (1993) Am J Gastroenterol , vol.88 , pp. 1198-1205
    • Korelitz, B.I.1    Adler, D.J.2    Mendelsohn, R.A.3    Sacknoff, A.4
  • 12
    • 75149116327 scopus 로고    scopus 로고
    • The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: special situations
    • Van Assche G, Dignass A, Reinisch W, et al. The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: special situations. J Crohn’s Colitis. 2010;4:63–101.
    • (2010) J Crohn’s Colitis , vol.4 , pp. 63-101
    • Van Assche, G.1    Dignass, A.2    Reinisch, W.3
  • 13
    • 0018117298 scopus 로고
    • Double-blind withdrawal trial of azathioprine as maintenance treatment for Crohn’s disease
    • PID: 81986
    • O’Donoghue DP, Dawson AM, Powel-Tuck K, Brown RL, Lennard-Jones JE. Double-blind withdrawal trial of azathioprine as maintenance treatment for Crohn’s disease. Lancet. 1978;2:955–957.
    • (1978) Lancet , vol.2 , pp. 955-957
    • O’Donoghue, D.P.1    Dawson, A.M.2    Powel-Tuck, K.3    Brown, R.L.4    Lennard-Jones, J.E.5
  • 14
    • 0030041584 scopus 로고    scopus 로고
    • Long-term follow up of patients with Crohn’s disease treated with azathioprine or 6-mercaptopurine
    • COI: 1:STN:280:DyaK287kvVOiug%3D%3D, PID: 8551879
    • Bouhnik Y, Lémann M, Mary JY, et al. Long-term follow up of patients with Crohn’s disease treated with azathioprine or 6-mercaptopurine. Lancet. 1996;347:215–219.
    • (1996) Lancet , vol.347 , pp. 215-219
    • Bouhnik, Y.1    Lémann, M.2    Mary, J.Y.3
  • 15
    • 0032747481 scopus 로고    scopus 로고
    • Optimum duration of treatment with 6-mercaptopurine for Crohn’s disease
    • COI: 1:CAS:528:DyaK1MXnvFSjtr0%3D, PID: 10566725
    • Kim PS, Zlatanic J, Korelitz BI, Gleim GW. Optimum duration of treatment with 6-mercaptopurine for Crohn’s disease. Am J Gastroenterol. 1999;94:3254–3257.
    • (1999) Am J Gastroenterol , vol.94 , pp. 3254-3257
    • Kim, P.S.1    Zlatanic, J.2    Korelitz, B.I.3    Gleim, G.W.4
  • 16
    • 2942612097 scopus 로고    scopus 로고
    • Randomized controlled azathioprine withdrawal after more than two years treatment in Crohn’s disease: increased relapse rate the following year
    • COI: 1:CAS:528:DC%2BD2cXlsFyiurs%3D
    • Vilien M, Dahlerup JF, Munck LK, Nørregaard P, Grønbaek K, Fallingborg J. Randomized controlled azathioprine withdrawal after more than two years treatment in Crohn’s disease: increased relapse rate the following year. Aliment Pharmacol Therap. 2004;19:1147–1152.
    • (2004) Aliment Pharmacol Therap , vol.19 , pp. 1147-1152
    • Vilien, M.1    Dahlerup, J.F.2    Munck, L.K.3    Nørregaard, P.4    Grønbaek, K.5    Fallingborg, J.6
  • 17
    • 77149158526 scopus 로고    scopus 로고
    • Current smoking, not duration of remission, delays Crohn’s disease relapse following azathioprine withdrawal
    • PID: 19462422
    • Sokol H, Seksik P, Nion-Larmurier I, Vienne A, Beaugerie L, Cosnes J. Current smoking, not duration of remission, delays Crohn’s disease relapse following azathioprine withdrawal. Inflamm Bowel Dis. 2010;16:362–363.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 362-363
    • Sokol, H.1    Seksik, P.2    Nion-Larmurier, I.3    Vienne, A.4    Beaugerie, L.5    Cosnes, J.6
  • 18
    • 20444483170 scopus 로고    scopus 로고
    • A randomized, double-blind, controlled withdrawal trial in Crohn’s disease patients in long-term remission on azathioprine
    • PID: 15940616
    • Lémann M, Mary J-Y, Colombel J-F, et al. A randomized, double-blind, controlled withdrawal trial in Crohn’s disease patients in long-term remission on azathioprine. Gastroenterology. 2005;128:1812–1818.
