How useful is optogenetic activation in determining neuronal function within dynamic circuits?

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 29, 2015, Pages E3755-

  Grace, Kevin P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC NERVE CELL; HUMAN; LATERODORSAL TEGMENTAL NUCLEUS; LETTER; NERVE CELL; OPTOGENETICS; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; PONS RETICULAR FORMATION; PRIORITY JOURNAL; REM SLEEP; ANIMAL; MALE; PHYSIOLOGY; TEGMENTUM;

ANIMALS; CHOLINERGIC NEURONS; MALE; SLEEP, REM; TEGMENTUM MESENCEPHALI;

EID: 84937936209     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1506188112     Document Type: Letter

References (5)

1. Van Dort CJ, et al. (2015) Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep. Proc Natl Acad Sci USA 112(2):584-589.
2. Huitron-Resendiz S, et al. (2005) Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons. J Neurosci 25(23):5465-5474.
3. Grace KP, Vanstone LE, Horner RL (2014) Endogenous cholinergic input to the pontine REM sleep generator is not required for REM sleep to occur. J Neurosci 34(43):14198-14209.
4. Pollock MS, Mistlberger RE (2005) Microinjection of neostigmine into the pontine reticular formation of the mouse: Further evaluation of a proposed REM sleep enhancement technique. Brain Res 1031(2):253-267.
5. Jego S, et al. (2013) Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus. Nat Neurosci 16(11):1637-1643.