Childhood-onset systemic lupus erythematosus in Singapore: Clinical phenotypes, disease activity, damage, and autoantibody profiles

Lupus

Volumn 24, Issue 9, 2015, Pages 998-1005

  Tan, J H T ^a   Hoh, S F ^a   Win, M T M ^b   Chan, Y H ^b   Das, L ^a   Arkachaisri, T ^a,c  

^a KK WOMEN'S AND CHILDREN'S HOSPITAL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

childhood onset systemic lupus erythematosus; Singapore; Systemic lupus erythematosus

Indexed keywords

ACETYLSALICYLIC ACID; ALENDRONIC ACID; AUTOANTIBODY; AZATHIOPRINE; CALCIUM; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYCHLOROQUINE; METHOTREXATE; MYCOPHENOLATE MOFETIL; PREDNISOLONE; RITUXIMAB; STEROID; THALIDOMIDE; VITAMIN D; ANTINUCLEAR ANTIBODY;

ADOLESCENT; ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; AVASCULAR NECROSIS; BONE NECROSIS; CATARACT; CHILD; CHILDHOOD DISEASE; CHILDHOOD ONSET SYSTEMIC LUPUS ERYTHEMATOSUS; CHINESE; CLUSTER ANALYSIS; COHORT ANALYSIS; CONTROLLED STUDY; DEMOGRAPHY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ACTIVITY; DISEASE REGISTRY; FEMALE; FEVER; HEMATOLOGIC DISEASE; HUMAN; IMMUNOFLUORESCENCE TEST; IMMUNOSUPPRESSIVE TREATMENT; INDIAN; INFLAMMATION; KIDNEY DISEASE; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHADENOPATHY; MAJOR CLINICAL STUDY; MALAY (PEOPLE); MALE; NEPHRITIS; NEUROLOGIC DISEASE; ONSET AGE; OSTEOPOROSIS; OUTCOME ASSESSMENT; PHENOTYPE; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SCHOOL CHILD; SEROLOGY; SINGAPORE; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIA; VALIDATION STUDY; BLOOD; IMMUNOLOGY; LUPUS ERYTHEMATOSUS, SYSTEMIC; PATHOLOGY; PRESCHOOL CHILD;

ADOLESCENT; AGE OF ONSET; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; COHORT STUDIES; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; OUTCOME ASSESSMENT (HEALTH CARE); PHENOTYPE; SINGAPORE;

EID: 84937864831     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203315584413     Document Type: Article

References (41)

