The social burden of hypoglycemia in the elderly

Acta Diabetologica

Volumn 52, Issue 4, 2015, Pages 677-685

  Nicolucci, Antonio ^a,b   Pintaudi, Basilio ^b   Rossi, Maria Chiara ^b   Messina, Roberto ^c   Dotta, Francesco ^a,d,e   Frontoni, Simona ^a   Caputo, Salvatore ^a,f   Lauro, Renato ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b Department of Clinical Pharmacology and Epidemiology Fondazione Mario Negri Sud ^*  (Italy)

^c FederAnziani   (Italy)

^d UNIVERSITY OF SIENA   (Italy)

^e Fondazione Umberto Di Mario ONLUS   (Italy)

^f CATHOLIC UNIVERSITY   (Italy)

Author keywords

Distress; Elderly; Fear of hypoglycemia; Hypoglycemia; Quality of life

Indexed keywords

INSULIN; ORAL ANTIDIABETIC AGENT;

AGED; ARTICLE; ASSESSMENT OF HUMANS; CLINICAL FEATURE; CLINICAL PRACTICE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DEMOGRAPHY; DIABETES RELATED DISTRESS; DISEASE ASSOCIATION; DISEASE DURATION; DISTRESS SYNDROME; FEAR; FEAR OF HYPOGLYCEMIA; FEAR OF HYPOGLYCEMIA QUESTIONNAIRE; FEMALE; HIGH RISK POPULATION; HUMAN; HYPOGLYCEMIA; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROBLEM AREAS IN DIABETES SHORT FORM 5; PSYCHOLOGICAL WELL BEING; QUALITY OF LIFE; QUESTIONNAIRE; SEX RATIO; SOCIAL BURDEN; SOCIAL PROBLEM; SYMPTOMATIC HYPOGLYCEMIA; WELL BEING INDEX 5; CHEMICALLY INDUCED; COMPLICATION; DIABETES MELLITUS, TYPE 2; ETIOLOGY; ITALY; MENTAL STRESS; MIDDLE AGED; PREVALENCE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYPOGLYCEMIA; INSULIN; ITALY; MALE; MIDDLE AGED; PREVALENCE; QUALITY OF LIFE; STRESS, PSYCHOLOGICAL; SURVEYS AND QUESTIONNAIRES;

EID: 84937814788     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-015-0717-0     Document Type: Article

References (39)