    • (2005) Gastroenterology , vol.128 , pp. 1812-1818
    • Lémann, M.1    Mary, J.-Y.2    Colombel, J.-F.3
  • 19
    • 58149136086 scopus 로고    scopus 로고
    • Azathioprine withdrawal in patients with Crohn’s disease maintained on prolonged remission: a high risk of relapse
    • PID: 18849016
    • Treton X, Bouhnik Y, Mary JY, et al. Azathioprine withdrawal in patients with Crohn’s disease maintained on prolonged remission: a high risk of relapse. Clin Gastroenterol Hepatol. 2009;7:80–85.
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 80-85
    • Treton, X.1    Bouhnik, Y.2    Mary, J.Y.3
  • 20
    • 0036278519 scopus 로고    scopus 로고
    • The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 years review
    • COI: 1:CAS:528:DC%2BD38XislOqsLs%3D, PID: 11889067
    • Fraser AG, Orchard TR, Jewell DP. The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 years review. Gut. 2002;50:485–489.
    • (2002) Gut , vol.50 , pp. 485-489
    • Fraser, A.G.1    Orchard, T.R.2    Jewell, D.P.3
  • 21
    • 37249004748 scopus 로고    scopus 로고
    • The long-term efficacy of azathioprine does not wane after four years of continuous treatment in patients with steroid-dependent luminal Crohn’s disease
    • Mantzaris GJ, Roussos A, Christidou A, et al. The long-term efficacy of azathioprine does not wane after four years of continuous treatment in patients with steroid-dependent luminal Crohn’s disease. J Crohn’s Colitis. 2007;1:28–34.
    • (2007) J Crohn’s Colitis , vol.1 , pp. 28-34
    • Mantzaris, G.J.1    Roussos, A.2    Christidou, A.3
  • 22
    • 79959722442 scopus 로고    scopus 로고
    • Mark Dalzell A, Srinivasan R, El-Matary W. Relapse rate following azathioprine withdrawal in maintaining remission for Crohn’s disease: a meta-analysis
    • PID: 21476031
    • French H. Mark Dalzell A, Srinivasan R, El-Matary W. Relapse rate following azathioprine withdrawal in maintaining remission for Crohn’s disease: a meta-analysis. Dig Dis Sci. 2011;56:1929–1936.
    • (2011) Dig Dis Sci , vol.56 , pp. 1929-1936
    • French, H.1
  • 23
    • 70449100743 scopus 로고    scopus 로고
    • Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study
    • COI: 1:CAS:528:DC%2BD1MXhtlyjtLrE, PID: 19837455
    • Beaugerie L, Brousse N, Bouvier AM, et al. Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study. Lancet. 2009;374:1617–1625.
    • (2009) Lancet , vol.374 , pp. 1617-1625
    • Beaugerie, L.1    Brousse, N.2    Bouvier, A.M.3
  • 24
    • 84863432006 scopus 로고    scopus 로고
    • Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease
    • PID: 22271569
    • Sokol H, Beaugerie L, Maynadié M, et al. Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2012;18:2063–2071.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 2063-2071
    • Sokol, H.1    Beaugerie, L.2    Maynadié, M.3
  • 25
    • 80054862378 scopus 로고    scopus 로고
    • Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC3MXhtlOksbzE, PID: 21708105
    • Peyrin-Biroulet L, Khosrotehrani K, Carrat F, et al. Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease. Gastroenterology. 2011;141:1621–1628.
    • (2011) Gastroenterology , vol.141 , pp. 1621-1628
    • Peyrin-Biroulet, L.1    Khosrotehrani, K.2    Carrat, F.3
  • 27
    • 0027164795 scopus 로고
    • Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience
    • COI: 1:STN:280:DyaK2c3ivFGntQ%3D%3D, PID: 8174958
    • Connell WR, Kamm MA, Ritchie JK, Lennard-Jones JE. Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience. Gut. 1993;34:1081–1085.
    • (1993) Gut , vol.34 , pp. 1081-1085
    • Connell, W.R.1    Kamm, M.A.2    Ritchie, J.K.3    Lennard-Jones, J.E.4
  • 28
    • 41349088375 scopus 로고    scopus 로고
    • Risk factors for opportunistic infections in patients with inflammatory bowel disease
    • PID: 18294633
    • Toruner M, Loftus EV Jr, Harmsen WS, et al. Risk factors for opportunistic infections in patients with inflammatory bowel disease. Gastroenterology. 2008;134:929–936.
    • (2008) Gastroenterology , vol.134 , pp. 929-936
    • Toruner, M.1    Loftus, E.V.2    Harmsen, W.S.3
  • 29
    • 0024457688 scopus 로고
    • 6-mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity
    • COI: 1:STN:280:DyaK3c%2FisVKqsQ%3D%3D, PID: 2802419
    • Present DH, Meltzer SJ, Krumholz MP, Wolke A, Korelitz BI. 6-mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity. Ann Intern Med. 1989;111:641–649.