1. Mina R, Brunner HI,. Pediatric lupus: are there differences in presentation, genetics, response to therapy, and damage accrual compared with adult lupus? Rheum Dis Clin 2010; 36: 53-80, vii-viii.
2. Klein-Gitelman M, Reiff A, Silverman ED,. Systemic lupus erythematosus in childhood. Rheum Dis Clin 2002; 28: 561-577, vi-vii.
3. Tucker LB, Uribe AG, Fernandez M,. Adolescent onset of lupus results in more aggressive disease and worse outcomes: results of a nested matched case-control study within LUMINA, a multiethnic US cohort (LUMINA LVII). Lupus 2008; 17: 314-322.
4. Tucker LB,. Making the diagnosis of systemic lupus erythematosus in children and adolescents. Lupus 2007; 16: 546-549.
5. Rood MJ, ten Cate R, van Suijlekom-Smit LW,. Childhood-onset systemic lupus erythematosus: clinical presentation and prognosis in 31 patients. Scand J Rheumatol 1999; 28: 222-226.
6. Font J, Cervera R, Espinosa G,. Systemic lupus erythematosus (SLE) in childhood: analysis of clinical and immunological findings in 34 patients and comparison with SLE characteristics in adults. Ann Rheum Dis 1998; 57: 456-459.
7. Costallat LT, Coimbra AM,. Systemic lupus erythematosus: clinical and laboratory aspects related to age at disease onset. Clin Exp Rheumatol 1994; 12: 603-607.
8. Hiraki LT, Benseler SM, Tyrrell PN, Hebert D, Harvey E, Silverman ED,. Clinical and laboratory characteristics and long-term outcome of pediatric systemic lupus erythematosus: a longitudinal study. J Pediatri 2008; 152: 550-556.
9. Brunner HI, Gladman DD, Ibanez D, Urowitz MD, Silverman ED,. Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus. Arthritis Rheum 2008; 58: 556-562.
10. Zonana-Nacach A, Camargo-Coronel A, Yanez P,. Measurement of damage in 210 Mexican patients with systemic lupus erythematosus: relationship with disease duration. Lupus 1998; 7: 119-123.
11. Petri M,. Hopkins lupus cohort: 1999 update. Rheum Dis Clin 2000; 26: 199-213, v.
12. Mok CC, Ho CT, Wong RW, Lau CS,. Damage accrual in southern Chinese patients with systemic lupus erythematosus. J Rheumatol 2003; 30: 1513-1519.
13. Danchenko N, Satia JA, Anthony MS,. Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Lupus 2006; 15: 308-318.
14. Mackie FE, Kainer G, Adib N,. The national incidence and clinical picture of SLE in children in Australia: a report from the Australian Paediatric Surveillance Unit. Lupus 2015; 24: 66-73.
15. Samanta A, Feehally J, Roy S, Nichol FE, Sheldon PJ, Walls J,. High prevalence of systemic disease and mortality in Asian subjects with systemic lupus erythematosus. Ann Rheum Dis 1991; 50: 490-492.
16. Wang F, Wang CL, Tan CT, Manivasagar M,. Systemic lupus erythematosus in Malaysia: a study of 539 patients and comparison of prevalence and disease expression in different racial and gender groups. Lupus 1997; 6: 248-253.
17. Dung NT, Loan HT, Nielsen S, Zak M, Petersen FK,. Juvenile systemic lupus erythematosus onset patterns in Vietnamese children: a descriptive study of 45 children. Pediatr Rheumatol Online J 2012; 10: 38-38.
18. Gulay CB, Dans LF,. Clinical presentations and outcomes of Filipino juvenile systemic lupus erythematosus. Pediatr Rheumatol Online J 2011; 9: 7-7.
19. Supavekin S, Chatchomchuan W, Pattaragarn A, Suntornpoch V, Sumboonnanonda A,. Pediatric systemic lupus erythematosus in Siriraj Hospital. J Med Assoc Thailand 2005; 88 (Suppl 8): S115-S123.
20. Department of Statistics Singapore. Population trends 2014, www.singstat.gov.sg/Publications/publications-and-papers/population-and-population
21. To CH, Mok CC, Tang SS, Ying SK, Wong RW, Lau CS,. Prognostically distinct clinical patterns of systemic lupus erythematosus identified by cluster analysis. Lupus 2009; 18: 1267-1275.
22. To CH, Petri M,. Is antibody clustering predictive of clinical subsets and damage in systemic lupus erythematosus? Arthritis Rheum 2005; 52: 4003-4010.
23. Hochberg MC,. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40: 1725-1725.
24. Decker JL,. American Rheumatism Association nomenclature and classification of arthritis and rheumatism (1983). Arthritis Rheum 1983; 26: 1029-1032.
25. Weening JJ, D Agati VD, Schwartz MM,. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol 2004; 15: 241-250.
26. Gladman DD, Ibanez D, Urowitz MB,. Systemic lupus erythematosus disease activity index 2000. J Rheumatol 2002; 29: 288-291.
27. Ibanez D, Urowitz MB, Gladman DD,. Summarizing disease features over time: I. Adjusted mean SLEDAI derivation and application to an index of disease activity in lupus. J Rheumatol 2003; 30: 1977-1982.
28. Ibanez D, Gladman DD, Urowitz MB,. Adjusted mean Systemic Lupus Erythematosus Disease Activity Index-2K is a predictor of outcome in SLE. J Rheumatol 2005; 32: 824-827.
29. Gladman D, Ginzler E, Goldsmith C,. The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum 1996; 39: 363-369.
30. Arkachaisri T,. Pediatric rheumatology in Southeast Asia: insights from the Singapore experience. Curr Rheumatol Rep 2011; 13: 117-122.
31. Tan JHT, Hoh SF, Arkachaisri T,. Paediatric rheumatology clinic population in Singapore: the KKH experience. Proc Singapore Healthcare 2012; 21: 265-271.
32. Ramirez Gomez LA, Uribe OU, Uribe OO,. Childhood systemic lupus erythematosus in Latin America. The GLADEL experience in 230 children. Lupus 2008; 17: 596-604.
33. Wang LC, Yang YH, Lu MY, Chiang BL,. Retrospective analysis of mortality and morbidity of pediatric systemic lupus erythematosus in the past two decades. J Microbiol Immunol Infect 2003; 36: 203-208.
34. Wikipedia. Singapore, http://en.wikipedia.org/wiki/Singapore (accessed 8 August 2014).
35. Gedalia A, Molina JF, Molina J, Uribe O, Malagon C, Espinoza LR,. Childhood-onset systemic lupus erythematosus: a comparative study of African Americans and Latin Americans. J Natl Med Assoc 1999; 91: 497-501.
36. Pluchinotta FR, Schiavo B, Vittadello F, Martini G, Perilongo G, Zulian F,. Distinctive clinical features of pediatric systemic lupus erythematosus in three different age classes. Lupus 2007; 16: 550-555.
37. Hoffman IE, Lauwerys BR, De Keyser F,. Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus. Ann Rheum Dis 2009; 68: 412-415.
38. Wu XY, Song HM, Zeng XF,. Clinical manifestations, laboratory test, treatment and outcome of neuropsychiatric involvement in pediatric systemic lupus erythematosus patients. Chin J Pediatr 2009; 47(4): 286-290.
39. Jurencak R, Fritzler M, Tyrrell P, Hiraki L, Benseler S, Silverman E,. Autoantibodies in pediatric systemic lupus erythematosus: ethnic grouping, cluster analysis, and clinical correlations. J Rheumatol 2009; 36: 416-421.
40. Brunner HI, Silverman ED, To T, Bombardier C, Feldman BM,. Risk factors for damage in childhood-onset systemic lupus erythematosus: cumulative disease activity and medication use predict disease damage. Arthritis Rheum 2002; 46: 436-444.
41. Ravelli A, Duarte-Salazar C, Buratti S,. Assessment of damage in juvenile-onset systemic lupus erythematosus: a multicenter cohort study. Arthritis Rheum 2003; 49: 501-507.