1. Kahn SE, Cooper ME, Del Prato S (2014) Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet 383(9922):1068–1083. doi:10.1016/S0140-6736(13)62154-6
2. Gill TM, Gahbauer EA, Han L, Allore HG (2010) Trajectories of disability in the last year of life. N Engl J Med 362(13):1173–1180. doi:10.1056/NEJMoa0909087
3. Stahn A, Pistrosch F, Ganz X, Teige M, Koehler C, Bornstein S, Hanefeld M (2014) Relationship between hypoglycemic episodes and ventricular arrhythmias in patients with type 2 diabetes and cardiovascular diseases: silent hypoglycemias and silent arrhythmias. Diabetes Care 37(2):516–520. doi:10.2337/dc13-0600
4. Nordin C (2014) The proarrhythmic effect of hypoglycemia: evidence for increased risk from ischemia and bradycardia. Acta Diabetol 51(1):5–14. doi:10.1007/s00592-013-0528-0
5. Malabu UH, Vangaveti VN, Kennedy RL (2014) Disease burden evaluation of fall-related events in the elderly due to hypoglycemia and other diabetic complications: a clinical review. Clin Epidemiol 14(6):287–294. doi:10.2147/CLEP.S66821
6. Whitmer RA, Karter AJ, Yaffe K, Quesenberry CP Jr, Selby JV (2009) Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 301(15):1565–1572
7. Pilotto A, Noale M, Maggi S, Addante F, Tiengo A, Perin PC, Rengo G, Crepaldi G (2014) Hypoglycemia is independently associated with multidimensional impairment in elderly diabetic patients. Biomed Res Int. doi:10.1155/2014/906103
8. Kong AP, Yang X, Luk A, Ma RC, So WY, Ozaki R, Ting R, Cheung K, Ho CS, Chan MH, Chow CC, Chan JC (2014) Severe hypoglycemia identifies vulnerable patients with type 2 diabetes at risk for premature death and all-site cancer: the Hong Kong diabetes registry. Diabetes Care 37(4):1024–1031. doi:10.2337/dc13-2507
9. Bonds DE, Miller ME, Bergenstal RM, Buse JB, Byington RP, Cutler JA, Dudl RJ, Ismail-Beigi F, Kimel AR, Hoogwerf B, Horowitz KR, Savage PJ, Seaquist ER, Simmons DL, Sivitz WI, Speril-Hillen JM, Sweeney ME (2010) The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ 8(340):b4909. doi:10.1136/bmj.b4909
10. Tsujimoto T, Yamamoto-Honda R, Kajio H, Kishimoto M, Noto H, Hachiya R, Kimura A, Kakei M, Noda M (2014) Prediction of 90-day mortality in patients without diabetes by severe hypoglycemia: blood glucose level as a novel marker of severity of underlying disease. Acta Diabetol [Epub ahead of print]
11. Budnitz DS, Pollock DA, Weidenbach KN, Mendelsohn AB, Schroeder TJ, Annest JL (2006) National surveillance of emergency department visits for outpatient adverse drug events. JAMA 296(15):1858–1866
12. Lundkvist J, Berne C, Bolinder B, Jonsson L (2005) The economic and quality of life impact of hypoglycemia. Eur J Health Econ 6(3):197–202
13. Barendse S, Singh H, Frier BM, Speight J (2012) The impact of hypoglycaemia on quality of life and related patient-reported outcomes in type 2 diabetes: a narrative review. Diabet Med 29(3):293–302
14. Cryer PE (2002) Hypoglycaemia: the limiting factor in the glycaemic management of Type 1 and Type 2 diabetes. Diabetologia 45:937. doi:10.1111/j.1464-5491.2011.03416.x
15. Speight J, Reaney MD, Barnard KD (2009) Not all roads lead to Rome-a review of quality of life measurement in adults with diabetes. Diabet Med 26(4):315–327. doi:10.1111/j.1464-5491.2009.02682.x
16. Depablos-Velasco P, Salguero-Chaves E, Mata-Poyo J, Derivas-Otero B, García-Sánchez R, Viguera-Ester P (2014) Quality of life and satisfaction with treatment in subjects with type 2 diabetes: results in Spain of the PANORAMA study. Endocrinol Nutr 61(1):18–26. doi:10.1016/j.endonu.2013.05.005
17. Bech P, Gudex C, Johansen KS (1996) The WHO (ten) well-being index: validation in diabetes. Psychother Psychosom 65:183–190
18. Hajos TR, Pouwer F, Skovlund SE, Den Oudsten BL, Geelhoed-Duijvestijn PH, Tack CJ et al (2013) Psychometric and screening properties of the WHO-5 well-being index in adult outpatients with Type 1 or Type 2 diabetes mellitus. Diabet Med 30:e63–e69. doi:10.1111/dme.12040
19. Report Conference (2004) 2nd International DAWN Summit: a call-to-action to improve psychosocial care for people with diabetes. Pract Diabetes Int 21:201–208
20. Peyrot M, Rubin RR, Lauritzen T, Snoek FJ, Matthews DR, Skovlund SE (2005) Psychosocial problems and barriers to improved diabetes management: results of the cross-national diabetes attitudes, wishes and needs (DAWN) study. Diabet Med 22:1379–1385