    • (1989) Ann Intern Med , vol.111 , pp. 641-649
    • Present, D.H.1    Meltzer, S.J.2    Krumholz, M.P.3    Wolke, A.4    Korelitz, B.I.5
  • 30
    • 79953781031 scopus 로고    scopus 로고
    • Who wants to take a thiopurine holiday?
    • COI: 1:CAS:528:DC%2BC3MXkt1ehsro%3D, PID: 21468062
    • Higgins PD. Who wants to take a thiopurine holiday? Am J Gastroenterol. 2011;106:556–558.
    • (2011) Am J Gastroenterol , vol.106 , pp. 556-558
    • Higgins, P.D.1
  • 31
    • 0034075584 scopus 로고    scopus 로고
    • Azathioprine for maintenance of remission in Crohn’s disease: benefits outweigh the risk of lymphoma
    • COI: 1:CAS:528:DC%2BD3cXktlaiur4%3D, PID: 10833475
    • Lewis JD, Schwartz JS, Lichtenstein GR. Azathioprine for maintenance of remission in Crohn’s disease: benefits outweigh the risk of lymphoma. Gastroenterology. 2000;118:1018–1024.
    • (2000) Gastroenterology , vol.118 , pp. 1018-1024
    • Lewis, J.D.1    Schwartz, J.S.2    Lichtenstein, G.R.3
  • 32
    • 84875371455 scopus 로고    scopus 로고
    • Long-term outcome of patients with Crohn’s disease who respond to azathioprine
    • COI: 1:CAS:528:DC%2BC3sXhslCit7o%3D, PID: 23142207
    • Camus M, Seksik P, Bourrier A, et al. Long-term outcome of patients with Crohn’s disease who respond to azathioprine. Clin Gastroenterol Hepatol. 2013;11:389–394.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 389-394
    • Camus, M.1    Seksik, P.2    Bourrier, A.3
  • 33
    • 33748626581 scopus 로고    scopus 로고
    • Long-term effectiveness of azathioprine in IBD beyond 4 years: a European multicenter study in 1176 patients
    • COI: 1:CAS:528:DC%2BD28Xpt1Ont78%3D, PID: 16927148
    • Holtmann M, Krummenaeur F, Claas C, et al. Long-term effectiveness of azathioprine in IBD beyond 4 years: a European multicenter study in 1176 patients. Dig Dis Sci. 2006;51:1516–1524.
    • (2006) Dig Dis Sci , vol.51 , pp. 1516-1524
    • Holtmann, M.1    Krummenaeur, F.2    Claas, C.3
  • 34
    • 0018292707 scopus 로고
    • Rederived values of the eight coefficients of the Crohn’s Disease Activity Index (CDAI)
    • COI: 1:STN:280:DyaE1M3jslGnsw%3D%3D, PID: 467941
    • Best WR, Becktel JM, Singelton JW. Rederived values of the eight coefficients of the Crohn’s Disease Activity Index (CDAI). Gastroenterology. 1979;77:843–846.
    • (1979) Gastroenterology , vol.77 , pp. 843-846
    • Best, W.R.1    Becktel, J.M.2    Singelton, J.W.3
  • 35
    • 0028873006 scopus 로고
    • Usual therapy improves perianal Crohn’s disease as measured by a new disease activity index. McMaster IBD Study Group
    • COI: 1:STN:280:DyaK2M7ptVansw%3D%3D, PID: 7884173
    • Irvine EJ. Usual therapy improves perianal Crohn’s disease as measured by a new disease activity index. McMaster IBD Study Group. J Clin Gastroenterol. 1995;20:27–32.
    • (1995) J Clin Gastroenterol , vol.20 , pp. 27-32
    • Irvine, E.J.1
  • 36
    • 0024587749 scopus 로고
    • A new measure of health status for clinical trials in inflammatory bowel disease
    • COI: 1:STN:280:DyaL1M7itFequg%3D%3D, PID: 2644154
    • Guyatt G, Mitchell A, Irvine EJ, et al. A new measure of health status for clinical trials in inflammatory bowel disease. Gastroenterology. 1989;96:804–810.
    • (1989) Gastroenterology , vol.96 , pp. 804-810
    • Guyatt, G.1    Mitchell, A.2    Irvine, E.J.3
  • 37
    • 10744224387 scopus 로고    scopus 로고
    • Comparison of scheduled and episodic treatment strategies of infliximab in Crohn’s disease
    • COI: 1:CAS:528:DC%2BD2cXhvV2rsbs%3D, PID: 14762776
    • Rutgeerts P, Feagan BG, Lichtenstein GR, et al. Comparison of scheduled and episodic treatment strategies of infliximab in Crohn’s disease. Gastroenterology. 2004;126:402–413.
