Quantifying the healthcare costs of treating severely bleeding major trauma patients: A national study for England

Critical Care

Volumn 19, Issue 1, 2015, Pages

  Campbell, Helen E ^a   Stokes, Elizabeth A ^a   Bargo, Danielle N ^b   Curry, Nicola ^c   Lecky, Fiona E ^d   Edwards, Antoinette ^d   Woodford, Maralyn ^d   Seeney, Frances ^e   Eaglestone, Simon ^f   Brohi, Karim ^f   Gray, Alastair M ^a   Stanworth, Simon J ^g  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ELI LILLY AND COMPANY   (United States)

^c CHURCHILL HOSPITAL   (United Kingdom)

^d SALFORD ROYAL NHS FOUNDATION TRUST   (United Kingdom)

^e NHS BLOOD AND TRANSPLANT   (United Kingdom)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BLEEDING; COHORT ANALYSIS; COST BENEFIT ANALYSIS; COST OF ILLNESS; DEMOGRAPHY; DISEASE SEVERITY; FEMALE; HEALTH CARE COST; HOSPITAL DISCHARGE; HOSPITAL PATIENT; HOSPITAL READMISSION; HUMAN; INJURY; INJURY SCALE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RESOURCE MANAGEMENT; UNITED KINGDOM; AGED; ARTIFICIAL VENTILATION; BLOOD COMPONENT THERAPY; CLINICAL AUDIT; ECONOMICS; EMERGENCY HEALTH SERVICE; ENGLAND; HEMORRHAGE; HOSPITAL COST; HOSPITAL EMERGENCY SERVICE; HOSPITALIZATION; INTENSIVE CARE; MIDDLE AGED; WOUNDS AND INJURIES;

ADULT; AGED; BLOOD COMPONENT TRANSFUSION; CRITICAL CARE; EMERGENCY MEDICAL SERVICES; EMERGENCY SERVICE, HOSPITAL; ENGLAND; FEMALE; HEMORRHAGE; HOSPITAL COSTS; HOSPITALIZATION; HUMANS; INJURY SEVERITY SCORE; MALE; MEDICAL AUDIT; MIDDLE AGED; PATIENT READMISSION; RESPIRATION, ARTIFICIAL; WOUNDS AND INJURIES;

EID: 84937865359     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-015-0987-5     Document Type: Article

References (30)

1. Curry N, Hopewell S, Doree C, Hyde C, Brohi K, Stanworth S. The acute management of trauma hemorrhage: a systematic review of randomized controlled trials. Crit Care. 2011;15:R92.
2. Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, et al. The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess. 2013;17:1-79.
3. Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, et al. Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med. 2011;39:2652-8.
4. Stanworth SJ, Morris TP, Gaarder C, Goslings JC, Maegele M, Cohen MJ, et al. Reappraising the concept of massive transfusion in trauma. Crit Care. 2010;14:R239.
5. Fuller G, Bouamra O, Woodford M, Jenks T, Stanworth S, Allard S, et al. Recent massive blood transfusion practice in England and Wales: view from a trauma registry. Emerg Med J. 2012;29:118-23.
6. Driessen A, Schäfer N, Albrecht V, Schenk M, Fröhlich M, Stürmer EK, et al. Infrastructure and clinical practice for the detection and management of trauma-associated haemorrhage and coagulopathy. Eur J Trauma Emerg Surg. 2014. doi: 10.1007/s00068-014-0455-y .
7. Morris S, Ridley S, Munro V, Christensen MC. Cost effectiveness of recombinant activated factor VII for the control of bleeding in patients with severe blunt trauma injuries in the United Kingdom. Anaesthesia. 2007;62:43-52.
8. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313:471-82.
9. Christensen MC, Nielsen TG, Ridley S, Lecky FE, Morris S. Outcomes and costs of penetrating trauma injury in England and Wales. Injury. 2008;39:1013-25.
10. Christensen MC, Ridley S, Lecky FE, Munro V, Morris S. Outcomes and costs of blunt trauma in England and Wales. Crit Care. 2008;12:R23.
11. Dzik W, Blajchman M, Fergusson D, Hameed M, Henry B, Kirkpatrick A, et al. Clinical review: Canadian national advisory committee on blood and blood products - massive transfusion consensus conference 2011: report of the panel. Crit Care. 2011;15:242.
12. Robinson R. Cost-effectiveness analysis. BMJ. 1993;307:793-5.
13. The Trauma Audit and Research Network. TARN. https://www.tarn.ac.uk/ . (2014). Accessed 15 June 2014.
14. Stanworth SJ, Davenport R, Curry N, Seeney F, Eaglestone S, Edwards A, et al. Continuing High Mortality from Trauma Haemorrhage and Opportunities for Improvement in Transfusion Practice: An Observational Study in England and Wales (submitted).
15. Department of Health. NHS National Schedule of Reference Costs 2012-13. https://www.gov.uk/government/publications/nhs-reference-costs-2012-to-2013 . (2013). Accessed 12 Jan 2014.
16. Dasta JF, McLaughlin TP, Mody SH, Piech CT. Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Crit Care Med. 2005;33:1266-71.
17. Curtis L. Unit costs of health and social care 2013. Canterbury: Personal and Social Services Research Unit, University of Kent; 2013.
18. White IR, Royston P, Wood AM. Multiple imputation using chained equations: issues and guidance for practice. Stat Med. 2011;30:377-99.
19. Briggs A, Clark T, Wolstenholme J, Clarke P. Missing... presumed at random: cost-analysis of incomplete data. Health Econ. 2003;12:377-92.
20. Health and Social Care Information Centre. Hospital Episode Statistics. http://www.hscic.gov.uk/hes . (2013). Accessed 15 Jan 2014.
21. Campbell H, Stokes E, Bargo D, Logan R, Mora A, Hodge R, et al. Costs and quality of life associated with acute upper gastrointestinal bleeding in the UK: cohort analysis of patients in a cluster randomised trial. BMJ Open. 2015;5:e007230.
22. Nixon R, Wonderling D, Grieve R. Non-parametric methods for cost-effectiveness analysis: the central limit theorem and the bootstrap compared. Health Econ. 2010;19:316-33.
23. Office for National Statistics. Table 1: 2010-based subnational population projections by sex and five year age groups for England and the Regions. In: 2010-based subnational population projections for England. London: Office for National Statistics; 2012.
24. Spahn D, Bouillon B, Cerny V, Coats T, Duranteau J, Fernandez-Mondejar E, et al. Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care. 2013;17:R76.
25. Weir S, Salkever DS, Rivara FP, Jurkovich GJ, Nathens AB, MacKenzie EJ. One-year treatment costs of trauma care in the USA. Expert Rev Pharmacoecon Outcomes Res. 2010;10:187-97.
26. Information Services Division Scotland. Theatres Costs-Detailed Tables-R142X. http://www.isdscotland.org/Health-Topics/Finance/Costs/Detailed-Tables/Theatres.asp . (2013). Accessed 1 Feb 2014.
27. World Health Organisation Expert Committee. The selection and use of essential medicines. WHO technical report series. Geneva, Switzerland: World Health Organisation; 2006.
28. Royal Pharmacutical Society of Great Britain. British National Formulary 66. London: BMJ Group and RPS Publishing; 2013.
29. Trauma.org. Resuscitation: the trauma team. http://www.trauma.org/archive/resus/traumateam.html . (1995). Accessed 12 Oct 2013.
30. Little R, Rubin D. Statistical analysis with missing data. New York: J Wiley and Sons; 1987.