21. Skovlund SE, Peyrot M (2005) The diabetes attitudes, wishes, and needs (DAWN) program: a new approach to improving outcomes in diabetes care. Diabetes Spectr 18:136–142. doi:10.3109/13814788.2012.704360
22. International Diabetes Federation (2004) Putting people at the centre of care: DAWN in action. Diabetes Voice 49:1–49
23. Henkel V, Mergl R, Kohnen R, Maier W, Möller HJ, Hegerl U (2003) Identifying depression in primary care: a comparison of different methods in a prospective cohort study. BMJ 326:200–201
24. de Wit M, Pouwer F, Gemke RJ, Delemarre-van de Waal HA, Snoek FJ (2007) Validation of the WHO-5 Well-Being Index in adolescents with type 1 diabetes. Diabetes Care 30:2003–2006
25. McGuire BE, Morrison TG, Hermanns N, Skovlund S, Eldrup E, Gagliardino J et al (2010) Short-form measures of diabetes-related emotional distress: the problem areas in diabetes scale (PAID)-5 and PAID-1. Diabetologia 53:66–69. doi:10.1007/s00125-009-1559-5
26. Polonsky WH, Anderson BJ, Lohrer PA, Welch G, Jacobson AM, Aponte JE et al (1995) Assessment of diabetes-related distress. Diabetes Care 18:754–760
27. Welch G, Weinger K, Anderson B, Polonsky WH (2003) Responsiveness of the problem areas in diabetes (PAID) questionnaire. Diabet Med 20:69–72
28. Nicolucci A, Kovacs Burns K, Holt RI, Comaschi M, Hermanns N, Ishii H, Kokoszka A, Pouwer F, Skovlund SE, Stuckey H, Tarkun I, Vallis M, Wens J, Peyrot M (2013) DAWN2 Study Group. Diabetes attitudes, wishes and needs second study (DAWN2™): cross-national benchmarking of diabetes-related psychosocial outcomes for people with diabetes. Diabet Med 30(7):767–777. doi:10.1111/dme.12245
29. Östenson CG, Geelhoed-Duijvestijn P, Lahtela J, Weitgasser R, Markert Jensen M, Pedersen-Bjergaard U (2014) Self-reported non-severe hypoglycaemic events in Europe. Diabet Med 31(1):92–101. doi:10.1111/dme.12261
30. Kulzer B, Seitz L, Kern W (2014) Real-world patient-reported rates of non-severe hypoglycaemic events in Germany. Exp Clin Endocrinol Diabetes 122(3):167–172. doi:10.1055/s-0033-1363688
31. Brod M, Christensen T, Bushnell DM (2012) The impact of non-severe hypoglycemic events on daytime function and diabetes management among adults with type 1 and type 2 diabetes. J Med Econ 15(5):869–877. doi:10.3111/13696998.2012.686465
32. Frier BM (2007) Living with hypoglycaemia. In: Frier BM (ed) Hypoglycaemia in Clinical Diabetes, 2nd edn. Wiley, Chichester
33. Kovacs Burns K, Nicolucci A, Holt RI, Willaing I, Hermanns N, Kalra S, Wens J, Pouwer F, Skovlund SE, Peyrot M (2013) DAWN2 study group. Diabetes attitudes, wishes and needs second study (DAWN2™): cross-national benchmarking indicators for family members living with people with diabetes. Diabet Med 30(7):778–788. doi:10.1111/dme.12239
34. Akram K, Pedersen-Bjergaard U, Borch-Johnsen K, Thorsteinsson B (2006) Frequency and risk factors of severe hypoglycemia in insulin-treated type 2 diabetes: a literature survey. J Diabetes Complicat 20:402–408
35. Gonzalez JS, Delahanty LM, Safren SA, Meigs JB, Grant RW (2008) Differentiating symptoms of depression from diabetes-specific distress: relationships with self-care in type 2 diabetes. Diabetologia 51(10):1822–1825. doi:10.1007/s00125-008-1113-x
36. Anderson RM, Funnell MM (2010) Patient empowerment: myths and misconceptions. Patient Educ Couns 79(3):277–282. doi:10.1016/j.pec.2009.07.025
37. Alvarez-Guisasola F, Yin DD, Nocea G, Qiu Y, Mavros P (2010) Association of hypoglycemic symptoms with patients’ rating of their health-related quality of life state: a cross sectional study. Health Qual Life Outcomes 8:86. doi:10.1186/1477-7525-8-86
38. Bradley C, Speight J (2002) Patient perceptions of diabetes and diabetes therapy: assessing quality of life. Diabetes Metab Res Rev 18:S64–S69
39. Gulli G, Frasson S, Borzì V, Fontanella A, Grandi M, Marengo C, Nicolucci A, Pastorelli R, Solerte B, Gatti A, Raimondo FC, Bonizzoni E, Gussoni G, Mazzone A, Ceriello A (2014) Effectiveness of an educational intervention on the management of type 2 diabetic patients hospitalized in Internal Medicine: results from the FADOI-DIAMOND study. Acta Diabetol 51(5):765–770. doi:10.1007/s00592-014-0585-z