    • (2004) Gastroenterology , vol.126 , pp. 402-413
    • Rutgeerts, P.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 38
    • 0017042882 scopus 로고
    • Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design
    • COI: 1:STN:280:DyaE2s%2FoslGnsw%3D%3D, PID: 795448
    • Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer. 1976;34:585–612.
    • (1976) Br J Cancer , vol.34 , pp. 585-612
    • Peto, R.1    Pike, M.C.2    Armitage, P.3
  • 39
    • 0022367719 scopus 로고
    • Long-term immunosuppressive treatment in Crohn’s disease
    • COI: 1:STN:280:DyaL287ltFegug%3D%3D, PID: 3912958
    • Nyman M, Hansson I, Eriksson S. Long-term immunosuppressive treatment in Crohn’s disease. Scand J Gastroenterol. 1985;20:1197–1203.
    • (1985) Scand J Gastroenterol , vol.20 , pp. 1197-1203
    • Nyman, M.1    Hansson, I.2    Eriksson, S.3
  • 40
    • 0018290191 scopus 로고
    • National Cooperative Crohn’s Disease Study: results of drug treatment
    • COI: 1:STN:280:DyaE1M3jslGnsA%3D%3D, PID: 38176
    • Summers RW, Switz DM, Sessions JT, et al. National Cooperative Crohn’s Disease Study: results of drug treatment. Gastroenterology. 1979;77:847–869.
    • (1979) Gastroenterology , vol.77 , pp. 847-869
    • Summers, R.W.1    Switz, D.M.2    Sessions, J.T.3
  • 41
    • 0034067784 scopus 로고    scopus 로고
    • Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BD3cXis1ens7w%3D, PID: 10734022
    • Dubinsky MC, Lamothe S, Yang HY, et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology. 2000;118:705–713.
    • (2000) Gastroenterology , vol.118 , pp. 705-713
    • Dubinsky, M.C.1    Lamothe, S.2    Yang, H.Y.3
  • 42
    • 83555174812 scopus 로고    scopus 로고
    • Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC38XhtlOrsb0%3D, PID: 22050052
    • Chouchana L, Narjoz C, Beaune P, Loriot MA, Roblin X. Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease. Aliment Pharmacol Ther. 2012;35:15–36.
    • (2012) Aliment Pharmacol Ther , vol.35 , pp. 15-36
    • Chouchana, L.1    Narjoz, C.2    Beaune, P.3    Loriot, M.A.4    Roblin, X.5
  • 43
    • 84890562279 scopus 로고    scopus 로고
    • Randomised clinical trial: individualised vs. weight-based dosing of azathioprine in Crohn’s disease
    • COI: 1:CAS:528:DC%2BC3sXhvFOjsLjL, PID: 24237037
    • Dassopoulos T, Dubinsky MC, Bentsen JL, et al. Randomised clinical trial: individualised vs. weight-based dosing of azathioprine in Crohn’s disease. Aliment Pharmacol Ther. 2014;39:163–175.
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 163-175
    • Dassopoulos, T.1    Dubinsky, M.C.2    Bentsen, J.L.3
  • 44
    • 77953726380 scopus 로고    scopus 로고
    • International AZT-2 Study Group. Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn’s disease with endoscopic recurrence: efficacy and safety results of a randomized, double-blind, double-dummy, multicentre trial
    • COI: 1:CAS:528:DC%2BC3cXos1Ghtbs%3D, PID: 20551460
    • Reinisch W, Angelberger S, Petritsch W, et al. International AZT-2 Study Group. Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn’s disease with endoscopic recurrence: efficacy and safety results of a randomized, double-blind, double-dummy, multicentre trial. Gut. 2010;59:752–759.
    • (2010) Gut , vol.59 , pp. 752-759
    • Reinisch, W.1    Angelberger, S.2    Petritsch, W.3
  • 45
    • 77953801701 scopus 로고    scopus 로고
    • Review article: malignancy on thiopurine treatment with special reference to inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC3cXpslWls74%3D, PID: 20412066
    • Smith MA, Irving PM, Marinaki AM, Sanderson JD. Review article: malignancy on thiopurine treatment with special reference to inflammatory bowel disease. Aliment Pharmacol Ther. 2010;32:119–130.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 119-130
    • Smith, M.A.1    Irving, P.M.2    Marinaki, A.M.3    Sanderson, J.D.4


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