A 90-day study of sub-chronic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in Sprague Dawley rats

International Journal of Nanomedicine

Volumn 9, Issue , 2014, Pages

  Park, Hark Soo ^a   Kim, Seon Ju ^a   Lee, Taek Jin ^a   Kim, Geon Yong ^a   Meang, Eunho ^a   Hong, Jeong Sup ^a   Kim, Su Hyon ^a   Koh, Sang Bum ^a   Hong, Seung Guk ^a   Sun, Yle Shik ^a   Kang, Jin Seok ^b   Kim, Yu Ri ^c   Kim, Meyoung Kon ^c   Jeong, Jayoung ^d   Lee, Jong Kwon ^d   Son, Woo Chan ^e   Park, Jae Hak ^f  

^a Korea Testing and Research Institute   (South Korea)

^b Namseoul University   (South Korea)

^c Korea University   (South Korea)

^d National Institute of Food and Drug Safety Evaluation   (South Korea)

^e University of Ulsan College of Medicine   (South Korea)

^f Seoul National University   (South Korea)

Author keywords

No observed adverse effect level; Oral toxicity study; Positive charge; ZnO

Indexed keywords

ALBUMIN; HEMOGLOBIN; ZINC OXIDE NANOPARTICLE; CATION; METAL NANOPARTICLE; ZINC OXIDE;

ACINAR CELL; ALBUMIN BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATROPHY; AUTOPSY; BIOACCUMULATION; BODY WEIGHT; CELL VOLUME; CHEMICAL ANALYSIS; CHRONIC TOXICITY; CONTROLLED STUDY; DEATH; EDEMA; ERYTHROCYTE COUNT; EXPERIMENTAL STUDY; FEMALE; FLUID INTAKE; FOOD INTAKE; FUNCTIONAL ASSESSMENT; GASTRIC MUCOSA; GASTRITIS; HEMATOCRIT; HEMOGLOBIN DETERMINATION; HISTOPATHOLOGY; MALE; NONHUMAN; ORGAN WEIGHT; PARTICLE SIZE; PROTEIN DETERMINATION; RAT; RETINA DISEASE; SALIVATION; SPRAGUE DAWLEY RAT; TOXICITY TESTING; URINALYSIS; VISUAL SYSTEM EXAMINATION; ANIMAL; CHEMISTRY; DRUG EFFECTS; ORAL DRUG ADMINISTRATION; PANCREAS; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; CATIONS; EDEMA; METAL NANOPARTICLES; PANCREAS; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; TOXICITY TESTS, SUBCHRONIC; ZINC OXIDE;

EID: 84937955374     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S57927     Document Type: Article

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